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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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单螺杆蒸汽压缩机喷水趋壁成膜特性研究

工程热物理学报 2025年第1期46卷 144-150页

作者：代泽宇王增丽中国石油大学(华东)新能源学院青岛266580

为实现单螺杆蒸汽压缩机喷水参数的合理调控,本文通过建立三维单螺旋槽道模型,开展了湿压缩过程喷入冷却水趋壁成膜过程的数值模拟研究,分析了槽道内形成有效水膜的覆盖面积以及喷水质量流量、速度、角度和螺杆转速等关键参数对其影响... 详细信息

为实现单螺杆蒸汽压缩机喷水参数的合理调控,本文通过建立三维单螺旋槽道模型,开展了湿压缩过程喷入冷却水趋壁成膜过程的数值模拟研究,分析了槽道内形成有效水膜的覆盖面积以及喷水质量流量、速度、角度和螺杆转速等关键参数对其影响规律。研究结果表明,喷水质量流量对形成有效水膜覆盖面积影响最大,最大增幅为6.77×10^(−4) m^(2);喷水速度、角度及螺杆转速引起的有效水膜覆盖面积增幅依次为喷水质量流量引起增幅的59.85%、50.68%和47.79%。

关键词：单螺杆压缩机湿压缩过程数值模拟趋壁成膜特性影响规律

State of the art of lightweight aggregates used in lightweight refractories for working lining of high-temperature furnaces

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Journal of Iron and Steel Research International 2024年第6期31卷 1320-1343页

作者： Wei Zhang wen-yong dai Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina Research and Development Department AGC Plibrico(Dalian)Industries Inc.Dalian 116600LiaoningChina

Lightweight refractories for the working lining of high-temperature furnaces play an important role in the smelting of advanced steels and *** prepare lightweight refractories for the working lining of high-temperature furnaces,the synthesis of lightweight aggregates is the ***,the research on the synthesis of lightweight aggregates with high service temperature,low thermal conductivity,high strength,and good slag resistance has received widespread *** available literature on the synthesis of lightweight aggregates was summarized,including corundum,mullite,mullite-corundum,spinel,corundum-spinel,cordierite,cordierite-mullite,calcium hexaluminate,corundum-calcium hexaluminate,bauxite,magnesia,magnesia-based,and forsterite-based ***,the future development trend of lightweight aggregates was proposed.

关键词： Lightweight aggregate Lightweight refractory Working lining Apparent porosity Closed porosity Thermal conductivity Pore-forming approach

A Generalization of a Theorem of Liao

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Acta Mathematica Sinica,English Series 2006年第1期22卷 207-210页

作者： Xiong Ping dai zuo Ling ZHOU Depatment of Mathematics Nanjing University Nanjing 210093 P. R. China Lingnan College of Zhongshan University Guangzhou 510275 P. R. China

Let X be a metrizable space and let φ：R× X → X be a continuous flow on X. For any given {φt}-invariant Borel probability measure, this paper presents a {φt}-invariant Borel subset of X satisfying the requirements of the classical ergodic theorem for the contiImous flow （X, {φt}）. The set is more restrictive than the ones in the literature, but it might be more useful and convenient, particularly for non-uniformly hyperbolic systems and skew-product flows.

关键词： Ergodic theorem Liao theory

A New Phenylpropanoid Glycoside from Dragon＇s Blood of Dracaena cambodiana

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Chemical Research in Chinese Universities 2013年第3期29卷 483-486页

作者： SHEN Hai-yan WANG Hui zuo wen-jian ZHAO You-xing LUO Ying MEI wen-li dai Hao-fu Key Laboratory of Biology and Genetic Resources of Tropical Crops Ministry of Agriculture Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 571101 P R. China Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine Haikou 571101 P. R. China Horticultural and Garden College Hainan University Haikou 570228 P. R. China

A new phenylpropanoid glycoside, named cambodianin F（1）, together with three known compounds, 1-O-β-D-glucopyranosyl-2-hydroxy-4-allylbenzene（ 2 ）, 1-O-（ 6-O-a-L-rhamnopyranosyl-β-D-glucopyranosyl）-2-hydroxy- 4-allylbenzene（3） and 1,2-di-O-β-D-glucopyranosyl-4-allylbenzene（4） was isolated from the dragon＇s blood of Dracaena cambodiana. The new compound was elucidated by HR-ESI-MS and spectroscopic techniques（UV, IR, 1D and 2D NMR）.

关键词： Dragon's blood Dracaena cambodiana Cambodianin F

Surface-confined persistent luminescence with amplified FRET efficiency for cell-cell communication monitoring

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Science China Chemistry 2025年

作者： Ziyun Miao wenjing dai Yubin Jin Bing Qi Jiayi Chen Lingling Qiu Yurong Wei Jie Wang The Key Lab of Health Chemistry&Molecular Diagnosis of Suzhou College of ChemistryChemical Engineering&Materials ScienceSoochow University

Microbial communication monitoring is vital for understanding the mechanisms beneath gut microbiota equilibrium, infections,and biomanufacturing. Herein, we reported monitoring bacterial communication by surface-confined persistent ***, we constructed core-shell structured Zn1.4Ga1.2Ge0.4O4@Zn1.4Ga1.2Ge0.4O4:Cr（ZGGO@ZGGO:Cr） persistent luminescence nanoparticles（PLNPs） with amplified FRET efficiency for the detection of azoreductase（AzoR） that participates in bacterial communication. ZGGO@ZGGO:Cr nanoparticles were functionalized with an azo black hole quencher（ZGGO@ZGGO:Cr-BHQ-3）. Due to the proximity of surface-confined persistent luminescence with the surface-bound BHQ-3,ZGGO@ZGGO:Cr-BHQ-3 exhibited a FRET efficiency up to 1.6 times that of traditional ZGGO:Cr-BHQ-3. Further, the specific catalytic reduction of azo bonds in BHQ-3 by bacterial extracellular AzoR recovers the persistent luminescence of ZGGO@ZGGO:Cr. ZGGO@ZGGO:Cr-BHQ-3 displayed superior sensitivity and speed in detecting extracellular AzoR over ZGGO:Cr-BHQ-3, attributed to its surface-confined persistent luminescence. We found that the peak secretion of AzoR occurs during the exponential growth period of bacteria including S. aureus and E. coli based on the persistent luminescence recovery rate of ZGGO@ZGGO:Cr-BHQ-3. Furthermore, ZGGO@ZGGO:Cr-BHQ-3 was used to probe the communication between different bacterial species. R. palustris is a kind of lycopene-production bacteria. We found that the cohabitation of R. palustris and S. putrefaciens boosted both AzoR secretion and lycopene production. Moreover, the secretion and activity of AzoR positively correlated with lycopene production, suggesting that AzoR may participate in the communication between R. palustris and S. putrefaciens to promote lycopene production. This study offers a robust method to enhance PLNP-based biosensing sensitivity and provides a promising strategy for microbial communication monitoring.

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong Xiao Chen Chen Shuo Wang Zi-Yin dai Hideo Kimura Cui Ni Chuan-Xin Hou Xue-Qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

Hydrodynamic improvement of a goose-head pattern braided reach in lower Yangtze River

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Journal of Hydrodynamics 2019年第3期31卷 614-621页

作者： wen-hong dai Wei Ding State Key Laboratory of Hydrology- Water Resources and Hydraulic Engineering Nanjing 210098 China College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Hohai University Nanjing 210098 China

The Three Gorges Reservoir (TGR) began operation in 2003 with alterations in the natural hydrological regime and with severe environmental impacts. Baguazhou Reach, a goose-head pattern of braided channels in the lower Yangtze River has emerged due to a series of changes in the water and sediment conditions caused by the TGR. This paper makes simulations of the hydrodynamic characteristics under the condition of clear water releasing from the TGR and analyzes the features of deformation within the branches of the reach, as well as predicts the future development of the hydrodynamic improvement and the additional fluvial processes. The results show that the decline of the tributary is mainly due to the weakening of the inflow energy and the channel resistance. The particular protective measures can effectively improve the hydrodynamic performance and the present situation but, they all result in a deflection of the main water flow and increase the local velocity, and over the long term, leading to the deposition in the junction areas, where a special protection is required.

关键词： Braided channel hydrodynamic enhancement