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Novel glucose-lowering drugs for non-alcoholic fatty liver disease

World Journal of diabetes 2021年第1期12卷 84-97页

作者： zuo-di fu Xiao-Ling Cai Wen-Jia Yang Ming-Ming Zhao Ran Li Yu-Feng Li Department of Endocrinology Beijing Friendship Hospital Pinggu CampusBeijing 101200China Department of Endocrinology and Metabolism Peking University People’s HospitalBeijing 100044China The Institute of Cardiovascular Sciences School of Basic Medical SciencesHealth Science CenterPeking UniversityBeijing 100079China Sport Science School Beijing Sport UniversityBeijing 100078China Department of Endocrinology Beijing Friendship Hospital Pinggu CampusCapital Medical UniversityBeijing 101200China

BACKGROUND The efficacy of novel glucose-lowering drugs in treating non-alcoholic fatty liver disease(NAFLD)is *** To evaluate the efficacy of glucose-lowering drugs dipeptidyl peptidase-4(DPP-4)inhibitors,glucagon-like peptide-1 receptor agonists(GLP-1 RAs),and sodiumglucose cotransporter 2(SGLT2)inhibitors in treating NAFLD and to perform a comparison between these *** Electronic databases were systematically *** inclusion criteria were:Randomized controlled trials comparing DPP-4 inhibitors,GLP-1 RAs,or SGLT2 inhibitors against placebo or other active glucose-lowering drugs in NAFLD patients,with outcomes of changes in liver enzyme[alanine aminotransferase(ALT)and/or aspartate aminotransferase(AST)]from *** Nineteen studies were finally included in this *** with placebo or other active glucose-lowering drug treatment,treatment with DPP-4 inhibitors,GLP-1 RAs,and SGLT2 inhibitors all led to a significant decrease in ALT change and AST change from *** difference between the DPP-4 inhibitor and SGLT2 inhibitor groups in ALT change was significant in favor of DPP-4 inhibitor treatment(Pdicating a beneficial effect in improving liver injury and reducing liver fat in NAFLD patients.

关键词： Non-alcoholic fatty liver disease Glucose-lowering drug Meta-analysis dipeptidyl peptidase-4 inhibitor Sodium-glucose cotransporter 2 inhibitor Glucagon-like peptide-1 receptor agonist

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Measuring accessibility of bus system based on multi-source traffic data

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Geo-Spatial Information Science 2020年第3期23卷 248-257,I0005页

作者： Yufan zuo Zhiyuan Liu Xiao fu School of Transportation Southeast UniversityNanjingChina Jiangsu Key Laboratory of Urban ITS Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic TechnologiesSoutheast UniversityNanjingChina

Accessibility is a representative indicator for evaluating the supply of bus *** studies have evaluated the accessibility from different *** the interaction among land use,bus timetable arrangement and individual factors,a more holistic accessibility measurement is proposed to combine static and dynamic characteristics from multisource traffic *** rationale of the proposed model is verified by a case study of bus system in Shenzhen,China,which is carried out to find the spatial and temporal discrepancy of service of bus *** is found that the adjustment of bus schedule to time-varying travel demand can affect accessibility of bus system and that Land-use development,average bus speed and bus facilities all have positive effects on accessibility of bus *** findings provide sig-nificant reference for transport planning and *** proposed model is not limited to accessibility measuring of bus system,but also applicable to other travel modes.

关键词： Accessibility bus system multi-source traffic data spatial-temporal distribution

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Limit theorems for supremum of Gaussian processes over a random interval

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Applied Mathematics(A Journal of Chinese Universities) 2018年第3期33卷 335-343页

作者： LIN fu-ming PENG zuo-xiang School of Statistics and Management Shanghai University of Finance and Economics School of Mathematics and Statistics Sichuan University of Science & Engineering School of Mathematics and Statistics Southwestern University

Let {X(t), t ≥ 0} be a centered stationary Gaussian process with correlation r(t)such that 1-r(t) is asymptotic to a regularly varying function. With T being a nonnegative random variable and independent of X(t), the... 详细信息

关键词： stationary Gaussian process supremum of a process regularly varying functions random intervals

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Achieving stable relaxor antiferroelectric P phase in NaNbO_(3)-based lead-free ceramics for energy-storage applications

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Journal of Materiomics 2022年第3期8卷 618-626页

作者： Aiwen Xie Jian fu Ruzhong zuo Institute of Electro Ceramics&Devices School of Materials Science and EngineeringHefei University of TechnologyHefei230009China Anhui Key Laboratory of High-performance Non-ferrous Metal Materials School of Materials Science and EngineeringAnhui Polytechnic UniversityWuhu241000China

Compared with antiferroelectric(AFE)orthothombic R phases,AFE orthothombic P phases in Na NbO_(3)(NN)ceramics have been rarely investigated,particularly in the field of energy-storage *** main bottlenedk is closely related to the contradiction between d fficultly achieved stable relaxor AFE P phase and easily induced P-R phase transition during modifying dhemical ***,we reporta novel lead-free AFE ceramic of(1-x)NN-x(Bi_(0.5)K_(0.5))ZrO_(3)((1-x)NN-xBKZ)with a pure AFE P phase str ucture,which exhibits excellent energy-storage characteristics,such as an ultrahigh recoverable energy density(W_(rec))-4.4 J/cm^(3) at x=0.11,a large powder density P_(D)-104 MW/cm^(3) and a fast discharge rate t_(0.9)-45 *** analysis of polarization-field response,Raman spectrum and transmission elecron microscopy demonstrates that the giant amplification of W_(rec) by≥177% should be ma inly ascribed to the simultaneously and effectively enhanced AFE P phase stbility and its relaxor dharacteristics,resulting in a diffused reversible electric field-induced AFE P-ferroelectric phase transition with concurrently *** driving electric *** from mast(1-x)NN-xABO_(3) systems,it was found that the reduced polarizability of B-site cations dominates the enhanced AFE P-phase stability in(1-x)NN-xBKZ ceramics,but the almost unchanged tolerance factor tends to ause the AFE R phase to be induced at a relatively high x value.

关键词： Lead-free ceramic Relaxor antiferroelectric Energy-storage capacitor NaNbO_(3) Phase transition

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Time Sequence Change-Point Model of Electrostatic State Parameters of Aircraft Engine

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 126-134页

作者： fu Yu Wei Dongdong zuo Hongfu Feng Zhengxing College of Aeronautical Engineering Civil Aviation University of China College of Civil Aviation Nanjing University of Aeronautics and Astronautics

Electrostatic monitoring technology of particle charging information can facilitate online monitoring of aero-engine,which effectively enhances engine fault diagnosis and health *** traditional engine state monitoring technologies,aircraft engine monitoring by gas path electrostatic monitoring not only covers the predicted information source itself,but also detects the information that can provide an early warnings for initial fault states through gas path charging *** paper establishes a non-stationary time sequence change-point model for anomaly recognition of electrostatic signals based on change-point theory combined with difference method of non-stationary time ***,electrostatic induction data were utilized by the engine life test for a particular aircraft to validate the proposed *** results indicate that the activity level and the event rate were0.5—0.8(nc)and 50%,respectively,which were far greater than 4—12(pc)and 0—4% under normal working conditions of the engine.

关键词： aero-engine state identification electrostatic monitoring technology time series change-point statistics

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Microstructures and fatigue properties of electron beam welds with beam oscillation for heavy section TC4-DT alloy

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Chinese Journal of Aeronautics 2014年第4期27卷 1015-1021页

作者： fu Pengfei Mao Zhiyong zuo Congjin Wang Yajun Wang Chunming College of Materials Science and Engineering Huazhong University of Science and Technology Science and Technology on Power Beam Processes Laboratory Beijing Aeronautical Manufacturing Technology Research Institute Institute of Mechanical Engineering and Automation Beihang University

With the development of the manufacturing technology, electron beam welding（EBW） is capable of producing titanium alloy large parts in aero fields. To increase the applications and improve the properties, EBW with beam oscillation was investigated on TC4-DT alloy with50 mm thickness. We detected the welding samples by X-ray NDT, observed the microstructures of the welds, and tested the fatigue properties of the joints. The results showed that EBW with beam oscillation improved the weld morphology as well as welding quality, and the microstructure homogeneity of the welds and HAZ along the weld penetration were also improved. The fatigue properties of the joints with beam oscillation were more excellent than those of conventional EBW, even equal to those of the base metal under high stresses. The influences of the processing and the microstructure on the properties with beam oscillation were discussed.

关键词： Beam oscillation Electron beam welding(EBW) Fatigue Microstructure Titanium alloy

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MOdiS image super-resolution via learned topic dictionaries and regression matrices

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光电工程 2017年第10期44卷 957-965页

作者： Deng zuo Faculty of Electrical Engineering and Computer Science Ningbo University

Moderate resolution imaging spectroradiometer(MOdiS) imaging has various applications in the field of ground monitoring,cloud classification and meteorological ***,the limitations of the sensors and external disturbance make the resolution of image still limited in a certain *** goal of this paper is to use a single image super-resolution(SISR) method to predict a high-resolution(HR) MOdiS image from a single low-resolution(LR) ***,although the method based on sparse representation has tackled the ill-posed problem effectively,two fatal issues have been ***,many methods ignore the relationships among patches,resulting in some unfaithful ***,the high computational complexity of sparse coding using l_1 norm is needed in reconstruction *** this work,we discover the semantic relationships among LR patches and the corresponding HR patches and group the documents with similar semantic into topics by probabilistic Latent Semantic Analysis(p LSA).Then,we can learn dual dictionaries for each topic in the low-resolution(LR) patch space and high-resolution(HR) patch space and also pre-compute corresponding regression matrices for dictionary ***,for the test image,we infer locally which topic it corresponds to and adaptive to select the regression matrix to reconstruct HR image by semantic *** method discovered the relationships among patches and pre-computed the regression matrices for ***,our method can greatly reduce the artifacts and get some speed-up in the reconstruction *** manifests that our method performs MOdiS image super-resolution effectively,results in higher PSNR,reconstructs faster,and gets better visual quality than some current state-of-art methods.

关键词：成像光谱仪地面监测编码计算方法

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Application of Acid Modified Catalysts with different SiO_(2) Contents in the Hydrocracking of Light Cycle Oil for Light Aromatics Production

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China Petroleum Processing & Petrochemical Technology 2023年第1期25卷 105-114页

作者： Zhong fu zuo Tongjiu Xie Yonggang Lu Jiangyin Key Laboratory of Oil&Gas Fine Chemicals Ministry of EducationXinjiang Uyghur Autonomous RegionSchool of Chemical EngineeringXinjiang UniversityUrumqi 830046China

A series of functionalized USY/SiO_(2) zeolite composite supports were synthesized using the coating coprecipitation method,with tetraethyl orthosilicate(TEOS)as the silicon source and different ratios of USY to *** metals nickel(Ni)and molybdenum(Mo)were loaded onto the supports using the impregnation ***,a series of hydrogenation catalysts were *** characterization results showed that,compared with the USY catalyst,the addition of a certain quantity of SiO_(2) resulted in the disappearance of the strong acid sites on the catalyst,the number of weak acid and medium strong acid sites decreased,and a certain number of secondary mesoporous structures were *** addition of SiO_(2) reduced the secondary cracking of benzene,toluene,xylene,and ethylbenzene(BTXE)effectively,while excessive amounts of SiO_(2) reduced the hydrogenation activity of the catalyst,leading to a decline in the final yield of *** a maximum SiO_(2) content of 45%,the hydrogenation depth of light cycle oil(LCO)reached an optimum *** hydrogenation performance of LCO was investigated in a fixed bed reactor at 380℃,4 MPa,and H2/oil volume ratio of 800:1,where the gasoline and diesel fractions reached 80.00%and 16.74%,***-YS45 had the highest BTXE selectivity,and the final yield of BTXE reached 21.27%.

关键词： zeolite catalyst hydrocracking SiO_(2) LCO BTXE

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Analysis and Research of the Evidence Theory for Group Decision 36

Analysis and Research of the Evidence Theory for Group Decis...

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第36届中国控制会议

作者： Wenchuan Yang Wen zuo Zhen fu School of Network Security Beijing University of Posts and Telecommunication

ISBN: (纸本)9781538629185

Under the cloud computing environment,expert-based group decision is proposed for fuzzy comprehensive evaluation problem,which has not been studied in the area of secure multi-party *** paper proposes expert-based group decision with the shapley-evidential *** theory put forward based on the evidence *** approach can effectively deal with the relevance,importance,little evidence synthetic *** practical example is given to show the availability of the given *** experimental results map out the correct possibilities for our *** the end,an example is put forward to validate this method with practical decision-making effect.

关键词： estimation information trapezoid fuzzy number the mutual recognition

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Removal effect on Mesocyclops leukarti and mutagenicity with chlorine dioxide

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Journal of Environmental Sciences 2006年第5期18卷 891-896页

作者： zuo Jin-long CUI fu-yi QU BO ZHU Gui-bing School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China Research Center for Eco-Environmental Sciences China Academy of Sciences Beijing 100085 China

Mesocyclops leukarti of zooplankton propagates excessively in eutrophic water body and it cannot be effectively inactivated by the conventional drinking water treatment process. In order to tackle this problem, a study of removal effect on Mesocylops leukarti with chlorine dioxide in a waterworks was performed. The results showed that Mesocyclops leukarti could be effectively removed from water by 1.0 mg/L chlorine dioxide prcoxidation combined with the conventional drinking water treatment process. Higher oxidizability and molecular state of chlorine dioxide in water is the key to the inactivation of Mesocyclops leukarti. The chlorite, disinfection by-products （DBPs） of chlorine dioxide, was stable at 0.45 mg/L, which is lower than that critical value of the USEPA. GC-MS examination showed that the quantity of organic substance in the water treated by chlorine dioxide obviously decreased. Ames test further revealed that the mutagenicity was reduced by chlorine dioxide with respect to prechlorine. The propagation ofMesocyclops leukorti can be inactivated effectively and safely by chlorine dioxide pre-oxidation.

关键词： chlorine dioxide disinfection by-products (DBPs) Mesocyclops leukarti preoxidation mutagenicity

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