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Exosomes derived from microglia overexpressing miR-12.-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury

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Neural Regeneration Research 2024年第9期19卷 2010-2018页

作者： Yan Wang Dai li Lan Zhang Zhenyu Yin Zhaoli Han Xintong Ge Meimei li Jing Zhao Shishuang Zhang Yan zuo Xiangyang Xiong Han Gao Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institute Tianjin Medical University General HospitalTianjinChina

We previously reported that miR-12.-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain ***,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains *** this study,we first used an HT2. scratch injury model to mimic traumatic brain injury,then co-cultured the HT2. cells with BV2.microglia expressing high levels of *** found that exosomes containing high levels of miR-12.-3p attenuated apoptosis and endoplasmic reticulum ***,luciferase reporter assay analysis confirmed that miR-12.-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-12.-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured ***,we delivered microglia-derived exosomes containing miR-12.-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly *** findings suggest that,after repetitive mild traumatic brain injury,miR-12.-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum ***,microglia-derived exosomes containing miR-12.-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury.

关键词： apoptosis C/EBP homologous protein endoplasmic reticulum stress exosome inositol-requiring enzyme 1α microglia miR-12.-3p neuron repetitive mild traumatic brain injury X-box binding protein 1

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Saponin Ⅰ from Shuitianqi(Rhizoma Schizocapasae Plantagineae) inhibits metastasis by negatively regulating the transforming growth factor-β1/Smad7 network and epithelial-mesenchymal transition in the intrahepatic metastasis Bagg's Albino/c mouse model

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Journal of Traditional Chinese Medicine 2024年第4期44卷 642-651页

作者： LYU Meixian ZHOU Huan ZHI limin ZHOU Jinling GAN Rizhi QIN Yanping HE Nengting zuo Qiqi li Hao DONG Min liANG Gang Pharmaceutical College Guangxi Medical UniversityNanning 530022China Department of Pharmacy Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530022China Drug clinical trial Facility office the People's Hospital of Guangxi Zhuang Autonomous RegionNanning 530022China College of Pharmacy Guangxi University of Chinese MedicineNanning 530022China Department of Pharmacy the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530005China Department of Pharmacy People's Hospital of Guangxi HezhouHezhou 542899China Department of Pharmacy Guangzhou Women and Children's Medical Center Liuzhou HospitalLiuzhou 545000China Department of Pharmacy First Affiliated Hospital of Gannan Medical UniversityGannan 341000China

OBJECTIVE:To examine the influence of SaponinⅠfrom Shuitianqi(Rhizoma Schizocapasae Plantagineae)(SSPHⅠ)on hepatocellular carcinoma(HCC)metastasis,and to elucidate the underlying ***:The intrahepatic metastasis Bagg's Albino/c(BALB/c)mouse model was established with human hepatocellular carcinomas(HepG2.cells,then treated with normal saline(once per day),cisplatin(2.mg/kg,once every 2.d),and SSPHⅠ(2.,50,and 75 mg/kg,once per day).Then,we assessed alterations in the hepatic pathology and target protein expressions in the intrahepatic metastasis BALB/c mouse model using a series of molecular biology ***:Based on our analysis,SSPHⅠsignificantly alleviated hepatocyte necrosis and tumor cells ***,SSPHⅠsuppressed extracellular matrix(ECM)degradation and angiogenesis via a decrease in matrix etalloproteinase-2.MMP-2.,MMP-9,CD31,CD34,and vascular endothelial growth factor(VEGF)***,SSPHⅠrepressed invasion and metastasis by suppressing the transforming growth factor-β1(TGF-β1)/Smad7 axis and epithelial-mesenchymal transition(EMT),as evidenced by the scarce TGF-β1,Ncadherin,and Vimentin expressions,and elevated Smad7 and E-cadherin ***:The SSPHⅠ-mediated negative regulation of the TGF-β1/Smad7 axis and EMT are critical for the inhibition of HCC invasion and metastasis.

关键词： carcinoma,hepatocellular epithelial-mesenchymal transition transforming growth factor beta1 Smad7 protein Saponin I from Shuitianqi(Rhizoma Schizocapasae Plantagineae)

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Ni/ZSM-5 Catalysts for light Olefin Oligomerization:Effects of Supports and Ni Sites on Activity and Selectivity

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China Petroleum Processing & Petrochemical Technology 2024年第3期26卷 15-23页

作者： zuo Qi liang Ke Ma Yirong Jia Yangxiao liao Mingjie Zheng Jiajun li Ruifeng li Wenlin College of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuanShanxi 030024China

A series of Ni/ZSM-5 containing a small amount of Ni was prepared by an ion exchanged *** impact of the n(SiO_(2.)/n(Al_(2.O_(3))ratio on the catalytic activity was studied using the samples 0.09Ni/ZSM-5(60)and 0.09Ni/ZSM-5(130).To determine the interaction between the Ni species and acid sites on the surface of the catalyst,the catalysts were characterized by N2.adsorption-desorption,X-ray diffraction(XRD),scanning electron microscopy(SEM),and UV-vis *** performance of the catalysts for the catalytic oligomerization of 1-hexene was investigated in *** nickel species were found to be uniformly distributed in all the *** was discovered that the oligomerization activity of the catalyst can be improved using Ni species;however,the contribution of Brønsted acids in oligomerization reactions is greater than that of Ni sites and Lewis acids.

关键词： nickel zeolite acid sites oligomerization catalyst

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Adipose-derived stem cells in diabetic foot care:Bridging clinical trials and practical application

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World Journal of Diabetes 2024年第6期15卷 1162-1177页

作者： Song-Lu Tseng lin Kang Zhu-Jun li li-Quan Wang Zi-Ming li Tian-Hao li Jie-Yu Xiang Jiu-zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences BeijingBeijing 100021China

Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of ***-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in *** extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain *** this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of *** review begins with a discussion of the classification and clinical management of diabetic foot *** then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing ***,the review discusses the preclinical strategies to enhance ADSC *** review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention *** conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.

关键词： Adipose-derived stem cells Diabetic foot ulcers Wound healing Clinical

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Clinical characteristics of peripapillary hyperreflective ovoid mass-like structures in myopic children

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1292-1299页

作者： Lu Zhang zuo-Hui-Zi Yi Xuan Jiang Gong-Peng Sun Fang Zhao li Zhang Yi Xiang Chang-Zheng Chen Department of Ophthalmology the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Eye Center Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To describe the characteristics of peripapillary hyperreflective ovoid mass-like structure(PHOMS)in myopic children and to investigate factors associated with ***:This retrospective observational study included 101 eyes of 101 children(age≤17y)with *** included patients underwent comprehensive clinical *** nerve canal parameters,including disc diameter,optic nerve head(ONH)tilt angle,and border tissue angle were measured using serial enhanced-depth imaging spectral-domain optical coherence tomography(EDI-OCT).Based on the optic disc drusen consortium’s definition of PHOMS,eyes were classified as PHOMS group and non-PHOMS *** was categorized according to ***:Sixty-seven(66.3%)eyes were found with *** PHOMS could only be detected by optical coherence tomography(OCT).Medium PHOMS could be seen with blurred optic disc borders corresponding to *** most frequent location of PHOMS was at the nasosuperior(91%,61 of 67 eyes)to ONH *** axial length and spherical equivalent were more myopic in the PHOMS group than in the non-PHOMS group(both P2.),P2..70(2..90-43.81)vs 45.62.35.18-60.45),P2.6,95%CI=1.2.9-8.718,P=0.019)and ONH tilt angle(OR=3.2.5,95%CI=1.42.-7.542.P=0.005)were significantly correlated with *** was no disc diameter associated with *** the linear regression analysis,border tissue angle was negatively associated with PHOMS height(β=-2.2.7,Plitated an understanding of the mechanism of PHOMS.

关键词： peripapillary hyperreflective ovoid masslike structure myopia optic disc edema enhanced-depth imaging spectral-domain optical coherence tomography

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Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH

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Chinese Chemical Letters 2024年第6期35卷 392-397页

作者： Yong-Dan Zhao Yidan Wang Rongrong Wang lina Chen Hengtong zuo Xi Wang Jihong Qiang Geng Wang Qingxia li Canqi Ping Shuqiu Zhang Hao Wang School of Pharmacy Shanxi Medical UniversityTaiyuan 030001China National Center for Nanoscience and Technology Beijing 100190China Artemisinin Research Center Institute of Chinese Materia MedicaBeijing 100700China

Artemisinin(ART)resistance has been an emerging clinical problem,severely compromising antimalarial efficacy and threatening the global malaria elimination *** intensive studies about the molecular mechanism for ART resistance are under way,no effective therapeutic targets for reversing resistance have been ***,we explore glutathione(GSH)as a therapeutic target to develop a thermo-responsive nanoplatform to specifically co-deliver ART and GSH synthesis inhibitor(L-buthionine sulfoximine,BSO)in a sustained manner,effectively reversing ART resistance in *** combining with BSO,ART exerts increased antimalarial activity with reduced half-maximal inhibitory concentration(IC50)by 7.43-fold in ART-resistant *** work reveals that the GSH in ART-resistant parasites can be a promising therapeutic target for reversing ART resistance,paving the way for developing drug candidates and intelligent nanomedicines in malaria therapy.

关键词： Nanomedicines Drug delivery Artemisinins resistance Malaria Glutathione

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Ferricyanide-Promoted Oxidative Activation and ligation of Protein Thioacids in Neutral Aqueous Media

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CCS Chemistry 2024年第8期6卷 2031-2043页

作者： Guo-Chao Chu Lu-Jun liang Rui Zhao Yan-Yan Guo Chun-Tong li Chong zuo Huasong Ai Xiao Hua Zi-Chen li Yi-Ming li Lei liu NewCornerstone Science Laboratory Tsinghua-Peking Center for Life SciencesMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyCenter for Synthetic and Systems BiologyDepartment of ChemistryTsinghua UniversityBeijing 100084 School of Food and Biological Engineering Hefei University of TechnologyHefei 230009 Center for BioAnalytical Chemistry Hefei National Laboratory of Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026 Department of Chemistry University of Science and Technology of ChinaHefei 230026

Ferricyanide-promoted oxidative activation of Nacylatedα-aminothioacids for amide bond formation withα-aminonitriles was recently shown to be a plausible pathway for prebiotic peptide *** we describe the finding that by adding sodium azide and thiols,ferricyanide oxidation can elicit highly efficient and clean conversion of fully unprotected peptide or protein thioacids in neutral aqueous media to the corresponding *** transformation enables the development of ferricyanide-promoted thioacid-based native chemical ligation(NCL)as a new redox-based method for chemical protein synthesis,which does not need to change pH and is therefore operationally easy for ligation at small *** effectiveness of the ferricyanide-promoted thioacid-based NCL was illustrated by synthesis of an ISG15-modified MDA5 segment under nondenaturing conditions and synthesis of an acetylated ubiquitin(Ub)-modified histone H2. through an N-to-C sequential *** work broadens the concept of on-demand oxidative activation strategy for protein ligation and provides a new useful supplement to the repertoire of methods for chemical protein synthesis,particularly for studies on proteins carrying Ub family modifications.

关键词： chemical protein synthesis protein thioacid ferricyanide oxidation native chemical ligation ubiquitin family modifications

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Investigation on the Novel High-performance Copper/Graphene Composite Conductor for High Power Density Motor

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 80-85页

作者： Jiaxiao Wang Tingting zuo Jiangli Xue Yadong Ru Yue Wu Zhuang Xu Yongsheng liu Zhaoshun Gao Puqi Ning Tao Fan Xuhui Wen li Han liye Xiao Shanghai University of Electric Power Shanghai 200090Chinaand the Institute of Electrical EngineeringChinese Academy of SciencesShanghai 200090China the Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China with Shanghai University of Electric Power Shanghai 200090China

High-performance Cu/Graphene composite wire synergistically strengthened by nano Cr_(3)C_(2. phase was directly synthesized via hot press sintering followed by severe cold plastic deformation, using liquid paraffin and CuCr alloy powder as the raw materials. Since graphene is in situ formed under the catalysis of copper powder during the sintering process, the problem that graphene is easy to agglomerate and difficult to disperse uniformly in the copper matrix has been solved. The nano Cr_(3)C_(2.-particles nailed at the interface favor to improve the interface bonding. The Cu/Graphene composite possesses high electrical conductivity, hardness, and plasticity. The composite wire exhibits high electrical conductivity of 96.93% IACS, great tensile strength of 488MPa, and excellent resistance to softening. Even after annealing at 400℃ for 1 h, the tensile strength can still reach 2.8 MPa with a conductivity of about 99.14% *** wire's temperature coefficient of resistance(TCR) is largely reduced to 0.0035/℃ due to the complex structure,which leads the wire to present low resistivity at higher temperatures. Such Cu/Graphene composite wire with excellent comprehensive performance has a good application prospect in high-power density motors.

关键词： Cu/Graphene composite Mechanical properties Electrical property Microstructure Temperature coefficient of resistance

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Supramolecular systems for bioapplications:recent research progress in China

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Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-Yang liu Xiao-Yong Yu Yu-Chen Pan Hang Yin Shuang Chao Yujie li He Ma Minzan zuo Kun-Xu Teng Jun-li Hou Yong Chen Dong-Sheng Guo Ruibing Wang Yuxin Pei Zhichao Pei Jiang-Fei Xu Xiao-Yu Hu Chunju li Qing-Zheng Yang Leyong Wang Yu liu Zhan-Ting li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

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Revealing the specific regulations of nitric oxide on the postharvest ripening and senescence of bitter melon fruit

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aBIOTECH 2024年第1期5卷 29-45页

作者： Hongwei Wang ling li lili Ma Alisdair R.Fernie Anzhen Fu Chunmei Bai Zhaoze Sang Susu Guo Fan Zhang Qing Wang Yanyan Zheng Jinhua zuo Key Laboratory of Vegetable Postharvest Processing Ministry of AgricultureBeijing Key Laboratory of Fruits and Vegetable Storage and ProcessingKey Laboratory of Biology and Genetic Improvement of Horticultural Crops(North China)of Ministry of AgricultureKey Laboratory of Urban Agriculture(North)of Ministry of AgricultureBeijing Vegetable Research CenterInstitute of Agro-Products Processing and Food NutritionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China College of Food Science and Biotechnology Tianjin Agricultural UniversityTianjin 300392China Max Planck Institute of Molecular Plant Physiology 14476 Potsdam GolmGermany Institute of Food Science and Technology Chinese Academy of Agricultural SciencesBeijingChina

Bitter melon fruit is susceptible to yellowing,softening,and rotting under room-temperature storage conditions,resulting in reduced commercial *** oxide(NO)is an important signaling molecule and plays a crucial role in regulating the fruit postharvest *** this study,we investigated the effects of NO treatment on changes in sensory and firmness of bitter melon fruit during postharvest ***,transcriptomic,metabolomic,and proteomic analyses were performed to elucidate the regulatory mechanisms through which No treatment delays the ripening and senescence of bitter melon *** results show that differentially expressed genes(DEGs)were involved in fruit texture(CSLE,β-Gal,and PME),plant hormone signal transduction(ACS,JAR4,and AUX2.),and fruit flavor and aroma(SUS2.LOX,and GDH2..In addition,proteins differentially abundant were associated with fruit texture(PLY,PME,and PGA)and plant hormone signal transduction(PBL15,JAR1,and PYL9).Moreover,No significantly increased the abundance of key enzymes involved in the phenylpropanoid biosynthetic pathway,thus enhancing the disease resistance and alleviating softening of bitter melon ***,differential metabolites mainly included phenolic acids,terpenoids,and *** results provide a theoretical basis for further studies on the physiological changes associated with postharvest ripening and senescence of bitter melon fruit.

关键词： Bitter melon NO treatment Postharvest Ripening and senescence

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