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Effect of supplementing Qi and promoting blood circulation therapy on left ventricular remodeling: a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2020年第3期40卷 365-375页

作者： Mao Shuai zuo tian Jiang Lu Zhang Minzhou Key Discipline of Integrated Chinese and Western Medicine Second Clinical CollegeGuangzhou University of Chinese MedicineGuangzhou 510405China Cardiovascular Institute Stanford University School of MedicineStanford 94305USA Department of Critical Care Medicine Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China

OBJECTIVE: To evaluate the effectiveness of an adjuvant therapy from Traditional Chinese Medicine for supplementing Qi and promoting blood circulation(CMSQPBC) on left ventricular remodeling in patients after myocardial infarction(MI).METHODS: Randomized controlled trials were identified in the Cochrane Library, Embase, Web of Science, PubMed, China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, China Science and Technology Journal Database, Wanfang databases, reviews, and reference lists of relevant articles. The weighted mean difference(WMD) was calculated for changes in the left ventricular ejection fraction(LVEF), LV end-diastolic volume(LVEDV) and LV end-systolic volume(LVESV) from baseline to follow-up(> 3 months) by using random-effects Meta-analysis. The primary outcome was change in LVEF, and secondary outcomes were changes in LV dimensions including LVEDV and ***: A total of 10 trials(enrolling 854 participants, median follow-up six months) evaluated the association between CMSQPBC and changes in LV function and volume. Compared with the control group, CMSQPBC significantly improved LVEF(854 patients;WMD: 4.97%, 95% CI: 3.78-6.15;P < 0.001)and attenuated the enlargement of LVEDV(607 patients;WMD:-7.89 mL, 95% CI:-11.54 to-4.24;P<0.001) and LVESV(364 patients;WMD =-5.80 mL,95% CI,-9.60 to-2.01;P < 0.01).CONCLUSION: CMSQPBC may reverse deleterious pathological remodeling after myocardial infarction. Higher quality and more rigorous randomized trials with larger sample sizes are needed to further confirm the findings.

关键词： Ventricular remodeling Myocardial infarction Reinforcing Qiactivating blood Qi-deficiency blood stasis Systematic review Meta-analysis

Numerical Simulation on the Resistance Performance of Ice-Going Container Ship Under Brash Ice Conditions

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China Ocean Engineering 2018年第5期32卷 546-556页

作者： GUO Chun-yu ZHANG zuo-tian tian Tai-ping LI Xia-yan ZHAO Da-gang College of Shipbuilding Engineering Harbin Engineering University SUMEC Marine Co. Ltd.

Ice resistance prediction is a critical issue in the preliminary design of ships navigating brash ice conditions, which is closely related to the safety of a ship to navigate encounter brash ice, and has significant effects on the kinds of propellers and motor power needed. In research on this topic, model tests and full-scale tests on ships have thus far been the primary approaches. In recent years, the application of the finite element method(FEM) has also attracted interest. Some researchers have conducted numerical simulations on ship–ice interactions using the fluid–structure interaction(FSI) method. This study used this method to predict and analyze the resistance of an ice-going ship, and compared the results with those of model ship tests conducted in a towing tank with synthetic ice to discuss the feasibility of the FEM. A numerical simulation and experimental methods were used to predict the brash ice resistance of an ice-going container ship model in a condition with three concentrations of brash ice(60%, 80%, and 90%). A comparison of the results yielded satisfactory agreement between the numerical simulation and the experiments in terms of both observed phenomena and resistance values, indicating that the proposed numerical simulation has significant potential for use in related studies in the future.

关键词： brash ice resistance fluid–structure interaction(FSI) finite element method(FEM) numerical simulation model ship test

Moving target defense:state of the art and characteristics

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Frontiers of Information Technology & Electronic Engineering 2016年第11期17卷 1122-1153页

作者： Gui-lin CAI Bao-sheng WANG Wei HU tian-zuo WANG College of Computer National University of Defense Technology

Moving target defense(MTD) has emerged as one of the game-changing themes to alter the asymmetric situation between attacks and defenses in cyber-security. Numerous related works involving several facets of MTD have been published. However, comprehensive analyses and research on MTD are still absent. In this paper, we present a survey on MTD technologies to scientifically and systematically introduce, categorize, and summarize the existing research works in this field. First, a new security model is introduced to describe the changes in the traditional defense paradigm and security model caused by the introduction of MTD. A function-and-movement model is provided to give a panoramic overview on different perspectives for understanding the existing MTD research works. Then a systematic interpretation of published literature is presented to describe the state of the art of the three main areas in the MTD field, namely, MTD theory, MTD strategy, and MTD evaluation. Specifically,in the area of MTD strategy, the common characteristics shared by the MTD strategies to improve system security and effectiveness are identified and extrapolated. Thereafter, the methods to implement these characteristics are concluded. Moreover, the MTD strategies are classified into three types according to their specific goals, and the necessary and sufficient conditions of each type to create effective MTD strategies are then summarized, which are typically one or more of the aforementioned characteristics. Finally, we provide a number of observations for the future direction in this field, which can be helpful for subsequent researchers.

关键词： Moving target defense Security model Function-and-movement model Characteristics

Design of H_∞ robust fault detection filter for nonlinear time-delay systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第10期7卷 1733-1741页

作者： BAI Lei-shi HE Li-ming tian zuo-hua SHI Song-jiao Department of Automation Shanghai Jiao Tong University Shanghai 200240 China

In this paper, the robust fault detection filter (RFDF) design problems are studied for nonlinear time-delay systems with unknown inputs. First, a reference residual model is introduced to formulate the RFDF design problem as an H∞ model-matching problem. Then appropriate input/output selection matrices are introduced to extend a performance index to the time-delay systems in time domain. The reference residual model designed according to the performance index is an optimal residual generator, which takes into account the robustness against disturbances and sensitivity to faults simultaneously. Applying robust H∞ optimization control technique, the existence conditions of the RFDF for nonlinear time-delay systems with unknown inputs are presented in terms of linear matrix inequality (LMI) formulation, independently of time delay. An illustrative design example is used to demonstrate the validity and applicability of the proposed approach.

关键词： Nonlinear time-delay systems Robust fault detection filter iRFDF H∞ optimization Linear matrix inequality (LMI)

Predictive value of NLR, Fib4, and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 155-165页

作者： tian-zuo Kuang Meng Xiao Yong-Fan Liu Department of Hepatobiliary Surgery Ji’an Central People’s HospitalJi’an 343000Jiangxi ProvinceChina

BACKGROUND Neutrophil-lymphocyte ratio(NLR),fibrosis index based on four factors(Fib4),aspartate aminotransferase-to-platelet ratio index(APRI)can be used for prognostic evaluation of hepatocellular ***,no study has established an individualized prediction model for the prognosis of hepatocellular carcinoma based on these *** To screen the factors that affect the prognosis of hepatocellular carcinoma and establish a nomogram model that predicts postoperative liver failure after hepatic resection in patients with hepatocellular *** In total,220 patients with hepatocellular carcinoma treated in our hospital from January 2022 to January 2023 were *** were divided into 154 participants in the modeling cohort,and 66 in the validation *** analysis of the changes in NLR,Fib4,and APRI levels in 154 patients with hepatocellular carcinoma before liver resection and at 3 mo,6 mo,and 12 mo postoperatively was *** logistic regression to analyze the influencing factors on the occurrence of liver failure in hepatocellular carcinoma patients,roadmap prediction modeling,and validation,patient work characteristic curves(ROCs)to evaluate the predictive efficacy of the model,calibration curves to assess the consistency,and decision curve analysis(DCA)to evaluate the model’s validity were also *** Binary logistic regression showed that Child-Pugh grading,Surgical site,NLR,Fib4,and APRI were all risk factors for liver failure after hepatic resection in patients with hepatocellular *** modeling cohort built a column-line graph model,and the area under the ROC curve was 0.986[95%confidence in terval(CI):0.963-1.000].The patients in the validation cohort utilized the column-line graph to predict the probability of survival in the validation cohort and plotted the ROC curve with an area under the curve of the model of 0.692(95%CI:0.548-0.837).The deviation of the actual outcome curves from the c

关键词： Hepatocellular carcinoma Hepatic resection Liver failure Influencing factors Columnar graphs

Numerical and experimental studies of hydrodynamic performance of bionic leading-edge tubercle airfoil

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Journal of Hydrodynamics 2019年第6期31卷 1240-1249页

作者： Chun-yu Guo zuo-tian Zhang Xu-xiang Cao Tie-cheng Wu Yu-min Su College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China

This paper studies the bionic tubercle airfoils based on the NACA 0020 prototype airfoil,with 7 models derived from different designs of the span-chord ratios and different tubercle types,along with the option of the wave airfoil surface matching the leading-edge *** water experiments are conducted to test the airfoil profile at a Reynolds number of 3×10^5 and an angle of attack of 0°-30°.Data are recorded by a four-component force balance and the resulted lift,drag,and force moment are *** the analysis of the hydrodynamic characteristics and the flow field characteristics,it is shown that the stall of the tubercle airfoils is milder without an evident stalling angle as compared with that of the normal airfoil *** lift coefficient of the optimized airfoil is significantly elevated at the angle where the NACA 0020 airfoil is in the stall *** lift-drag ratio is also markedly improved at the same *** optimal airfoil profile is finally identified and a further optimization plan is proposed based on the comparison results against the CFD numerical simulation.

关键词： Bionic tubercle computational fluid dynamics stall

Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors

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Biomedical and Environmental Sciences 2024年第2期37卷 133-145页

作者： LIU Xiao CAO Ying LIN Xiao Wan GAO Dan Yang MIAO Hui Hui LI tian zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ***,the underlying mechanism is yet *** study aimed to explore the changes in metabolites in three specific brain regions and saliva of older mice with postoperative delirium behavior and to identify potential non-invasive *** Eighteen-month-old male C57/BL6 mice were randomly assigned to the anesthesia/surgery or control *** tests were conducted 24 h before surgery and 6,9,and 24 h after *** C3(C3)and S100 calcium-binding protein B protein(S100beta)levels were measured in the hippocampus,and a metabolomics analysis was performed on saliva,hippocampus,cortex,and amygdala *** In total,43,33,38,and 14 differential metabolites were detected in the saliva,hippocampus,cortex,and amygdala,respectively.“Pyruvate”“alpha-linolenic acid”and“2-oleoyl-1-palmitoy-snglycero-3-phosphocholine”are enriched in one common pathway and may be potential non-invasive biomarkers for *** changes were observed in the three brain regions,with the upregulation of 1-methylhistidine and downregulation of *** Dysfunctions in energy metabolism,oxidative stress,and neurotransmitter dysregulation are implicated in the development of *** identification of changes in the level of salivary metabolite biomarkers could aid in the development of noninvasive diagnostic methods for POD.

关键词： Metabolomic Postoperative delirium(POD) Mechanism Biological marker

Different strategies in biomass allocation across elevation in two Gentiana plants on the Yunnan-Guizhou Plateau, China

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Journal of Mountain Science 2020年第11期17卷 2750-2757页

作者： ZHANG Ji WANG Yuan-zhong GAO Hong-kai zuo Zhi-tian YANG Shao-bing CAI Chuan-tao CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China Medicinal Plants Research Institute Yunnan Academy of Agricultural SciencesKunming 650200China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai 200241China School of Geographic Sciences East China Normal UniversityShanghai 200241China Center of Economic Botany Core Botanical GardensChinese Academy of SciencesMenglaYunnan 666303China

Patterns of biomass allocation among organs in plants are important because they influence many growth *** Yunnan-Guizhou Plateau(YGP)is considered to be one of the most sensitive areas in China to climate changes,but we know little about how current climatic gradients on the plateau influence plant biomass *** rigescens and ***,on the YGP,are important species because they are used in traditional Chinese *** therefore analyzed the biomass allocation patterns of the two species across an elevation gradient(1000–2810 m a.s.l.)on the YGP to understand and predict the impact of climate change on these plant *** found that the total biomass,reproductive biomass,vegetative biomass,aboveground biomass,and belowground biomass in *** were all significantly larger than those in ***(ptiana plants on the *** studies are needed to investigate other environmental factors,such as nutrients and light,and genetic factors,in order to understand the trend of reproductive allometry along the environmental *** study has implications for the ma

关键词： Allometry Reproductive investment Climate Environment Herbaceous plant

Dexmedetomidine Promotes Angiogenesis and Vasculogenic Mimicry in Human Hepatocellular Carcinoma through α^(2)-AR/HIF-1α/VEGFA Pathway

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Biomedical and Environmental Sciences 2022年第10期35卷 931-942页

作者： FANG Tao LIN Li YE Zhi Jian FANG Lian SHI Shuai YU Ke Da MIAO Hui Hui LI tian zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Anesthesiology The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000ZhejiangChina IVF centre The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000ZhejiangChina

Objective Dexmedetomidine(DEX),the most specificα^(2)-adrenergic receptor agonist widely used for its sedative and analgesic properties,has been reported to upregulate HIF-1αexpression to protect hypoxic and ischemic ***,it is largely unclear whether DEX can also upregulate Hypoxiainducible factor-1 alpha(HIF-1α)expression and its downstream vascular endothelial growth factor-A(VEGFA)in cancer tissues with oxygen-deficient tumor *** We used SMMC-7721 cells,MHCC97-H cells,and a mouse model of orthotopic hepatic carcinoma to explore the effect of DEX on angiogenesis and vasculogenic mimicry(VM)and its *** normoxic(20%O^(2))and hypoxic(1%O^(2))conditions,DEX was used to intervene cells,and yohimbine was used to rescue *** The results showed that DEX promoted angiogenesis and VM in human liver cancer cells within a certain dose range,and the addition of yohimbine inhibited this *** could activate HIF-1α/VEGFA pathway,which was further verified by silencing HIF-1α.Consistently,in vivo results also showed that DEX can up-regulate HIF-1α/VEGFA expression,and enhance the number of VM channels and microvessel density(MVD).Conclusion We believe that HIF-1α/VEGFA might be an important signaling pathway by which DEX promotes angiogenesis and VM formation in human hepatocellular carcinoma,whereasα^(2)-adrenergic receptor mediation might be the critical mechanisms.

关键词： Hepatocellular carcinoma Dexmedetomidine Yohimbine α^(2)-adrenergic receptor HIF-1a VEGFA Vascular mimicry Angiogenesis