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多孔中药固体片剂孔隙率的太赫兹有效介质模型研究

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红外与毫米波学报 2024年第3期43卷 344-353页

作者：李旭张梦圆赵雯玥左剑朱卫丰李哲施宇蕾张存林首都师范大学物理系太赫兹光电子学教育部重点实验室北京100048 江西中医药大学现代中药制剂教育部重点实验室江西南昌330004

目前对中药片剂的孔隙测量,一般采用的是具有破坏性的密度测量方法,缺乏无损量化方法。太赫兹辐射能用于无损的提取药物若干光学信息。针对直压型中药片剂,通过太赫兹时域和频域信号处理等不同方法分别计算各种片剂的有效折射率,发现两... 详细信息

目前对中药片剂的孔隙测量,一般采用的是具有破坏性的密度测量方法,缺乏无损量化方法。太赫兹辐射能用于无损的提取药物若干光学信息。针对直压型中药片剂,通过太赫兹时域和频域信号处理等不同方法分别计算各种片剂的有效折射率,发现两种方法得到的有效折射率和片剂的孔隙率均呈良好的线性关系。根据有效折射率特性,利用四种有效介质模型提取了中药片剂的孔隙率并进行量化回归,通过交叉验证与相对分析误差(RPD)发现通过时域信号处理的有效折射率得到的孔隙率回归模型解释性与验证准确性更高,其中最佳模型是Bruggeman模型(RPD=11.3325)。为中药多孔粉体制剂工艺优化提供支持。

关键词：太赫兹光谱有效折射率有效介质理论中药片剂孔隙率

基于知识图谱的电网工程建筑信息模型质量检查方法

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吉林大学学报（工学版） 2024年第3期54卷 807-814页

作者：姜文明齐立忠张苏荣经国武宏波左超张晓龙中国建筑科学研究院有限公司北京构力科技有限公司北京100013 国网经济技术研究院有限公司北京102209

利用知识图谱技术改进了建筑信息模型(BIM)的质量审查方法,选取电网工程的BIM模型为研究对象,开发了基于知识图谱的BIM模型检查系统,以验证其是否符合电网工程相关规范和标准。以某电气工程项目的BIM模型为案例,生成了检验报告,结果验... 详细信息

利用知识图谱技术改进了建筑信息模型(BIM)的质量审查方法,选取电网工程的BIM模型为研究对象,开发了基于知识图谱的BIM模型检查系统,以验证其是否符合电网工程相关规范和标准。以某电气工程项目的BIM模型为案例,生成了检验报告,结果验证了本文方法的可行性和实用性。该技术为建筑设计与信息技术的深度融合提供了新的方向。

关键词：工程管理知识图谱电网工程建筑信息模型检查方法

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“罕见遗传病”混合式课程的设计与教学实施

中国优生与遗传杂志 2024年第8期32卷 1752-1755页

作者：刘雯杨玲郭锋左伋复旦大学基础医学院细胞与遗传医学系上海200032

通过混合式教学方法,讲授罕见遗传疾病的病因、发病机制、病变过程和临床表型;学习罕见病从亲代传至子代的遗传规律,了解其诊断、治疗和防控的手段、技术。以情景模拟的体验式教学结合虚拟实验开展遗传咨询的实践教学。从而系统地向医... 详细信息

通过混合式教学方法,讲授罕见遗传疾病的病因、发病机制、病变过程和临床表型;学习罕见病从亲代传至子代的遗传规律,了解其诊断、治疗和防控的手段、技术。以情景模拟的体验式教学结合虚拟实验开展遗传咨询的实践教学。从而系统地向医学相关专业学生介绍罕见遗传疾病。

关键词：遗传病罕见病遗传咨询

Gut Microbiome Alterations in COVID-19

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Genomics, Proteomics & Bioinformatics 2021年第5期19卷 679-688页

作者： Tao zuo Xiaojian Wu Weiping wen Ping Lan Guangdong Institute of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510655China Center for Fecal Microbiota Transplantation Research The Sixth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510655China Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510655China Department of Otorhinolaryngology Head and Neck SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510080China Guangzhou Key Laboratory of Otorhinolaryngology Guangzhou 510080China Department of Otorhinolaryngology Head and Neck SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen UniversitySun Yat-sen UniversityGuangzhou 510655China

Since the outset of the coronavirus disease 2019(COVID-19)pandemic,the gut microbiome in COVID-19 has garnered substantial interest,given its significant roles in human health and *** evidence is unveiling that the gut microbiome is broadly altered in COVID-19,including the bacterial microbiome,mycobiome,and ***,the gut microbial ecological network is significantly weakened and becomes sparse in patients with COVID-19,together with a decrease in gut microbiome *** the existence of severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2),the gut microbiome of patients with COVID-19 is also characterized by enrichment of opportunistic bacteria,fungi,and eukaryotic viruses,which are also associated with disease severity and ***,a multitude of symbiotic bacteria and bacteriophages are decreased in abundance in patients with *** gut microbiome features persist in a significant subset of patients with COVID-19 even after disease resolution,coinciding with‘long COVID’(also known as postacute sequelae of COVID-19).The broadly-altered gut microbiome is largely a consequence of SARS-CoV-2 infection and its downstream detrimental effects on the systemic host immunity and the gut *** impaired host immunity and distorted gut microbial ecology,particularly loss of low-abundance beneficial bacteria and blooms of opportunistic fungi including Candida,may hinder the reassembly of the gut microbiome post *** investigation is necessary to fully understand the role of the gut microbiome in host immunity against SARS-CoV-2 infection,as well as the long-term effect of COVID-19 on the gut microbiome in relation to the host health after the pandemic.

关键词： COVID-19 Gut Microbiome Immunity Infection

‘‘Complexation–precipitation'' metal separation method system and its application in secondary resources

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Rare Metals 2014年第4期33卷 369-378页

作者： zuo-Ren Nie Li-wen Ma Xiao-Li Xi College of Materials Science and Engineering Beijing University of Technology

Recovery processes of secondary resources usually encounter problems because of the diverse com- positions of wastes. To enhance the applicability of tradi- tional hydrometallurgical process toward secondary resources, the adjustment of components is necessary. In traditional hydrometallurgical separation, precipitation and complexation are extensively used. However, their com- bination as a specific metal separation method has not yet been studied in detail. This approach is very promising for solving problems caused by changeable components during recycling processes of secondary resources. This paper reviews the effects of precipitation and complexation in metal separation processes, and a metal separation method system of ＂complexation-precipitation＂ developed to adjust the components of secondary resources is introduced.

关键词： Secondary resources Complexation-precipitation Method system Metal separation

针灸辅助改善冻融胚胎移植疗效的网状meta分析

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World Journal of Acupuncture-Moxibustion 2024年第2期34卷 103-116页

作者：罗敏辉谭艳左耀辰石文英王鑫章薇湖南中医药大学长沙410208 湖南中医药大学第一附属医院长沙410007

Objective:To evaluate the clinical effect of acupuncture-moxibustion as the adjuvant therapy on frozenthawed embryo transfer(FET)using network ***:In PubMed,Embase,Cochrane Library,Chinese National Knowledge Infrastructure(CNKI),Wanfang database(WanFang),VIP database and Chinese Biomedical Literature Database(SinoMed),the randomized controlled trials(RCTs)of the adjuvant therapy of acupuncture-moxibustion for FET were retrieved,from database inception to April 1,*** risk of bias assessment tool was used to screen and evaluate the quality of the included studies,and RevMan 5.3,GeMTC0.14.3 and Stata16.0 software were adopted to complete the network ***:Twenty-nine RCTs comprising 2880 patients were finally included,involving 17 interventions and 4 outcome *** results of network meta-analysis showed that the top three therapies under each outcome based on the magnitude of SUCRA values were:(1)Clinical pregnancy rate(CPR,%):"transcutaneous electrical acupoint stimulation+herbal medicine"(76.4),"moxibustion+herbal medicine"(74.7),"acupuncture+moxibustion"(73.3);(2)Biochemical pregnancy rate(BPR):"moxibustion+herbal medicine"(89.3),"acupuncture+moxibustion"(82.1),"acupuncture+herbal medicine"(78.7);(3)Endometrial thickness:"acupoint injection+Western medicine"(87.2),auricular therapy(76.8),"acupuncture+herbal medicine"(73.5);(4)Type A endometrial morphology rate:"acupoint injection+Western medicine"(78.3),"moxibustion+herbal medicine"(58.0)and"acupuncture+moxibustion"(52.6).Conclusion:The combined treatment of acupuncture-moxibustion was superior to single therapy for FET *** combined therapy of transcutaneous electrical acupoint stimulation and herbal medicine had the best effect for improving CPR,"moxibustion+herbal medicine"obtained the best average comprehensive effect,and"acupoint injection+Western medicine"was conductive to ameliorate the endome trial thickness and *** to the limitations of e

关键词： Acupuncture Moxibustion Frozen-thawed embryotransfer Pregnancy rate Endometriumthickness Endometrial morphology Networkmeta-analysis

真空紫外光电离质谱法在烟气老化研究中的应用

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质谱学报 2024年第5期45卷 656-665页

作者：马兰温作赢彭晓萌赵锋叶绍鑫谢恺顾学军王健中国科学院合肥物质科学研究院安徽光学精密机械研究所安徽合肥230031 中国科学技术大学安徽合肥230026 安徽中烟工业有限责任公司烟草化学安徽省重点实验室安徽合肥230088

本文应用自主研发的真空紫外光电离飞行时间质谱仪,原位在线检测燃烧型卷烟、加热不燃烧型卷烟和电子烟产生的烟气气溶胶,表征其气相成分及颗粒相成分。结果表明,3种烟气气溶胶的化学组成差异显著,其中燃烧型卷烟的成分含量及物种丰度... 详细信息

本文应用自主研发的真空紫外光电离飞行时间质谱仪,原位在线检测燃烧型卷烟、加热不燃烧型卷烟和电子烟产生的烟气气溶胶,表征其气相成分及颗粒相成分。结果表明,3种烟气气溶胶的化学组成差异显著,其中燃烧型卷烟的成分含量及物种丰度远大于新型烟草制品,其气相和颗粒相的整体信号强度分别约为新型烟草制品的100倍和10倍。检出的气溶胶成分中含有大量不饱和化合物,这些物质在环境中极易被氧化并生成新的超细颗粒物。结合Teflon反应腔分别模拟以上3种类型的烟气气溶胶在不同臭氧浓度下的老化过程,结果均有超细颗粒物生成。超细颗粒物的形成条件与前体物的含量和成分分布有关,燃烧型卷烟气溶胶在室内O_(3)浓度下就可以很快形成超细颗粒物,而新型烟草制品则需要更高浓度的O_(3)或更长的老化时间。

关键词：光电离质谱在线测量烟气老化超细颗粒物室内污染

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Crystallization behavior of F-free mold fluxes

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International Journal of Minerals,Metallurgy and Materials 2011年第2期18卷 150-158页

作者： zuo-tai Zhang Guang-hua wen Ying-yi Zhang College of Engineering Peking University Beijing 100871 China College of Materials Science and Engineering Chongqing University Chongqing 400044 China

The time-temperature-transformation （TTT） diagrams of F-free mold fluxes was constructed using single hot thermocouple technique （SHTT） and confocal scanning laser microscopy （CSLM） to study the crystallization behavior of F-free mold fluxes. The tendency of crystallization is found to increase whereas the incubation time decreases with increasing basicity. Zirconia addition enhances the crystallization tendency due to its limited solubility in the slag melt and the solid particles acting as nucleation sites. Pseudo-wollastonite is found to precipitate in the slag with low basicity （CS-1 and CS-2）, kilchoanite and larnite are formed with further increasing basicity （CS-3）, and larnite is finally formed as the basicity beyond unit （CS-4）. The crystal morphology changes with varying compositions and isothermal temperatures. The measured growth rate is found to be linear with time under isothermal conditions and decreases with increasing isothermal temperature.

关键词： continuous casting mold fluxes crystallization zirconia crystal growth

A Surrogate Model for a CAES Radial Inflow Turbine with Test Data-Based MLP Neural Network Algorithm

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Journal of Thermal Science 2023年第6期32卷 2081-2092页

作者： WANG Xing ZHU Yangli LI wen zuo Zhitao CHEN Haisheng National Energy Large Scale Physical Energy Storage Technologies R&D Center(Bijie) Bijie551712China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing101408China

It is usually to conduct a full-scale three-dimensional flow analysis for a radial turbine to find a way to increase the efficiency of a Compressed Air Energy Storage(CAES)***,long solving time and huge consumption of computing resources become a major obstacle to the ***,in present study,a surrogate model with test data-based multi-layer perceptron(MLP)Neural Network is proposed to overcome the *** of complex flow field solving process,it provides reliable turbine aerodynamic performance and flow field distribution characteristics in a short solution time by“learning the measurement results”.The validation results illustrated that the predicted maximum relative errors of isentropic efficiency,corrected mass flow rate and corrected power are only 0.03%,0.22%and 0.26%*** predicted flow distribution parameters in chamber,shroud cavity and outlet region of rotor are also basically consistent with the experimental *** the chamber,it can be found that a pressure stagnation point is observed at circumferential angle of 270°when total pressure ratio is *** the shroud cavity,obvious pressure variation is found near outlet of shroud cavity which although labyrinth seals *** outlet of rotor,obvious variations of velocity and pressure are found in the 0.0–0.4 and 0.6–0.8 of blade *** the same time,obvious variations of velocity and pressure are found in the 0.0–0.4 and 0.6–0.8 of blade height and this is because the influence of upper passage vortex,lower passage vortex and end wall secondary *** present study can provide further reference for the dynamic performance evaluation of CAES radial inflow turbine.

关键词： CAES surrogate model radial inflow turbine MLP neural network