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Association of Serum Folate and Vitamin B_(12) Concentrations with Obesity in Chinese Children and Adolescents

Biomedical and Environmental Sciences 2024年第3期37卷 242-253页

作者： ZHU Qian Rang KOK E Dieuwertje BEKELE Hailu Tesfaye MANUSAMA Koen ZHANG Jing Xian XIE Wei ZONG wen Qi zuo Hui ZHANG Jian KAMPMAN Ellen DAI Yue Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009JiangsuChina Division of Human Nutrition and Health Wageningen University&ResearchWageningen 176700 AAThe Netherlands School of Public Health Medical College of Soochow UniversitySuzhou 215123JiangsuChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective This study aimed to evaluate the associations of serum folate and/or vitamin B12 concentrations with obesity among Chinese children and *** A cross-sectional study was conducted including 3,079 Chinese children and adolescents,aged 6 to 17 years,from Jiangsu,*** indices,such as,children's body mass index(BMI),BMI z-scores,waist circumference,and waist-to-height ratio were *** linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B12 levels with anthropometric indices and odds of *** We observed that serum vitamin B12 concentrations were inversely associated with all anthropometric indices and the odds of general obesity[odds ratio(OR)=0.68;95%confidence interval(CI)=0.59,0.78]and abdominal obesity(OR=0.68;95%CI=0.60,0.77).When compared to participants with both serum vitamin levels in the two middle quartiles,those with both serum folate and vitamin B12 levels in the highest quartile were less prone to general(OR=0.31,95%CI=0.19,0.50)or abdominal obesity(OR=0.46,95%CI=0.31,0.67).Conversely,participants with vitamin B12 levels in the lowest quartile alongside folate levels in the highest quartile had higher odds of abdominal obesity(OR=2.06,95%CI=1.09,3.91).Conclusion Higher serum vitamin B12 concentrations,but not serum folate concentrations,were associated with lower odds of childhood *** and adolescents with high levels of vitamin B12 and folate were less likely to be obese.

关键词： Folate Vitamin B12 Childhood obesity Micronutrient

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Clinical evolution of antisynthetase syndrome-associated interstitial lung disease after COVID-19 in a man with Klinefelter syndrome:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1144-1149页

作者： Xiang-Xiang Wu Jian Cui Shi-Yao Wang Tian-Tian Zhao Ya-Fei Yuan Long Yang Wei zuo wen-Jian Liao Department of Respiratory and Critical Care The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina China-Japan Friendship Jiangxi Hospital Nanchang 330006Jiangxi ProvinceChina Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

BACKGROUND This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome(AS)following coronavirus disease 2019(COVID-19)in a 33-year-old man diagnosed with Klinefelter syndrome(KS).CASE SUMMARY A 33-year-old man with a diagnosis of KS was admitted to the Department of Pulmonary and Critical Care Medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of *** tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs,accompanied by signs of partial bronchial *** next-generation sequencing of the bronchoalveolar lavage fluid suggested absence of pathogen.A biopsy specimen revealed organizing pneumonia with alveolar septal ***,extensive auto-antibody tests showed strong positivity for anti-SSA,anti-SSB,anti-Jo-1,and *** multidisciplinary discussions,the patient received a final diagnosis of AS,leading to rapidly progressing respiratory *** This study underscores the clinical progression of AS-associated interstitial lung disease subsequent to viral infections such as COVID-19 in patients diagnosed with KS.

关键词： Antisynthetase syndrome COVID-19 Klinefelter syndrome Interstitial lung disease Anti-Jo-1 Case report

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FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1803-1824页

作者： Xian-Ze Xie Lei zuo Wei Huang Qiao-Mei Fan Ya-Yun weng wen-Dong Yao Jia-Li Jiang Jia-Qi Jin Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310018Zhejiang ProvinceChina Anhui Province Huainan City Shou County Agricultural Machinery Affairs Management Center Huainan 232200Anhui ProvinceChina

BACKGROUND Stomach adenocarcinoma(STAD)is one of the main reasons for cancer-related deaths *** investigation aimed to define the connection between STAD and Cuproptosis-related genes(CRGs).Cuproptosis is a newly identified form of mitochondrial cell death triggered by *** To explore the identification of potential biomarkers for STAD disease based on *** A predictive model using Gene Ontology(GO),Least Absolute Shrinkage and Selection Operator(LASSO),Kyoto Encyclopedia of Genes and Genomes(KEGG),Gene Set Variation Analysis(GSVA),and Gene Set Enrichment Analysis analyzed gene interconnections,focusing on 3 copper-related genes and their expression in The Cancer Genome *** for mRNA-miRNA and mRNA-transcription factor interactions were *** prognostic significance of CRG scores was evaluated using time-receiver operating characteristic,Kaplan-Meier curves,and COX regression *** was conducted with datasets GSE26942,GSE54129,and *** of copper-related differ-entially expressed genes was also analyzed in various human tissues and gastric cancer subpopulations using the human protein *** Three significant genes(FDX1,LIAS,MTF1)were identified and selected via LASSO analysis to predict and classify individuals with STAD into high and low CRG score *** genes were down-regulated in both risk *** and KEGG analyses highlighted their involvement mainly in the electron transport *** validating their differential expression,FDX1 emerged as the most accurate diagnostic marker for gastric ***,the RCircos package localized FDX1 on chromosome *** Our study revealed that FDX1 could be a potential biomarker and treatment target for gastric malignancy,providing new ideas for further scientific research.

关键词： Stomach adenocarcinoma disease Copper death FDX1 prognostic biomarkers Cuproptosis-related genes

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高分辨率罗兰圆光学系统的色差校正方法研究

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光谱学与光谱分析 2024年第7期44卷 2011-2017页

作者：陈吉文陈作儿北方工业大学电气与控制工程学院北京100144

罗兰圆光学系统优点众多,但系统中因平凸透镜的使用,导致各特征波长色散后的成像点在罗兰圆附近产生了一定量的偏移量,使得各波长成像点依次排列在一条曲面上。由于目前新型采集器件线阵CMOS或CCD的使用,而这类传感器的感光面是一个平面... 详细信息

罗兰圆光学系统优点众多,但系统中因平凸透镜的使用,导致各特征波长色散后的成像点在罗兰圆附近产生了一定量的偏移量,使得各波长成像点依次排列在一条曲面上。由于目前新型采集器件线阵CMOS或CCD的使用,而这类传感器的感光面是一个平面,因此导致结果产生较严重的色差。提出了一种使用加权最小二乘法拟合像面的色差校正方法,并计算出系统像面的中心偏移距和偏移倾斜角这两个校正参数,将其引入原本罗兰圆光学系统进行色差校正,从而确定线阵光电传感器像面的最佳位置,实现高分辨率。此外在真空紫外光谱中C、P和S等元素非常重要,可使用本文提出的基于加权最小二乘法的色差校正方法,通过增加这类元素权值占比,实现最优分辨率。最后通过Zemax软件进行光学仿真,完成了罗兰圆光学系统的仿真以及优化。并给出170~410 nm波段点列图的成像宽度仿真以及各元素特征波长在CMOS传感器上所采集到的光谱图,推算出其实际应用中的分辨率,其照度光谱图显示其分辨率均可保持在0.02 nm,接近系统理论最佳分辨率。研究结果表明基于加权最小二乘法拟合像面的方法,可实现罗兰圆光学系统的色差校正,实现高分辨率。

关键词：罗兰圆光学系统平凸透镜色差校正高分辨率加权最小二乘法

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Single-center retrospective study of the diagnostic value of doubleballoon enteroscopy in Meckel’s diverticulum with bleeding

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1043-1054页

作者： Tian He Chao Yang Jing Wang Ji-Sheng Zhong Ai-Hua Li Ya-Jing Yin Li-Ling Luo Chun-Mei Rao Nian-Fen Mao Qiang Guo Zan zuo wen Zhang Ping Wan Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceThe Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Medicine Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina School of Medicine Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina Department of Gastroenterology Qujing Hospital of Traditional Chinese MedicineQujing 655000Yunnan ProvinceChina Department of Gastroenterology Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina

BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract ***,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula *** To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with *** The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of ***(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 *** incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)was30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before *** endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal u

关键词： Meckel’s diverticulum with bleeding Double-balloon colonoscopy 99mTc-pertechnetate scanning Capsule endoscopy Ectopic gastric mucosa

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Probing the peripheral self-generated magnetic field distribution in laser-plasma magnetic reconnection with Martin-Puplett interferometer polarimeter

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Chinese Physics B 2024年第4期33卷 129-134页

作者：张雅芃姚嘉文刘正东马作霖仲佳勇 Department of Astronomy Beijing Normal UniversityBeijing 100875China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China

Magnetic reconnection of the self-generated magnetic fields in laser-plasma interaction is an important laboratory method for modeling high-energy density astronomical and astrophysical *** use the Martin-Puplett interferometer(MPI)polarimeter to probe the peripheral magnetic fields generated in the common magnetic reconnection configuration,two separated coplanar plane targets,in laser-target *** introduce a new method that can obtain polarization information from the interference pattern instead of the sinusoidal function fitting of the intensity.A bidirectional magnetic field is observed from the side view,which is consistent with the magneto-hydro-dynamical(MHD)simulation results of self-generated magnetic field *** find that the cancellation of reverse magnetic fields after averaging and integration along the observing direction could reduce the magnetic field strength by one to two orders of *** indicates that imaging resolution can significantly affect the accuracy of measured magnetic field strength.

关键词： laser-plasma experiment polarimeter self-generated magnetic field magnetic reconnection

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遥感图像密集小目标全方位精准检测算法

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吉林大学学报（工学版） 2024年第4期54卷 1105-1113页

作者：张云佐郭威李文博石家庄铁道大学信息科学与技术学院石家庄050043 河北省电磁环境效应与信息处理重点实验室石家庄050043

针对遥感图像中目标排列密集且方向不相同,导致现有检测算法难以准确定位实例目标的问题,提出了一种遥感图像密集小目标全方位精准检测算法。首先,为提升特征提取能力,在主干网络的残差结构中引入Meta-ACON激活函数,自适应地学习信道特... 详细信息

针对遥感图像中目标排列密集且方向不相同,导致现有检测算法难以准确定位实例目标的问题,提出了一种遥感图像密集小目标全方位精准检测算法。首先,为提升特征提取能力,在主干网络的残差结构中引入Meta-ACON激活函数,自适应地学习信道特征的重要性;其次,提出一种加强连接特征金字塔网络,重新设计了用于深浅层特征融合的侧向连接部分,并在同层次特征图输入与输出之间添加了跳跃连接,丰富特征语义信息;再次,引入角度预测分支,使用环形平滑标签方法将角度回归问题转化为分类问题,在实现目标框旋转的同时解决了旋转框边界突变的问题;最后,设计针对旋转检测框的后处理方法(Rotate-Soft-NMS),通过抑制检测框的置信度去除相邻的重复旋转检测框。在DOTA数据集上的实验结果表明:该算法的平均精度均值达到76.15%,相比于基准模型YOLOv5m提升了5.22%,与其他先进算法相比取得了最好的检测结果。本文算法对复杂遥感场景的目标具有更优的检测效果。

关键词：计算机应用遥感目标检测 Meta-ACON激活函数加强连接特征金字塔网络角度预测旋转检测框

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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科学通报 2024年

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase SpeF and P450 monooxygenase SpeG, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, SpeF/SpeG metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-mA with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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益肾安胎化瘀方对肾虚血瘀型早期先兆流产合并绒毛膜下血肿患者凝血指标及妊娠结局的影响

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中国中西医结合杂志 2024年第1期44卷 31-36页

作者：杨琳左文婷江苏省中医院南京中医药大学附属医院检验科南京210000 江苏省中医院南京中医药大学附属医院生殖医学科南京210000

目的回顾性分析益肾安胎化瘀方联合孕激素对肾虚血瘀型先兆流产合并绒毛膜下血肿(SCH)患者的妊娠结局及凝血指标的影响。方法92例诊断为早期先兆流产合并绒毛膜下血肿的患者(肾虚血瘀型),根据入院后有无使用中药,分为观察组和对照组,每... 详细信息

目的回顾性分析益肾安胎化瘀方联合孕激素对肾虚血瘀型先兆流产合并绒毛膜下血肿(SCH)患者的妊娠结局及凝血指标的影响。方法92例诊断为早期先兆流产合并绒毛膜下血肿的患者(肾虚血瘀型),根据入院后有无使用中药,分为观察组和对照组,每组46例,观察两组临床疗效有效率、SCH面积、孕三项、凝血指标及妊娠结局。结果(1)临床有效率及中医主、次症状评分:观察组临床总有效率93.48%(43/46),对照组52.17%(24/46),两组比较,差异有统计学意义(χ^(2)=39.864,P<0.01);与本组治疗前比较,观察组治疗7、14天后各主、次症状评分均显著下降(P<0.01),对照组14天后阴道出血、夜尿频数、面色晦暗评分显著下降(P<0.01);组间比较,观察组治疗7、14天后各主、次症状评分均显著低于对照组(P<0.01);(2)SCH、SCH面积/孕囊(GS)面积比值、孕三项、凝血指标及子宫动脉阻力指数(RI):与本组治疗前比较,治疗7天后,观察组SCH、SCH/GS、子宫动脉RI均显著降低(P<0.05),血雌二醇(E_(2))、β-人绒毛膜促性腺激素(β-HCG)显著升高(P<0.05),对照组SCH/GS显著降低(P<0.05),E_(2)、β-HCG显著升高(P<0.05);治疗14天后,观察组SCH、SCH/GS、血浆D-二聚体(D-D)、血小板聚集率(ADP)、RI显著降低(P<0.05),E_(2)、孕酮(P)、β-HCG显著升高(P<0.05),对照组SCH、SCH/GS显著降低(P<0.05)。组间比较,观察组显著优于对照组(P<0.05)。(3)两组住院天数观察组(7.63±3.49)天,对照组(9.47±4.77)天,阴道血止时间观察组(3.17±2.14)天,对照组(4.41±2.05)天,观察组住院天数、阴道血止时间均显著低于对照组(t1=2.122,t2=2.834,P<0.05);(4)观察组足月产率[84.78%(39/46)]高于对照组[56.52%(26/46)],早产率[6.52%(3/46)]低于对照组[17.39%(8/46)],流产率[8.69%(4/46)]低于对照组[26.09%(12/46)],其中足月产率、流产率比较,差异有统计学意义(χ_(1)^(2)=4.842,P<0.05;χ_(2)^(2)=8.859,P<0.01)。结论益肾安胎化瘀方联合地屈孕酮、黄体酮注射液对肾虚血瘀型早期先兆流产合并SCH患者,能缩短阴道出血时间,促进SCH吸收,改善凝血功能,降低子宫动脉RI,促进P、β-HCG的分泌,从而减少住院天数,降低流产率、早产率,提高足月产率。

关键词：益肾安胎化瘀方肾虚血瘀先兆流产合并绒毛膜下血肿凝血指标妊娠结局中西医结合

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数字新基建、要素市场化与中国制造业价值链升级

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技术经济与管理研究 2024年第7期 76-83页

作者：王正左文进上海财经大学浙江学院浙江金华321000

选取我国2012—2022年30个省级行政区面板数据,借助动态面板数据模型,实证检验数字新基建对制造业价值链升级的影响及作用机制。结果显示:数字新基建对制造业价值链升级具有显著正向影响,且该结论经过一系列内生性及稳健性检验后仍成立... 详细信息

选取我国2012—2022年30个省级行政区面板数据,借助动态面板数据模型,实证检验数字新基建对制造业价值链升级的影响及作用机制。结果显示:数字新基建对制造业价值链升级具有显著正向影响,且该结论经过一系列内生性及稳健性检验后仍成立。数字新基建对制造业价值链升级的促进作用存在显著区域异质性,具体表现为对东部地区省份、“一带一路”沿线省份制造业价值链升级的促进作用更强。进一步检验发现,数字新基建可通过推动要素市场化发展间接促进制造业价值链升级。基于此,应积极部署新一轮数字新基建项目,均衡分布数字新基建资源,有序推进要素市场化改革,以期推动中国制造业全球价值链向更高位势攀升。

关键词：数字新基建要素市场化制造业价值链升级

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