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武汉市昼夜温差对60岁及以上老年人缺血性心脏病住院量的影响

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环境与职业医学 2024年第8期41卷 898-904页

作者：吴亚静刘星媛秦孟雪杜雅婷左秀然邹宇量武汉大学公共卫生学院流行病与卫生统计学系/健康管理研究中心武汉市卫生健康信息中心

[背景]昼夜温差（DTR）与老年人心血管健康密切相关，但是缺少关于DTR与老年人缺血性心脏病（IHD）的研究。[目的]探究DTR对武汉市60岁及以上老年人IHD每日住院量的影响。[方法]获取2017年1月1日至2018年12月31日期间武汉市全部二级及... 详细信息

[背景]昼夜温差（DTR）与老年人心血管健康密切相关，但是缺少关于DTR与老年人缺血性心脏病（IHD）的研究。[目的]探究DTR对武汉市60岁及以上老年人IHD每日住院量的影响。[方法]获取2017年1月1日至2018年12月31日期间武汉市全部二级及以上医院IHD老年住院患者信息和同期气象数据及空气污染数据，根据每日最高温度和最低温度计算每日DTR。采用基于类泊松分布的分布滞后非线性模型分析DTR与60岁及以上老年人住院的关联。以DTR的第1百分位数（P1:1.8℃）、第5百分数（P5:2.9℃）、95百分位数(P95:14.3℃)和第99百分位数(P99:16.2℃)来评估极端DTR对武汉市60岁及以上老年人IHD住院的影响。进一步根据性别、年龄（60～74岁和≥75岁）、不同亚型（急性IHD和慢性IHD）进行分层，分别分析DTR对不同性别、年龄和不同亚型IHD住院的影响。[结果]共纳入武汉市2017年至2018年60岁及以上老年人首次IHD住院病例64 212例。武汉市DTR与老年居民IHD住院风险累积滞后7 d的暴露-反应关系呈现“J型”分布，最适DTR为5.0℃，DTR越大，滞后时间越长，老年人因IHD住院风险越高。极高DTR（P99:16.2℃）在暴露当天（lag 0）效应明显，滞后7 d时的累积效应达到1.58（95%CI:1.25～1.99）。DTR对不同性别、年龄人群的IHD和不同亚型IHD的总体影响与总人群呈现相似特征。与急性IHD （RR=1.29,95%CI:1.04～1.61）相比，高DTR对慢性IHD住院的影响更大（RR=1.46,95%CI:1.20～1.79）。在累积滞后7 d时，60～74岁老年人（RR=1.78,95%CI:1.30～2.42）比≥75岁（RR=1.35,95%CI:1.08～1.70）老年人IHD住院受高DTR的影响更大。[结论]高DTR能显著增加老年人IHD住院风险，慢性IHD患者和60～74岁的老年人受到高DTR的影响更为明显。

关键词：老年人昼夜温差缺血性心脏病分布滞后非线性住院风险

学科前沿成果为载体的国家一流课程生物化学教学与育人有机融合的探索与实践

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微生物学杂志 2024年第4期44卷 119-128页

作者：闫荣玲廖阳李常健覃佐东曾二青湖南科技学院化学与生物工程学院湖南永州425199

局限教材有限内容与课堂有限时空的传统教学,不能很好地契合新时代金课标准以及高素质人才培养的需要。借助信息技术在课程教学不同环节融入学科前沿研究成果是优化教学内容、突破时空界限、提高学生素养、促进教学与育人有机融合的有... 详细信息

局限教材有限内容与课堂有限时空的传统教学,不能很好地契合新时代金课标准以及高素质人才培养的需要。借助信息技术在课程教学不同环节融入学科前沿研究成果是优化教学内容、突破时空界限、提高学生素养、促进教学与育人有机融合的有效途径。国家一流本科课程“生物化学”教学团队借助学银在线、微信共享、虚拟仿真等信息化平台,把学科前沿成果巧妙融入课中教学活动或课前、课后的自主任务中,创新了课程教学模式与方法,提升了学生学习兴趣,夯实了学生综合能力,同时熏陶了学生创新思维、求真品质、人文素养、家国情怀,很好地实现了课程教学创新与思政育人的有机融合。

关键词：生物化学前沿成果教学模式教学效果思政育人信息技术

髌骨磁共振影像组学特征预测骨关节炎放射学进展的诊断价值

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川北医学院学报 2024年第5期39卷 577-582页

作者：姜海彭宜秦思宇左后东川北医学院附属医院放射科·医学影像四川省重点实验室四川南充637000 川北医学院附属成都新华医院放射科四川成都610073

目的:探讨基线时髌骨磁共振成像(MRI)影像组学特征,建立预测膝骨关节炎(OA)放射学进展的影像组学模型。方法:回顾性分析骨关节炎倡议(OAI)中的FNIH生物标志物联盟项目数据集,将584名研究对象分为训练组(n=408)和验证组(n=176)。训练组中... 详细信息

目的:探讨基线时髌骨磁共振成像(MRI)影像组学特征,建立预测膝骨关节炎(OA)放射学进展的影像组学模型。方法:回顾性分析骨关节炎倡议(OAI)中的FNIH生物标志物联盟项目数据集,将584名研究对象分为训练组(n=408)和验证组(n=176)。训练组中,病例203例,对照205例;验证组中,病例和对照均为88例。采用最小绝对收缩和选择算子(LASSO)进行特征选择、支持向量机(SVM)建立影像组学模型和临床模型。采用曲线下面积(AUC)评估模型预测能力。结果:影像组学模型训练组及验证组AUC分别为0.809和0.781;临床模型训练组及验证组模型AUC分别为0.648及0.614。经DeLong检验表明影像组学模型优于临床模型(P<0.05)。结论:髌骨MRI影像组学模型对膝关节OA放射学进展的预测效能较高,优于现有临床模型。

关键词：骨关节炎影像组学髌骨磁共振

Novel Mesoporous Hydroxyapatite/Chitosan Composite for Bone Repair

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Journal of Bionic Engineering 2012年第2期9卷 243-251页

作者： Jingzhe Zhang guangyao Liu Qiong Wu Jianlin zuo Yanguo qin Jincheng wa.g Orthopedic Department China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China

The objective of the present investigation was to evaluate the osteogenic properties of mesoporous Hydroxyapatite/Chitosan （HAJCS） composite in vitro and in vivo. HA/CS composite was successfully prepared and synthesized using a freeze-drying method, and then characterized by Scanning Electron Microscope （SEM）. Results show that the mesoporous HA/CS composite presents high surface area and porosity. The effects of mesoporous HA/CS on early adhesion, proliferation and differentiation of osteoblast cells in vitro were measured. MTT cytotoxicity test and cell adhesion test show that the composite has good biocompatibility and promotes cell viability and proliferation. In vitro tests show that osteoblast-like cells on the composite surfaces are able to adhere, proliferate, and migrate through the pores. These cells maintained similar expression levels of osteoblastic-associated markers namely Collagen type I （COL-I）, Bone Morphogenetic Protein 2（BMP-2）. Histologic analysis and radiological analysis in vivo also prove that mesoporous HA/CS composite can be used to repair bone defect as a new kind of bone grafting materials.

关键词： hydroxyapatite/chitosan composite bone repair biocompatibility freeze-drying

Pyrene Derivate Functionalized with Acetylene for Organic Field Effect Transistors

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Chinese Journal of Chemical Physics 2015年第6期28卷 -页

作者： zuo-qin Liang Jie Zhou Xiao-mei wa.g Xu-tang Tao Jiangsu Key Laboratory for Environment Functional Materials School of Chemistry Biology and Material Engineering Suzhou University of Science and Technology Suzhou 215009 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China

A new X-shaped compound (SiPy) functionalized with acetylene bonds in the 1-, 3-, 6-, and 8-positions of the pyrene core has been synthesized by Sonogashira coupling reactions. Its photophysical, thermal, and organic field effect transistor (OFET) properties as well as the film morphologies have been investigated. SiPy exhibits high stability which is evidenced by thermal gravimetric analysis. The atomic force microscopy images reveal that the morphol- ogy of thin films depends on the substrate temperature. The film OFET devices based on SiPy were constructed and exhibited p-type performances.

关键词： Pyrene Acetylene Organic field effect transistors Carrier mobility On/off ratio

Piezotronics in two-dimensional materials

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InfoMat 2021年第9期3卷 987-1007页

作者： qin Zhang Shanling zuo Ping Chen Caofeng Pan Center on Nanoenergy Research Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi UniversityNanningChina CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijingChina School of Nanoscience and Technology University of Chinese Academy of SciencesBeijingChina

The fascinating two-dimensional(2D)materials are being potentially applied in various fields from science to engineering benefitting from the charming physical and chemical properties on optics,electronics,and magnetism,compared with the bulk crystal,while piezotronics is a universal and pervasive phenomenon in the materials with broking center symmetry,promoting the new field and notable achievements of piezotronics in 2D materials with higher accuracy and *** example,20 parts per billion of the detecting limitations in NO_(2)sensor,500μm of spatial strain resolution in flexible devices,and 0.363 eV output voltage in *** this review,three categories of 2D piezotronics materials are first introduced ranging from organic to inorganic data,among which six types of 2D inorganic materials are emphasized based on the geometrical arrangement of different ***,the microscopic mechanism of carrier transport and separation in 2D piezotronic materials is highlighted,accompanied with the presentation of four measured ***,the developed applications of 2D piezotronics are discussed comprehensively including different kinds of sensors,piezo-catalysis,nanogenerators and information ***,we suggest the challenges and provide the ideas for qualitative-quantitative research of microscopic mechanism and large-scale integrated applications of 2D piezotronics.

关键词： carrier transport flexible devices piezotronics two-dimensional materials

基于结构方程模型云南省4个民族农村老年人尼古丁依赖情况及其影响因素分析

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中国公共卫生 2024年第5期40卷 545-549页

作者：李国晖刘岚刘杜丽余孜孜左梅黄友李芹蔡乐国家卫健委毒品依赖和戒治重点实验室昆明650500 昆明医科大学公共卫生学院昆明650500

目的了解云南省汉族、傣族、哈尼族和白族4个民族农村老年人尼古丁依赖情况及其影响因素,为制定减轻尼古丁依赖症状的防控策略提供参考依据。方法于2021年7月—2022年5月采用多阶段分层随机抽样方法在云南省抽取5800名汉族、傣族、哈尼... 详细信息

目的了解云南省汉族、傣族、哈尼族和白族4个民族农村老年人尼古丁依赖情况及其影响因素,为制定减轻尼古丁依赖症状的防控策略提供参考依据。方法于2021年7月—2022年5月采用多阶段分层随机抽样方法在云南省抽取5800名汉族、傣族、哈尼族和白族≥60岁农村老年人进行问卷调查,采用主成分分析法构建社会经济地位综合得分,并应用结构方程模型分析4个民族农村老年人尼古丁依赖的影响因素。结果最终纳入分析的云南省5642名4个民族农村老年人中,有尼古丁依赖者935人,尼古丁依赖率为16.57%。汉族、傣族、哈尼族和白族农村老年人的尼古丁依赖率分别为17.34%、11.64%、16.41%和20.87%,不同民族农村老年人的尼古丁依赖率差异有统计学意义(χ^(2)=44.410,P<0.001)。结构方程模型分析结果显示,性别、民族、社会经济地位和是否尝试戒烟对老年人尼古丁依赖有直接和间接影响,其总路径系数分别为-0.33、-0.03、0.08和-0.06;其中,性别通过每日吸烟量产生间接影响,民族和是否尝试戒烟通过社会支持产生间接影响,社会经济地位通过社会支持和每日吸烟量产生间接影响,其作用路径系数分别为-0.07、-0.01、-0.01和0.03;社会支持和每日吸烟量对老年人尼古丁依赖有直接影响,其路径系数分别为-0.06和0.18。结论云南省4个民族农村老年人的尼古丁依赖情况存在明显的民族差异,尤其应加强男性、每日吸烟量多、社会经济地位高、社会支持评分低、未尝试戒烟和白族老年人尼古丁依赖的预防和控制工作。

关键词：尼古丁依赖影响因素老年人农村民族结构方程模型

Structural,electronic,and magnetic properties of vanadium atom-adsorbed MoSe2 monolayer

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Chinese Physics B 2017年第2期26卷 392-398页

作者： Ping Llu Zhen-Zhen qin Yun-Liang Yue Xu zuo College of Electronic Information and Optical Engineering Nankai University Tianjin 300071 China

Using the first-principles calculations, we study the structural, electronic, and magnetic properties of vanadium adsorbed MoSe_2 monolayer, and the magnetic couplings between the V adatoms at different adsorption concentrations. The calculations show that the V atom is chemically adsorbed on the MoSe_2 monolayer and prefers the location on the top of an Mo atom surrounded by three nearest-neighbor Se atoms. The interatomic electron transfer from the V to the nearestneighbor Se results in the polarized covalent bond with weak covalency, associated with the hybridizations of V with Se and Mo. The V adatom induces local impurity states in the middle of the band gap of pristine MoSe_2, and the peak of density of states right below the Fermi energy is associated with the V- dz^2 orbital. A single V adatom induces a magnetic moment of 5 μBthat mainly distributes on the V-3d and Mo-4d orbitals. The V adatom is in high-spin state, and its local magnetic moment is associated with the mid-gap impurity states that are mainly from the V-3d orbitals. In addition,the crystal field squashes a part of the V-4s electrons into the V-3d orbitals, which enhances the local magnetic *** magnetic ground states at different adsorption concentrations are calculated by generalized gradient approximations（ggA） and ggA＋U with enhanced electron localization. In addition, the exchange integrals between the nearest-neighbor V adatoms at different adsorption concentrations are calculated by fitting the first-principle total energies of ferromagnetic（FM） and antiferromagnetic（AFM） states to the Heisenberg model. The calculations with ggA show that there is a transition from ferromagnetic to antiferromagnetic ground state with increasing the distance between the V adatoms. We propose an exchange mechanism based on the on-site exchange on Mo and the hybridization between Mo and V, to explain the strong ferromagnetic coupling at a short distance between the V adatoms. However, the ferromagneti

关键词： V-adatom MoSe2 monolayer magnetic moment magnetic coupling first-principles calculation

Species Abundance in a Forest Community in South China：A Case of Poisson Lognormal Distribution

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Journal of Integrative Plant Biology 2005年第7期47卷 801-810页

作者： zuo-YunYIN HaiREN Qian-MeiZHANg Shao-LinPENg qin-FenggUO guo-YiZHOU SouthChinaBotanicalgarden（formerlySouthChinaInstituteofBotany） theChineseAcademyofSciencesGuangzhou510650China／／GuangdongForestResearchInstituteGuangzhou510520China SouthChinaBotanicalgarden（formerlySouthChinaInstituteofBotany） theChineseAcademyofSciencesGuangzhou510650China SouthChinaBotanicalgarden（formerlySouthChinaInstituteofBotany） theChineseAcademyofSciencesGuangzhou510650China／／SchoolofLifeSciencesZhongshanUniversityGuangzhou510275China SouthChinaBotanicalgarden（formerlySouthChinaInstituteofBotany） theChineseAcademyofSciencesGuangzhou510650China／／USGeologicalSurveyJamestownND58401USA

: Case studies on Poisson lognormal distribution of species abundance have been rare, especially in forest communities. We propose a numerical method to fit the Poisson lognormal to the species abundance data at an evergreen mixed forest in the Dinghushan Biosphere Reserve, South China. Plants in the tree, shrub and herb layers in 25 quadrats of 20 m× 20 m, 5 m× 5 m, and 1 m× 1 m were surveyed. Results indicated that: (i) for each layer, the observed species abundance with a similarly small median, mode, and a variance larger than the mean was reverse J-shaped and followed well the zero-truncated Poisson lognormal; (ii) the coefficient of variation, skewness and kurtosis of abundance, and two Poisson lognormal parameters (& and μ) for shrub layer were closer to those for the herb layer than those for the tree layer; and (iii) from the tree to the shrub to the herb layer, the α and the coefficient of variation decreased, whereas diversity increased. We suggest that: (i) the species abundance distributions in the three layers reflects the overall community characteristics; (ii) the Poisson lognormal can describe the species abundance distribution in diverse communities with a few abundant species but many rare species; and (iii) 1/α should be an alternative measure of diversity.

关键词： Dinghushan Biosphere Reserve forest community maximum likelihood estimate (MLE) reverse J-shaped curve species abundance distribution (SAD) value-trying method zero-truncated Poisson lognormal (PLN) distribution