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Chromosome-scale genomes of Quercus sichourensis and Quercus rex provide insights into the evolution and adaptation of Fagaceae

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Journal of Genetics and Genomics 2024年第5期51卷 554-565页

作者： Xue Liu Weixiong Zhang Yongting Zhang Jing Yang Peng Zeng zunzhe tian Weibang Sun Jing Cai Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'anShaanxi 710072China Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

The Fagaceae,a plant family with a wide distribution and diverse adaptability,has garnered significant interest as a subject of study in plant speciation and ***,certain Fagaceae species are regarded as highly valuable wood resources due to the exceptional quality of their *** this study,we present two high-quality,chromosome-scale genome sequences for Quercus sichourensis(848.75 Mb)and Quercus rex(883.46 Mb).Comparative genomics analysis reveals that the difference in the number of plant disease resistance genes and the nonsynonymous and synonymous substitution ratio(Ka/Ks)of protein-coding genes among Fagaceae species are related to different environmental ***,most genes related to starch synthesis in the investigated Quercoideae species are located on a single chromosome,as compared to the outgroup species,Fagus ***,resequencing and population analysis of *** and *** reveal that *** has lower genetic diversity and higher deleterious mutations compared to *** high-quality,chromosome-level genomes and the population genomic analysis of the critically endangered *** and *** will provide an invaluable resource as well as insights for future study in these two species,even the genus Quercus,to facilitate their conservation.

关键词： Adaptation Quercus sichourensis Quercusrex Chromosome-scale genome assembly Tandem duplication genes Extremely small populations

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Deep intraspecific divergence in Lancea tibetica（Mazaceae） distributed over the Qinghai-Tibetan Plateau

Deep intraspecific divergence in Lancea tibetica（Mazaceae）...

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中国植物学会第十六次全国会员代表大会暨85周年学术年会

作者： Mingze Xia zunzhe tian Faqi Zhang Gulzar Khan Qingbo Gao Rui Xing Yu Zhang Jingya Yu Shilong Chen Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of Sciences University of Chinese Academy of Sciences Qinghai Provincial Key Laboratory of Crop Molecular Breeding

Lancea tibetica,endemic to Qinghai-Tibetan Plateau（QTP）,is an important traditional Tibetan medicine,used in the treatment of leukaemia,intestinal angina,heart diseases and *** we investigated genetic diversity and past population dynamics of ***,using 429 individuals distributed in 29 populations all over *** generated chloroplast DNA（cpDNA） and nuclear ITS sequences for all the populations and *** results revealed a significant genealogical and geographical structure within the distribution range of *** haplotypes divided all populations into two lineages: the north one and *** and Bayangela mountains appear to act as a topological barrier,and probably played an important role towards the gene flow between both *** time between both lineages based on nuclear ITS sequences dated to 8.63 Mya,which corresponded well to the uplifting of QTP during Late Miocene and *** ecological differences found between the two lineages,seem to represent species-specific characteristics and are sufficient to keep both lineages separated to a high degree.

关键词： Deep divergence Qinghai-Tibetan Plateau Lancea tibetica population genetic structure phylogeography demography

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A Blockchain-Based Access Control Scheme for Reputation Value Attributes of the Internet of Things

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Computers, Materials & Continua 2024年第1期78卷 1297-1310页

作者： Hongliang tian Junyuan tian College of Electrical Engineering Northeast Electric Power UniversityJilin132012China

The Internet of Things(IoT)access controlmechanism may encounter security issues such as single point of failure and data *** address these issues,a blockchain-based IoT reputation value attribute access control scheme is ***,writing the reputation value as an attribute into the access control policy,and then deploying the access control policy in the smart contract of the blockchain system can enable the system to provide more fine-grained access control;Secondly,storing a large amount of resources fromthe Internet of Things in Inter Planetary File System(IPFS)to improve system throughput;Finally,map resource access operations to qualification tokens to improve the performance of the access control *** simulation experiments based on the Hyperledger Fabric *** simulation experimental results,it can be seen that the access control system can achieve more fine-grained and dynamic access control while maintaining high throughput and low time delay,providing sufficient reliability and security for access control of IoT devices.

关键词： Blockchain IoT access control Hyperledger Fabric

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Robust adaptive radar beamforming based on iterative training sample selection using kurtosis of generalized inner product statistics

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Journal of Systems Engineering and Electronics 2024年第1期35卷 24-30页

作者： tian Jing ZHANG Wei School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Electromagnetic Space Security Chengdu 610036China

In engineering application,there is only one adaptive weights estimated by most of traditional early warning radars for adaptive interference suppression in a pulse reputation interval(PRI).Therefore,if the training samples used to calculate the weight vector does not contain the jamming,then the jamming cannot be removed by adaptive spatial *** the weight vector is constantly updated in the range dimension,the training data may contain target echo signals,resulting in signal cancellation *** cope with the situation that the training samples are contaminated by target signal,an iterative training sample selection method based on non-homogeneous detector(NHD)is proposed in this paper for updating the weight vector in entire range *** principle is presented,and the validity is proven by simulation results.

关键词： adaptive radar beamforming training sample selection non-homogeneous detector electronic jamming jamming suppression

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Transformer and GAN-Based Super-Resolution Reconstruction Network for Medical Images

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Tsinghua Science and Technology 2024年第1期29卷 197-206页

作者： Weizhi Du Shihao tian Arts&Sciences College Washington University in St.LouisSt.LouisMO 63130USA Department of Electric and Computing Engineering Cornell UniversityIthacaNY 14850USA

Super-resolution reconstruction in medical imaging has become more demanding due to the necessity of obtaining high-quality images with minimal radiation dose,such as in low-field magnetic resonance imaging(MRI).However,image super-resolution reconstruction remains a difficult task because of the complexity and high textual requirements for diagnosis *** this paper,we offer a deep learning based strategy for reconstructing medical images from low resolutions utilizing Transformer and generative adversarial networks(T-GANs).The integrated system can extract more precise texture information and focus more on important locations through global image matching after successfully inserting Transformer into the generative adversarial network for picture ***,we weighted the combination of content loss,adversarial loss,and adversarial feature loss as the final multi-task loss function during the training of our proposed model *** comparison to established measures like peak signal-to-noise ratio(PSNR)and structural similarity index measure(SSIM),our suggested T-GAN achieves optimal performance and recovers more texture features in super-resolution reconstruction of MRI scanned images of the knees and belly.

关键词： super-resolution image reconstruction Transformer generative adversarial network(GAN)

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CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu tianyi tian Lu Wang Yinmei tian tian tian Yuanyuan Guo Hu Zhou Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-MDSCs)are highly infiltrated in SMAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-MDSCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-MDSC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of SMAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in SMAD4-deficient CRC.

关键词： SMAD4-deficient CRC Metastasis G-MDSCs TGF-β CCR1 TGFBR2

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Capturing metal clusters at the strong-interaction region to reverse Ostwald ripening

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Science China Materials 2024年第4期67卷 1363-1364页

作者： Shuheng tian Ding Ma Beijing National Laboratory for Molecular Sciences New Cornerstone Science LaboratoryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

High-temperature interactions induce sintering of metal nanoparticles(NPs) on heterogeneous catalyst surfaces, leading to reduced surface area and active site loss through Ostwald ripening [1]. This irreversible deactivation necessitates costly catalyst replacement, notably impacting metals like copper in hydrogenation and reforming reactions [2].

关键词： catalyst reforming irreversible

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DeepSI:A Sensitive-Driven Testing Samples Generation Method of Whitebox CNN Model for Edge Computing

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Tsinghua Science and Technology 2024年第3期29卷 784-794页

作者： Zhichao Lian Fengjun tian School of Cyber Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

In recent years,Deep Learning(DL)technique has been widely used in Internet of Things(IoT)and Industrial Internet of Things(IIoT)for edge computing,and achieved good *** more and more studies have shown the vulnerability of neural ***,it is important to test the robustness and vulnerability of neural *** specifically,inspired by layer-wise relevance propagation and neural network verification,we propose a novel measurement of sensitive neurons and important neurons,and propose a novel neuron coverage criterion for robustness *** on the novel criterion,we design a novel testing sample generation method,named DeepSI,which involves definitions of sensitive neurons and important ***,we construct sensitive-decision paths of the neural network through selecting sensitive neurons and important ***,we verify our idea by setting up several experiments,then results show our proposed method achieves superior performances.

关键词： neuron sensitivity Layer-wise Relevance Propagation(LRP) neural network verification deeplearning testing

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粗毛肉果草青藏高原新分布

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西北植物学报 2017年第7期37卷 1447-1449页

作者：迟晓峰张发起田尊哲陈世龙中国科学院西北高原生物研究所高原生物适应与进化重点实验室西宁810008 中国科学院大学北京100049

报道了青藏高原通泉草科(Mazaceae)肉果草属(Lancea)粗毛肉果草(Lancea hirsuta Bonati)新分布。该种分布于西藏八宿县(30°12′3.8″N,97°16′48″E)、西藏林周县(30°4′58.8″N,91°16′48″E)、西藏当雄县(30°32′24″N,91°20′24″E)和青海杂多县(33°4′48″N,95°9′36″E),该次发现将中国该种自然分布区扩大到西藏、青海等地,海拔分布也增加至4 300m。凭证标本现存于中国科学院青藏高原生物标本馆(HNWP)。

关键词：粗毛肉果草青藏高原新分布

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Frequency Domain Fatigue Evaluation on SCR Girth-Weld Based on Structural Stress

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China Ocean Engineering 2024年第2期38卷 255-270页

作者： ZHANG Long ZHAO tian-feng College of Safety and Ocean Engineering China University of Petroleum(Beijing)Beijing 102249China

The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating *** harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone to fatigue *** structural stress fatigue theory and Master S-N curve method provide accurate predictions for the fatigue damage on the welded joints,which demonstrate significant potential and compatibility in multi-axial and random fatigue ***,we propose a new frequency fatigue model subjected to welded joints of SCR under multiaxial stress,which fully integrates the mesh-insensitive structural stress and frequency domain random process and transforms the conventional welding fatigue technique of SCR into a spectrum analysis technique utilizing structural ***,a full-scale FE model of SCR with welds is established to obtain the modal structural stress of the girth weld and the frequency response function(FRF)of modal coordinate,and a biaxial fatigue evaluation about the girth weld of the SCR can be achieved by taking the effects of multi-load correlation and pipe-soil interaction into *** research results indicate that the frequency-domain fatigue results are aligned with the time-domain results,meeting the fatigue evaluation requirements of the SCR.

关键词： SCR girth weld random vibration self(cross)power spectrum structural stress method biaxial fatigue damage

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