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Hepatitis C Virus and Hepatocellular Carcinoma:A Narrative Review

Journal of Clinical and Translational Hepatology 2018年第1期6卷 79-84页

作者： Page Axley zunirah ahmed Sujan Ravi Ashwani K. Singa Department of Medicine University of Alabama at BirminghamBirminghamALUSA Division of Gastroenterology and Hepatology University of Alabama at BirminghamAL 35294-0012USA

Hepatocellular carcinoma(HCC)is a leading cause of liverrelated death *** C virus(HCV)infection is a major cause of advanced hepatic fibrosis and cirrhosis,with significantly increased risk for development of *** morbidity and mortality of HCV-related HCC remains high,as rates of HCV cirrhosis continue to *** long-term goal of antiviral therapy for chronic HCV is to reduce complications from cirrhosis,including *** advent of new direct-acting antivirals with high rates of virological clearance has revolutionized cure of HCV *** the development of HCC in HCV patients who achieve disease sustained virologic response is reduced,these patients remain at risk for HCC,particularly those patients with advanced fibrosis and *** review outlines the epidemiology of HCC in chronic HCV,various mechanisms,risk factors and pathophysiology that contribute to this disease process,screening recommendations,and the available data on the impact of new direct-acting antiviral treatment on the development on HCC.

关键词： Hepatitis C Hepatocellular carcinoma Direct-acting antiviral Viral hepatitis

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Viral hepatitis:A narrative review of hepatitis A–E

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World Journal of Meta-Analysis 2022年第3期10卷 99-121页

作者： zunirah ahmed Akshay Shetty David W Victor Sudha Kodali Division of Gastroenterology and Hepatology Underwood Center for Digestive DisordersHouston Methodist HospitalHoustonTX 77030United States Department of Gastroenterology and Hepatology University of CaliforniaLos AngelesCA 90095United States Department of Hepatology J C Walter Jr Transplant CenterSherrie and Alan Conover Center for Liver Disease and TransplantationWeill Cornell Medical CollegeHoustonTX 77030United States

Viral hepatitis continues to be a major health concern leading to hepatic decompensation ranging from acute hepatitis to cirrhosis and hepatocellular *** hepatic and extrahepatic manifestations are not only debilitating but also associated with a significant economic *** the last two decades,the field of virology has made significant breakthroughs leading to a better understanding of the pathophysiology of viral hepatitis,which in turn has led to new therapeutic *** advent of direct-acting antiviral agents changed the landscape of hepatitis C virus(HCV)therapy,and new drugs are in the pipeline for chronic hepatitis B virus(HBV)*** has also been a significant emphasis on screening and surveillance programs,widespread availability of vaccines,and linkage of *** these efforts,significant gaps persist in care,and there is a pressing need for increased collaboration and teamwork across the globe to achieve a reduction of disease burden and elimination of HBV and HCV.

关键词： Viral hepatitis Recent advances Novel therapies Barriers to cure Future direction

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