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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao yini Li dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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Analysis for the residual prestress of composite barrel for railgun with tension winding

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Defence Technology（防务技术） 2020年第4期16卷 893-899页

作者： dong-mei yin Bao-ming Li Hong-cheng Xiao National Key Laboratory of Transient Physics Nanjing University of Science&TechnologyNanjing210094China

Based on the elastic theory of cylindrical shells and the theory of composite laminates,a prediction model for the residual prestress of the simplified round composite barrel for railgun is *** the fibre pretension is considered in this model.A three dimensional numerical simulation for the residual prestress in the railgun barrel is carried out,by combining the temperature differential method with the element birth and death *** results obtained by the two methods are *** reveals that the distribution trends of residual prestress are *** the difference for residual prestress in the filament wound composite housing of barrel is relatively *** same finite element method is used to analysis the residual prestress in the non-simplified composite barrels for railgun,which are under different control modes of winding *** results mean that the residual prestress in barrel will increase while the taper coefficient for winding is ***,the sealing performance in bore is improved,but the strength of the filament wound composite housing *** addition,the axial and circumferential residual prestress in the filament wound composite housing with constant torque winding are close to the ones in iso-stress design for barrel.

关键词： Railgun Barrel Composite materials Filament winding Winding tension Residual prestress

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Effect of Dynamic Pressure Feedback Orifice on Stability of Cartridge-Type Hydraulic Pilot-Operated Relief Valve

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Chinese Journal of Mechanical Engineering 2023年第4期36卷 227-241页

作者： Yaobao yin dong Wang Junyong Fu Hong-chao Jian School of Mechanical Engineering Tongji UniversityShanghai 201804China Shanghai Aerospace Control Technology Institute Shanghai 201109China China North Vehicle research institute Beijing 100072China

Current research on pilot-operated relief valve stability is primarily conducted from the perspective of system dynamics or stability criteria,and most of the existing conclusions focus on the spool shape,damping hole size,and pulsation frequency of the ***,the essential factors pertaining to the unstable vibration of relief valves remain *** this study,the dynamic behavior of a pilot-operated relief valve is investigated using the frequency-domain *** result suggests that the dynamic pressure feedback orifice is vital to the dynamic characteristics of the valve.A large orifice has a low flow *** this case,the fluid in the main spring chamber flows freely,which is not conducive to the stability of the relief ***,a small orifice may create significant flow resistance,thus restricting fluid *** this case,the oil inside the main valve spring chamber is equivalent to a high-stiffness liquid *** main mass-spring vibration system has a natural frequency that differs significantly from the operating frequency of the relief valve,which is conducive to the stability of the relief *** agreement is obtained between the theoretical analysis and *** results indicate that designing a dynamic pressure feedback orifice of an appropriate size is beneficial to improving the stability of hydraulic pilot-operated relief *** addition,the dynamic pressure feedback orifice reduces the response speed of the relief *** study comprehensively considers the stability,rapidity,and immunity of relief valves and expands current investigations into the dynamic characteristics of relief valves from the perspective of classical control theory,thus revealing the importance of different parameters.

关键词： Pilot-operated relief valve Dynamic pressure feedback orifice Stability Rapidity Immunity

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Synthesis and Characterization of La(OH)_3 Nanorods by Hydrothermal Microemulsion Method

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Chinese Chemical Letters 2005年第12期16卷 1659-1662页

作者： Yi dong yin Guang Yan HONG Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 School of Chemistry and Materials Science Heilongjiang University Harbin 150080 Graduate School of the Chinese Academy of Sciences Beijing 100049

La（OH）3 nanorods with diameters of 20-40 nm and lengths of 200-300 nm were synthesized by a hydrothermal microemulsion method. The structure and morphology of the final products were characterized by X-ray powder diffraction （XRD）, transmission electron microscopy （TEM）, and field emission scanning electron microscope （FESEM）.

关键词： One dimensional nanostructures La(OH)3 nanorods hydrothermal microemulsion

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A Note on Quasi-weakly Almost Periodic Point

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Acta Mathematica Sinica,English Series 2015年第4期31卷 637-646页

作者： Qi YAN Jian dong yin Tao WANG Department of Mathematics Nanchang University

Recently, He et al. [On quasi-weakly almost periodic points. Sci. China Math., 56, 597- 606 （2013）] constructed two binary sub-shifts to solve an open problem posed by Zhou and Feng in [Twelve open problems on the exact value of the Hausdorff measure and on topological entropy： A brief survey of recent results. Nonlinearity, 17, 493-502 （2004）]. In this paper, we study more dynamical properties of those two binary sub-shifts. We show that the first one has zero topological entropy and is transitive but not weakly mixing, while the second one has positive topological entropy and is strongly mixing.

关键词： Topological entropy weakly almost periodic point quasi-weakly almost periodic point,strongly mixing

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Temporal changes in the spinal cord transcriptome after peripheral nerve injury

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Neural Regeneration Research 2020年第7期15卷 1360-1367页

作者： Jian Weng dong-dong Li Bao-Guo Jiang Xiao-Feng yin Department of Orthopedics and Trauma Peking University People's HospitalBeijingChina Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhenGuangdong ProvinceChina Department of Surgery the 517th Hospital of the People's Liberation ArmyXinzhouShanxi ProvinceChina

Peripheral nerve injury may trigger changes in mRNA levels in the spinal *** key mRNAs is important for improving repair after nerve *** study aimed to investigate changes in mRNAs in the spinal cord following sciatic nerve injury by transcriptomic *** left sciatic nerve denervation model was established in C57 BL/6 *** left L4–6 spinal cord segment was obtained at 0,1,2,4 and 8 weeks after severing the sciatic *** expression profiles were generated by RNA *** sequencing results of spinal cord mRNA at 1,2,4,and 8 weeks after severing the sciatic nerve were compared with those at 0 weeks by bioinformatic *** identified 1915 differentially expressed mRNAs in the spinal cord,of which 4,1909,and 2 were differentially expressed at 1,4,and 8 weeks after sciatic nerve injury,*** results indicated that the number of differentially expressed mRNAs in the spinal cord was highest at 4 weeks after sciatic nerve *** mRNAs were associated with the cellular response to lipid,ATP metabolism,energy coupled proton transmembrane transport,nuclear transcription factor complex,vacuolar proton-transporting V-type ATPase complex,inner mitochondrial membrane protein complex,tau protein binding,NADH dehydrogenase activity and hydrogen ion transmembrane transporter *** these mRNAs,Sgk1,Neurturin and Gpnmb took part in cell growth and *** analysis showed that these mRNAs were mainly involved in aldosterone-regulated sodium reabsorption,oxidative phosphorylation and collecting duct acid *** assessment indicated that these mRNAs were associated with inflammation and cell morphology *** findings show that the number and type of spinal cord mRNAs involved in changes at different time points after peripheral nerve injury were *** number of differentially expressed mRNAs in the spinal cord was highest at 4 weeks after sciatic nerve *** results

关键词： deep sequencing expression profile gene therapy mRNAs nerve regeneration peripheral nerve injury RNA sequencing sciatic nerve injury spinal cord transcriptome

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Several Transitive Properties and Devaney's Chaos

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Acta Mathematica Sinica,English Series 2016年第3期32卷 373-383页

作者： Tao WANG Jian dong yin Qi YAN Department of Mathematics Nanchang University

The relation among transitivity, indecomposability and Z-transitivity is discussed. It is shown that for a non-wandering system （each point is non-wandering）, indecomposability is equivalent to transitivity, and for the dynamical systems without isolated points, Z-transitivity and transitivity are equivalent. Besides, a new transitive level as weak transitivity is introduced and some equivalent conditions of Devaney＇s chaos are given by weak transitivity. Moreover, it is proved that both d- shadowing property and d-shadowing property imply weak transitivity.

关键词： Devaney's chaos indecomposability Z-transitivity weak transitivity

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Classifications of Isoparametric Hypersurfaces in Randers Space Forms

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Acta Mathematica Sinica,English Series 2020年第9期36卷 1049-1060页

作者： Qun HE Pei Long dong Song Ting yin School of Mathematical Sciences Tongji UniversityShanghai 200092P.R.China Department of Mathematics and Computer Science Tongling UniversityTongling 244000P.R.China Key Laboratory of Applied Mathematics(Putian University) Fujian Province University

In this paper,we give the complete classifications of isoparametric hypersurfaces in Randers space *** studying the principal curvatures of anisotropic submanifolds in a Randers space(N,F)with the navigation data(h,W),we find that a Randers space form(N,F,dμBH)and the corresponding Riemannian space(N,h)have the same isoparametric hypersurfaces,but in general,their isoparametric functions are *** give a necessary and sufficient condition for an isoparametric function of(N,h)to be isoparametric on(N,F,dμBH),from which we get some examples of isoparametric functions.

关键词： Isoparametric hypersurface Randers space form principal curvature anisotropic sub-manifold

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New hybridization of PO, SBR, and MoM for scattering by large complex conducting objects

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Journal of Systems Engineering and Electronics 2007年第4期18卷 726-730页

作者： dong Chunzhu Geng Fangzhi yin Hongcheng Wang Chao National Electromagnetic Scattering Lab. Beijing 100854 P. R. China Dept. of Electronic Warfare AFRA Wuhan 430019 P. R. China

As a marked extension of the traditional MoM-PO （method of moment-physical optics） hybrid method, a new hybridization of PO, SBR, and MoM （MoM-SBR/PO） is presented to calculate the multireflection contribution in the PO region efficiently by introducing the method of SBR based on RDN notion, which avoids the time-consuming iterative procedure and the choice of proper Green＇s function. As compared with the traditional MoM-PO hybrid method, the calculation efficiency of the proposed method is greatly improved, and its validity is verified by numerical results.

关键词： the method of moment (MoM) physical optics (PO) hybrid method shooting and bouncing ray(SBR) EM scattering radar cross section (RCS)

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Prediction and programming of microemulsion phase behavior simulation

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Petroleum Science 2022年第3期19卷 1401-1410页

作者： dong-Qi Wang Dai-yin yin Jun-Da Wang Ya-Zhou Zhou Cheng-Li Zhang Department of Petroleum Engineering Northeast Petroleum UniversityDaqing163318China Key Laboratory of Enhanced Oil Recovery (Northeast Petroleum University)Ministry of EducationChina PetroChina Refining&Chemicals Company Beijing100007China

In the process of microemulsion flooding,microemulsion phase state may be affected by the adsorption of core and the distribution of oil and water,and the upper phase,the middle phase or the lower phase microemulsion will *** description of microemulsion phase state and quantitative discrimination of equilibrium phase composition are of great theoretical value and research significance for the design of microemulsion flooding system and improving the recovery efficiency of ***,in this paper,microemulsion phase model is deeply *** at the difficulty of solving the existing Hand model and the unknown parameters of the improved HLD-NAC model,we introduce the binodal curve range parameter D and the asymmetric migration degree parameter B,and establish a new phase behavior description method of the binodal curve,the two-phase plait point lines and the III-phase node *** the phase discrimination programming of microemulsion was carried out,and the change laws of phase number,phase type and mass fraction of equilibrium phases of any microemulsion system under different salinity were *** results show that the simulation results of microemulsions accord with the salinity scanning law,and can accurately identify the complex microemulsion phase states.

关键词： Microemulsion Phase model Conditions for phase discrimination Programming Salinity scanning

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