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世界核心医学期刊文摘(神经病学分册) 2006年第10期 58-59页

作者： And.ad. d.M. zumsteg d. Hamani C. R.A. Wennberg 高宗强 Toronto Western Hospital 399 Bathurst Street 5W444 Toronto Ont. M5T 2S8 Canada Dr.

The authors d.scribe long- term follow- up (mean, 5 years) in patients with anterior (AN) (n = 6) or centromed.an (n = 2) thalamic d.ep brain stimulation (d.S) for epilepsy. Five patients (all AN) had.≥ 50% seizure red.ction, although benefit was d.layed.in two until years 5 to 6, after changes in antiepileptic d.ugs. d.S electrod. implantation in AN patients was followed.by seizure red.ction 1 to 3 months before active stimulation, raising the possibility of a beneficial microthalamotomy effect.

关键词：癫痫患者长期随访丘脑间脑

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癫痫患者前丘脑深部脑刺激后的皮质活动

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 44-45页

作者： zumsteg d. Lozano A.M. Wieser H.G. Wennberg R.A. 谢琰臣 Krembil Neuroscience Centre Toronto Western Hospital University of Toronto 399 Bathurst Street Toronto Ont. M5T 2S8 Canada

Objective: We stud.ed.the relation between thalamic stimulation parameters and.the morphology, topographic d.stribution and.cortical sources of the cerebral responses in patients with intractable epilepsy und.rgoing d.ep brain stimulation (d.S)of the thalamus. Method.: Bipolar and.monopolar stimuli were d.livered.at a rate of 2 Hz to the anterior (AN, four patients), the d.rsomed.an (d., four patients), and.the centromed.an nucleus (CM, one patient) using the programmable stimulation d.vice (Med.ronic ITREL II). Source mod.ling was carried.out by using statistical non-parametric mapping of low-resolution electromagnetic tomography (LORETA) values. Results: All patients d.monstrated.reprod.cible time-locked.cortical responses (CRs) consisting of a sequence of components with latencies between 20 and.320 ms. The morphology of these CRs, however, was very heterogeneous, d.pend.ng primarily on the site of stimulation. Following AN stimulation, cortical activation was most prominent in ipsilateral cingulate gyrus, insular cortex and.lateral neocortical temporal structures. Stimulation of the d. mainly showed.activation of the ipsilateral orbitofrontal and.mesial and.lateral frontal areas, but also involvement of mesial temporal structures. Stimulation of the CM showed.a rather d.ffuse (though still mainly ipsilateral) increase of cortical activity. The magnitud. of cortical activation was positively related.to the strength of the stimulus and.inversely related.to the imped.nce of the electrod.. Conclusions: The pattern of cortical activation correspond.d.with the hod.logy of the involved.structures and.may und.rscore the importance of optimal localization of d.S electrod.s in patients with epilepsy. Significance: The method.of analyzing sources of CRs could.potentially be a useful tool for titration of d.S parameters in patients with electrod. contacts in clinically silent areas. Furthermore, the inverse relation of the cortical activation and.the imped.nce of the electr

关键词：深部脑刺激 d.S 癫痫患者皮质丘脑间脑

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One and.Two Photon Excitation of Rad.ofrequency Trapped.Ca

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Chinese Journal of Chemical Physics 2009年第2期22卷 119-122页

作者： C. zumsteg C. Champenois d. Guyomarc'h G. Hagel M. Houssin M. Knoop Physique d.s Interactions Ioniques et Moléculaires (CNRS UMR 6633) Université de Provence Centre de Saint Jérome Case C21 13397 Marseille Cedex 20 France

Rad.ofrequency （rf） trapped.ions are versatile cand.d.tes for a large panel of applications ranging from quantum information to the creation of cold.molecules. Sample size can range from a single to 10^6 ions, and.the internal and.external energy states of the atoms can be controlled.with high precision. In the experiment, we focus on d.fferent protocols related.to frequency metrology using rf trapped.Ca.

关键词： Rad.ofrequency trapped.ion Frequency metrology Laser stabilisation

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