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Gonadotrophin-releasing hormone agonist-induced pituitary adenoma apoplexy and casual finding of a parathyroid carcinoma:A case report and review of literature

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World Journal of Clinical Cases 2019年第20期7卷 3259-3265页

作者： vanessa Trivino Olga Fidalgo Antía Juane Jorge Pombo Fernando Cordido Department of Endocrinology Complejo Hospitalario Universitario A CorunaA Coruna 15006Spain Department of pathological anatomy Complejo Hospitalario Universitario A CorunaA Coruna 15006Spain

BACKGROUND Pituitary apoplexy represents one of the most serious,life threatening endocrine emergencies that requires immediate ***-releasing hormone agonist(GnRHa)can induce pituitary apoplexy in those patients who have insidious pituitary adenoma *** SUMMARY A 46-year-old woman,with a history of hypertension and menorrhagia was transferred to our hospital from a secondary care hospital after complaints of headache and vomiting,with loss of consciousness 5 min after an injection of *** drug was prescribed by her gynecologist due to the presence of uterine *** clinical neurological examination revealed right cranial nerve III palsy,ptosis and movement limitation of the right *** first clinical consideration was a pituitary *** hormonal analysis revealed mild hyperprolactinemia and high follicle stimulating hormone level;PTH and calcium was high with glomerular filtration rate mildly to moderately decrease.A computed tomography scan,revealed an enlarged pituitary gland(3.5 cm)impinging upon the optic chiasm with bone involvement of the *** contrast media administration,the lesion showed homogeneous enhancement with high-density focus that suggests hemorrhagic infarction of the *** endoscopic surgery was perfomed and adenomatous tissue was *** was positive for luteinizing hormone(LH)and follicular-stimulating hormone(FSH).A solid hypoechoic nodule(14 mm x 13 mm x 16 mm)was found in the caudal portion of the right thyroid lobe after a parathyroid ultrasound.A genetic test of Multiple Endocrine Neoplasia type 1(MEN1)was negative.A right lower parathyroidectomy was performed and the pathologic study showed the presence of an encapsulated parathyroid carcinoma of 1.5 cm.A MEN type 4 genetic test was performed result was *** This case demonstrates an uncommon complication of GnRH agonist therapy in the setting of a pituitary macroadenoma an

关键词： Pituitary apoplexy Pituitary adenoma Primary hyperparathyroidism MEN type 1 MEN type 4 Parathyroid carcinoma Case report

Ion Channels in Plant Bioenergetic Organelles, Chloroplasts and Mitochondria： From Molecular Identification to Function

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Molecular Plant 2016年第3期9卷 371-395页

作者： Luca Carraretto Enrico Teardo vanessa Checchetto Giovanni Finazzi Nobuyuki Uozumi Ildiko Szabo Department of Biology University of Padova Padova 35121 Italy CNR Institute of Neuroscience University of Padova Padova 35121 Italy UMR 5168 Laboratoire de Physiologie Cellulaire Vegetale (LPCV) CNRS/UJF / INRA / CEA Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV) CEA Grenoble 38054 Grenoble France Department of Siomolecular Engineering Graduate Schoo~ of Engineering Tohoku University Aobayama 6-6-07 Sendai 980-8579 Japan

Recent technical advances in electrophysiological measurements, organelle-targeted fluorescence imaging, and organelle proteomics have pushed the research of ion transport a step forward in the case of the plant bioenergetic organelles, chloroplasts and mitochondria, leading to the molecular identification and functional characterization of several ion transport systems in recent years. Here we focus on channels that mediate relatively high-rate ion and water flux and summarize the current knowledge in this field, focusing on targeting mechanisms, proteomics, electrophysiology, and physiological function. In addition, since chloroplasts evolved from a cyanobacterial ancestor, we give an overview of the information available about cyanobacterial ion channels and discuss the evolutionary origin of chloroplast channels. The recent molecular identification of some of these ion channels allowed their physiological functions to be studied using genetically modified Arabidopsis plants and cyanobacteria. The view is emerging that alteration of chloroplast and mitochondrial ion homeostasis leads to organelle dysfunction, which in turn significantly affects the energy metabolism of the whole organism. Clear-cut identification of genes encoding for chan- nels in these organelles, however, remains a major challenge in this rapidly developing field. Multiple stra- tegies including bioinformatics, cell biology, electrophysiology, use of organelle-targeted ion-sensitive probes, genetics, and identification of signals eliciting specific ion fluxes across organelle membranes should provide a better understanding of the physiological role of organellar channels and their contribution to signaling pathways in plants in the future.

关键词： ion channels chloroplasts mitochondria cyanobacteria endosymbiosis plant physiology

Non-cycloplegic spherical equivalent refraction in adults:comparison of the double-pass system,retinoscopy,subjective refraction and a table-mounted autorefractor

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 618-625页

作者： Meritxell Vilaseca Montserrat Arjona Jaume Pujol Elvira Peris vanessa Martìnez Centre for Sensors Instruments and Systems Development(CD6)Technical University of Catalonia University Vision Centre (CUV) Department of Optics and OptometryTechnical University of Catalonia

AIM:To evaluate the accuracy of spherical equivalent(SE) estimates of a double-pass system and to compare it with retinoscopy,subjective refraction and a table mounted ***:Non-cycloplegic refraction was performed on 125 eyes of 65 healthy adults(age 23.5±3.0 years) from October 2010 to January 2011 using retinoscopy,subjective refraction,autorefraction(Auto kerato refractometer TOPCON KR-8100,Japan) and a double pass system(Optical Quality Analysis System,OQAS,Visiometrics S.L.,Spain).Nine consecutive measurements with the double-pass system were performed on a subgroup of 22 eyes to assess *** evaluate the trueness of the OQAS instrument,the SE laboratory bias between the double pass system and the other techniques was ***:The SE mean coefficient of repeatability obtained was *** correlations could be established between the OQAS and the SE obtained with retinoscopy(r=0.956,P<0.001),subjective refraction(r=0.955,P<0.001) and autorefraction(r=0.957,P<0.001).The differences in SE between the double-pass system and the other techniques were significant(P<0.001),but lacked clinical relevance except for retinoscopy;Retinoscopy gave more hyperopic values than the double-pass system-0.51±0.50D as well as the subjective refraction-0.23±0.50D;More myopic values were achieved by means of autorefraction 0.24±0.49D. CONCLUSION:The double-pass system provides accurate and reliable estimates of the SE that can be used for clinical *** technique can determine the correct focus position to assess the ocular optical ***,it has a relatively small measuring range in comparison with autorefractors(-8.00 to +5.00D),and requires prior information on the refractive state of the patient.

关键词： double-pass system optical quality retinoscopy autorefraction subjective refraction accuracy repeatability trueness

Effect of viscosity on the avalanche dynamics and flow transition of wet granular matter

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Particuology 2021年第6期19卷 64-75页

作者： Jens H.Kasper vanessa Magnanimo Sjoerd D.M.de Jong Arjan Beek Ahmed Jarray Multi-Scale Mechanics(MSM) Thermal and Fluid EngineeringFaculty of Engineering Technology.University ofTwenteP.O.Box 2177500 AE EnschedeThe Netherlands Construction Management and Engineering(CME) Faculty of Engineering TechnologyUniversity ofTwenteP.O.Box 2177500 AE EnschedeThe Netherlands

The dynamic behaviour of granular flows is important in geo-mechanics and industrial applications,yet poorly *** studied the effects of liquid viscosity and particle size on the dynamics of wet granular material flowing in a slowly rotating drum,in order to detect the transition from the avalanching to the continuous flow regime.A discrete element method(DEM)model,in which contact forces and cohesive forces were considered,was employed to simulate this flow *** model was validated experimentally,using glass beads in a wooden drum and water–glycerol mixtures to tune the liquid *** DEM simulations showed comparable results to the experiments in terms of average slope angle and avalanche *** observed that the avalanche amplitude,flow layer velocity and granular temperature decrease as the liquid viscosity *** effect is more pronounced for smaller sized *** increase in viscous forces causes the flowing particles to behave as a bulk,pushing the free surface towards a convex *** addition,avalanches become less pronounced and the granular flow transitions from the avalanching regime to the continuous *** avalanching flow regime is marked by intermittent rigid body movement of the particulate bed and near-zero drops in the granular temperature,while no rigid body movement of the bed occurs in the continuous flow *** identified the avalanching-continuous flow transition region as a function of a dimensionless granular Galileo number.

关键词： Granular avalanche Transition Cohesion Viscosity Rotary drum DEM

Human viral pathogens are pervasive in wastewater treatment center aerosols

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Journal of Environmental Sciences 2018年第5期30卷 45-53页

作者： Evelyne Brisebois Marc Veillette vanessa Dion-Dupont Jacques Lavoie Jacques Corbeil AlexANDer Culley Caroline Duchaine Universite Laval Pavillon Alexandre Vachon1045ave de la MedecineQuebecQC GIVOA6Canada CRIUCPQ 2725 Chemin Sainte-FoyQuebecQC GIV 4G5Canada IRSST 505 Boulevard de Maisonneuve OMontréalQCH3A 3C2Canada CRCHU 2705 Boulevard LaurierRC-709QuébecQCG1V 4G2Canada

Wastewater treatment center（WTC） workers may be vulnerable to diseases caused by viruses, such as the common cold, influenza and gastro-intestinal infections. Although there is a substantial body of literature characterizing the microbial community found in wastewater, only a few studies have characterized the viral component of WTC aerosols,despite the fact that most diseases affecting WTC workers are of viral origin and that some of these viruses are transmitted through the air. In this study, we evaluated in four WTCs the presence of 11 viral pathogens of particular concern in this milieu and used a metagenomic approach to characterize the total viral community in the air of one of those WTCs. The presence of viruses in aerosols in different locations of individual WTCs was evaluated and the results obtained with four commonly used air samplers were *** detected four of the eleven viruses tested, including human adenovirus（h Ad V）,rotavirus, hepatitis A virus（HAV） and Herpes Simplex virus type 1（HSV1）. The results of the metagenomic assay uncovered very few viral RNA sequences in WTC aerosols, however sequences from human DNA viruses were in much greater relative abundance.

关键词： Airborne viruses Air sampling Wastewater treatment plants Viral metagenomics

An unusual case of renal calculi leading to myocardial infarction and cardiogenic shock

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World Journal of Emergency Medicine 2017年第2期8卷 148-150页

作者： vanessa Santos James Espinosa Alan Lucerna Andrew Caravello Department of Emergency Medicine Rowan University SOM Kennedy University Hospital Stratford NJ USA

INTRODUCTION The presentation of cardiogenic shock （CS） is usually straightforward, and includes hypotension, absence of hypovolemia, and clinical signs of poor tissue perfusion such as oliguria, cyanosis, cool extremities and altered mentation. The most common etiology of CS is acute myocardial infarction, Here, we report a case of a 42-year-old male who presented with right flank pain, nausea and vomiting initially thought to be nephrolithiasis, which he had a history of but was ultimately diagnosed with CS due to a type II myocardial infarction. This case illustrates the importance of having a broad differential diagnosis especially when a patient＇s vital signs take a drastic turn since this patient initially resembled someone with nephrolithiasis.

关键词： myocardial infarction cardiogenic shock

The“genetic erosion”of the soil ecosystem

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International Soil and Water Conservation Research 2013年第1期1卷 11-18页

作者： Giuseppe Lo Papa vanessa Palermo Carmelo Dazzi Dipartimento di Scienze Agrarie e Forestali University of PalermoItaly

This paper takes into consideration the influence of human activities on the loss of pedodiversity in a Mediterranean area due to large scale *** particular it examines the quantitative and qualitative soil changes in a period of 53 years(from 1955 to 2008)evaluating the loss of soil diversity at soil subgroups level of the USDA Soil Taxonomy *** following indices were used:richness;Shannon’s diversity index;Simpson diversity index;Shannon’s evenness index;Simpson’s evenness *** this case study,considering what we observed in time,the human intervention in soil transformation could increase the diversity in the landscape in an initial phase,but forwarding by large scale farming the result is a huge loss of pedodiversity in time,as diversity indices remarkably have *** analysis enabled identification of disappeared soil types,with their unique history of *** our opinion this strongly reflects a sort of“genetic erosion”of the soil types,resulting in a substantial weakening of the whole pedo-ecosystem.

关键词： Pedodiversity Anthropogenic soil Soil genetic erosion

The emerging role of probiotics in neurodegenerative diseases:new hope for Parkinson’s disease?

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Neural Regeneration Research 2021年第4期16卷 628-634页

作者： vanessa Castelli Michele d’Angelo Massimiliano Quintiliani Elisabetta Benedetti Maria Grazia Cifone Annamaria Cimini Department of Life Health and Environmental SciencesUniversity of L’AquilaItaly SIRE Srl NaplesItaly Sbarro Institute for Cancer Research and Molecular Medicine Department of BiologyTemple UniversityPhiladelphiaPAUSA

Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are *** components of the gut could play a key role in the gut-brain axis,which is a bidirectional system between the central nervous system and the enteric nervous *** in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic,autoimmune,cancer,and,notably,neurodegenerative *** can alter the microbiota composition,affecting the gutbrain axis *** nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions,including the use of *** and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry,modulating different *** review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy,confirming that gut microbiota modulation influences different pro-survival *** investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary.

关键词： age-related diseases brain dysbiosis gut-brain axis microbiota neurodegeneration nutraceuticals Parkinson’s disease probiotics SLAB51

Should mast cells be considered therapeutic targets in multiple sclerosis?

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Neural Regeneration Research 2020年第11期15卷 1995-2007页

作者： Karen Henriette Pinke Sofia Fernanda Goncalves Zorzella-Pezavento vanessa Soares Lara Alexandrina Sartori Institute of Biosciences Department of Microbiology and ImmunologySao Paulo State University(UNESP)BotucatuSao PauloBrazil Bauru School of Dentistry Department of SurgeryStomatologyPathology and RadiologyUniversity of Sao PauloBauruSao PauloBrazil

Mast cells are immune cells of the myeloid lineage that are found throughout the body,including the central nervous *** perform many functions associated with innate and specific immunity,angiogenesis,and vascular ***,they have been implicated in a series of pathologies(e.g.,hypersensitivity reactions,tumors,and inflammatory disorders).In this review,we propose that this cell could be a relevant therapeutic target in multiple sclerosis,which is a central nervous system degenerative *** support this proposition,we describe the general biological properties of mast cells,their contribution to innate and specific immunity,and the participation of mast cells in the various stages of multiple sclerosis and experimental autoimmune encephalomyelitis *** final part of this review is dedicated to an overview of the available mast cells immunomodulatory drugs and their activity on multiple sclerosis and experimental autoimmune encephalomyelitis,including our own experience related to the effect of ketotifen fumarate on experimental autoimmune encephalomyelitis evolution.

关键词： central nervous system degenerative disease experimental autoimmune encephalomyelitis immunity immunomodulatory drugs inflammatory disease ketotifen fumarate mast cells multiple sclerosis therapeutic target