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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

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Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim H.Maleki ahmad Reza Bahrami Maryam M.Matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative Medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

Robust design of sliding mode control for airship trajectory tracking with uncertainty and disturbance estimation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 242-258页

作者： WASIM Muhammad ALI Ahsan CHOUDHRY Mohammad ahmad SHAIKH Inam Ul Hasan SALEEM Faisal Department of Aeronautics and Astronautics Engineering Institute of Space TechnologyIslamabad 44000Pakistan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan Department of Measurements and Control Systems Silesian University of TechnologyGliwice 44-101Poland The Joint Doctoral School Silesian University of TechnologyGliwice 44-100Poland

The robotic airship can provide a promising aerostatic platform for many potential *** applications require a precise autonomous trajectory tracking control for *** has a nonlinear and uncertain *** is prone to wind disturbances that offer a challenge for a trajectory tracking control *** paper addresses the airship trajectory tracking problem having time varying reference path.A lumped parameter estimation approach under model uncertainties and wind disturbances is opted against distributed *** uses extended Kalman filter(EKF)for uncertainty and disturbance *** estimated parameters are used by sliding mode controller(SMC)for ultimate control of airship trajectory *** comprehensive algorithm,EKF based SMC(ESMC),is used as a robust solution to track airship *** proposed estimator provides the estimates of wind disturbances as well as model uncertainty due to the mass matrix variations and aerodynamic model *** stability and convergence of the proposed method are investigated using the Lyapunov stability *** simulation results show that the proposed method efficiently tracks the desired *** method solves the stability,convergence,and chattering problem of SMC under model uncertainties and wind disturbances.

关键词： airship chattering extended Kalman filter(EKF) model uncertainties estimation sliding mode controller(SMC)

Integrated geoscience databanks for interactive analysis and visualization

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International Journal of Digital Earth 2013年第S02期6卷 41-49页

作者： Khalid Amin khan Gulraiz Akhter zulfiqar ahmad K-tron Research Inc. RawalpindiPakistan Department of Earth Sciences Quaid-i-Azam UniversityIslamabadPakistan

There has been a worldwide revolution in geoscientific data availability and *** effectively infinite and instantaneous free access to geoscientific data from the World Wide System of Geoscience Data Centers and Virtual Observatories is *** addition,national databanks and commercially available large exploration data-sets also *** distributed data resources impose challenges for the future to move toward their objective integration and visualization to discover new *** advancements can facilitate meaningful interpretations and decision-making for the benefit of society at global and local *** article presents the Digital Earth initiative at a national level to address multiple domains,such as effective management of natural resources,interactive planning of exploration activities and monitoring,mapping and mitigation of natural *** discusses a distributed geospatial data infrastructure and its importance in geoscientific data integration for efficient and interactive data retrieval,analysis and *** examples are presented to demonstrate the advantages of integrated visualization in geoscientific analysis.

关键词： distributed data geospatial data integration spatial data infrastructure data analysis visualization digital country

Data-driven Distributionally Adjustable Robust Chance-constrained DG Capacity Assessment

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 115-127页

作者： Masoume Mahmoodi Seyyed Mahdi Noori Rahim Abadi ahmad Attarha Paul Scott Lachlan Blackhall the College of Engineering and Computer Science The Australian National UniversityCanberraAustralia

Moving away from fossil fuels towards renewable sources requires system operators to determine the capacity of distribution systems to safely accommodate green and distributed generation(DG).However,the DG capacity of a distribution system is often underestimated due to either overly conservative electrical demand and DG output uncertainty modelling or neglecting the recourse capability of the available *** improve the accuracy of DG capacity assessment,this paper proposes a distributionally adjustable robust chance-constrained approach that utilises uncertainty information to reduce the conservativeness of conventional robust *** proposed approach also enables fast-acting devices such as inverters to adjust to the real-time realisation of uncertainty using the adjustable robust counterpart *** achieve a tractable formulation,we first define uncertain chance constraints through distributionally robust conditional value-at-risk(CVaR),which is then reformulated into convex quadratic *** subsequently solve the resulting large-scale,yet convex,model in a distributed fashion using the alternating direction method of multipliers(ADMM).Through numerical simulations,we demonstrate that the proposed approach outperforms the adjustable robust and conventional distributionally robust approaches by up to 15%and 40%,respectively,in terms of total installed DG capacity.

关键词： Distributed generation(DG)capacity assessment distributionally robust optimisation chance-constrained optimisation distribution system

Association of spiritual well-being with quality of life among undergraduate nursing students

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Journal of Integrative Nursing 2024年第1期6卷 49-54页

作者： ahmad SHAHID Hina HUSSAIN Nazia SHUAIB ahmad RASOOL Fatima YOUNIS Zoya NASAB Department of Nursing Professional College of Nursing and Health SciencesIslamabadPakistan Department of Nursing Rawal Institute of Health SciencesIslamabadPakistan Department of Nursing Rawal College of NursingIslamabadPakistan School of Nursing and Health Zhengzhou UniversityZhengzhouChina

Objective:The study was conducted with the aim of determining the spiritual well-being(SWB)of nursing students and its association with quality of life(QOL).Materials and Methods:A cross-sectional analytical study was conducted with a sample size of 504 nursing students collected from January 2023 to March 2023 in the nursing institutes of Khyber Pakhtunkhwa,Pakistan,using convenient sampling techniques.A Spiritual Health and Life-Orientation Measure(SHALOM)questionnaire for SWB and K-27 QOL(K-27 QOL)instrument were used for data collection that contains three ***:The number of female participants was in the majority(50.4%)compared to male nurses(49.6%).The overall mean score of SWB of the students was 3.79±0.48,while the mean K-27 QOL score was 3.73±*** were significant differences between the groups of gender(P=0.001),while no significant difference within the groups of semester(P=0.061)and college status(0.285).In QOL,there were significant differences within the groups of semester(P=0.000)and college status(P=0.036)while no significant difference in gender category(P=0.480).SHALOM score is positively and moderately correlated with QOL score(r=0.597,P<0.05).Conclusion:Spiritual practices are one of the important factors that are associated positively with QOL,therefore to enhance the QOL,it will require spiritual practices.

关键词： Nursing education nursing student quality of life spiritual nursing care spirituality well‑being

Unraveling the therapeutic mechanisms of myristic acid and luteolin 7-rutinoside in oral cancer: insights from network pharmacology and molecular docking analysis

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Pharmacology Discovery 2024年第2期4卷 1-9页

作者： Ansari Vikhar Danish ahmad Misba Ruhi Syed Ayaz Ali Qazi Yasar Mohd.Mukhtar khan Subur W khan Mohammed Imran Anees Y.B.Chavan College of Pharmacy Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India Maulana Azad College Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India

Background:The compound Luteolin-7-rutinoside(L7R)is a flavone derivative of luteolin,predominantly identified in plant species belonging to the families ***,Myristic acid is characterized by its structure as a 14-carbon,unsaturated fatty *** this investigation,we endeavor to elucidate the putative mechanisms underlying the therapeutic effects of Myristic Acid and Luteolin 7-rutinoside in the context of oral cancer treatment,employing network pharmacology coupled with molecular docking ***:The protein targets of Myristic Acid and Luteolin 7-rutinoside were identified through a search on the Swiss Target ***,a compound-target network was constructed using Cytoscape *** associated with OC were retrieved from the OMIM and GeneCards *** overlap between compound targets and OC-related targets was determined,and the resulting shared targets were subjected to protein-protein interaction(PPI)network analysis using the STRING ***,gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were conducted on the identified *** docking were performed to investigate the interactions between the core target and the active ***:The component target network comprises 103 nodes and 102 *** the proteins in the protein-protein interaction(PPI)network,those with higher degrees are TNF,PPARG,and *** through Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways indicates that the treatment of OC with Myristic Acid and Luteolin 7-rutinoside primarily involves the regulation of miRNA transcription and inflammatory *** identified signaling pathways include Pathways in cancer,PPAR signaling pathway,EGFR signaling pathway,and TNF signaling *** docking studies reveal that Luteolin 7-rutinoside and Myristic acid exhibit higher affinity towards TNF,PPARG,TP53,and ***:This study

关键词： myristic acid luteolin 7-rutinoside network pharmacology oral cancer molecular docking

Mechanistic insights toward identification and interaction of plant parasitic nematodes:A review

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Soil Ecology Letters 2024年第1期6卷 11-27页

作者： Bisma Jan Ali Haider Shah Mudasir ahmad Bhat Arif Tasleem Jan Ishfaq ahmad Wani Ali Asghar Shah Section of Microbiology Baba Ghulam Shah Badshah UniversityRajouriJ&K185234India Department of Biotechnology Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Botany Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Zoology School of Biosciences and BiotechnologyBaba Ghulam Shah Badshah University RajouriJ&K185234India

Nematode identification serves as an important param-eter to study their behaviour,importance and *** of classical morphometric based identifica-tion methods prove to be lacking due to insufficient knowledge on morphological variations among closely related *** approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for nematode *** and certain protein-based nematode-associated molecular patterns(NAMPs),can be perceived by the host plants,and can initiate a signalling *** review primarily emphasizes on an updated account of different classical and modern tools used for the identification of *** we also summa-rize the mechanism of some important signalling pathways which are involved in the different plant nematode *** constitute most diverse and least studied group of soil inhabiting *** are ecologically and physiologically important,however,wide range of nematodes show harmful impact on the individuals that live within their *** parasitic nematodes(PPNs)are transparent,pseudocoelomate,free living or parasitic *** lack morphometric identification methods due to insufficient knowl-edge on morphological variations among closely related *** such,molecular approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for their *** invade the defense response of different plant species,parasitic nematodes have evolved different molecular *** and certain protein-based nematode-associated molecular patterns(NAMPs),can be perceived by the host plants,and can initiate a signaling *** overcome the host confrontation and develop certain nematode feeding sites,some members can inject effectors into

关键词： nematode identification plant nematode interaction DNA fingerprinting nematode-associated molecular patterns signaling path-ways

Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency Medicine 2024年第4期15卷 283-288页

作者： David ahmad Haidar David Mintz Brandon M Wubben Omar Rizvi Srikar Adhikari Department of Emergency Medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of Medicine Tucson 85724USA Department of Emergency Medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency Medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:We aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:We conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:We included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).The most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

Security and Privacy Challenges in SDN-Enabled IoT Systems: Causes, Proposed Solutions,and Future Directions

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Computers, Materials & Continua 2024年第8期80卷 2511-2533页

作者： ahmad Rahdari ahmad Jalili Mehdi Esnaashari Mehdi Gheisari Alisa A.Vorobeva Zhaoxi Fang Panjun Sun Viktoriia M.Korzhuk Ilya Popov Zongda Wu Hamid Tahaei Institute of Artificial Intelligence Shaoxing UniversityShaoxing312000China Department of Computer Engineering Gonbad Kavous UniversityGonbad-e Kavus49717-99151Iran Faculty of Computer Engineering K.N.Toosi University of TechnologyTehran196976-4499Iran Department of Computer Science and Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai602105India Secure Information Technologies Department National Research University ITMOSt.Petersburg197101Russia School of Electrical and Computer Engineering Shiraz UniversityShiraz71946–84334Iran Department of Computer Science and Engineering Islamic Azad UniversityDamavand***Iran Department of R&D Shenzhen BKD Co.Ltd.Shenzhen518000China

Software-Defined Networking(SDN)represents a significant paradigm shift in network architecture,separating network logic from the underlying forwarding devices to enhance flexibility and centralize ***-rently,the Internet of Things(IoT)connects numerous devices to the Internet,enabling autonomous interactions with minimal human ***,implementing and managing an SDN-IoT system is inherently complex,particularly for those with limited resources,as the dynamic and distributed nature of IoT infrastructures creates security and privacy challenges during SDN *** findings of this study underscore the primary security and privacy challenges across application,control,and data planes.A comprehensive review evaluates the root causes of these challenges and the defense techniques employed in prior works to establish sufficient secrecy and privacy *** investigations have explored cutting-edge methods,such as leveraging blockchain for transaction recording to enhance security and privacy,along with applying machine learning and deep learning approaches to identify and mitigate the impacts of Denial of Service(DoS)and Distributed DoS(DDoS)***,the analysis indicates that encryption and hashing techniques are prevalent in the data plane,whereas access control and certificate authorization are prominently considered in the control plane,and authentication is commonly employed within the application ***,this paper outlines future directions,offering insights into potential strategies and technological advancements aimed at fostering a more secure and privacy-conscious SDN-based IoT ecosystem.

关键词： Security privacy-preserving software-defined network internet of things