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Effects of a low-radiotoxicity uranium salt(uranyl acetate) on biochemical and hematological parameters of the catfish,Clarias gariepinus

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Chinese Journal of Oceanology and Limnology 2016年第1期34卷 109-117页

作者： khalid.A.AL-GHANIM zubair AHMAD Hmoud F.Al-Kahem AL-BALAWI Fahad AL-MISNED Shahid MABOOB El-Amin M.SULIMAN Department of Zoology College of ScienceP.O.Box 2455King Saud University

Specimens of Clarias gariepinus were treated with lethal(70,75,80,85,90,and 95 mg/L) and sub-lethal concentrations(8,12 and 16 mg/L) of uranyl acetate,a low-radiotoxicity uranium salt. The LC 50 value was registered as 81.45 mg/L. The protein and glycogen concentrations in liver and muscles were decreased in the fish exposed to sub-lethal concentrations. The red blood cell(RBC) and white blood cell(WBC) counts,haemoglobin(Hb) concentration and haematocrit(Hct) values were decreased. Different blood indices like mean corpuscular volume(MCV),mean corpuscular haemoglobin(MCH) and mean corpuscular haemoglobin concentration(MCHC) were negatively affected. Level of plasma glucose was elevated whereas protein was decreased. The level of calcium concentration(Ca) was declined in the blood of exposed fish whereas magnesium(Mg) remains unchanged. The activity level of glutamic-oxaloacetic transaminase(GOT) and glutamic-pyruvic transaminase(GPT) was elevated in exposed fish. These effects were more pronounced in the last period of exposure and in higher concentrations. Results of the present study indicate that uranyl acetate has adverse effects on C larias gariepinus and causes changes in the biochemical and hematological parameters of the fish.

关键词： Clarias gariepinus uranyl acetate sub-lethal concentration biochemical and haematological parameters

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A novel homozygous frameshift variant in DNAH8 causes multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family

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Asian Journal of Andrology 2023年第3期25卷 350-355页

作者： Sobia Dil Asad Khan Ahsanullah Unar Meng-Lei Yang Imtiaz Ali Aurang Zeb Huan Zhang Jian-Teng Zhou Muhammad zubair khalid Khan Shun Bai Qing-Hua Shi Division of Reproduction and Genetics The First Affiliated Hospital of University of Science and Technology of ChinaSchool of Basic Medical SciencesDivision of Life Sciences and MedicineBiomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei 230027China

Multiple morphological abnormalities of the sperm flagella(MMAF)is a severe form of asthenozoospermia categorized by immotile spermatozoa with abnormal flagella in ***-exome sequencing(WES)is used to detect pathogenic variants in patients with *** this study,a novel homozygous frameshift variant(c.6158_6159insT)in dynein axonemal heavy chain 8(DNAH8)from two infertile brothers with MMAF in a consanguineous Pakistani family was identified by *** transcription-polymerase chain reaction(RT-PCR)confirmed DNAH8 mRNA decay in these patients with the DNAH8 ***–eosin staining and transmission electron microscopy revealed highly divergent morphology and ultrastructure of sperm flagella in these ***,an immunofluorescence assay showed the absence of DNAH8 and a reduction in its associated protein DNAH17 in the patients'***,our study expands the phenotypic spectrum of patients with DNAH8-related MMAF worldwide.

关键词： DNAH8 gene mutation male infertility multiple morphological abnormalities of the sperm flagella

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Autoimmune diabetes from pembrolizumab:A case report and review of literature

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World Journal of Clinical Oncology 2023年第11期14卷 535-543页

作者： Hardikkumar Bhanderi Farhan khalid zubair Hassan Bodla Tayyeb Muhammad Doantrang Du Trishala Meghal Department of Internal Medicine Monmouth Medical CenterLong branchNJ 07740United States Department of Internal Medicine University of Central Florida College of MedicineGainesvilleFL 32303United States Department of Hematology-Oncology Monmouth Medical CenterLong BranchNJ 07740United States

BACKGROUND Immunotherapy,specifically the use of checkpoint inhibitors such as pembrolizumab,has become an important tool in personalized cancer *** inhibitors target proteins on T-cells that regulate the immune response against tumor ***,which targets the programmed cell death 1 receptor on T-cells,has been approved for the treatment of metastatic melanoma and nonsmall cell lung ***,it can also lead to immune-related side effects,including pneumonitis,colitis,thyroid abnormalities,and rare cases of type 1 *** SUMMARY The case presented involves an adult patient in 30s with breast cancer who developed hyperglycemia after receiving pembrolizumab *** patient was diagnosed with diabetic ketoacidosis and further investigations were performed to evaluate for new-onset type 1 *** patient had a history of hypothyroidism and a family history of breast *** for diabetic ketoacidosis was initiated,and the patient was discharged for close follow-up with an *** This literature review highlights the occurrence of diabetic ketoacidosis and newonset type 1 diabetes in patients receiving pembrolizumab treatment for different types of ***,the article emphasizes the therapeutic benefits of immunotherapy in cancer treatment,particularly pembrolizumab,while also highlighting the potential side effect of immune-related diabetes that can occur in a small percentage of *** we present a case where pembrolizumab lead to development of diabetes after a few cycles highlighting one of the rare yet a serious toxicity of the drug.

关键词： Pembrolizumab Breast cancer Autoimmune diabetes Keytruda Immunotherapy Case report

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A recurrent homozygous missense mutation in CCDC103 causes asthenoteratozoospermia due to disorganized dynein arms

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Asian Journal of Andrology 2022年第3期24卷 255-259页

作者： Muhammad zubair Ranjha Khan Ao Ma Uzma Hameed Mazhar Khan Tanveer Abbas Riaz Ahmad Jian-Teng Zhou Wasim Shah Ansar Hussain Nisar Ahmed Ihsan Khan khalid Khan Yuan-Wei Zhang Huan Zhang Li-Min Wu Qing-Hua Shi The First Affiliated Hospital of USTC The CAS Key Laboratory of Innate Immunity and Chronic DiseasesSchool of Life SciencesCAS Center for Excellence in Molecular Cell ScienceCollaborative Innovation Center of Genetics and DevelopmentUniversity of Science and Technology of ChinaHefei 230027China Institute of Industrial Biotechnology Government College UniversityLahore 54000Pakistan Medical Genetics Research Laboratory Department of BiotechnologyQuaid-i-Azam UniversityIslamabad 45320Pakistan

Asthenoteratozoospermia is one of the most severe types of qualitative sperm *** cases are due to mutations in genes encoding the components of sperm flagella,which have an ultrastructure similar to that of motile ***-coil domain containing 103(CCDC103)is an outer dynein arm assembly factor,and pathogenic variants of CCDC103 cause primary ciliary dyskinesia(PCD).However,whether CCDC103 pathogenic variants cause severe asthenoteratozoospermia has yet to be ***-exome sequencing(WES)was performed for two individuals with nonsyndromic asthenoteratozoospermia in a consanguineous family.A homozygous CCDC103 variant segregating recessively with an infertility phenotype was identified(ENST00000035776.2,c.461A>C,***154Pro).CCDC103 ***154Pro was previously reported as a high prevalence mutation causing PCD,though the reproductive phenotype of these PCD individuals is *** electron microscopy(TEM)of affected individuals’spermatozoa showed that the mid-piece was severely damaged with disorganized dynein arms,similar to the abnormal ultrastructure of respiratory ciliary of PCD individuals with the same ***,our findings expand the phenotype spectrum of CCDC103 ***154Pro as a novel pathogenic gene for nonsyndromic asthenospermia.

关键词： asthenoteratozoospermia CCDC103 dynein arms male infertility

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