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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Treatment for COVID-19 patients in Vietnam: Analysis of time-to-recovery

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Asian Pacific Journal of Tropical Medicine 2020年第9期13卷 397-401页

作者： Khuong Quynh Long Hoang hong Hanh Tran Thi Tuyet Hanh la Ngoc Quang Hoang Van Minh Hanoi University of Public Health 1A Duc Thang RoadDuc Thang WardNorth Tu Liem DistrictHanoiVietnam

Objective:To describe the recovery time and related factors among COVID-19 patients in ***:We used the secondary data obtained from the official database of the Ministry of Health of Vietnam and other public data sources that were available by April 9 th,*** proportional hazards model was carried out to identify factors related to recovery time among COVID-19 ***:By April 9 th,2020,the cumulative number of COVID-19 cases detected in Vietnam was 255,of which 129(50.6%)patients had fully *** median recovery time of patients was 17(95%CI=16-19)*** patients had a lower likelihood of recovery(HR=0.98,95%CI=0.97-0.99,P<0.001),whereas patients with a history of international incoming travel had a higher likelihood of recovery(HR=1.57,95%CI=1.03-2.40,P=0.036).There was no statistically significant difference in the recovery time of patients treated in different hospital ***:More attention is needed for older patients and who did not have international travel *** confirmed with COVID-19 could be treated at local health facilities to avoid unnecessary referrals and burdens to specialized hospitals at the central level.

关键词： COVID-19 Coronavirus Recovery Vietnam

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Nerve growth factor catches copper in neuronal inning

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Neural Regeneration Research 2020年第4期15卷 665-666页

作者： Diego la Mendola Department of Pharmacy University of Pisa

The physiological effect of neurotrophic factors and their role in Alzheimer’s disease(AD):Neurotrophins(NTs)are a family of homologues proteins that play an essential role in neuronal cells growth,survival and *** proteins include the nerve growth factor(NGF),the brain derived neurotrophic factor(BDNF),NT-3 and NT-3,also known as NT-4/5.

关键词： Alzheimer copper differentiation.

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q-Deformation of W (2 , 2) Lie Algebra Associated with Quantum Groups

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Acta Mathematica Sinica,English Series 2012年第11期28卷 2213-2226页

作者： la Mei YUAN Academy of Fundamental and Interdisciplinary Sciences Harbin Institute of Technology Wu Wen-Tsun Key laboratory of Mathematics University of Science and Technology of China

The q-deformation of W（2, 2） Lie algebra is well defined based on a realization of this Lie algebra by using the famous bosonic and fermionic oscillators in physics. Furthermore, the quantum group structures on the q-deformation of W（2, 2） Lie algebra are completely determined. Finally, the 1-dimensional central extension of the q-deformed W（2, 2） Lie algebra is studied, which turns out to be coincided with the conventional W（2, 2） Lie algebra in the q → 1 limit.

关键词： W(2 2) Lie algebra q-deformation quantum group central extension

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On Standard Invariants of Bi-polymatroidal Ideals

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Algebra Colloquium 2014年第2期21卷 267-274页

作者： Monica la Barbiera University of Messina Department of'Mathematics Viale Ferdinando Stagno d'Aleontres 31 98166 Messina Italy

The standard invariants of the bi-polymatroidal ideals of Veronese type are computed.

关键词： bi-polymatroidal ideals linear quotients

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Radiomics in pancreatic cancer for oncologist:Present and future

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 356-361页

作者： Carolina de la Pinta Radiation Oncology Department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Radiomics is changing the world of medicine and more specifically the world of *** diagnosis and treatment improve the prognosis of patients with *** treatment,the evaluation of the response will determine future *** oncology,every change in treatment means a loss of therapeutic options and this is key in pancreatic *** has been developed in oncology in the early diagnosis and differential diagnosis of benign and malignant lesions,in the evaluation of response,in the prediction of possible side effects,marking the risk of recurrence,survival and prognosis of the *** studies have validated its use to differentiate normal tissues from tumor tissues with high sensitivity and specificity,and to differentiate cystic lesions and pancreatic neuroendocrine tumor grades with texture *** addition,these parameters have been related to survival in patients with pancreatic cancer and to response to radiotherapy and *** review aimed to establish the current status of the use of radiomics in pancreatic cancer and future perspectives.

关键词： Pancreatic cancer Radiomics Radiogenomics

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Stereotactic body radiotherapy in pancreatic adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 14-19页

作者： Carolina de la Pinta Radiation Oncology Department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding *** review aimed at the SBRT application in the treatment of pancreatic *** sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December *** used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were *** articles were assessed for validity and relevant ***:Optimal doses and fractionation have not yet been ***,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to ***,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic ***:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.

关键词： Chemoradiotherapy Pancreatic adenocarcinoma Radiotherapy Stereotactic body radiotherapy Stereotactic ablative radiotherapy

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Deduction and Validation of an Eulerian-Eulerian Model for Turbulent Dilute Two-Phase Flows by Means of the Phase Indicator Function-Disperse Elements Probability Density Function

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Chinese Journal of Chemical Engineering 2000年第3期8卷 189-202页

作者： Santiago laín Ricardo Aliod MVT-UST Fachbereich Ingenieurwissenschaften Martin-Luther-UniversitatHalle-WittenbergD-06099Halle(Saale)GermanyFluid Mechanica DepartmentE.U.Politecnica de Huesca.University of ZaragozaCarretera Zaragoza km.6722071 HuescaSpain

A statistical formalism overcoming some conceptual and practical difficulties arising in existing two-phase flow (2PHF) mathematical modelling has been applied to propose a model for dilute 2PHF turbulent Hows. Phase interaction terms with a clear physical meaning enter the equations and the formalism provides some guidelines for the avoidance of closure assumptions or the rational approximation of these terms. Continuous phase averaged continuity, momentum, turbulent kinetic energy and turbulence dissipation rate equations have been rigorously and systematically obtained in a single step. These equations display a structure similar to that for single-phase flows. It is also assumed that dispersed phase dynamics is well described by a probability density function (pdf) equation and Eulerian continuity, momentum and fluctuating kinetic energy equations for the dispersed phase are deduced. An extension of the standard k-e turbulence model for the continuous phase is used. A gradient transport model is adopted for the dispersed phase fluctuating fluxes of momentum and kinetic energy at the non-colliding, large inertia limit. This model is then used to predict the behaviour of three axisymmetric turbulent jets of air laden with solid particles varying in size and concentration. Qualitative and quantitative numerical predictions compare reasonably well with the three different sets of experimental results, studying the influence of particle size, loading ratio and flow confinement velocity.

关键词： two-phase flow turbulence phase indicator function pdf ensemble average jet

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水工混凝土抗冲磨试验方法(水下钢球法)改进研究

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中国农村水利水电 2014年第4期 126-128页

作者：吐尔洪.吐尔地王怀义新疆维吾尔自治区水利水电科学研究院乌鲁木齐830049 新疆水利水电材料工程技术研究中心乌鲁木齐830049

研究通过改进水工混凝土抗冲磨（水下钢球法）两个试验参数,第一个是冲磨介质钢球的形貌,将现行规范中圆形表面光滑的钢球形貌,改为带有尖角的圆形六面体;第二是调整了钢球的级配及数量.通过对比试验表明：与现行规范方法相比,改进后方... 详细信息

研究通过改进水工混凝土抗冲磨（水下钢球法）两个试验参数,第一个是冲磨介质钢球的形貌,将现行规范中圆形表面光滑的钢球形貌,改为带有尖角的圆形六面体;第二是调整了钢球的级配及数量.通过对比试验表明：与现行规范方法相比,改进后方法对于高强混凝土,其磨损率提高一倍及抗冲磨强度减少一半,磨损后试件表面严重磨损,平均磨损深度从2～4 mm增加到10～35 mm,反映了混凝土本体而非表层的抗冲磨性能,磨损效果显著提高,更能反映C40以上高性能抗冲磨混凝土的磨损速度和抗冲磨强度.

关键词：抗冲磨混凝土水下钢球法抗冲磨强度抗压强度

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Inferring the dynamics of “black-box” systems using a learning machine

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Science China(Physics,Mechanics & Astronomy) 2021年第7期64卷 72-81页

作者： hong Zhao Department of Physics Xiamen UniversityXiamen361005China lanzhou Center for Theoretical Physics Lanzhou UniversityLanzhou730000China

Given a segment of a time series of a system at a particular set of parameter values, is it possible to infer the dynamic behavior of the system in its parameter space? Here, we show that this goal can be achieved to a certain extent using a self-evolution learning machine. It is found that following an appropriate training strategy that monotonously decreases the cost function, the learning machine in different training stages is just like the system at different parameter sets. Consequently, the dynamic properties of the system are, in turn, usually revealed in the simple-to-complex order. The underlying mechanism can be attributed to the training strategy, which results in the learning machine collapsing to a qualitatively equivalent system of the system behind the time series. Thus, the learning machine enables a novel way of probing the dynamic properties of a “black-box” system without artificially establishing the equations of motion. The given illustrative examples include a representative model of low-dimensional nonlinear dynamical systems and a spatiotemporal model of reaction-diffusion systems.

关键词： prediction learning machine inverse problems “black-box”system nonlinear dynamics

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