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Efficacy and safety of individually tailored antiplatelet therapy in patients with acute coronary syndrome after coronary stenting： a single center, randomized, feasibility study

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Journal of Geriatric Cardiology 2015年第1期12卷 23-29页

作者： Hong-Chang ZHU Yi LI Shao-Yi GUAN Jing LI Xiao-Zeng wang Quan-min JING zu-Lu wang Ya-Ling HAN Second Affiliated Hospital of Dalian Medical University Dalianl 16023 Shandong Province China Cardiovascular Institute General Hospital of Shenyang Military Region Shenyang 110016 Liaoning Province China

Background Low responsiveness to clopidogrel （LRC） is associated with increased risk of ischemic events. This study was aimed to explore the feasibility of tailored antiplatelet therapy according to the responsiveness to clopidogrel. Methods A total of 305 clopidogrel naive patients with acute coronary syndromes （ACS） undergoing coronary stenting were randomly assigned to receive standard （n = 151） or tailored （n = 154） antiplatelet therapy. The ADP-induced platelet aggregation tests by light transmission aggregometry were performed to identify LRC patients assigned to the tailored group. The standard antiplatelet regimen was dual antiplatelet therapy with aspirin and clopidogrel. The tailored antiplatelet therapy was standard regimen for non-LRC patients and an additional 6-month cilostazol treatment for LRC patients. The primary efficacy outcome was the composite of cardiovascular death, myocardial infarction or stroke at one year. Results LCR was present in 26.6% （41/154） of patients in the tailored group. The percentage platelet aggregation for LCR patients was significantly decreased at three days after adjunctive cilostazol treatment （77.5% ± 12.1% vs. 64.5% ± 12.1%, P 〈 0.001）. At one year follow-up, a non-significant 37% relative risk reduction of primary events were observed in the tailored group as compared to the standard group （5.8% vs. 9.3%, P = 0.257）. There were no differences in the rates of stent thrombosis and hemorrhagic events between the two groups. Conclusions Tailored antiplatelet therapy for ACS patients after coronary stenting according to responsiveness to clopidogrel is feasible. However, its efficacy and safety need further confirmation by clinical trials with larger sample sizes.

关键词： Acute coronary syndrome Antiplatelet therapy Clopidogrel Coronary stenting

Human microbiome is a diagnostic biomarker in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 109-115页

作者： Ben-Chen Rao Jia-min Lou Wei-Jie wang Ang Li Guang-Ying Cui zu-Jiang Yu Zhi-Gang Ren Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Gene Hospital of Henan Province Precision Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Hepatocellular carcinoma(HCC)is the third leading cause of cancer mortality *** evidence indicates a close relationship between HCC and the human ***,we reviewed the important potential of the human microbiota as a diagnostic biomarker of *** sources:Several innovative studies have investigated the characteristics of the gut and oral micro-biomes in patients with HCC and proposed that the human microbiome has the potential to be a diag-nostic biomarker of *** from February 1999 to February 2019 was searched in the PubMed database using the keywords"microbiota"or"microbiome"or"microbe"and"liver cancer"or"hepato-cellular carcinoma",and the results of clinical and experimental studies were ***:Specific changes occur in the human microbiome of patients with ***,the gut mi-crobiome and oral microbiome can be used as non-invasive diagnostic biomarkers for ***,they also have certain diagnostic potential for precancerous diseases of *** diagnostic potential of the blood microbiota and ascites microbiota in HCC will be gradually discovered in the ***:The human microbiome is valuable to the diagnosis of HCC and provides a novel strategy for targeted therapy of *** human microbiome may be widely used in the diagnosis,treatment and prognosis for multiple system diseases or cancers in the future.

关键词： Human microbiome Gut microbiome Oral microbiome Hepatocellular carcinoma Diagnostic biomarker

Reaction behavior of MgO refractory with high-Mn and high-Al steel

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Journal of Iron and Steel Research International 2024年第6期31卷 1389-1398页

作者： Ling-zhong Kong Lin zu Jie Yang Xi-min Zang Xin Yang ming Kang School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina

To understand the mechanism of the interfacial reaction between high-Mn and high-Al steel and MgO refractory,a series of laboratory experiments as well as thermodynamic calculations were *** effects of Mn and Al contents in the steel and the reaction time on the interfacial reaction were *** was observed that the erosion of the MgO refractory is caused by the reaction of Al and Mn in the steel with MgO in the refractory,which would lead to the formation of(Mn,Mg)O·Al_(2)O_(3) spinel and(Mn,Mg)O solid *** formation mechanism of the spinel and solid solution is as *** Al in the steel firstly reacts with MgO in the refractory to generate MgO·Al_(2)O_(3) spinel,and then,the spinel reacts with Mn in the steel to form(Mn,Mg)O·Al_(2)O_(3) ***,the MnO in the spinel reacts with the MgO in the inner refractory to form(Mn,Mg)O solid *** addition,only(Mn,Mg)O·Al_(2)O_(3) spinel is present in the interfacial reaction layer of the refractory when the Al content in the steel is sufficient.

关键词： High-Mn high-Al steel MgO refractory Reaction behavior Spinel

Preoperative risk factor analysis in orthotopic liver transplantation with pretransplant artificial liver support therapy

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World Journal of Gastroenterology 2006年第31期12卷 5055-5059页

作者： Jin-Zhong Yuan Qi-Fa Ye Ling-Ling Zhao Ying-Zi ming Hong Sun Shai-Hong Zhu zu-Fa Huang min-min wang Blood Purification Center Xiangya Transplantation Institute Third Xiangya Hospital of Central South University Changsha 410013 Hunan Province China

AIM： To assess the value of pre-transplant artificial liver support in reducing the pre-operative risk factors relating to early mortality after orthotopic liver transplantation （OLT）. METHODS： Fifty adult patients with various stages and various etiologies undergoing OLT procedures were treated with molecular adsorbent recycling system （MARS） as preoperative liver support therapy. The study included two parts, the first one is to evaluate the medical effectiveness of single MARS treatment with some clinical and laboratory parameters, which were supposed to be the therapeutical pre-transplant risk factors, the second part is to study the patients undergoing OLT using the regression analysis on preoperative risk factors relating to early mortality （30 d） after OLT. RESULTS： In the 50 patients, the statistically significant improvement in the biochemical parameters was observed （pre-treatment and post-treatment）. Eight patients avoided the scheduled Ltx due to significant relief of clinical condition or recovery of failing liver function, 8 patients died, 34 patients were successfully bridged to Ltx, the immediate outcome of this 34 patients within 30d observation was： 28 kept alive and 6 patients died. CONCLUSION： Pre-operative SOFA, level of creatinine, INR, TNF-α, IL-10 are the main preoperative risk factors that cause early death after operation, MARS treatment before transplantion can relieve these factors significantly.

关键词： Liver transplantation Artificial liver Sequential Organ Failure Assessment Risk factors analysis

Optimal Bandwidth Scheduling for Resource-constrained Networks

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自动化学报 2009年第4期35卷 443-448页

作者： LI zu-Xin wang Wan-Liang CHENG Xin-min School of Information Engineering Huzhou Teachers College Huzhou 313000 P.R. China College of Information Engineering Zhejiang University of Technology Hangzhou 310032 P. R. China

In networked control systems (NCSs) with resource constraints, there is an unavoidable tradeoff between the control performance and the quality of service. To address these problems, we present multi-objective programming with a set of constraints to optimize control performance and bandwidth consumption for the first time. Thanks to robust nonlinear approximate function and computational cost, a feed-forward neural network as optimal approximator is employed. The role of the neural network, which provides a good approximation to the optimal solution, dynamically allocates the bandwidth of each control loop so that the overall system performance is maximized while bandwidth consumption is minimized. Preliminary simulation results show that the proposed optimal strategy is an effective tradeoff method between the control performance and bandwidth consumption in networked control applications.

关键词：网络控制系统优化带宽调度资源约束网络服务质量

A new technology for treating waste incineration fly ash by shaft furnace

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Journal of Iron and Steel Research International 2021年第7期28卷 773-784页

作者： Cui wang Long-zhi Chen Zheng-jian Liu Yang Li Yao-zu wang Ke-xin Jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

At present,lots of municipal solid wastes(MSWs)are treated by incineration technology,which produces a large amount of fly ash that needs to be treated innocuously.A new method of using metallurgical shaft furnace to treat the MSW fly ash was thus proposed,and some research was done for this ***,the basic physical properties of MSW fly ash were analyzed,and then,the briquetting experiment and melting treatment of MSW fly ash were *** the process of briquet-ting,the influence of different factors(water content,cement content,forming pressure and curing time)on the compressive strength of the briquettes was *** results showed that with the increase in water content,cement content,forming pressure and curing time,the compressive strength of the briquettes increased ***,the compressive strength of the briquettes showed a downward trend when these values exceeded a specific *** the melting experiment,it was found that some heavy metals(such as Cr,Be and Ba)could be solidified in the slag when the fly ash was treated at 1450℃ for 50 min,and the leaching toxicity of heavy metals was lower than the landfill standard of waste in *** the same time,the decomposition rate of dioxins in fly ash reached 99.66%after melting treatment.

关键词： Fly ash Shaft furnace Compressive strength Melting treatment Heavy metal Dioxin

Impact of Intraoperative Blood Pressure Control and Temporary Parent Artery Blocking on Prognosis in Cerebral Aneurysms Surgery

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Chinese Medical Sciences Journal 2016年第2期31卷 89-94页

作者： min Xu Zheng-song Gu Cun-zu wang Xiao-feng Lu Ding-chao Xiang Zhi-cheng Yuan Qiao-yu Li min Wu Department of Neurosurgery Kunshan Hospital of Traditional Chinese MedicineKunshan Affiliated Hospital of Nanjing University of Chinese Medicine Department of Neurosurgery Northern Jiangsu People's Hospital Department of Neurosurgery Zhenjiang Hospital of Traditional Chinese Medicine Department of Neurosurgery Wound Institute of Jiangsu University Department of Neurosurgery Zhenjiang First People's Hospital Department of Neurosurgery the Affiliated Hospital of Jiangsu University

Objective In cerebral aneurysm clipping and embolization, blood pressure control and temporaryparent artery blocking are common methods to prevent aneurysm rupture. Their influence on the prognosis isuncertain. In thi... 详细信息

关键词： cerebral aneurysm intraoperative blood pressure control prognosis temporary parent artery blocking

Midazolam in rabbits terminates dysrhythmias caused by intracerebroventricular ropivacaine

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 668-676页

作者： Yao-min ZHU zu-yi YUAN Hui WU Dan-dan ZHOU Gui-xia JING Department of Anesthesiology the First Affiliated Hospital School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Department of Cardiology the First Affiliated Hospital School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China

The current study was designed to investigate the mechanisms by which ropivacaine may act within the central nervous system （CNS） to produce cardiotoxicity. Eighty New Zealand rabbits were divided into four groups randomly. In Group 1,20 rabbits received intracerebroventricular （icv） saline, and then received icv ropivacaine 30 min later. In Group 2, 20 rabbits received icv ropivacaine. Whenever dysrhythmias continued for more than 5 min, 0.1 ml saline was administered into the left cerebral ventricle. Ten minutes later, 0.1 ml midazolam was given into the left lateral ventricle. In Group 3, 20 rabbits received icv ropivacaine, and once the dysrhythmias developed, the inspired isoflurane concentration was increased from 0.75% to 1.50%. In Group 4, 20 animals received an intravenous （iv） phenylephrine infusion until dysrhythmias occurred. In Group 1, the rabbits did not develop dysrhythmias in response to icv saline, whereas dysrhythmias did develop in these animals after icv ropivacaine. In Group 2, icv saline had no effect on the dysrhythmias; however, icv midazolam terminated cardiac dysrhythmias. In Group 3, an increase in the concentration of the inspired isoflurane had no effect on dysrhythmias. In Group 4, icv midazolam had no effect on dysrhythmias in response to iv phenylephdne. Ropivacaine administered directly into the CNS is capable of producing cardiac dysrhythmias; midazolam terminated dysrhythmias presumably by potentiation of y-aminobutyric acid （GABA） receptor activity. Our results suggest that ropivacaine produces some of its cardiotoxicity not only by the direct cardiotoxicity of the drug, but also by the CNS effects of ropivacaine.

关键词： Ropivacaine Cardiotoxicity Ventricular cerebrospinal fluid Central nervous system (CNS) Dysrhythmias Midazolam

IL-33 Downregulates Hepatic Carboxylesterase 1 in Acute Liver Injury via Macrophage-derived Exosomal miR-27b-3p

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1130-1142页

作者： Ping Gao min Li Jingli Lu Daochun Xiang Ximin wang Yanjiao Xu Yue zu Xinlei Guan Guodong Li Chengliang Zhang Wuhan Children’s Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Tongji Hospital Affiliated with Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiChina The First Affiliated Hospital of Zhengzhou University ZhengzhouChina The Central Hospital of Wuhan Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Wuhan Forth Hospital WuhanHubeiChina

Background and Aims:We previously reported that carboxylesterase 1(CES1)expression was suppressed following liver *** study aimed to explore the role of interleukin(IL)-33 in liver injury and examine the mechanism by which IL-33 regulates ***:IL-33 and CES1 levels were determined in the livers of patients and lipopolysaccharide(LPS)-,acetaminophen(APAP)-treated *** constructed IL-33 and ST2 knockout(KO)***2-enriched immune cells in livers were screened to identify the responsible ***-derived exosome(MDE)activity was tested by adding exosome ***-RNAs(miRs)were extracted from control and IL-33-stimulated MDEs(IL-33-MDEs)and subjected miR sequencing(miR-Seq).Candidate miR was tested in vitro and in vivo and its binding of a target gene was assessed by luciferase reporter ***-vector cellular transfection and transcript silencing were used to examine pathways mediating IL-33 suppression of ***:Patient liver IL-33 and CES1 expression levels were inversely ***1 downregulation in liver injury was rescued in both IL-33–deficient and ST2 KO *** were shown to be responsible for IL-33 ***-33-MDEs reduced CES1 levels in *** miR-Seq and qRT-PCR demonstrated increased miR-27b-3p levels in IL-33-MDEs;miR-27b-3p was implicated in Nrf2 ***-33 inhibition of miR-27b-3p was found to be ***:IL-33–ST2–GATA3 pathway signaling increases miR-27b-3p content in MDEs,which upon being internalized by hepatocytes reduce CES1 expression by inhibiting *** elucidation of this mechanism in this study contributes to a better understanding of CES1 dysregulation in liver injury.

关键词： IL-33 Carboxylesterase 1 miR-27b-3p Liver injury