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Room-temperature coherent manipulation of single-spin qubits in silicon carbide with a high readout contrast

National Science Review 2022年第5期9卷 89-98页

作者： Qiang Li Jun-Feng wang Fei-Fei Yan Ji-Yang Zhou Han-Feng wang He Liu Li-Ping Guo Xiong Zhou Adam Gali Zheng-Hao Liu zu-qing wang Kai Sun Guo-Ping Guo Jian-Shun Tang Hao Li Li-Xing You Jin-Shi Xu Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physics and Technology Wuhan University Department of Atomic Physics Budapest University of Technology and Economics Wigner Research Centre for Physics State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences(CAS)

Spin defects in silicon carbide(SiC) with mature wafer-scale fabrication and micro/nano-processing technologies have recently drawn considerable *** room-temperature single-spin manipulation of colour centres in SiC has been demonstrated,the typically detected contrast is less than 2%,and the photon count rate is also ***,we present the coherent manipulation of single divacancy spins in 4 H-SiC with a high readout contrast(-30%) and a high photon count rate(150 kilo counts per second)under ambient conditions,which are competitive with the nitrogen-vacancy centres in *** between a single defect spin and a nearby nuclear spin is also *** further provide a theoretical explanation for the high readout contrast by analysing the defect levels and decay *** the high readout contrast is of utmost importance in many applications of quantum technologies,this work might open a new territory for SiC-based quantum devices with many advanced properties of the host material.

关键词： silicon carbide single divacancy defects spin coherent control high readout contrast bright photon emission

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Effectiveness and safety of adjunctive non-drug measures in improving respiratory symptoms among patients with severe COVID-19:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2024年第6期22卷 637-644页

作者： Xuan Yin Zhu Jin Feng Li Li Huang Yan-mei Hu Bo-chang Zhu zu-qing wang Xi-ying Li Jian-ping Li Lixing Lao Yi-qun Mi Shi-fen Xu Acupuncture and Moxibustion Department Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Medical Department Shanghai Seventh People's Hospital Shanghai University of Traditional Chinese Medicine Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese Medicine Shanghai Xuhui District Central Hospital Virginia University of Integrative Medicine

Background: The outbreak of coronavirus disease 2019（COVID-19） infection posed a huge threat and burden to public healthcare in late 2022. Non-drug measures of traditional Chinese medicine（TCM）, such as acupuncture, cupping and moxibustion, are commonly used as adjuncts in China to help in severe cases,but their effects remain ***: To observe the clinical effect of TCM non-drug measures in improving respiratory function and symptoms among patients with severe ***, setting, participants and interventions: This study was designed as a multicenter, assessor-blind,randomized controlled trial. Hospitalized patients with COVID-19 were randomly assigned to the treatment or control group. The treatment group received individualized TCM non-drug measures in combination with prone position ventilation, while the control group received prone position ventilation only for 5 consecutive *** outcome measures: The primary outcome measures were the percentage of patients with improved oxygen saturation（SpO2） at the end of the 5-day intervention, as well as changes of patients' respiratory rates. The secondary outcome measures included changes in SpO2and total score on the self-made respiratory symptom scale. The improvement rate, defined as a 3-day consecutive increase in SpO2, the duration of prone positioning, and adverse events were recorded as ***: Among the 198 patients included in the intention-to-treat analysis, 159（80.3%） completed all assessments on day 5, and 39（19.7%） patients withdrew from the study. At the end of the intervention,71（91%） patients in the treatment group had SpO2above 93%, while 61（75.3%） in the control group reached this level. The proportion of participant with improved SpO2was significantly greater in the intervention group（mean difference [MD] = 15.7; 95% confidence interval [CI]: 4.4, 27.1; P = 0.008）.Compared to the baseline, with daily treatment there were significant daily decreases in respiratory rates i

关键词： Non-drug measures Prone positioning COVID-19 Oxygen saturation Traditional Chinese medicine

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Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun wang qing Shi Guofan Zhang Yuxuan Zhu Binbin Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

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Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： qing He Zhen wang Yuchen wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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手扶拖拉机手把振动测试和评价方法的初步研究

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江苏工学院学报 1984年第4期 19-31页

作者：苏清祖王锦雯

本文分析了国际标准化组织所通过的手—臂受振的评价准则,并根据手扶拖拉机的具体工作情况,提出了对手扶拖拉机手把振动的评价方法。文中还分析了各种测试方法的应用场合及精度分析。

关键词：手扶拖拉机初步研究田园式拖拉机振动测试振动测量评价方法

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Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： Bai, Jie Jia, Jian Hui wang, Yu Yang, Chun Cheng Jiang, qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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轮式拖拉机前桥载荷谱测取方法的初步研究

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农业机械学报 1982年第2期 30-42页

作者：苏清祖王锦雯镇江农机学院

本文介绍了测取拖拉机前轮空间载荷的贴片方案、仪器布置及标定方法。并叙述了对样本的几种检验以判断数据的性质和样本的概率密度函数。然后根据分布函数作外推从而获得单一工况的载荷谱,经多种工况合成即得合成载荷谱。

关键词：正态分布表初步研究轮式拖拉机标准正态分布单位正态分布区间数载荷谱应力谱平稳性前桥

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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi qing Yifei Chen Jilian Zou Meiling Jia Qian wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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