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Prostate Health Index(phi)and its derivatives predict Gleason score upgrading after radical prostatectomy among patients with low-risk prostate cancer

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Asian Journal of Andrology 2022年第4期24卷 406-410页

作者： Jia-Qi Yan Da Huang Jing-Yi Huang Xiao-Hao Ruan Xiao-Ling Lin Zu-Jun Fang Yi Gao Hao-Wen Jiang Yi-Shuo Wu Rong Na Dan-Feng Xu Department of Urology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Urology Huashan HospitalFudan UniversityShanghai 200040China.

To analyze the performance of the Prostate Health Index(phi)and its derivatives for predicting Gleason score(GS)upgrading between prostate biopsy and radical prostatectomy(RP)in the Chinese population,an observational,prospective RP cohort consisting of 351 patients from two medical centers was established from January 2017 to September 2020.Pathological reclassification was determined by the Gleason Grade Group(GG).The area under the receiver operating characteristic curve(AUC)and logistic regression(LR)models were used to evaluate the predictive performance of predictors.In clinically low-risk patients with biopsy GG≤2,phi(odds ratio[OR]=1.80,95%confidence interval[95%CI]:1.14-2.82,P=0.01)and its derivative phi density(PHID;OR=2.34,95%CI:1.30-4.20,P=0.005)were significantly associated with upgrading to GG≥3 after RP,and the results were confirmed by multivariable analysis.Similar results were observed in patients with biopsy GG of 1 for the prediction of upgrading to RP GG≥2.Compared to the base model(AUC=0.59),addition of the phi or PHID could provide additional predictive value for GS upgrading in low-risk patients(AUC=0.69 and 0.71,respectively,both P<0.05).In conclusion,phi and PHID could predict GS upgrading after RP in clinically low-risk patients.

关键词： Gleason score Prostate Health Index prostate biopsy prostate cancer radical prostatectomy upgrading

Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 408-420页

作者： FENG Min-chao LUO fang HUANG Liang-jiang LI Kai CHEN zu-min LI Hui YAO Chun QIN Bai-jun CHEN Guo-zhong The First Clinical Medical College Guangxi University of Traditional Chinese MedicineNanning 530000China Guangxi Key Laboratory of Molecular Biology of Traditional Chinese Medicine and Preventive Medicine Nanning 530000China Graduate School Guangxi University of Traditional Chinese MedicineNanning 530000China Department of Gastroenterology the First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530023China

Objective: To identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge.,(Dahuang-Danshen, DH-DS) and the mechanism underlying its therapeutic efficacy in acute pancreatitis(AP)using a network pharmacology approach and validate the findings in animal experiments. Methods: Network pharmacology analysis was used to elucidate the mechanisms underlying the therapeutic effects of DH-DS in AP. The reliability of the results was verified by molecular docking simulation and molecular dynamics simulation.Finally, the results of network pharmacology enrichment analysis were verified by immunohistochemistry,Western blot analysis and real-time quantitative PCR, respectively. Results: Sixty-seven common targets of DH-DS in AP were identified and mitogen-activated protein kinase 3(MAPK3), Janus kinase 2(JAK2), signal transducer and activator of transcription 3(STAT3), protein c-Fos(FOS) were identified as core targets in the protein interaction(PPI) network analysis. Gene ontology analysis showed that cellular response to organic substance was the main functions of DH-DS in AP, and Kyoto Encyclopedia of Genes and Genomes analysis showed that the main pathway included Th17 cell differentiation. Molecular docking simulation confirmed that DH-DS binds with strong affinity to MAPK3, STAT3 and FOS. Molecular dynamics simulation revealed that FOS-isotanshinone Ⅱ and STAT3-dan-shexinkum d had good binding capacity. Animal experiments indicated that compared with the AP model group, DH-DS treatment effectively alleviated AP by inhibiting the expression of interleukin-1β, interleukin-6 and tumor necrosis factor-α, and blocking the activation of Th17 cell differentiation(P<0.01). Conclusion: DH-DS could inhibit the expression of inflammatory factors and protect pancreatic tissues,which would be functioned by regulating Th17 cell differentiation-related m RNA and protein expressions.

关键词： Rheum palmatum L. Salvia miltiorrhiza Bge. molecular docking simulation network pharmacology acute pancreatitis Th17 cell differentiation

高质量发展背景下农民参与乡村治理的制度建构精细化研究——基于安徽省S市3村的调查

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石家庄铁道大学学报（社会科学版） 2024年第1期18卷 66-72页

作者：祖小朵方军安徽财经大学财政与公共管理学院安徽蚌埠233030

农村地区是中国基层治理的重要阵地.提高农民参与乡村治理体系建设的精细化水平,对于乡村社会具有现实意义.深入研究农民参与乡村治理制度建构精细化是实现乡村振兴和基层治理现代化的基础,让农民参与乡村治理在适合的制度条件下运转起... 详细信息

农村地区是中国基层治理的重要阵地.提高农民参与乡村治理体系建设的精细化水平,对于乡村社会具有现实意义.深入研究农民参与乡村治理制度建构精细化是实现乡村振兴和基层治理现代化的基础,让农民参与乡村治理在适合的制度条件下运转起来,提升乡村治理水平,有助于加速促进乡村现代化治理体系的形成以及乡村振兴的实现.在高质量发展背景下,对安徽省S市3村制度建设进行考察.研究发现,在具体的实践过程中,出现了参与冷漠化、制度错位、非制度参与、传统乡土意识式微等现象.因此,需要培育村民治理主体意识、规范权力实践主体、完善村规民约,既要引导村民有序参与,又要重新唤醒他们在农村的归属感,要采取多种措施,使村民自治工作在适当的制度条件下开展.

关键词：农民参与乡村治理制度建构精细化高质量发展

“三治融合”中治理共同体实现机制及成效探究——基于安徽省S市的调查值

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成都大学学报（社会科学版） 2023年第5期 27-39页

作者：方军祖小朵安徽财经大学财政与公共管理学院安徽蚌埠233030

“三治融合”将自治、法治、德治结合起来实现乡村社会有效治理,对实现各治理主体在乡村治理中发挥治理能动性具有重要作用。本文以安徽省S市为研究样本,总结“三治融合”乡村治理体系的实践逻辑与内在机理,发现该市通过创新发展集体经... 详细信息

“三治融合”将自治、法治、德治结合起来实现乡村社会有效治理,对实现各治理主体在乡村治理中发挥治理能动性具有重要作用。本文以安徽省S市为研究样本,总结“三治融合”乡村治理体系的实践逻辑与内在机理,发现该市通过创新发展集体经济,以集体经济为纽带赋能各类村级组织,通过村规民约和多元主体耦合,实现三治的有机融合,形成了乡村治理共同体。为了探究“三治融合”治理模式的治理成效,运用二元逻辑回归分析方法实证分析了村民对“三治融合”治理模式的满意度及其影响因素。结果发现,“三治融合”治理模式满足了村民的治理需求,应继续强化自治机制,优化法治环境,提升德治水平。

关键词： “三治融合” 多元主体乡村治理共同体合作共治

高质量发展背景下特色小镇巩固脱贫成果路径研究——以砀山县良梨镇为例

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宿州学院学报 2022年第11期37卷 19-24页

作者：祖小朵方军安徽财经大学财政与公共管理学院安徽蚌埠233030

脱贫攻坚战取得全面胜利后,精准扶贫工作进入了后精准扶贫时期,如何实现特色小镇巩固拓展脱贫攻坚成果,并向乡村振兴平稳过渡,是值得研究的重要理论问题和现实问题。特色小镇是实现乡村振兴的重要载体,砀山县酥梨小镇是安徽省创建的省... 详细信息

脱贫攻坚战取得全面胜利后,精准扶贫工作进入了后精准扶贫时期,如何实现特色小镇巩固拓展脱贫攻坚成果,并向乡村振兴平稳过渡,是值得研究的重要理论问题和现实问题。特色小镇是实现乡村振兴的重要载体,砀山县酥梨小镇是安徽省创建的省级特色小镇,以其独特的自然资源和文化资源区别于其他特色小镇。在高质量发展背景下,分析砀山县酥梨小镇巩固脱贫成果的基础,根据小镇巩固脱贫成果的价值提出砀山县酥梨小镇巩固脱贫成果的创新路径。

关键词：精准扶贫脱贫成果乡村振兴特色小镇高质量发展

Environmental characteristics of sandstorm of Minqin Oasis in China for recent 50 years

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Journal of Environmental Sciences 2005年第5期17卷 857-860页

作者： ZHANG Ke-cun QU Jian-jun zu Rui-ping fang Hai-yan Key Laboratory of Desert and Desertification Cold and Arid Regions Environmental and Engineering Research Institute. Chinese Academy ofSciences Lanzhou 730000 China

The purpose of this present study is to investigate the frequency and variation of sandstorm in Minqin Oasis. Using daily observational data of sandstorm and other meteorologic data from 1954 to 2000, we have illuminated the relationship between sandstorm, meteorological parameters and human activities. The results of the analysis show that the highest frequency of sandstorms occurrence and their duration mainly focus on March, April and May, especially in April. Most of sandstorms occur from midday to nightfall, but relative few appear from midnight to forenoon, which apparently correlates to the daily variations of atmospheric thermal stability within atmospheric boundary layer. Monthly mean and annual mean duration of sandstorms coincide well with the frequencies of sandstorm occurrence.

关键词： Minqin Oasis sandstorm environmental characteristics

ROC曲线分析卵泡刺激素及黄体生成素辅助诊断女童性早熟的价值

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中国当代儿科杂志 2012年第6期14卷 441-444页

作者：王祖芳李桂军嘉兴市妇幼保健院市立三一医院检验科浙江嘉兴314051

目的探讨卵泡刺激素(FSH)、黄体生成素(LH)、LH/FSH比值在辅助鉴别诊断女童性早熟中的临床价值。方法 220例假性性早熟和61例真性性早熟女童均进行促性腺激素释放激素(GnRH)兴奋试验。统计实验前和实验后30 min、60 min FSH、LH检测结... 详细信息

目的探讨卵泡刺激素(FSH)、黄体生成素(LH)、LH/FSH比值在辅助鉴别诊断女童性早熟中的临床价值。方法 220例假性性早熟和61例真性性早熟女童均进行促性腺激素释放激素(GnRH)兴奋试验。统计实验前和实验后30 min、60 min FSH、LH检测结果并计算LH/FSH比值。ROC曲线分析FSH、LH、LH/FSH比值用于诊断性早熟的敏感度并确定最佳诊断截点。结果通过LH、LH/FSH比值判别性早熟ROC曲线下面积为0.90和0.95。LH峰值截点为10.15 IU/L,敏感度、特异性分别为0.92和0.89;LH/FSH比值截点为0.60,漏诊率为6.0%,特异性为0.91。若患者检测结果满足LH峰值>10.15 TU/L、LH/FSH比值>0.60两个条件中任何一个即诊断为真性性早熟,则敏感度、特异性分别为0.97、0.94;若两个条件同时满足才诊断为真性性早熟,则特异性为1.00,敏感度为0.85。结论 LH峰值>10.15 IU/L且LH/FSH比值>0.60时,可鉴别诊断为真性性早熟,若两个条件中仅一者满足,为防止漏诊或误诊,应进一步随访观察,以明确诊断。

关键词：性早熟卵泡刺激素黄体生成素鉴别诊断女童

Diagnostic value of endobronchial ultrasound guided transbronchial needle aspiration in superior vena cava syndrome

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Chinese Medical Journal 2013年第23期126卷 4453-4456页

作者： ZHOU zu-li ZHAO Hui LI Yun SUI Xi-zhao XIE Zhen CHEN Ke-zhong YANG Feng LI Feng-wei LIU jun ZHENG Hong-fang WANG jun Department of Thoracic Surgery Peking University People's Hospital Beijing 100044 China Department of Pathology Peking University People's Hospital Beijing 100044 China Department of Thoracic Surgery Beijing Aerospace Hospital Beijing 100076 China

Background The pathological diagnosis is of critical importance to the subsequent treatment for the pathients with superior vena cava syndrome （SVCS）.The aim of this study is to report our experience in the diagnosis of SVCS by endobronchial ultrasound guided transbronchial needle aspiration （EBUS-TBNA）.Methods The data of 520 patients who underwent EBUS-TBNA from September 2009 to May 2012 at our institution were reviewed.Of these,there were 14 males and 6 females （mean age of 59.1 years） with SVCS who received EBUS-TBNA that were included in the analysis.Results The mean short axis diameter of the paratracheal lesions was （3.32±1.79） cm （range,1.69 to 9.50 cm） and 6 cases also had subcarinal lymph node enlargement with a mean short axis diameter of （2.14±0.49） cm （range,1.73 to 3.01 cm）.An average of 4.3 punctures was performed per lesion.Malignancy was confirmed in 16 cases （10 small cell carcinomas,4 adenocarcinomas,1 squamous cell carcinoma and 1 Hodgkin lymphoma）.In two patients,pathological examination of tissue revealed no evidence of malignancy and for 13 to 24 months of follow-up.One patient from whom adequate tissue was not obtained refused further surgical biopsy since he had undergone endovascular stenting of the SVC.One patient in whom a diagnosis was not obtained by EBUS-TBNA underwent thoracoscopic biopsy and the final diagnosis was B cell non-Hodgkin＇s lymphoma.The diagnosis accuracy of EBUS-TBNA in SVCS was 18/20 patients.Conclusion EBUS-TBNA is a highly effective and safe procedure for the diagnosis of SVCS.

关键词： endobronchial ultrasound transbronchial needle aspiration superior vena cava syndrome diagnosis

c-jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 30-37页

作者： Rong-Rong Wang Cheng-fang Li De-zu Wang Cheng-Wu Zhang Gui-Xiang Liu Qingdao University Department of Ophthalmology Jimo Traditional Chinese Medicine Hospital Department of Ophthalmology Affiliated Qingdao Hiser Hospital of Qingdao University Institute of Advanced Materials Nanjing Tech University Department of Ophthalmology Affiliated Hospital of the Medical College of Qingdao University

AIM: To illustrate the isoform-specific role and mechanism of c-jun N-terminal kinases(JNKs) in mouse optic nerve axotomy induced neurotrauma. METHODS: We firstly investigated the expression of JNK1, JNK2, and JNK3 in the retinal ganglion cells(RGCs) by double-immunofluorescent staining. Then we created optic nerve axotomy model in wild type as well as JNK1, JNK2, JNK3, isoform specific gene deficiency mice. With that, we checked the protein expression profile of JNKs and its active form, and quantified the survival RGCs number by immunofluorescence staining. We further explored the molecules underlying isoform specific protective effect by real-time polymerase chain reaction(PCR) and Western blotting assay. RESULTS: We found that all the three isoforms of JNKs were expressed in the RGCs. Deficiency of JNK3, but not JNK1 or JNK2, significantly alleviated optic nerve axotomyinduced RGCs apoptosis. We further established that expression of Noxa, a pro-apoptotic member of BH3 family, was significantly suppressed only in JNK3 gene deficiency mice. But tumor necrosis factor receptor 1(TNFR1) and Fas, two key modulators of death receptor mediated apoptosis pathway, did not display obvious change in the expression. CONCLUSION: It is suggested that mitochondria mediated apoptosis, but not death receptor mediated apoptosis got involved in the JNK3 gene deficiency induced RGCs protection. Our study provides a novel insight into the isoform-specific role of JNKs in neurotrauma and indicates some cues for its therapeutics.

关键词： retinal ganglion cells c-jun N-terminal kinases optic nerve mitochondria Noxa neurotrauma