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Successful percutaneous drainage of a giant hydatid cyst in the liver

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World Journal of Gastroenterology 2006年第5期12卷 812-814页

作者： István Battyány zsuzsanna Herbert Tamás Rostás ron vincze Adrien Fülp Zoltán Harmat Beáta Gasztony Department of Radiology University of PécsHungary 1~(st)Department of Medicine University of PécsHungary

A 35-year-old female was hospitalized for abdominal pain, bloating, and vomiting. Plain X-ray pictures exhibited bowel obstruction for which she underwent emergency surgery. On the second postoperative day, she started to complain about dull right upper quadrant abdominal pain and bloating. Abdominal CT scans revealed very large cystic lesion with an inhomogeneous fluid content. The cyst occupied the whole right lobe of the liver compressing the surrounding organs and dislocating the left lobe of the liver towards the left hypochondrium （Figure 1）. Additionally, several more cysts of various sizes were seen in the whole abdomen. This radio-morphology raised the possibility of a hydatid disease （caused by ruptured hydatid cyst） confirmed through positive echinococcus IgG serology （ELISA）. Interestingly, no hypereosinophilia could be detected through repeated blood tests.

关键词： Echinococcosis Giant hydatid cyst PAIR technique Percutaneous drainage Anaphylaxis

The Biomathematics Is a Borderland Science

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Journal of Philosophy Study 2022年第1期12卷 18-25页

作者： Janos vincze Gabriella vincze-Tiszay Health Human International Environment Foundation BudapestHungary

In the latter decades,biomathematics played an important role in life ***,a great variety of biomathematical methods are applied in biology and *** every mathematical procedure that is useful in physics,chemistry,engineering,and economics has also found an important application in the life *** present,many life scientists are really interested in going deeply into *** attempt to apply biomathematics to the life systems involves three ***,we observe the phenomena and formulate a biomathematical description in the form of a differential equation,algebraic equation,statistic comparison or *** then temporarily forget the real life system and use biomathematical reasoning to solve the *** stage may involve inventing new biomathematics or extending what ***,we return to the real life system and interpret this solution in terms of reality;this interpretation may require experimental ***,the most difficult stage is the first one;this is certainly so in biology and medicine at present we hardly know enough about the“laws”governing the components of life systems to write down their appropriate relationships with confidence.

关键词： borderland science axiomatisation mathematics biplogy biomathematical modeling

The role of electrocardiography in the elaboration of a new paradigm in cardiac resynchronization therapy for patients with nonspecific intraventricular conduction disturbance

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Journal of Geriatric Cardiology 2016年第2期13卷 118-125页

作者： Andras Vereckei Gabor Katona zsuzsanna Szelenyi Gabor Szenasi Balint Kozman Istvan Karadi The 3rd Department of Medicine School of Medicine Semmelweis University Budapest Hungary Institute of Pathophysiology Semmelweis University Budapest Hungary Ardinsys Ltd. Budapest Hungary

Cardiac resynchronization therapy （CRT） is associated with a favorable outcome only in patients with left bundle branch block （LBBB） pattern and in patients with a QRS duration 〉 150 ms, in patients with non-LBBB pattern with a QRS duration of 120-150 ms usually is not beneficial. After adjusting for QRS duration, QRS morphology was no longer a determinant of the clinical response to CRT. In contrast to the mainstream view, we hypothesized that the unfavorable CRT outcome in patients with non-LBBB and a QRS duration of 120-150 ms is not due to the QRS morphology itself, but to less dyssynchrony and unfavorable patient characteristics in this subgroup, such as more ischemic etiology and greater prevalence of male patients compared with patients with LBBB pattern. Further, the current CRT technique is devised to eliminate the dyssynchrony present in patients with LBBB pattern and inappropriate to eliminate the dyssynchrony in patients with non-LBBB pattern. We also hypothesized that electrocardiography may also provide information about the presence of interventricular and left intraventricular dyssynchrony and the approximate location of the latest activated left ventricular （LV） region. To this end, we devised new ECG criteria to estimate interventricular and LV intraventricular dyssynchrony and the approximate location of the latest activated LV region. Our preliminary data demonstrated that the latest activated LV region in patients with nonspecific intraventricular conduction disturbance （NICD） pattern might be at a remote site from that present in patients with LBBB pattern, which might necessitate the invention of a novel CRT technique for patients with NICD pattern. The application of the new interventricular and LV intraventricular dyssynchrony ECG criteria and a potential novel CRT technique might decrease the currently high nonresponder rate in patients with NICD pattern.

关键词： Cardiac resynchronization therapy Electrocardiography Heart failure

Quality of care in inflammatory bowel diseases: What is the best way to better outcomes?

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World Journal of Gastroenterology 2018年第22期24卷 2363-2372页

作者： Matthew Strohl Lorant Gonczi zsuzsanna Kurt Talat Bessissow Peter L Lakatos Division of Gastroenterology McGill University Health Center First Department of Medicine Semmelweis University

Inflammatory bowel disease(IBD) is a lifelong, progres-sive disease that has disabling impacts on patient's lives. Given the complex nature of the diagnosis of IBD and its management there is consequently a large economic burden seen across all health care systems. Quality in-dicators(QI) have been created to assess the different fa?ades of disease management including structure, process and outcome components. Their development serves to provide a means to target and measure quality of care(Qo C). Multiple different QI sets have been published in IBD, but all serve the same purpose of trying to achieve a standard of care that can be attained on a national and international level, since there is still a major variation in clinical practice. There have been many recent innovative developments that aim to improve Qo C in IBD including telemedicine, home biomarker assessment and rapid access clinics. These are some of the novel advancements that have been shown to have great potential at improving Qo C, while offloading some of the burden that IBD can have vis-a-vis emergency room visits and hospital admissions. The aim of the current review is to summarize and discuss available QI sets and recent developments in IBD care including telemedicine, and to give insight into how the utilization of these tools could benefit the Qo C of IBD patients. Additionally, a treating-to-target structure as well as evidence surrounding aggressive management directed at tighter disease control will be presented.

关键词： Inflammatory bowel disease Telemedicine Quality indicators Quality of care Treat-to-target

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The Human Mind

Journal of Philosophy Study 2023年第2期13卷 60-67页

作者： Janos vincze Gabriella vincze-Tiszay Health Human International Environment Foundation BudapestHungary

The development of speech may have been the critical step in the development of the *** parallel with biological evolution,with the accumulation of gene differences,cultural evolution,the accumulation of experiences and ideas in symbolic form,***,the most significant stage of development is the development of the cerebral *** are estimated one million cortical modules in each *** cells and sensory organs have well-determined centers,quasi“representative sites”in the brain;the stimuli of a sensory organ always flow into the corresponding *** cortical projection of the main moving field is similar to the sensor field-a moving *** involved in fine movements are represented over a larger area than muscles of other parts of the *** is a process of selection:only the memories that are important,interesting,significant for us are kept-the rest we ***,language,is central to the development of the ability to think and to the biological success of the human *** of the most beautiful features of humankind is that they can live in a world of *** can imagine things they have never seen or never experienced.

关键词： knowledge human brain sensory cells speech

Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012

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World Journal of Gastroenterology 2015年第23期21卷 7272-7280页

作者： Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz zsuzsanna Vegh zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos First Department of Medicine Semmelweis University Department of Medicine Csolnoky Ferenc Province Hospital

AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem ***: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively ***: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate *** CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease ***: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization.

关键词： Crohn's disease Hospitalization Recurrence Predictor Population-based Biological therapy

Positioning of old and new biologicals and small molecules in the treatment of inflammatory bowel diseases

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World Journal of Gastroenterology 2018年第32期24卷 3567-3582页

作者： Jason Reinglas Lorant Gonczi zsuzsanna Kurt Talat Bessissow Peter L Lakatos Department of Gastroenterology McGill University Health CenterMontrealQuébec H4A 3J1Canada First Department of Medicine Semmelweis UniversityH-1083BudapestKoranyi S.2AHungary

The past decade has brought substantial advances in the management of inflammatory bowel diseases(IBD). The introduction of tumor necrosis factor(TNF) antagonists, evidence for the value of combination therapy, the recog-nition of targeting lymphocyte trafficking and activation as a viable treatment, and the need for early treatment of high-risk patients are all fundamental concepts for current modern IBD treatment algorithms. In this article, authors review the existing data on approved biologicals and small molecules as well as provide insight on the current positioning of approved therapies. Patient stratification for the selection of specific therapies, therapeutic targets and patient monitoring will be discussed as well. The thera-peutic armamentarium for IBD is expanding as novel and more targeted therapies become available. In the absence of comparative trials, positioning these agents is becoming difficult. Emerging concepts for the future will include an emphasis on the development of algorithms which will facilitate a greater understanding of the positioning of novel biological drugs and small molecules in order to best tailor therapy to the patient. In the interim, anti-TNF therapy remains an important component of IBD therapy with the most real-life evidence and should be considered as first-line therapy in patients with complicated Crohn's disease and in acute-severe ulcerative colitis. The safety and efficacy of these ‘older' anti-TNF therapies can be optimized by adhering to therapeutic algorithms which combine clinical and objective markers of disease severityand response to therapy.

关键词： Inflammatory bowel disease Small molecule Positioning Biologic Therapeutic

Comparison of long-term outcome between patients aged 〈 65 years vs. ≥ 65 years after atrial fibrillation ablation

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Journal of Geriatric Cardiology 2017年第9期14卷 569-574页

作者： zsuzsanna Kis Anna ME Noten Mihran Martirosyan Astrid A Hendriks Rohit Bhagwandien Tamas Szili-Torok Department of Cardiology Erasmus MC University Medical Center Rotterdam the Netherlands

Background Atrial fibrillation （AF） is the most frequent arrhythmia, and its prevalence is increasing with aging. We aimed to com-pare the long-term outcome data of patients 〈 65 years vs.≥ 65 years who underwent catheter ablation （CA） for drug-refractory AF. MethodsConsecutive patients with primary pulmonary vein isolation performed between March 2001 and December 2011, and those who completeda five-year of follow-up were divided into two groups： patients aged 〈 65 years into group 1, and patients aged ≥ 65 into group 2. Long-termoutcome data concerning mortality, thromboembolic events （TE） and success rates were compared between these groups. Results A totalnumber of 390 patients were included, group 1 contained 310 patients, and 80 patients in group 2. In group 2, patients had more often impairedrenal function （P 〈 0.001） and thyroid disease （P = 0.047）. A total of fifteen patients died during the 6.63 ± 2.1 years of follow-up, with a sig-nificantly higher incidence in the older group （8/80 vs. 7/310 patients, P = 0.004）. The majority of fatal outcome was due to cancerous dis-eases in both groups. No difference was observed concerning the long-term TE rate （12/310 vs. 4/80 patients, P = 0.75）. Rhythm controlfailed in 25.9% of the patients, with no difference between the groups： 26.4% in group 1 vs. 23.7% in group 2 （P = 0,67）, ConclusionsDespite growing prevalence of AF in aging population, the elderly patients are underrepresented in CA procedures. Similar clinical successand TE complication rate are observed between the age-groups. Our data suggest more liberal criteria might be applied while selecting pa-tients for AF ablation.

关键词： Atrial fibrillation Catheter ablation Clinical outcome The elderly Thromboembolic complication

The Biophysics Is a Borderland Science

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Journal of Philosophy Study 2021年第5期11卷 351-362页

作者： Janos vincze Health Human International Environment Foundation BudapestHungary

Biophysics as an immense spectrum comprehended by one of the most commonly applied borderland mental process embracing from the nature,through living systems up to spiritual processes brings it along inevitable that the reader will join issue here and there with the deductions of this book but in actual fact it was just one of the goals of this *** get hold of the biophysical view is not an easy task,because it applies mathematical apparatus to biological systems;on the other hand as a reward it guides to fascinating results,recognizing theoretically which conformity of rules are valid on principle in the Universe in the inanimate-living-spiritual triple system from the lowest to the highest organizational *** this way one can make up the reader’s claim to consider systematically those problems arising from the various fields of science and life in the countless variety of interrelations and in their very different consequences.

关键词： borderland science three-dimensional model of sciences biophysical modelling hypothetical secondary brain uncertainty relations