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Cancer Communications 2024年第4期44卷 499-503页

作者： Xuechun Wang Anna Juncker-Jensen Gang Huang Mate Levente nagy Xuemin Lu Liang Cheng Xin Lu Department of Biological Sciences Boler-Parseghian Center for Rare and Neglected DiseasesHarper Cancer Research InstituteUniversity of Notre DameNotre DameINUSA NeoGenomics Laboratories Inc.Aliso ViejoCAUSA Department of Pathology and Laboratory Medicine Brown University Warren Alpert Medical SchoolLifespan Academic Medical CenterLegorreta Cancer Center at Brown UniversityProvidenceRIUSA Tumor Microenvironment and Metastasis Program Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolisINUSA

Dear Editor,Tertiary lymphoid structures(TLSs)are organized clus-ters of immune cells found in non-lymphoid tissues of chronic inflammation,including solid tumors[1].High endothelial venules(HEVs)positive for peripheral node addressin(PNAd)are present in TLSs and may pro-vide highway entry for ***-residing TLSs may be formed by the concerted actions of cytokines and chemokines,a finding supported by the relation between a 12-chemokine signature and TLSs[2].

关键词： bladder lymphoid inflammation

Simple identification approach for trace heteroatom-containing compounds in petroleum fraction by Automated Mass Spectral Deconvolution and Identification System

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色谱 2016年第9期34卷 925-932页

作者： Moustafa nagy E Mahmoud Kout El-Kloub Fars Institute of Inorganic and Analytical Chemistry University of Munster Germany Munster 48149 Department of Chemistry Women's College for Arts Science and Education Ain Shams University Egypt Cairo 11566

Here we present a simple yet effective gas chromatography-mass spectrometry (GC-MS) identification approach for the detection of heteroatom-containing compounds (HACCs) in petroleum fractions. The MS/AMDIS (Automated Mass Spectral Deconvolution and Identification System) program was used to identify parts per million (ppm) HACC concentrations in petroleum fractions in place of traditional techniques (extraction and standard injection). Polycyclic aromatic sulfur heterocycles (S-PAHs) were used as model compounds to confirm the validity of the AMDIS identifiers, which were compared with extracted results using the off-line X-calibur software. AMDIS was able to identify ppm concentrations of S-PAHs in oil condensate. There was good agreement between experimental and AMDIS identification results for S-PAHs in oil condensate. AMDIS was also used to detect nitrogen-containing compounds (NCCs) and alkylphenols in oil condensate. Our results confirmed the presence of 2-methylbenzothiazole, carbazole, and 2,4-ditertbutyl phenol. In a crude oil sample, AMDIS identification of m/z=191 biomarkers was consistent with empirical results. Therefore, AMDIS can help to reduce the number of experimental steps in identification protocols.

关键词： Automated Mass Spectral Deconvolution and Identification System (AMDIS) heteroatom-containing compounds petroleum identification

Negative Pressure Wound Therapy—An Effective, Minimally Invasive Therapeutic Modality in Burn Wound Management

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International Journal of Clinical Medicine 2015年第5期6卷 301-306页

作者： Endre nagy István Juhász Burn and Dermatosurgery Unit at Department of Dermatology University of Debrecen Clinical Center Debrecen Hungary Coordinating Department of Surgical Specialties Faculty of Dentistry University of Debrecen Debrecen Hungary

Despite the advancement in burn therapy in the last decades the treatment of burn wounds still remains a challenging task. Infection is still a common complication;while sepsis remains the leading cause of death in severe burns. The research guided integration of new and effective techniques in burn wound management is mandatory. Negative pressure wound therapy (NPWT) is an effective and widely used technique in the management of problematic wounds. Previously existing indications include soft tissue traumas and chronic wounds such as diabetic, arterial, venous and pressure ulcers. The characteristics and challenges of these wounds have a lot in common with burns. Since the early 2000’s there are experiences with the use of NPWT for the healing of second degree burn wounds. Our clinical experience shows that it is a minimally invasive and effective way of improving burn wound management. In this article we give a review of the literature showing the mechanisms, unmapped future opportunities, financial issues, and possible adverse effects of NPWT in burn therapy.

关键词： NPWT Negative Pressure Wound Therapy VAC Vacuum-Assisted Closure Partial Thickness Burns

Gene therapy for liver tumours

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中国实验血液学杂志 1997年第3期5卷 285-286页

作者： nagy A.Habib FRCS ChM Department of Surgery Hammersmith HospitalDu Canc RoadLondon W12 ONNUKDepartment of SurgeryHammersmith HospitalDu Canc RoadLondon W12 ONNUKDepartment of SurgeryHammersmith HospitalDu Canc RoadLondon W12 ONNUK

Liver tumours are among the most commonmalignancies worldwide. The international incidenceof the disease is about l million cases per year (male:femalc, 4: 1 ). These include primary and secondarytumours. Cancer is known to be a genetic disease thatinvolves the alteration of activity of the products of atleast 2 genes, due to mutation (s) and/or otherfactors, e. g., the presence of viral oncoproteins. Thegenes most affected are the tumour suppressor

关键词： alteration tumour suppressor mutation transfection plasmid metastases morbidity spontaneously naked

遗传工程病毒与细菌在家禽疫病防制及诊断中的独特作用

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中国家禽 2002年第7期24卷 5-8页

作者： EVA nagy 耿拓宇江苏省家禽科学研究所扬州225003

遗传工程化细菌或病毒可以直接用作疫苗,也可生产亚单位疫苗和诊断试剂。通过遗传工程技术不仅在基础研究方面,而且在实践上可改进疫苗并能提供更为简便、快捷的诊断试剂,在保护家禽健康上具有无可比拟的优越性。

关键词：遗传工程病毒细菌家禽疫病防制诊断独特作用

Synthesis of Telechelic Polyisobutylenes and Polyethers and Their Characterization

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复旦学报（自然科学版） 2005年第5期44卷 805-807页

作者： Sándor Kéki Miklós nagy Gyoergy Deók László Orosz Miklós Zsuga Department of Applied Chemistry University of Debrecen H-4010 Debrecen Hungary

Telechelic polymers have attained great consideration as building blocks in the synthesis of block copolymers and networks. Telechelic polymers with various endgroups are also widely used materials for the preparation of polymeric prodrugs. Several methods have been reported to obtain functionalized polymers from the corresponding polyisobutylene (PIB) and polyether derivatives. In this presentation, we will demonstrate very versatile and powerful synthetic methods to obtain telechelic polymers.

关键词：聚异丁烯聚醚遥爪聚合物合成方法

A Proposed Approach for Measuring Maturity Level of Software Delivery

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Journal of Software Engineering and Applications 2024年第5期17卷 228-245页

作者： Osama Hassan Mansour Atef Raslan nagy Ramadan Faculty of Postgraduate Studies for Statistical Research Cairo University Cairo Egypt

Software delivery is vital for modern organizations, driving innovation and competitiveness. Measuring an organization’s maturity in software delivery is crucial for efficiency and quality. The Capability Maturity Model (CMM) framework provides a roadmap for improvement but assessing an organization’s CMM Level is challenging. This paper offers a quantitative approach tailored to the CMM framework, using Goal-Question-Metric (GQM) frame-works for each key process area (KPA). These frameworks include metrics and questions to compute maturity scores effectively. The study also refines practices into questions for a thorough assessment. The result is an Analysis Matrix that calculates weighted scores and an overall maturity score. This approach helps organizations assess and enhance their software delivery processes systematically, aiming for improved practices and growth.

关键词： CMM CMMI Software Delivery Maturity KPAs GQM Practices

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地震和大地电磁资料综合解释工作的进展

国外油气勘探 1993年第4期 504-516页

作者： Zoltan nagy 严又生

匈牙利石油天然气总公司寻找油气的工作正在其本土上展开。其中的大多数工作是在潘农盆地的几个次盆地中进行的。潘农盆地属于一种由较浅基岩断裂形成的小而深的盆地体系,常常被解释为中新世中期的弧后扩张盆地(Silverman 等,1991),详见... 详细信息

匈牙利石油天然气总公司寻找油气的工作正在其本土上展开。其中的大多数工作是在潘农盆地的几个次盆地中进行的。潘农盆地属于一种由较浅基岩断裂形成的小而深的盆地体系,常常被解释为中新世中期的弧后扩张盆地(Silverman 等,1991),详见图1。

关键词：大地电磁地震资料综合解释

新型包覆Pb纳米粒子液相色谱-串联质谱法用于鉴定沙特阿拉伯原油中的含氧化合物（英文）

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色谱 2018年第4期36卷 362-369页

作者： nagy E.MOUSTAFA Kout El-Kloub Fars MAHMOUD Egyptian Petroleum Research Institute Department of Chemistry Women's College for ArtsScience and EducationAin Shams University

Saudi Arabian crude oil is a super complex mixture and,up to now,there has been little research into its heteroatom-containing ***,oxygenated compounds(OCs)were isolated from Saudi Arabian oil using a Pd nanoparticle exchange complex,which formed between the nano-Pds and the oxygenated ***,polycyclic aromatic sulphur heterocycles(S-PAHs)are separated from petroleum oil via the same *** obtained results reveal that all the OC formulations with S-PAHs can be separated from the pre-isolated aromatic fraction of crude oil via this approach.S-PAHs are mixtures of benzothiophene and dibenzothiophene *** isolated OCs are composed mainly of hydroxyl *** liquid chromatography(LC)/electrospray ionization(ESI)in positive ion mode ESI(+)/tandem mass spectrometry(MS/MS)technique was used to assign the molecular weight distribution and identify the isolated *** LC/ESI(+)-MS/MS technique differentiates S-PAHs and OCs using protonated ***,LC/ESI(+)-MS/MS can be used to assign molecular weight distributions for both the groups as a single ***/MS in precursor ion mode was used for the immediate identification of the target S or O analytes.

关键词： liquid chromatography(LC) tandem mass spectrometry(MS/MS) Pd nanoparticles crude oil oxygenates

A Prospective, Randomized Trial to Evaluate the Efficacy of Virtual Reality Treatment Versus Traditional Balance Treatment in Patients with Stroke

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Journal of Sports Science 2016年第3期4卷 150-155页

作者： Zsanett Sipos Zsofia Hogye Zsuzsanna Vekerdy-nagy Department of Medical Rehabilitation and Physical Medicine Clinical Center University of Debrecen Debrecen 4032 NagyerdeiCircuit 98 Hungary Department of Pediatric Rehabilitation the Bethesda Children Hospital of the Hungarian Reformed Church Budapest 1146Bethesda Street 3 Hungary

Recovery from stroke needs different time and speed in every case depending on the brain capacity of neural plasticity. Based on neurophysiological researches high repetition of practice is required to induce neuroplastic changes and functional recovery of motor deficits. However, data from earlier studies shows that stroke patients generally perform a very limited number of movement repetitions in traditional therapy sessions. Virtual Reality therapy was found to be beneficial in improving trunk, hand, upper and lower extremity functions. However, reviews found no definitive conclusions regarding balance. The present study focuses on evaluating the efficacy of Nintendo WiiTM on balance and gait functions of stroke patients. Twenty one hemiparetic stroke patients were randomly assigned to either control or therapy groups. Effectiveness was evaluated by Fugl-Meyer balance subtest, Functional Ambulation Categories （FAC）, Romberg （R）, sharpened Romberg （SR）, one-legged stance （OLS）, six-meter walking test （6MWT） and timed up and go test （TUG）. The analysis revealed a significant effect of training with Nintendo Wii M for FAC z = 0.0267, FMBS z = 0.0046, OLST2 z = 0.0068 and OLS1 z = 0.0067 （affected side）. The control group demonstrated improvement in R （z = 0.0474） and SR （z = 0.0411）. In both groups improvement was detected in functional mobility and 6MWT （control group z = 0.0069, Wii groupz = 0.0123）. No significant differences were found between groups. Findings of the current study support that balance treatment with Nintendo WiiTM is similarly effective method to improve static balance and functional mobility when compared with conventional therapy.

关键词： Nintendo WiiTM stroke dynamic balance rehabilitation video game.