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Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastrotoxic chemicals and sucralfate: Possible new targets of pharmacologic agents

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World Journal of Gastroenterology 2007年第14期13卷 2053-2060页

作者： Lajos nagy Miki Nagata Sandor Szabo Departments of Pathology Brigham & Women's Hospital Harvard Medical SchoolBostonMassachusetts 02115and Pathology and Laboratory Medicine ServiceDiagnostic & Molecular Medicine HCGVA Medical Center9901 East 7th St. Long BeachCA 90822United States Depts. of 3rd Internal Medicine and Family MedicineFaculty of MedicineUniversity of PecsH-7632 PecsHungary Departments of Pathology Brigham & Women's Hospital Harvard Medical SchoolBostonMassachusetts 02115and Pathology and Laboratory Medicine ServiceDiagnostic & Molecular Medicine HCGVA Medical Center9901 East 7th St. Long BeachCA 90822United States

AIM： To investigate the role of major non-protein and protein sulfhydryls and disulfides in chemically induced gastric hemorrhagic mucosal lesions （HML） and the mechanism of gastroprotective effect of sucralfate.METHODS： Rats were given 1 mL of 75% ethanol, 25%NaCl, 0.6 mol/L HCI, 0.2 mol/L NaOH or 1% ammonia solutions intragastrically （i.g.） and sacrificed 1, 3, 6 or 12 min later. Total （reduced and oxidized） glutathione （GSH ＋ GSSG）, glutathione disulfide （GSSG）, protein free sulfhydryls （PSH）, protein-glutathione mixed disulfides （PSSG） and protein cystine disulfides （PSSP） were measured in gastric mucosa and liver.RESULTS： Reduced glutathione （GSH） was depleted in the gastric mucosa after ethanol, HCI or NaCl exposure,while oxidized glutathione （GSSG） concentrations increased, except by HCI and NaOH exposure. Decreased levels of PSH after exposure to ethanol were observed,NaCl or NaOH while the total protein disulfides were increased. Ratios of reduced to oxidized glutathione or sulfhydrils to disulfides were decreased by all *** changes in thiol homeostasis were detected in the liver after i.g. abbreviation should be spelled out the first time here administration of ethanol. Sucralfate increased the concentrations of GSH and PSH and prevented the ethanol-induced changes in gastric mucosal thiol concentrations.CONCLUSION： Our modified methods are now suitable for direct measurements of major protein and nonprotein thiols/disulfides in the gastric mucosa or liver.A common element in the pathogenesis of chemically induced HML and in the mechanism of gastroprotective drugs seems to be the decreased ratios of reduced and oxidized glutathione as well as protein sulfhydryls and disulfides.

关键词： Non-protein and protein thiol Gastricmucosal injury Gastroprotection Sucralfate

Examination of the Illness Representations among Children with T1DM in Relation to Mental Health Factors

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International Journal of Mental Health Promotion 2023年第8期25卷 961-969页

作者： Brigitta Munkácsi EnikőFelszeghy Flóra Kenyhercz Beáta Erika nagy Faculty of Medicine Department of Pediatrics Pediatric Psychology and Psychosomatic UnitKálmán Laki Doctoral SchoolUniversity of DebrecenDebrecen4032Hungary Department of Behavioural Sciences University of DebrecenDebrecen4032Hungary

The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral *** with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM,which may negatively affect glycemic control and adherence related to the *** aimed to investigate the association between mental health and type 1 diabetes including illness representation.115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen,***:PRISM-D,Child Depression Inventory(CDI),Cantril Ladder and Self-Rated Health,Glycosylaeted haemoglobin(HbA1C)were *** having depressive symptoms drew fewer circles with less *** not drawing any important relationships possessed more depressive *** diagnosed at a younger age displayed smaller distance between the Self-and *** PRISM-D test can be a promising tool to analyse emotional and cognitive representations and the psychological burden of T1DM.

关键词： T1DM illness representation mental health depression children and adolescents

Short-term microbial responses to soluble inorganic P input in a tropical lowland rain forest in Amazonia

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Pedosphere 2021年第6期31卷 964-972页

作者： Yuri W.L.DE SOUSA Erika BUSCARDO Carlos A.N.QUESADA Henrique E.M.NASCIMENTO Laszlo nagy National Research Institute for Amazonia Manaus 69067-375(Brazil) Department of Forestry University of BrasiliaBrasilia 70910-900(Brazil) Centre for Functional Ecology University of CoimbraCoimbra 3000-456(Portugal) Department of Animal Biology University of CampinasCampinas 13083-862(Brazil)

In non-flooded lowland rain forests with low soil phosphorus(P)in parts of Amazonia,P cycling largely occurs via leaf litter recycling by arbuscular mycorrhizal(AM)fungal *** high input of P into these ecosystems occurs during drought years with increased *** the length and frequency of drought events are projected to increase in the region,a single-dose nutrient addition experiment was carried out to test how this would impact P *** application rate of 4 kg P ha^(-1) was used,which corresponds to twice the amount of litter-derived P in an average *** was hypothesized that i)the added mineral P would be immobilized by soil microorganisms,leading to measurable increase in soil microbial biomass carbon(C)and P and ii)AM colonization rate would be reduced by the pulse in mineral P available for plant *** results did not support either of our *** addition of P did not have an effect on AM root colonization,nor was P immobilized by soil microbiota during the experimental *** lack of a difference between the control and treatment at our study site could be attributed to the relatively low one-off dose of P applied that did not change either the colonization rate of roots by AM fungi or the amount of soil available labile *** obtain a mechanistic understanding of the availability,capture,and use of P by plant-symbiont associations in tropical rain forest ecosystems,further integrated studies of the soil-plant system combining long-term nutrient manipulations,modeling,and experimental approaches are required.

关键词： Amazon basin arbuscular mycorrhizal fungi nutrient addition phosphorus cycling soil microbial biomass

Spatial cage solitons——taming light bullets

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Photonics Research 2022年第1期10卷 148-154页

作者： CHAO MEI IHAR BABUSHKIN TAMAS nagy GüNTER STEINMEYER Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy 12489 BerlinGermany School of Computer and Communication Engineering University of Science and Technology Beijing(USTB)Beijing 100083China Institute of Quantum Optics Leibniz University Hannover30167 HannoverGermany Institut für Physik Humboldt Universitat zu Berlin12489 BerlinGermany

Multimode nonlinear optics is used to overcome a long-standing limitation of fiber optics,tightly phase locking several spatial modes and enabling the coherent transport of a wave packet through a multimode fiber.A similar problem is encountered in the temporal compression of multimillijoule pulses to few-cycle duration in hollow gas-filled *** the fiber length to up to 6 m,hollow fibers have recently reached 1 TW of peak *** the remarkable utility of the hollow fiber compressor and its widespread application,however,no analytical model exists to enable insight into the scaling behavior of maximum compressibility and peak *** we extend a recently introduced formalism for describing mode locking to the analog scenario of locking spatial fiber modes *** formalism unveils the coexistence of two soliton branches for anomalous modal dispersion and indicates the formation of stable spatiotemporal light bullets that would be unstable in free space,similar to the temporal cage solitons in mode-locking *** model enables deeper understanding of the physical processes behind the formation of such light bullets and predicts the existence of multimode solitons in a much wider range of fiber types than previously considered possible.

关键词： locking solitons optics

Spectral Test Instrument for Color Vision Measurement

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Journal of Bionic Engineering 2005年第2期2卷 75-79页

作者： Balázs Vince nagy Gyrgy brahám Department of Mechatronics Optics and Instrumentation Budapest University of Technology and Economics Muegyetem rkp. 1-3 Budapest HUNGARY-1111Department of Mechatronics Optics and Instrumentation Budapest University of Technology and Economics Muegyetem rkp. 1-3 Budapest HUNGARY-1111

Common displays such as CRT or LCD screens have limited capabilities in displaying most color spectra correctly. The main disadvantage of these devices is that they work with three primaries and the colors displayed are the mixture of these three colours. Consequently these devices can be confusing in testing human color identification, because the spectral distribution of the colors displayed is the combined spectrum of the three primaries. We have developed a new instrument for spectrally correct color vision measurement. This instrument uses light emitting diodes (LEDs) and is capable of producing all spectra of perceivable colors, thus with appropriate test methods this instrument can be a reliable and useful tool in test~ing human color vision and in verifying color vision correction.

关键词： human color vision color vision measurement color spectrum LED instrument

Embedded Systems Design Using the TI MSP430 Series 1

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Wilkie’s syndrome as a cause of anxiety-depressive disorder:A case report and review of literature

丛书名： Embedded technology series

2003年

作者： Chris nagy

ISBN: (数字)9780080469881

ISBN: (纸本)9780750676236

Learn about designing, programming, and developing with the popular new Texas Instruments family of microcontrollers, the MSP430 series with this new book from Chris nagy. This product line is experiencing explosive growth due to its low-power consumption and powerful features, but very little design and application information is available other than what is offered by the manufacturer. The book fills a gap in the technical literature for embedded systems engineers by offering a more complete combination of technical data, example code, and descriptive prose than is available from the manufacturer reference information, and is useful to both professionals and hobbyists. Intended for embedded engineers who are new to the embedded field, or for the thousands of engineers who have experience with other microcontrollers (such as PICs, 8051s, or Motorola HC0x devices) but are new to the MSP430 line, Chris nagy offers a thorough and practical description of the device features, gives development guidelines, and provides design examples. Code examples are used in virtually every chapter and online. The book is divided into three sections: the first section provides detailed descriptions of the devices themselves; the second describes hardware/firmware development for the devices; the third is designed to incorporate information from the first two, and provide guidelines and examples of designs.

关键词： Embedded computer systemsDesign and constructionData processing.Texas Instruments MSP430 series microprocessors.

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World Journal of Clinical Cases 2022年第5期10卷 1654-1666页

作者： Raluca Cristina Apostu Lucian Chira Doina Colcear Andrei Lebovici Georgiana nagy Radu Razvan Scurtu Radu Drasovean Department of Surgery “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400001Romania Department of Psychiatry Clinical Infectious Disease HospitalCluj-Napoca 400000Romania Department of Radiology “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400006Romania Department of Internal Medicine "Iuliu Hatieganu"University of Medicine and Pharmacy Cluj-Napoca400006Romania

BACKGROUND Superior mesenteric artery syndrome is a disease with a complex diagnosis,and it is associated with complications that make it even harder to ***,a frequent association with psychiatric disorders has been *** numerous case reports and case series,the variability of the disease has not allowed the development of protocols regarding diagnosis and *** SUMMARY A 33-year-old woman presented with abdominal pain,nausea,and bile vomiting over the last 15 mo,associated with a 15-kg weight loss over the last three *** the onset of the symptoms,the patient was diagnosed with anxietydepressive disorder and treated *** examinations excluded an organic cause,and the cause of the symptoms was considered *** persistence of symptoms,even under treatment,prompted a computer tomography angiography examination of the abdomen and *** examination identified emergence at a sharp angle of 13.7°of the superior mesenteric artery,with a reduced distance between the artery and the anterior wall of the aorta up to a maximum of 8 mm.A diagnosis of aortomesenteric clamp was *** treatment by laparoscopic duodenojejunostomy was *** evolution was marked by a patent anastomosis at 1 mo,with a 10-kg weight gain and improvement of the associated *** This case report underlines two major *** aspect refers to the predisposition of patients with superior mesenteric artery syndrome to develop psychiatric disorders,with an excellent outcome when proper treatment is *** second aspect underlines the key role of a multidisciplinary approach and follow-up.

关键词： Wilkie’s syndrome Weight loss Anxiety-depressive disorder Duodenojejunostomy Laparoscopy Case report

Towards the optimization of management of hepatocellular carcinoma

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Frontiers of Medicine 2011年第3期5卷 271-276页

作者： Xi Feng Madhava Pai Malkhaz Mizandari Tinatin Chikovani Duncan Spalding Long Jiao nagy Habib Division of Surgery Department of Surgery and CancerImperial College LondonLondon W120NNUK Tbilisi 1st Hospital University Clinic High Technology Medical CenterTbilisi 0144Georgia

Hepatocellular carcinoma(HCC)is the fifth most common neoplasm in the world,closely correlated with viral hepatitis and liver *** vast majority of HCC patients present at a late stage and are unsuitable for surgery due to limited liver functional *** can involve major vessels or hilar structures,necessitating major liver resection and/or rendering liver resection unfeasible.A series of new technologies have been developed to optimise HCC *** cell therapy improves impaired liver functional reserve prior to liver *** radiofrequency ablation recanalises the portal vein invaded by tumour thrombus and endobiliary radiofrequency ablation restores and extends biliary patency of the bile duct invaded by *** radiofrequency assisted liver resection minimizes blood loss and avoids liver warm ischemia,while increasing parenchymal *** benefits combined maximize the safety of liver resection.

关键词： management hepatocellular carcinoma(HCC) radiofrequency(RF)ablation laparoscopic liver resection stem cell intravascular RF ablation endobiliary RF ablation

Prevalence and correlates of aggressive behavior in psychiatric inpatient populations

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World Journal of Psychiatry 2022年第1期12卷 1-23页

作者： Hunor Girasek Vanda Adél nagy Szabolcs Fekete Gabor S Ungvari Gábor Gazdag Department of Psychiatry and Psychiatric Rehabilitation Jahn Ferenc South Pest HospitalBudapest 1204Hungary Department of Psychiatry National Institute of Forensic PsychiatryBudapest 1108Hungary School of PhD Studies Semmelweis UniversityBudapest 1085Hungary Division of Psychiatry School of MedicineUniversity of Western AustraliaCrawley 6009Australia Section of Psychiatry University of Notre DameFremantle 6160Australia Department of Psychiatry and Psychotherapy Faculty of MedicineSemmelweis UniversityBudapest 1083Hungary

Aggressive behavior in patients with psychiatric disorders is attracting increasing research *** reason for this is that psychiatric patients are generally considered more likely to be aggressive,which raises a related question of whether diagnoses of psychiatric disorders predict the prevalence of aggressive *** aggression in psychiatric wards is crucial,because aggressive behavior not only endangers the safety of both patients and staff,but it also extends the hospitalization *** of aggressive behavior also need careful attention to ensure effective treatment *** literature review explores the relationship between aggressive behavior and psychiatric disorders and syndromes(dementia,psychoactive substance use,acute psychotic disorder,schizophrenia,bipolar affective disorder,major depressive disorder,obsessivecompulsive disorder,personality disorders and intellectual disability).The prevalence of aggressive behavior and its underlying risk factors,such as sex,age,comorbid psychiatric disorders,socioeconomic status,and history of aggressive behavior are discussed as these are the components that mostly contribute to the increased risk of aggressive *** tools commonly used to predict and detect aggressive behavior and to differentiate between different forms of aggressive behavior in both research and clinical practice are also *** aggression prevention programs can be developed based on the current findings of the correlates of aggressive behavior in psychiatric patients.

关键词： Aggression Mental disorders Inpatients Prevalence Risk factors Risk assessment