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The Clinical Value of the Self-Administered Kamath and Stothard’s Questionnaire in the Diagnostics of Carpal Tunnel Syndrome

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Open Journal of Therapy and rehabilitation 2021年第2期9卷 70-82页

作者： Ferenc Toth Elizabeth Kiss Csaba Marafko Jozsef Nemes zsolt Hegedus Barlborough Hospital Practice Plus Group Chesterfield UK Emersons Green Hospital Practice Plus Group Bristol UK

The clinician-administered Kamath and Stothard’s questionnaire is a recommended tool for assessing Carpal Tunnel Syndrome (CTS). The authors investigated whether the self-administered Kamath and Stothard’s questionnaire (KSQ) can categorize the severity of CTS according to the Nerve Conduction Study (NCS) and predict the outcome of Carpal Tunnel Release (CTR). One hundred and forty-two consecutive patients were enrolled in this prospective study, who completed the KSQ and were referred for NCS. Symptom relief after CTR was considered as the reference standard. KSQ’s scores were compared with the severity of CTS confirmed by NCS and the effectiveness of the surgery, Sensitivity and Positive Predictive Value (PPV) of the KSQ was calculated. The sensitivity of KSQ in each NCS severity category (mild, moderate, and severe CTS) was low (11.9% - 50.0%), however, the sensitivity and PPV of KSQ in the moderate + severe CTS category was 88.9% and 95.5%. The KSQ score of 5 or greater was found to be correlated with a successful CTR (sensitivity 92.8%, PPV of 90.2%). The study revealed that the KSQ with a score of 5 or greater is able to distinguish the mild conditions from moderate and severe ones. The KSQ’s score of 5 or greater also can predict the successful outcome of CTR. The authors believe that in addition to reducing the duration and cost of diagnostics, the KSQ can also reduce patient appointments and clinic time. Application of the KSQ may be of paramount importance in the current Covid pandemic era.

关键词： Carpal Tunnel Syndrome Nerve Conduction Study Self-Administered Questionnaire

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方竹笋膳食纤维作为益生元对乳酸菌生长的影响

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食品与发酵工业 2022年第6期48卷 174-180页

作者：赵泓舟杜木英 ZALAN zsolt HEGYI Ferenc 吴良如张同芳郑炯西南大学食品科学学院重庆400715 匈牙利农业与生命科学大学食品科学与技术研究所布达佩斯1011-1239 国家林业和草原局竹子研究开发中心浙江杭州310012

为了探究竹笋膳食纤维(bamboo shoot dietary fiber,BSDF)作为益生元对乳酸菌生长的影响,以常见益生元菊粉为对照,检测了BSDF在模拟胃肠液中的抗消化性,以及对乳酸菌L1(Lactobacillus fermentum)、L2(Lactobacillus plantaum)生长过程... 详细信息

为了探究竹笋膳食纤维(bamboo shoot dietary fiber,BSDF)作为益生元对乳酸菌生长的影响,以常见益生元菊粉为对照,检测了BSDF在模拟胃肠液中的抗消化性,以及对乳酸菌L1(Lactobacillus fermentum)、L2(Lactobacillus plantaum)生长过程中pH值、总酸含量和生长曲线的影响。结果表明,BSDF中总膳食纤维、不溶性膳食纤维、可溶性膳食纤维含量分别为64.90%、58.12%、6.78%,相对含量较高的单糖有葡萄糖(39.72%)、阿拉伯糖(12.77%)、木糖(12.69%)。BSDF在胃肠液中具有一定的抗消化性,模拟消化6 h后,BSDF在人工胃液(pH=3.5)和人工肠液(pH=7)的水解率分别为15.54%、31.08%,均低于菊粉对照组。对于乳酸菌L1,随着BSDF添加量的增加,培养基中的菌群浓度不断增加,BSDF相比于菊粉更有利于乳酸菌L1生长。对于乳酸菌L2,随着BSDF添加量的增加,总酸含量逐渐增大,乳酸菌的益生效应也随之增强。该研究可为BSDF作为益生元的开发利用提供理论参考。

关键词：竹笋膳食纤维乳酸菌抗消化实验益生效应生长曲线

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A 150 mV-1.2 V Fully-Integrated DC-DC Converter for Thermal Energy Harvesting

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Journal of Energy and Power Engineering 2013年第4期7卷 711-715页

作者： Giovanni Bassi Luigi Colalongo Anna richelli zsolt Kovacs-Vajna Department of lnformation Engineering University of Brescia Brescia 25123 Italy

With the increasing use of low voltage portable devices and wireless systems, energy harvesting has become an attractive approach to overcome the problems associated with battery life and power source. Among the different types of microenergy scavengers, the TEG （thermoelectric generators） are one of the most commonly used one. Unfortunately, due to the very small amount of voltage delivered by the TEG, an efficient DC/DC （direct current/direct current） conversion and power management techniques are needed. In this paper, a CMOS （complementary metal oxide semiconductor） fully-integrated DC/DC convener for energy harvesting applications is presented. The startup-voltage of the converter is about 140 mV, the output voltage exceeds 1.5 V, with a 20% power efficiency at least. The architecture for boosting such extremely low voltages is based on an ultra-low-voltage oscillator cross connected to two phase charge pump. The overall circuit does not require any external components and can be fully integrated in a standard CMOS low voltage technology. A test-chip has been designed in UMC （united microelectronics corporation） 180 nm CMOS process.

关键词： Energy harvesting DC/DC converter charge pump CMOS integrated circuits.

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干辣椒复水模型构建及复水后特性和发酵品质研究

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食品与发酵工业 2024年第15期50卷 222-230页

作者：郭美玲姚红黄璐晗武运武亚婷 zsolt Zalan 阚建全杜木英西南大学食品科学学院重庆400715 西南大学中匈食品科学合作研究中心重庆400715 川渝共建特色食品重庆市重点实验室重庆400715 新疆农业大学食品科学与药学学院新疆乌鲁木齐830052 新疆农业科学院农业质量标准与检测技术研究所新疆乌鲁木齐830091 匈牙利农业与生命科学大学食品研究所布达佩斯1022

为探究干辣椒复水后的加工适应性,选取西南地区常见的5个辣椒品种进行复水试验,采用主成分分析筛选综合得分最高的品种并以其为原料制备辣椒酱。结果表明,Peleg模型适用于料液比1:50(g:mL),恒温45℃干辣椒复水过程,复水90 min时5种辣椒... 详细信息

为探究干辣椒复水后的加工适应性,选取西南地区常见的5个辣椒品种进行复水试验,采用主成分分析筛选综合得分最高的品种并以其为原料制备辣椒酱。结果表明,Peleg模型适用于料液比1:50(g:mL),恒温45℃干辣椒复水过程,复水90 min时5种辣椒质构特性较好,微观结构最接近新鲜辣椒,其中二荆条为最适宜复水再加工辣椒品种。以鲜二荆条发酵辣椒酱(A)为对照,对比研究复水二荆条发酵辣椒酱(B)和复水二荆条加蔗糖发酵辣椒酱(C),辣椒酱A的总酸、还原糖和氨基酸含量显著高于辣椒酱B和C(P<0.05),但辣椒酱C的必需氨基酸含量占比(38.43%)最接近理想蛋白模式;辣椒酱B的辣度最高,添加蔗糖后辣椒酱C的辣度显著改善;辣椒酱C和A的感官评分最为接近。试验表明复水二荆条添加蔗糖发酵可提升复水辣椒酱的营养价值,感官品质也更接近鲜二荆条发酵辣椒酱。该研究结果可为复水辣椒的高值化应用提供理论参考。

关键词：干辣椒复水 Peleg模型二荆条辣椒酱

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Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes

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Nano research 2016年第6期9卷 1639-1662页

作者： Mans Broekgaarden ruud Weijer Massis Krekorian Bas van den IJssel Milan Kos Lindy K. Alles Albert C. van Wijk1 zsolt Bikadi Eszter Hazai Thomas M. van Gulik Michal Heger Department of Experimental Surgery Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the Netherlands Virtua Drug Ltd. Csalogany 4C H-1015 Budapest Hungary

Photodynamic therapy （PDT） is a tumor treatment modality in which a tumor- localized photosensitizer is excited with light, which results in local production of reactive oxygen species, destruction of tumor vasculature, tumor hypoxia, tumor cell death, and induction of an anti-tumor immune response. However, pre-existing tumor hypoxia may desensitize tumors to PDT by activating the hypoxia-inducible factor 1 （HIF-1） survival pathway. Therefore, we hypothesized that inhibition of HIF-1 with acriflavine （ACF） would exacerbate cell death in human epidermoid carcinoma （A431） cells. PDT of A431 tumor cells was per- formed using newly developed and optimized PEGylated cationic liposomes containing the photosensitizer zinc phthalocyanine （ZnPC）. Molecular docking revealed that ACF binds to the dimerization domain of HIF-la, and confocal microscopy confirmed translocation of ACF from the cytosol to the nucleus under hypoxia. HIF-1 was stabilized in hypoxic, but not normoxic, A431 cells following PDT. Inhibition of HIF-1 with ACF increased the extent of PDT-induced cell death under hypoxic conditions and reduced the expression of the HIF-1 target genes VEGF, PTGS2, and EDN1. Moreover, co-encapsulation of ACF in the aqueous core of ZnPC-containing liposomes yielded an adjuvant effect on PDT efficacy that was comparable to non-encapsulated ACF. In conclusion, HIF-1 contributes to A431 tumor cell survival following PDT with liposomal ZnPC. Inhibition of HIF-1 with free or liposomal ACF improves PDT efficacy.

关键词： cancer therapy confocal microscopy drug delivery system glucose metabolism hypoxia

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relationship between diabetes mellitus and cataract in Hungary

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 788-793页

作者： Anita Pék Dorottya Szabó Gábor LászlóSándor Gábor Tóth András Papp Zoltán zsolt Nagy Hans Limburg János Németh Department of Ophthalmology Semmelweis UniversityMária u.39.Budapest 1085Hungary Department of Ophthalmology Petz Aladár HospitalVasvári Pál u.2-4.Győr 9023Hungary Health Information Services Nijenburg 32LC1613 Grootebroekthe Netherlands

AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in *** effects of DM on the cataract surgical results were also in the focus of ***:Statistical data analysis of the results of the rapid Assessment of Avoidable Blindness with Diabetic retinopathy(rAAB+Dr)module conducted in Hungary in *** cross-sectional,population-based,national survey included 3523 people aged 50 years and *** of the survey were examined *** acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were ***:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with *** the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(Or=15.2%,Proved to be the most independent influencing risk factor(Or=49.9%,Presence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual ***:DM appears to be one of the main risk factors for developing *** risk factors,such as age,sex and environment also play an influencing *** does not seem to affect the occurrence of cataract surgical complications.

关键词： cataract diabetes mellitus rapid Assessment of Avoidable Blindness

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Characteristic Features of Lapis Lazuli from Different Provenances, revised by μXrF, ESEM, PGAA and PIXE

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Journal of Geological resource and Engineering 2019年第2期7卷 57-69页

作者： renate Noler Ines Feldmann zsolt Kasztovszky Zoltan Szokefalvi-Nagy Imre Kovacs BAM Federal Institute for Materials research and Testing 4.5 Analysis of Artefacts and Cultural Assets Unter den Eichen 44-46 12203 Berlin Germany BAM Federal Institute for Materials research and Testing 4.2 Materials and Air Pollutants Richard-Willst鋞ter Str.11 12489 Berlin Germany Centre for Energy research Hungarian Academy of Sciences H-1121 Konkoly-Thege Str. 29-33 Budapest Hungary Wigner research Centre for Physics Hungarian Academy of Sciences H-1121 Konkoly-Thege Str. 29-33 Budapest Hungary

The objective of this study is to find out, to what extent the geochemical characteristics of lapis lazuli can be utilized in respect to its provenance. A wide range of variables is taken into consideration depending on the quantity of samples analysed from a specific geological region and the methods applied. In order to provide evidence, a multi-technique analytical approach using μXrF, ESEM, PGAA and PIXE is applied to samples from the most famous deposits of lapis lazuli. Special elements determined as fingerprints are compared in relation to the forming conditions obvious in textural features. The results and statistical output allow a differentiation that enables an optimized local classification of the blue stone. An absolute requirement for all geo-tracing performed on blue colored cultural objects of unknown provenance is awareness of the limits of analysis. The possible sources of lapis lazuli are tested by analysing the blue pigment used as paint on murals and ink on manuscripts from the Silk road.

关键词： Lapis lazuli micro-XrF ESEM PGAA PIXE pigment analyses provenance studies

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Effect of herpesvirus infection on pancreatic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter Hegyi Balázs rdg Zoltán rakonczai Jr Tamás Takács János Lonovics Annamária Szabolcs réka Sári András Tóth Julius G Papp András Varró Mária K Kovács Mike A Gray Barry E Argent zsolt Boldogki First Department of Medicine Department of Biology Division of Cardiovascular Pharmacology School of Cell and Molecular Biosciences

AIM： To examine the effect of acute infection caused by herpesvirus （pseudorabies virus, PrV） on pancreatic ductal secretion. METHODS： The virulent Ba-DupGreen （BDG） and non- virulent Ka-rrEp01acgfp （KEG） genetically modified strains of PrV were used in this study and both of them contain the gene for green fluorescent protein （GFP）. Small intra/ interlobular ducts were infected with BDG virus （10^7 PFU/mL for 6 h） or with KEG virus （10^10 PFU/mL for 6 h）, while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 h. The rate of HCO3 secretion [base efflux -λ（B）] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification （1） after sudden blockage of basolateral base loaders with dihydro-4,4,- diisothiocyanatostilbene-2,2,-disulfonic acid （500 μmol/L） and amiloride （200 μmol/L）, and （2） after alkali loading the ducts by exposure to NH4Cl. All the experiments were performed in HCO3-buffered ringer solution at 37 ℃ （n = 5 ducts for each experimental condition）. Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning microscope.rESULTS： The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral anUgens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -λB-） 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -λB-）. After alkali loading the ducts, -λB-） was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected group. CONCLUSION： Incubation with the BDG or KEG strains of PrV results in an effective i

关键词： Pancreas Hypersecretion Ductal cells Infection Pseudorabies virus

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Uncorrected refractive errors are important causes of avoidable visual impairment in Hungary: re-evaluation of two existing national data sets

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 955-961页

作者： János Németh TennóDaiki Gábor LászlóSándor Hajnalka Keve Dorottya Szabó Gábor Tóth Gergely Dankovics István Barna Hans Limburg Zoltán zsolt Nagy Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary Department of Media and Education Informatics Eötvös Loránd UniversityBudapest 1117Hungary Department of Ophthalmology Petz Aladár HospitalGyör 9024Hungary Comprehensive Health Test Program of Hungary Szentendre 2000Hungary Department of Internal Medicine and Oncology Semmelweis UniversityBudapest 1083Hungary Health Information Services Grootebroek 1613The Netherlands

·AIM: To review existing data for the prevalence of corrected, uncorrected, and inadequately corrected refractive errors and spectacle wear in Hungary.·METHODS: Data from two nationwide cross-sectional studies were analysed. The rapid Assessment of Avoidable Blindness study collected population-based representative national data on the prevalence of visual impairment due to uncorrected refractive errors and spectacle coverage in 3523 people aged ≥50y(Group I). The Comprehensive Health Test Program of Hungary provided data on the use of spectacles in 80 290 people aged ≥18y(Group Ⅱ).·rESULTS: In Group I, almost half of the survey population showed refractive errors for distant vision, about 10% of which were uncorrected(3.2% of all male participants and 5.0% of females). The distance spectacle coverage was 90.7%(91.9% in males;90.2% in females). The proportion of inadequate distance spectacles was found to be 33.1%. Uncorrected presbyopia was found in 15.7% of participants. In all age groups(Group Ⅱ), 65.4% of females and 56.0% of males used distance spectacles,and approximately 28.9% of these spectacles were found to be inappropriate for dioptric power(with 0.5 dioptres or more). The prevalence of inaccurate distance spectacles was significantly higher in older age groups(71y and above) in both sexes.·CONCLUSION: According to this population-based data, uncorrected refractive errors are not rare in Hungary. Despite recent national initiatives, fur ther steps are required to reduce uncorrected refractive errors and associated negative effects on vision, such as avoidable visual impairment.

关键词： refractive errors uncorrected refractive errors spectacle wear inaccurate spectacles visual impairment

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同核异能素百年回顾

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物理 2021年第5期50卷 338-339页

作者：王一平孟杰(摘译) Philip Walker zsolt Podolyák 北京大学不详

同核异能素指原子核的长寿命激发态,通常发生γ跃迁、β衰变、裂变、α衰变、质子发射等衰变。原子核激发态的半衰期常不到1 ps。寿命多长才能被称为同核异能素并无统一界定。一般认为,为了能够计数,同核异能素的半衰期应该长于1 ns。... 详细信息

同核异能素指原子核的长寿命激发态,通常发生γ跃迁、β衰变、裂变、α衰变、质子发射等衰变。原子核激发态的半衰期常不到1 ps。寿命多长才能被称为同核异能素并无统一界定。一般认为,为了能够计数,同核异能素的半衰期应该长于1 ns。同核异能素通常可以通过重核裂变、重离子反应、超强激光等方法产生。自同核异能素被发现以来的一个世纪,核物理学家已经发现了近2500种半衰期大于10 ns的原子核激发态。

关键词：重离子反应重核裂变半衰期 α衰变 β衰变 γ跃迁激发态原子核

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