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二氧化钛气凝胶基质中金纳米粒子的光催化活性和结构(英文)

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催化学报 2013年第4期34卷 734-740页

作者： zsolt PAP Andreea rADU Izabella Jolan HIDI Georgian MELINTE Lucian DIAMANDESCU Traian POPESCU Lucian BAIA Virginia DANCIU Monica BAIA Faculty of Chemistry and Chemical Engineering Babes‐Bolyai University 11 Arany Janos str. 400028 Cluj-Napoca Romanla Faculty of Physics Babes‐Bolyai University 1 MihaiL Kogalniceanu str. 400084 Cluj-Napoca Romania National Institute of Materials Physics P.O.Box MG-777125 Bucharest-Magurele Romania Institute for Interdisciplinary research in Bio‐Nano‐Sciences Babes‐Bolyai University 42 Treboniu Laurian str 400271 Cluj-Napoca Romania

TiO2 -Au aerogels containing different amounts of gold nanoparticles of different sizes (5 and 16 nm) were successfully synthesized using a sol-gel procedure, and were tested for salicylic acid photodegradation under UV irradiation. The structure and morphology of the obtained materials were investigated using X-ray diffraction, transmission electron microscopy, and N2 adsorption-desorption measurements. UV-Vis spectroscopy was used to study the optical properties. The effects of the gold nanoparticles on the TiO2 crystallization process were twofold, as follows: (i) the number of crystallized zones was strongly related to the concentration of the gold nanoparticles, and (ii) the smaller gold particles increased the time taken for the crystallization of the samples. It was found that the noble metal-doped samples exhibited higher degradation rates compared with bare titania. It was found that the most active photocatalyst in each studied system was the sample with the highest concentration of gold nanoparticles. Additionally, the highest degradation rate value was obtained with the smallest Au nanoparticles (46.4 10-3 μmol/(L·s).

关键词： Nanomaterial Sol‐gel Titania Salicylic acid Photocatalytic performance

Interleukins and interleukin receptors in rheumatoid arthritis: research, diagnostics and clinical implications

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World Journal of Orthopedics 2014年第4期5卷 516-536页

作者： Lili Magyari Dalma Varszegi Erzsebet Kovesdi Patricia Sarlos Bernadett Farago Andras Javorhazy Katalin Sumegi zsolt Banfai Bela Melegh Department of Medical Genetics University of Pecs 7624 Pecs Hungary Szentagothai research Centre 7624 Pecs Hungary Department of Dermatology Venereology and Oncodermatology University of Pecs 7624 Pecs Hungary 1st Department of Internal Medicine University of Pecs 7623 Pecs Hungary Institute of Human Physiology and Clinical Experimental research Semmelweis University 1446 Budapest Hungary Department of Urology University of Pecs 7621 Pecs Hungary

rheumatoid arthritis(rA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologictargets for rA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for rA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics.

关键词： rheumatoid arthritis Interleukins Polymorphisms Immunologic targets Therapy

Introduction to special topic on exercise and oxidative stress

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Journal of Sport and Health Science 2020年第5期9卷 385-385页

作者： zsolt radak Scott K.Powers research Center of Molecular Exercise Science University of Physical EducationBudapest 1123Hungary Faculty of Sport Sciences Waseda UniversityTokorozawaSaitama 359-1192Japan Institute of Physical Education and Sport Science JGYPKUniversity of SzegedSzeged 6726Hungary Department of Applied Physiology and Kinesiology University of FloridaGainesvilleFL32608USA

The discovery that endurance exercise is associated with oxidative stress was first reported in *** the ensuing 4 decades,many studies confirmed this original *** investigations provided mechanistic insight into the sites of reactive oxygen species(rOS)production during exercise and the cellular consequences of an increase in rOS *** this special topic of the Journal of Sport and Health Science,we feature 4 state-of-the-art reviews on key topics linking exercise and oxidative stress.

关键词： linking consequences fir

Macroscale fluorescence imaging against autofluorescence under ambient light

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Light(Science & Applications) 2018年第1期7卷 151-162页

作者： ruikang Zhang raja Chouket Marie-Aude Plamont zsolt Kelemen Agathe Espagne Alison G.Tebo Arnaud Gautier Lionel Gissot Jean-Denis Faure Ludovic Jullien Vincent Croquette Thomas Le Saux PASTEUr Département de ChimieÉcole Normale SupérieurePSL UniversitySorbonne UniversitéCNRS75005 ParisFrance Institut Jean-Pierre Bourgin INRAAgroParisTechCNRSSaclay Plant Science(SPS)UniversitéParis-SaclayVersaillesFrance Laboratoire de Physique Statistique École Normale SupérieurePSL Research UniversityUniversitéParis Diderot Sorbonne Paris-CitéSorbonne UniversitéCNRS75005 ParisFrance Institut de biologie de l’École normale supérieure(IBENS) École Normale SupérieureCNRSINSERMPSL Research University75005 ParisFrance

Macroscale fluorescence imaging is increasingly used to observe biological ***,it may suffer from spectral interferences that originate from ambient light or autofluorescence of the sample or its *** this manuscript,we built a simple and inexpensive fluorescence macroscope,which has been used to evaluate the performance of Speed OPIOM(Out of Phase Imaging after Optical Modulation),which is a reference-free dynamic contrast protocol,to selectively image reversibly photoswitchable fluorophores as labels against detrimental autofluorescence and ambient *** tuning the intensity and radial frequency of the modulated illumination to the Speed OPIOM resonance and adopting a phase-sensitive detection scheme that ensures noise rejection,we enhanced the sensitivity and the signal-to-noise ratio for fluorescence detection in blot assays by factors of 50 and 10,respectively,over direct fluorescence observation under constant ***,we overcame the strong autofluorescence of growth media that are currently used in microbiology and realized multiplexed fluorescence observation of colonies of spectrally similar fluorescent bacteria with a unique configuration of excitation and emission ***,we easily discriminated fluorescent labels from the autofluorescent and reflective background in labeled leaves,even under the interference of incident light at intensities that are comparable to *** proposed approach is expected to find multiple applications,from biological assays to outdoor observations,in fluorescence macroimaging.

关键词： ambient illumination light

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运动与毒物兴奋效应

中国老年学杂志 2011年第11期31卷 2134-2136页

作者：赵丽熊开宇王正珍 zsolt radak 北京体育大学运动生理学教研室北京100084 不详

毒物兴奋效应（Hormesis）是当今毒理学界争论的热点问题,又称为＂低剂量有毒物质的刺激作用＂.目前认为毒物兴奋效应是指化学物在低于不可见的有害作用水平（NOXEL）以下的剂量具有兴奋或刺激的作用,与高剂量的作用相反,一般有益于受... 详细信息

毒物兴奋效应（Hormesis）是当今毒理学界争论的热点问题,又称为＂低剂量有毒物质的刺激作用＂.目前认为毒物兴奋效应是指化学物在低于不可见的有害作用水平（NOXEL）以下的剂量具有兴奋或刺激的作用,与高剂量的作用相反,一般有益于受试的生物体.其曲线特征指机体在应答诸如化学试剂、毒素或放射性等损伤时所表现出的一种钟形曲线的反应.

关键词：运动毒物兴奋效应

Toll-like receptor 4 and NOD2/CArD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations

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World Journal of Gastroenterology 2005年第10期11卷 1489-1495页

作者： Peter Laszlo Lakatos Laszlo Lakatos Ferenc Szalay Claudia Willheim-Polli Christoph (O|¨)sterreicher zsolt Tulassay Tamas molnar Walter reinisch Janos Papp Gyula Mozsik Hungarian IBD Study Group Peter Ferenci 1st Department of Medicine Laszlo Lakatos Department of Internal Medicine 4 2nd Department of Medicine Semmelweis University 2nd Department of MedicineSemmelweis UniversityBudapest:Laszlo PronaiAnnamaria NemethPal Miheller Erzsebet Hospital 1st Department of MedicineBudapest: Agota KovacsLaszlo Bene Szent Janos Hospital 1st Department of Medicine:Gyorgy Szekely University of Pecs 1st Department of MedicinePecs:Beata Gasztonyi University of Szeged 1st Department of MedicineSzeged:Ferenc NagyJanos Lonovics Semmelweis Hospital 1st Department of MedicineMiskolc:Laszlo Ujszaszy University of Debrecen 2nd Department of MedicineDebrecen:Istvan AltorjaiKaroly Palatka Kenezi Gy. County Hospital 2nd Department of MedicineDebrecen: Gyula G. Kiss County Hospital 2nd Department of MedicineZalaegerszeg Ferenc Tarnok Markusovszky Hospital2nd Department of MedicineSzombathely:Zoltan Dobronte Csolnoky F. County Hospital 1st Department of MedicineVeszprem:Zsuzsanna ErdelyiTunde PandurGabor Mester

AIM: To determine common NOD2/CArD15 mutations and TLr4 D299G polymorphism in Hungarian patients with CD. METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CArD15 mutations by denaturing high-performance liquid chromatography (confirmed by direct sequencing). TLr4 D299G was tested by PCr-rFLP. rESULTS: NOD2/CArD15 mutations were found in 185 patients (35.1%) and in 33 controls (16.5%,Pr702W (10.8% vs 6%, P= 0.02), SNP13/3020insC (19.4% vs 5%, Pr703C (2.1% vs 0%, P= 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908r was not increased. The frequency of TLr4 D299G was not different (CD: 9.9% vs controls: 12.0%). Variant NOD2/CArD15 allele was associated with an increased risk for CD (Orhet=1.71, 95%CI=1.12-2.6, P= 0.0001, Ortwo-risk alleles = 25.2, 95%CI =4.37- ,Prly disease onset (carrier: 26.4 years vs non-carrier: 29.8 years, P=0.0006), ileal disease (81.9% (?) 69.5%, Or = 1.99, 95%CI = 1.29-3.08, P= 0.02, presence of NOD2/CArD15 and TLr4: 86.7% vs 64.8%), stricturing behavior (Or = 1.69,95%CI = 1.13-2.55, P= 0.026) and increased need for resection (Or=1.71, 95%CI: 1.13-2.62, P= 0.01), but not with duration, extra-intestinal manifestations, familial disease or smoking. TLr4 exhibited a modifier effect: age of onset in wt/TLr4 D299G carriers: 27.4 years vs NOD2mut/TLr D299G: 23 years (P = 0.06), in NOD2mut/wt: 26.7 years. CONCLUSION: These results confirm that variant NOD2/ CArD15 (r702W, r703C and 3020insC) alleles are associated with earlier disease onset, ileal disease, stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLr4 D299G polymorphism was not different from controls, NOD2/TLr4 mutation carriers tended to present at earlier age.

关键词： Crohn's disease NOD2 CArD15 TLr4 Extraintestinal manifestation Phenotype

Microscopic colitis: A retrospective study of clinical presentation in 53 patients

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World Journal of Gastroenterology 2005年第9期11卷 1351-1355页

作者： zsolt Barta Gabriella Mekkel István Csíp(o|") László Tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher Third Department of Medicine Department of Pathology

AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and ***: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively ***: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation ***: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups.

关键词： Microscopic colitis Constipation Autoimmune

Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer

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World Journal of Gastroenterology 2006年第8期12卷 1192-1197页

作者： Miklós Tanyi Judith Olasz Géza Lukács Orsolya Csuka László Tóth Zoltán Szentirmay Zsuzsa ress zsolt Barta János L Tanyi László Damjanovich 1~(st)Department of Surgery University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Pathogenetics National Institute of OncologyBudapestHungary Department of Pathology University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Human and Experimental Tumor Pathology National Institute of OncologyBudapestHungary 3~(rd)Department of Medicine University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Obstetrics and Gynecology Baylor College of MedicineHoustonTXUnited States

AIM： To screen a suspected Hungarian HNPCC family to find specific mutations and to evaluate their effect on the presentation of the disease. METHODS： The family was identified by applying the Amsterdam and Bethesda Criteria. Immunohistochemistry was performed, and DNA samples isolated from tumor tissue were evaluated for microsatellite instability. The identification of possible mutations was carried out by sequencing the hMLH1 and hMSH2 genes. rESULTS： Two different mutations were observed in the index patient and in his family members. The first mutation was located in exon 7, codon 422 of hMSH2, and caused a change from Glu to STOP codon. No other report of such a mutation has been published, as far as we could find in the international databases. The second mutation was found in exon 3 codon 127 of the hMSH2 gene, resulting in Asp→Ser substitution. The second mutation was already published, as a non-pathogenic allelic variation. CONCLUSION： The pedigree analysis suggested that the newly detected nonsense mutation in exon 7 of the hMSH2 gene might be responsible for the development of colon cancers. In family members where the exon 7 mutation is not coupled with this missense mutation, colon cancer appears after the age of 40. The association of these two mutations seems to decrease the age of manifestation of the disease into the early thirties.

关键词： Hereditary nonpolyposis colon cancer Bethesda criteria Mutation hMLH1 hMSH2

revealing the topological phase diagram of ZrTe_(5) using the complex strain fields of microbubbles

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npj Computational Materials 2022年第1期8卷 1685-1691页

作者： Zoltán Tajkov Dániel Nagy Konrád Kandrai János Koltai LászlóOroszlány Péter Süle zsolt EHorváth Péter Vancsó Levente Tapasztó Péter Nemes-Incze Centre for Energy research Institute of Technical Physics and Materials Science1121BudapestHungary Department of Physics of Complex Systems ELTE Eötvös Loránd University1117BudapestHungary ELTE Eötvös Loránd University Department of Biological Physics1117BudapestHungary Budapest University of Technology and Economics 1111BudapestHungary

Topological materials host robust properties,unaffected by microscopic perturbations,owing to the global topological properties of the bulk electron *** in which the topological invariant can be changed by easily tuning external parameters are especially sought *** pentatelluride(ZrTe_(5))is one of a few experimentally available materials that reside close to the boundary of a topological phase transition,allowing the switching of its invariant by mechanical ***,we unambiguously identify a topological insulator–metal transition as a function of strain,by a combination of ab initio calculations and direct measurements of the local charge *** model quantitatively describes the response to complex strain patterns found in bubbles of few layer ZrTe_(5) without fitting parameters,reproducing the mechanical deformation-dependent closing of the band gap observed using scanning tunneling *** calculate the topological phase diagram of ZrTe_(5) and identify the phase at equilibrium,enabling the design of device architectures,which exploit the topological switching characteristics of the system.

关键词： density topological invariant