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Journal of Materials Science & Technology 2022年第8期103卷 197-208页

作者： zs.veres A.Roósz A.Rónaföldi A.Sycheva M.Svéda University of Miskolc Institute of Physical MetallurgyMetal Forming and Nanotechnology(UM)Hungary MTA-ME Materials Science Research Group ELKHHungary

During the last two decades,many algorithms were developed to simulate the solidification process for different casting methods like ingots,continuous casting of steel and the direct chill cast of *** performed under exactly known conditions and with the detailed knowledge of meso-and micro-structures are required for validating these *** aim of this paper is to give a data set to validate these *** solidification experiments were performed by using a rotating magnetic field(RMF)to study the effect of melt flow on the solidified micro-and meso-structure of the Al-7wt.%Si binary *** first and the third 1/3 parts of samples were solidified without magnetic stirring,and the second(middle)1/3 part was solidified by using magnetic *** magnetic induction was 10 m T,the temperature gradient was~7 K/mm,and the sample movement velocity was 0.1 mm/*** the longitudinal section of the sample,the columnar/equiaxed transition(CET),the equiaxed/columnar transition(ECT),the secondary dendrite arm spacing(SDAS),and the macrosegregation(concentration distribution and the amount of eutectic)were *** primary dendrite arm spacing(PDAS)and the grain structure were studied on the cross-section after color etching.

关键词： Al–7wt.%Si alloy Unidirectional solidification RMF magnetic stirring Meso-and microstructure

On the functions of astrocyte-mediated neuronal slow inward currents

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Neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： Balázs Pál Department of Physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,N-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current

Flood risk on arid alluvial fans:a case study in the Joghatay Mountains,Northeast Iran

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Journal of Mountain Science 2023年第5期20卷 1183-1200页

作者： Kaveh GHAHRAMAN Balázs NAGY Department of Physical Geography Eotvos Loránd UniversityPázmány Péter stny.1/CH-1117 BudapestHungary

Among the common hazards related to alluvial fans,flooding is one of the most ***,in populated alluvial fans,not only the natural processes are effective in floods,but the artificial structures and modifications can change the behavior of flooding and its potential *** study aims to indicate the flood-prone landforms in a set of populated alluvial fans in an arid region and investigate the role of anthropogenic activities in controlling/exacerbating flooding in alluvial *** achieve this goal,15 Ground Range Detected in High resolution(GRDH)SAR Sentinel-1 images,covering a total of 24 alluvial fans,were ***-processing and post-processing steps were applied to all images to identify flood-prone sections of the studied alluvial *** results showed that feeder channels,spreading sites,and wide interfluves are the most flood-prone landforms of alluvial *** terms of anthropogenic modifications to mitigate flooding,a rampart system is distributed in the study *** are levee like structures formed from the fan *** aim to mitigate flood hazard on residential areas,infrastructures,and agricultural lands of the study *** show that the rampart system can reduce the danger of floods,but it cannot be considered a long-term ***,a comprehensive flood protection system distributed throughout the whole alluvial fan system is *** also reveal that in regions where flood monitoring is challenging,SAR images can be used as a freely available data set to monitor and identify flooding hotspots.

关键词： Alluvial fan Flood Anthropogenic activities Rampart Sentineli SAR

Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors

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The Innovation 2024年第3期5卷 129-137页

作者： Balázs Gyorffy Department of Biophysics Medical SchoolUniversity of Pecs7624 PecsHungary Department of Bioinformatics Semmelweis University1094 BudapestHungary Cancer Biomarker Research Group Institute of Molecular Life SciencesHUN-REN Research Centre for Natural Sciences1117 BudapestHungary

Identifying genes with prognostic significance that can act as biomarkers in solid tumors can help stratify patients and uncover novel therapy ***,our goal was to expand our previous ranking analysis of survival-associated genes in various solid tumors to include colon cancer specimens with available transcriptomic and clinical data.A Gene Expression Omnibus search was performed to identify available datasets with clinical data and raw gene expression measurements.A combined database was set up and integrated into our Kaplan-Meier plotter,making it possible to identify genes with expression changes linked to altered *** a demonstration of the utility of the platform,the most powerful genes linked to overall survival in colon cancer were identified using uni-and multivariate Cox regression *** combined colon cancer database includes 2,137 tumor samples from 17 independent *** most significant genes associated with relapse-free survival with a false discovery rate below 1%in colon cancer carcinoma were RBPMS(hazard rate[HR]=2.52),TIMP1(HR=2.44),and COL4A2(HR=2.36).The three strongest genes associated with shorter survival in stage II colon cancer include CSF1R(HR=2.86),FLNA(HR=2.88),and TPBG(HR=2.65).In summary,a new integrated database for colon cancer is presented.A colon cancer analysis subsystem was integrated into our Kaplan-Meier plotter that can be used to mine the entire database(https://***).The portal has the potential to be employed for the identification and prioritization of promising biomarkers and therapeutic target candidates in multiple solid tumors including,among others,breast,lung,ovarian,gastric,pancreatic,and colon cancers.

关键词： colon tumors analysis

Artificial intelligence methods available for cancer research

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Frontiers of Medicine 2024年第5期18卷 778-797页

作者： Ankita Murmu Balázs Győrffy Institute of Molecular Life Sciences HUN-REN Research Centre for Natural SciencesBudapest 1117Hungary National Laboratory for Drug Research and Development Budapest 1117Hungary Department of Bioinformatics Semmelweis UniversityBudapest 1094Hungary Department of Biophysics University of PecsPecs 7624Hungary

Cancer is a heterogeneous and multifaceted disease with a significant global *** substantial technological advancements for battling cancer,early diagnosis and selection of effective treatment remains a *** the convenience of large-scale datasets including multiple levels of data,new bioinformatic tools are needed to transform this wealth of information into clinically useful decision-support *** this field,artificial intelligence(AI)technologies with their highly diverse applications are rapidly gaining *** learning methods,such as Bayesian networks,support vector machines,decision trees,random forests,gradient boosting,and K-nearest neighbors,including neural network models like deep learning,have proven valuable in predictive,prognostic,and diagnostic *** have recently employed large language models to tackle new dimensions of ***,leveraging the opportunity to utilize AI in clinical settings will require surpassing significant obstacles—a major issue is the lack of use of the available reporting guidelines obstructing the reproducibility of published *** this review,we discuss the applications of AI methods and explore their benefits and *** summarize the available guidelines for AI in healthcare and highlight the potential role and impact of AI models on future directions in cancer research.

关键词： machine learning artificial neural network deep learning natural language processing prediction guideline diagnosis

Research on Water-Taking Characteristics of Huanghua Power Plant Reach

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China Ocean Engineering 1998年第1期13卷 99-112页

作者： Tong, zs Ying, XY Qian, BF Nanjing Hydraul Res Inst Dept Hydraul Engn Nanjing 210029 Peoples R China

In this paper the water-taking characteristics of the first,the second and the third stage of theHuanghua Power Plant are studied by numerical model and physical *** results show that the pres-ent inlet channel only satisfies the supply need of the first stage of the power *** the riverbed of the in-let reach is properly dredged,the need of water supply for the third stage of the power plant could be met.

关键词： physical model numerical simulation cooling water tidal river

Large scale synthesis of oligoribonucleotides on PEG by the phosphite triester approach

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Chinese Journal of Chemistry 1995年第3期13卷 246-250页

作者： XU, zs YANG, ZW WANG, Y CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

Large scale synthesis of oligoribonucleotides has been successfully performed on PEG support by the phosphoramidite approach using t-butyldimethylsilyl to protect the 2'-hydroxyl group of ribonucleoside. By means of this procedure, the dodecamer r(AGUGGUCUUUGU) was synthesized in 98.1% average coupling yield, and 55 mg pure product was obtained from one gram of functionalized PEG.

关键词： OLIGORIBONUCLEOTIDES LARGE SCALE SYNTHESIS PHOSPHORAMIDITE APPROACH PEG SUPPORT

Sputtering Rates of Alloys in Glow Discharge

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Journal of Materials Science & Technology 1995年第4期11卷 295-298页

作者： REN, JS ZHANG, GS WANG, zs ZHAO, JW SHANGHAI UNIV SCI & TECHNOL SHANGHAI 200072PEOPLES R CHINA

The sputtering rates of alloys were investigated under constant Ar pressure and voltage supplied. The alloys studied in this work range from binary intermetallic alloys to ternary and quaternary alloys. It is revealed that the sputtering rates of alloy targets under steady states are q = 1/Sigma C-i/q(i)(0) where q is the sputtering rates of alloys, C-i the weight percentage of i-th component in the alloy, and q(i)(0) the sputtering rate of pure metal of i-th component.

关键词： Binary alloys

27-Ald-triterpenoid saponins from Adina rubella

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Chinese Journal of Chemistry 1997年第5期15卷 431-437页

作者： Fan, GJ He, zs Wu, HM Xu, JF Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China Chinese Acad Sci Shanghai Inst Organ Chem State Key Lab Bioorgan & Nat Prod Chem Shanghai 200032 Peoples R China

Four new triterpenoid saponins were isolated from the roots of Adina rubella Hance. They were characterized as adinaic acid 3 beta-O-[alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl(1-->2)-beta-D-glucurono-pyranoside-6-O-methyl ester]-28-O-beta-D-glucopyranoside, adinaic acid 3 beta-O-[alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl(1-->2)-beta-D-glucuronopyranoside-6-O-butyl ester]-28-O-beta-D-glucopyranoside, adinaic acid 3 beta-O-[beta-D-glucopyranosyl(1-->2)-beta-D-glucopyrnaosyl]-(28-->1)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl ester, 27-hydroxyursolic acid 3 beta-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl(1-->2)-beta-D-glucuronopyranoside-6-O-methyl ester]-28-O-beta-D-glycopyranoside. Their structures were elucidated by spectral methods, especially with the aid of 2D NMR techniques. Their complete assignments of the H-1 and C-13 NMR signals were carried out.

关键词： Adina rubella Hance Rubiaceae adinaic acid glycosides 27-ald-terpenoids

Prediction of the Resonance Characteristics of Combustion Chambers on the Basis of Large-Eddy Simulation

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Journal of Thermal Science 2005年第2期14卷 156-161页

作者： Franco MAGAGNATO Balázs PRITZ Horst BCHNER Martin GABI Department of Fluid Machinery University of Karlsruhe GermanyDepartment of Fluid Machinery University of KarlsruheGermanyEngler-Bunte-Institute/Division for Combustion Technology University of KarlsruheGermanyDepartment of Fluid Machinery University of KarlsruheGermany

In the last few years intensive experimental investigations were performed at the University of Karlsruhe to develop an analytical model for the Helmholtz resonator-type combustion system. In the present work the resonance characteristics of a Helmholtz resonator-type combustion chamber were investigated using large-eddy simulations (LES), to understand better the flow effects in the chamber and to localize the dissipation. In this paper the results of the LES are presented, which show good agreement with the experiments. The comparison of the LES study with the experiments sheds light on the significant role of the wall roughness in the exhaust gas pipe.

关键词： compressible large-eddy simulation combustion instabilities oscillating flow damping ratio.