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Viral Hepatitis B under Tenofovir in Ouagadougou (Burkina Faso)

Open Journal of Gastroenterology 2021年第8期11卷 141-150页

作者： Soudré Sandrine Marie-Odile Bobilwindé Napon Fahosiata zoungrana steve léonce Ouattara Zanga Damien Koura Mali Guingané Nanelin Alice Somda Sosthène Coulibaly Aboubacar Beni Da Nathalie Salou Rodrigue Bougouma Alain Sombié Arsène Roger Hepato-Gastroenterology Unit of the University Hospital Tengandogo Burkina Faso Africa Hepato-Gastroenterology Unit of the University Hospital Ouahigouya Burkina Faso Africa Gastroenterology Service of the University Hospital Souro Sanou Bobo-Dioulasso Burkina Faso Africa Gastroenterology Service of the University Hospital Bogodogo Ouagadougou Burkina Faso Africa Gastroenterology Service of the University Hospital Yalgado Ouédraogo Ouagadougou Burkina Faso Africa

Introduction: The treatment of viral hepatitis B is based on nucleotide analogs(s). In Burkina Faso, tenofovir is the most widely used because of its effectiveness and cost. The aim of this study was to describe viral hepatitis B under tenofovir in Ouagadougou. Material and Method: This was a longitudinal study, carried out in the outpatient department of the University Hospital of Tengandogo from May 1, 2013 to September 31, 2020, i.e. a period of seven (07) years and five (05) months. All patients with chronic hepatitis B virus who had been taking tenofovir for at least one year were included in the study. Cases of hepatocellular carcinoma and co-infections with hepatitis D, C and human immunodeficiency viruses were excluded from the study. Results: Of 321 patients with hepatitis B, 120 were on tenofovir and 34 were included in our study. These were 24 men and 10 women with an average age of 39 years. Hepatitis B was most often discovered following systematic or voluntary screening (44.1%) or pain in the right hypochondrium (23.5%). The mean initial viral load was 7.9 log. Ten patients had moderate compliance and four were non-compliant. No side effects were reported in 91.3% of cases. The virologic response was complete in 72.7% of patients after six months. Nine out of ten patients showed a biochemical response after 16 months. A histological response was observed in 19/27 patients within a mean of 26.7 months. HBs seroconversion was found in 2/24 patients. Conclusion: Tenofovir is effective in the treatment of viral hepatitis B, but HBs seroconversion is rarely achieved.

关键词： Viral Hepatitis B Tenofovir Compliance Tolerance Efficacy

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Nutritional and Clinical Rehabilitation of Severely Malnourished Children with <i>Moringa oleifera lam</i>. leaf Powder in Ouagadougou (Burkina Faso)

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Food and Nutrition Sciences 2013年第9期4卷 991-997页

作者： Urbain Zongo steve léonce zoungrana Aly Savadogo Alfred S. Traoré Department of Biochemistry-Microbiology University of Ouagadougou Ouagadougou Burkina Faso Department of Gastroenterology Clinique de L’amitié Ouagadougou Ouagadougou Burkina Faso.

Malnutrition in all its forms remains one of the most serious and neglected health problem. This longitudinal study referred pragmatic was carried out, which tested or aimed to assess the impact of Moringa leaf powder on the nutritional status of malnourished children. It was a pilot study in Ouagadougou severely malnourished children using Moringa as a nutritional supplement. We investigated the correlations and the impact of Moringa leaf powder on the nutritional status. A sample of 110 children aged 6 59 months were recruited and randomly selected and assigned to two treatments Group I and Group II. They received the CREN’s standard nutritional care diet but the Group I received more dose of 10 g of Moringa leaf powder per day. At the end, a significant improvement in the key parameters was recorded in both groups. However, the group receiving the Moringa supplement recorded a higher average weight gain (8.9 ± 4.3 g/kg/day, against 5.7 ± 2.72 g/kg/day in Group II) and a quicker recovery rate, with an average stay of 36 ± 16.54 days, against 57 ± 19.20 days amongst those not receiving the Moringa supplement. There is no significant improvement in hemoglobin rate in either group (p = 0.060 Group I, p = 0.063 Group II). Tolerability was considered to be good, as there were no recorded cases of medical admittance, no any occurrence of digestive disorders. The supplementation of Moringa leaf powder appears to be effective in improving the nutritional recovery of severely malnourished children.

关键词： Malnutrition Anthropometric Parameters Hemoglobin Side Effects Moringa leaves

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Overweight and Obesity: Epidemiological, Diagnostic and Therapeutic Aspects (Preliminary Study of 64 Cases Followed in Dietetic Consultation and Review of the literature)

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Food and Nutrition Sciences 2021年第11期12卷 1152-1163页

作者： steve léonce zoungrana Marius Somé Jean luc Kambiré Aly Savadogo Aboubacar Ouattara Alfred S. Traoré Center for Research in Biological Food and Nutritional Sciences University Joseph Ki Zerbo of Ouagadougou Ouagadougou Burkina Faso Departement of Surgery University of Ouahigouya Ouahigouya Burkina Faso

Obesity and excess weight are on the rise in developing countries, which is a source of legitimate concern on the part of the institutions responsible for the health of populations. Overweight and obesity are the fifth most common risk factor for death worldwide, killing at least 2.8 million people each year. In view of the importance of the subject and the lack of sufficient data in our context, it seemed appropriate to us to carry out this preliminary work in Burkina Faso on a population of subjects followed in consultation with Nutrition and Dietetics. The general objective of our work, of a descriptive cross-sectional type, was to describe the epidemiological, clinical, biological and therapeutic aspects of obesity in a population of consultants, black Africans over a period of one year. The study concerned three (03) private care establishments (clinics) in the city of Ouagadougou in which a Nutrition and Dietetics consultation was available. This was a descriptive cross-sectional study which concerned 64 patients followed in nutrition and dietetics consultations from January 2 to December 31, 2012. The material of the study is represented by the analysis of the files of 64 patients followed in consultation of Nutrition and Dietetics in three (03) medical clinics. The most affected age groups were 30 to 40 years (19 cases) and 40 to 50 years (18 cases);53 women (82.8%) and 11 men (17.2%), i.e. a sex ratio of 4.82. Among our patients, 12 people were overweight (18.75%), 23 had moderate type I obesity (35.94%), 15 severe type III (23.44%) and 14 had type III obesity massive (21.87%). Android-like obesity was predominant in 53 people (82.81%). Among our patients 16 (25%) presented with dyslipidemia, 49 (76.56%) had eating disorders. The most common cloudy snacking was observed in 33 people (67.35%). In terms of evolution and therapy, 31 people (48.44%) followed the diet at term;the others had either abandoned or discontinued treatment, namely t

关键词： Overweight Obesity Epidemiology Diagnosis Ouagadougou

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Sociodemographic Factors of Alcohol Consumption in a Population of Hospitalized Patients in Ouagadougou (Burkina Faso)

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Open Journal of Gastroenterology 2017年第3期7卷 96-104页

作者： Zanga Damien Ouattara Mali Koura Abdel Karim Serme Kounpilélimé Sosthène Somda Aboubacar Coulibaly steve léonce zoungrana Appolinaire Sawadogo Hepato-Gastroenterology Unit CHU Ouahigouya UFR/SDS CUP Ouahigouya Burkina Faso Hepato-Gastroenterology Unit CHU-SS Bobo Dioulasso Burkina Faso Hepato-Gastroenterology Unit CHU-YO Ouagadougou Burkina Faso

The prevalence of excessive alcohol consumption is high in our context. The fight against this scourge requires accurate identification of sociodemographic factors for a better communication strategy. Objective: To determine the sociodemographic factors associated with alcohol consumption in a population of hospitalized patients. Methods: A cross-sectional study was conducted during two months in 14 hospital departments of the University Hospital CHU-Yalgado Ouédraogo (CHUYO) in Ouagadougou, by interview and document review. All patients hospitalized for less than a year, aged 18 at least and consenting were included. Excessive alcohol consumption was defined as consumption ≥210 g/week in men and 140 g/week in women according to WHO, a score ≥8 in men and in women ≥7 by AUDIT Questionnaire, a score ≥2 according to the DETA questionnaire. Socio-demographic factors as age, sex, religion, educational level, marital status, occupation and salary status were filled for all patients. Results: A total of 391 patients were included. The average age was 44 ± 16.26 years and the sex ratio of 1.34. Among them, 135 (34.53%) were consumers of alcohol. The prevalence of excessive consumption ranged from 7.92% to 10.49%. A statistically significant relationship was found between alcohol consumption and sex (p 0.03), religion (p 0.01) and education level (p 0.01). On the contrary, no significant relationship was found between alcohol consumption, age, marital status and occupation. The salary status “employee” appears to promote the consumption of alcohol by some tools. Conclusion: The excessive consumption of alcohol is common in our population especially by educated men of non-Muslim religion. This hypothesis should be corroborated in a study within the general population to better set control strategies against this scourge.

关键词： Alcohol Sociodemographic Factors

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Treatment of HBeAg-Negative Chronic Hepatitis B Patients with Nucleos(t)ide Analogues in Burkina Faso

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Open Journal of Gastroenterology 2016年第12期6卷 387-396页

作者： Kounpiélimé Sosthène Somda Abdel Karim Sermé Aboubacar Coulibaly steve léonce zoungrana Inès Compaoré Serges Kouamou Damien Ouattara Roger Sombié Alain Bougouma Hepato-Gastroenterology Unit Teaching Hospital Yalgado Ouédraogo Ouagadougou Burkina Faso Gastroenterology Unit UFR/SDS CUP Ouahigouya Burkina Faso

The treatment of chronic hepatitis B (CHB) has increased significantly in recent years. In patients affected by HBeAg-negative CHB, it is necessary to distinguish the inactive carriers (low viral DNA 2000 IU/ml, normal AlT, histological lesions absent or minimal) who does not need treatment, and patients suffering from active CHB (DNA > 2000 IU/ml, high transaminases or fluctuating, significant fibrosis and/or necro-inflammatory activity > 1) who must be treated. The main purpose of treatment is to obtain a long-lasting viral suppression to improve the histological lesions and reduce the risk of evolution towards cirrhosis, liver failure and hepatocellular carcinoma (HCC). It about an indefinite treatment (unless HBsAg seroclearance) expensive and often inaccessible for the majority of our patients. Our study aimed to report the results of four years follow-up of HBeAg-negative patients treated by Nucleos(t)ide analogues (NAs) in Ouagadougou (Burkina Faso). It was a clinical observational study with 133 patients including 95 men;the average age was 41.2 years, completing the criteria of treatment. One hundred and twelve patients were treated by tenofovir (TDF), fourteen by lamivudine and seven co-infected HIV/HBV patients by Atripla® (combination TDF, Emtricitabine and Efavirenz). Virological and biochemical responses were respectively 100% and 94% after 4 years. The rate of HBsAg seroclearance was 1.5%. Twelve of fourteen patients (85.7%) had lamivudine resistance and no cases of resistance in the TDF and Atripla® groups. One co-infected patient developed HCC during treatment. Among patients treated by TDF, two cases of hypophosphatemia were noticed and no case of kidney failure. The treatment of CHB is certainly progressing;updated guidelines (EASl, AASlD) exist but should be adapted to the African context.

关键词： Chronic Hepatitis B HBeAg-Negative Nucleos(t)ide Analogues Tenofovir lamivudine Burkina Faso

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Patient Experience at Endoscopy Centers in Three West African Countries during the COVID-19 Pandemic

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Open Journal of Gastroenterology 2023年第4期13卷 161-169页

作者： Alice Nanelin Guingané Euloge Houndonougbo Jamila Abdouramane Soli léonce steve zoungrana Sandrine Soudré Aboubacar Coulibaly Sosthène Somda Roger Sombié Appolinaire Sawadogo Alain Bougouma Service d’hépato-Gastroentérologie CHU Bogodogo Ouagadougou Burkina Faso Service d’hépato-Gastroentérologie Hopital saint jean de Dieu Tanguiéta Bénin Service d’hépato-Gastroentérologie Hopital général de référence de Niamey Niamey Niger Service d’hépato-Gastroentérologie CHU Ouahigouya Ouagadougou Burkina Faso Service d’hépato-Gastroentérologie CHU Tengandogo Tengandogo Burkina Faso Service d’hépato-Gastroentérologie CHU Yalgado Ouédraogo Ouagadougou Burkina Faso Service d’hépato-Gastroentérologie CHU Sourou Sanou Bobo-Dioulasso Burkina Faso

Corona virus infection and the risk of contagiousness to medical personnel or patients during endoscopy necessitated further measures in the endoscopy rooms. The objective of this study was to assess the experience of patients in endoscopy rooms during the COVID-19 epidemic in West Africa. Patients and Methods: This was a multicenter cross-sectional study that took place over a period of 3 months (June to August 2020) in endoscopy centers in Burkina Faso, Benin and Niger. An online questionnaire was sent to patients who had performed upper digestive endoscopies, in 8 digestive endoscopy centers including private, public and religious structures. Depending on the choice of patients, questionnaires were either sent electronically or completed in the endoscopy room with the help of field investigators. The choice of centers was random from the list of centers and descriptive analyses were carried out. Results: A total of 294 patients responded to the online questionnaire. There were 37 lower and 257 upper gastrointestinal endoscopies. The female sex represented 52.1%. The wait times for obtaining an endoscopy appointment were considered satisfactory by 281 patients 95.6%. In the endoscopy departments, 112 patients, or 38.1%, were questioned about the risk factors for contamination of SARS-CoV-2. Among the risk factors found, 6 patients (2.0%) would have traveled abroad in the 2 weeks preceding the examination, 4 patients 1.4% had already been in contact with a subject at risk. The most frequent symptoms were chest pain (80 cases;27.2%), flu-like syndrome (29 cases;9.9%), cough (40 cases;13.6%), fever (46 cases;15.6%). In contrast, ageusia (7 cases;2.4%) and anosmia (5 cases;1.7%) were only found in very few patients. Twenty-two patients (7.5%) felt highly exposed to COVID-19 during the endoscopy examination and 144 patients (48.9%) rated the examination as satisfactory. Conclusion: Gastrointestinal symptoms initially described as rare are being reported with increasing

关键词： Endoscopy COVID-19 Patients Exposure Symptoms

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Fourier coefficients of restrictions of eigenfunctions

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Science China Mathematics 2023年第8期66卷 1849-1878页

作者： Emmett l.Wyman Yakun Xi steve Zelditch Department of Mathematics University of RochesterRochesterNY 14627USA School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China Department of Mathematics Northwestern UniversityEvanstonIL 60208USA

let{e_(j)}be an orthonormal basis of laplace eigenfunctions of a compact Riemannian manifold(M,g).let H■M be a submanifold and{ψ_(k)}be an orthonormal basis of laplace eigenfunctions of H with the induced *** obtain joint asymptotics for the Fourier coefficientsl^(2)(H)=∫He_(j),ψ_(k)dV_(H)of restrictionsγHe_(j)of e_(j)to *** particular,we obtain asymptotics for the sums of the norm-squares of the Fourier coefficients over the joint spectrum{(μ_(k),λ_(j))}^(∞)_(j,k-0)of the(square roots of the)laplacian△_(M)on M and the laplacian△_(H)on H in a family of suitably‘thick'regions in R^(2).Thick regions include(1)the truncated coneμ_(k)/λ_(j)∈[a,b]■(0,1)andλ_(j)≤λ,and(2)the slowly thickening strip|μ_(k)-cλ_(j)|≤w(λ)andλ_(j)≤λ,where w(λ)is monotonic and 1■w(λ)≤λ^(1/2).Key tools for obtaining the asymptotics include the composition calculus of Fourier integral operators and a new multidimensional Tauberian theorem.

关键词： eigenfunctions period integrals Kuznecov formula

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Autophagy in hepatitis C virus-host interactions:Potential roles and therapeutic targets for liver-associated diseases

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World Journal of Gastroenterology 2014年第19期20卷 5773-5793页

作者： Po-Yuan Ke steve S-l Chen Institute of Biomedical Sciences Academia Sinica Department of Biochemistry and Molecular Biology Graduate Institute of Biomedical Sciencesand Molecular Medicine Research CenterCollege of MedicineChang Gung University liver Research Center Chang-Gung Memorial Hospital PhD Program in Translational Medicine Kaohsiung Medical UniversityKaohsiung 80708 and Academia Sinica

Autophagy is a lysosome-associated,degradative process that catabolizes cytosolic components to recycle nutrients for further use and maintain cell *** C virus(HCV)is a major cause of chronic hepatitis,which often leads to end-stage liverassociated diseases and is a significant burden on worldwide public *** lines of evidence indicate that autophagy plays an important role in promoting the HCV life cycle in host ***,the diverse impacts of autophagy on a variety of signaling pathways in HCV-infected cells suggest that the autophagic process is required for balancing HCVhost cell interactions and involved in the pathogenesis of HCV-related liver ***,the detailed molecular mechanism underlying how HCV activates autophagy to benefit viral growth is still ***,how the autophagic response contributes to disease progression in HCV-infected cells remains largely ***,in this review,we overview the interplay between autophagy and the HCV life cycle and propose possible mechanisms by which autophagy may promote the pathogenesis of HCVassociated chronic liver ***,we outline the related studies on how autophagy interplays with HCV replication and discuss the possible implications of autophagy and viral replication in the progression of HCV-induced liver diseases,e.g.,steatosis and hepatocellular ***,we explore the potential therapeutics that target autophagy to cure HCV infection and its related liver diseases.

关键词： Autophagy Hepatitis C virus Steatosis Cirrhosis Hepatocellular carcinoma

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Digital neuromorphic technology: current and future prospects

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National Science Review 2024年第5期11卷 10-11页

作者： steve Furber Department of Computer Science The University of Manchester

Neuromorphic technology has diversified considerably from its origins in the seminal work by Carver Mead and his group at Caltech in the 1980s [1]. That early work focussed on the analogy between the equations describing the flow of ions in biological neurons and the equations describing the flow of carriers in field-effect transistors operating in the subthreshold region.

关键词： technology current future digital neuromorphic prospects

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light Perception:A Matter of Time

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Molecular Plant 2020年第3期13卷 363-385页

作者： Sabrina E.Sanchez Matias l.Rugnone steve A.Kay Department of Neurology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Optimizing the perception of external cues and regulating physiology accordingly help plants to cope with the constantly changing environmental conditions to which they are *** array of photoreceptors and intricate signaling pathways allow plants to convey the surrounding light information and synchronize an endogenous timekeeping system known as the circadian *** biological clock integrates multiple cues to modulate a myriad of downstream responses,timing them to occur at the best moment of the day and the ***,the mechanism underlying entrainment of the light-mediated clock is not *** review addresses known interactions between the light-signaling and circadian-clock networks,focusing on the role of light in clock entrainment and known molecular players in this process.

关键词： circadian clock light signaling Arabidopsis thaliana light entrainment photoreceptors signal integration

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