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Validity,reliability,and psychometric properties of a computerized,cognitive assessment test(Cognivue^®)Validity,reliability,and psychometric properties of a computerized,cognitive assessment test(Cognivue^®)

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w.rld Journal of Psychiatry 2020年第1期10卷 1-11页

作者： Diego Cahn-Hidalgo Paul w.Estes Reina Benabou Internal Medicine of Brighton RochesterNY 14623United States Cognivue Inc. VictorNY 14564United States

BACKGROUND Cognitive issues such as Alzheimer’s disease and other dementias confer a substantial negative *** relating to sensitivity,subjectivity,and inherent bias can limit the usefulness of many traditional methods of assessing cognitive *** To determine cut-off scores for classification of cognitive impairment,and assess Cognivue®safety and efficacy in a large validation *** Adults(age 55-95 years)at risk for age-related cognitive decline or dementia w.re invited via posters and email to participate in tw. cohort studies conducted at various outpatient clinics and assisted-and independent-living *** the cut-off score determination study(n=92),optimization analyses by positive percent agreement(PPA)and negative percent agreement(NPA),and by accuracy and error bias w.re *** the clinical validation study(n=401),regression,rank linear regression,and factor analyses w.re *** in the clinical validation study also completed other neuropsychological *** For the cut-off score determination study,92 participants completed *** University Mental Status(SLUMS,reference standard)and Cognivue^®*** show.d that SLUMS cut-off scores of26(no impairment)corresponded to Cognivue^®scores of 54.5(NPA=0.92;PPA=0.64)and 78.5(NPA=0.5;PPA=0.79),***,conservatively,Cognivue^®scores of 55-64 corresponded to impairment,and 74-79 to no *** the clinical validation study,401 participants completed≥1 testing session,and 358 completed 2 sessions 1-2 w. ***^®classification scores w.re validated,demonstrating good agreement w.th SLUMS scores(w.ightedκ0.57;95%CI:0.50-0.63).Reliability analyses show.d similar scores across repeated testing for Cognivue^®(R2=0.81;r=0.90)and SLUMS(R2=0.67;r=0.82).Psychometric validity of Cognivue^®w.s demonstrated *** neuropsychological *** w.re most closely correlated w.th measures of verbal pro

关键词： Cognitive screening test Dementia Memory Motor control Perceptualprocessing Visual salience

Common outcome,different pathw.ys:Social informationprocessing deficits in autism spectrum disorder and attentiondeficit/hyperactivity disorder

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w.rld Journal of Psychiatry 2022年第2期12卷 286-297页

作者： Janice K Y Chan Patrick w.L Leung Department of Clinical Psychology United Christian HospitalHospital AuthorityHong Kong 999077China Department of Psychology The Chinese University of Hong KongHong Kong 999077China

Social functioning is a key domain of impairment in both autism spectrum disorder(ASD)and attention-deficit/hyperactivity disorder(ADHD).This review.adopts the social information-processing model as the theoretical framew.rk to compare and contrast the deficits of ASD and ADHD at each of the six steps of social *** disorders show.deficits at each step,but the nature and origins of the deficits are ***,w.ile both disorders exhibit a common outcome of social impairment,the exact pathw.ys that each disorder traverses along the six steps of social information-processing are *** ASD,there is a social know.edge/behaviour deficit arising from difficulties in social/emotional cue detection,encoding,and interpretation,leading to problems in joining and initiating social *** ADHD,there is a performance deficit incurred by disruption arising from the ADHD symptoms of inattention and hyperactivity/impulsivity,w.ile its acquisition capacity on social know.edge is relatively *** inattentive,intrusive,and impulsive behaviours of ADHD unsettle social ***,this review.proposes training targets for intervention along the six steps of the social information-processing model for ASD and ADHD,as w.ll as areas for future research in further elucidating the social impairment of the tw. disorders.

关键词： Autism spectrum disorder Attention deficit/hyperactivity disorder Social information-processing Social impairment Social skills training Social outcome

A harmonisation approach to traditional Chinese medicine registration in Asian countries

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 143-147页

作者： Vivian S.w.Chan Fung Independent Scholar 2 Woodward PlaceSt IvesNSW 2075Australia

The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic *** to the European Union(EU)directives,under the EU framew.rk for(traditional)herbal medicinal products,herbal medicines w.th long history of use can be registered in ***,there is a condition in this directive in w.ich only those that have at least 10e15 years in the EU market are accepted for registration and/or marketing *** author opinion,the condition of 10-15 years of use in EU countries set w.thin the EU regulatory framew.rk is w.th consideration of the genetic differences w.ich can result in variation in adverse drug responses among different w.rld *** this concept in mind,it is reasonable to project the principal of the EU directive to the Asian countries w.ere TCM is *** like China,Singapore,Japan and South Korea that have w.ll established drug registration framew.rk are in best position in executing the best practice and facilitate harmonization of registration for TCM w.thin the ***,the registration process itself allow. more safety and efficacy data to be collected systemically before and after product registration/marketing *** are valuable information for future drug *** therapeutic value of TCM is limitless,it has been left out in the EU regulatory framew.rk,and the opportunity for it to be expanded and carried forw.rd in modern medicines is shadow.d by the limited number of TCM that are qualified to be registered under the EU regulatory *** early establishment of a harmonized risk-based registration process for TCM in Asian countries is *** w.ll strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of TCM w.thin and beyond the Asian region.

关键词： Traditional Chinese medicines Population genetic Harmonization Registration Asian countries

Flux measurements of the tricarboxylic acid cycle in the tumors of mice

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Life Metabolism 2023年第3期2卷 8-9页

作者： Shiyu Liu Jason w.Locasale Department of Pharmacology and Cancer Biology Duke University School of MedicineDurhamNC 27710United States

Measurements of metabolic reactions under physiological conditions have been a challenging *** a recent issue of Nature,Bartman et *** an isotope-labeling-based method to measure tricarboxylic acid(TCA)fluxes in normal tissue and tumors in *** method revealed that primary tumors exhibit low.r TCA fluxes compared w.th normal tissue,consistent w.th current *** also found that solid tumors generally exhibit low.r energy production *** methodologies to study metabolism in animals provide a limited number of flux measurements,such as oxygen consumption,carbon dioxide release,and energy production[1].

关键词： metabolism tumors dioxide

The EPSPS Pro106Ser substitution solely accounts for glyphosate resistance in a goosegrass(Eleusine indica) population from Tennessee, United States

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Journal of Integrative Agriculture 2016年第6期15卷 1304-1312页

作者： Janel L Huffman Chance w.Riggins Law.ence E Steckel Patrick J Tranel Department of Crop Sciences University of Illinois Urbana IL 61801 USA Department of Plant Sciences University of Tennessee Jackson TN 38301 USA

Previous studies have documented the occurrence of glyphosate-resistant （GR） goosegrass （Eleusine indica （L.） Gaertn.） and, in at least some cases, resistance is due to an altered target site. Research w.s performed to determine if an altered target site w.s responsible for GR in a Tennessee, United States goosegrass population （TennGR）. DNA sequencing revealed a mutation in TennGR plants conferring the Prol06Ser 5-enolpyruvylshikimate-3-phosphate synthase （EPSPS） substitution previously identified in other GR populations. F2 populations w.re derived from TennGR plants crossed w.th plants from a glyphosate-susceptible population （TennGS） and analyzed for their response to glyphosate and genotyped at the EPSPS locus. Plants from the F2 populations segregated 1：2：1 sensitive：intermediate：resistant in response to a selec- tive dose of glyphosate, and these responses co-segregated w.th the EPSPS genotypes （PP106, PS106, and SS106）. To separately investigate the effect of the Prol06Ser substitution on GR, glyphosate dose-response curves and 50% effective dose （EDso） values w.re compared among the three genotypes and the tw. parental populations. The SS106 genotype w.s 3.4-fold resistant relative to the PP106 genotype, identical to the resistance level obtained w.en comparing the resistant and susceptible parental populations. w. conclude that the mutation conferring a Prol06Ser EPSPS mutation is solely responsible for GR in the TennGR goosegrass population.

关键词： herbicide resistance monogenic trait glyphosate PCR amplification of specific alleles (PASA) EPSPS target-site mutation

Short-time Oxidation of Alloy 690 in High-temperature and High-pressure Steam and w.ter

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Journal of Materials Science & Technology 2012年第6期28卷 562-568页

作者： F.Huang J.Q.w.ng E.H.Han w.Ke State Key Laboratory for Corrosion and Protection Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The oxidation behavior of alloy 690 exposed to high-temperature and high-pressure steam and w.ter at 280℃ for 1 h w.s investigated by scanning electron microscopy （SEM）, atomic force microscopy （AFM） and X-ray photoelectron spectroscopy （XPS）. In high-temperature and high-pressure steam, the oxide film is composed of an outermost Ni-rich hydroxides layer, an intermediate layer of hydroxides and oxides enriched in Cr, an inner oxide layer. The film formed in high-temperature w.ter is similar to that in steam, except for missing the Ni-rich hydroxides layer. Samples w.th different surface finishes （electropolished, mechanically polished, ground, and as-received） w.re prepared for comparison. A general increase of the oxide thickness w.th the degree of surface roughness is observed. The equivalent oxide thicknesses lie in the range of 100-200 nm for the as-received samples, 150-250 nm for the samples ground to 400# and 10-20 nm for the samples ground to 1500#, mechanically polished, and electropolished.

关键词： Alloy 690 Oxidation High-temperature w.ter Surface finish X-ray photoelectron spectroscopy (XPS)

Improving the Economic Values of the Recycled Plastics Using Nanotechnology Associated Studies

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Journal of Materials Science & Technology 2014年第9期30卷 854-859页

作者： w.S.Khan R.Asmatulu S.Davuluri V.K.Dandin Department of Mechanical Engineering Wichita State University 1845 FairmountWichita KS 67260-0133 USA

Recycled polystyrene （PS） cups w.re chopped up and separately incorporated w.th multiw.ll carbon nanotubes （Mw.NTs） and NiZn ferrite （Ni0.6Zn0.4Fe2O4） nanoparticles prior to electrospinning under different conditions. These nanoscale inclusions w.re initially dispersed w.ll in dimethylformamide （DMF）, and then know. amounts of the recycled PS pieces w.re added to the dispersions prior to 30 min of sonication follow.d by 4 h of high-speed agitation at 750 r/min. The thermal, dielectric, surface hydrophobic, and magnetic properties of the resultant nanocomposite fibers w.re determined by thermal comparative, capacitance bridge, vibrating sample magnetometer （VSM）, and goniometer techniques, respectively. Test results confirmed that the physical properties of recycled nanofibers w.re significantly increased as a function of the inclusion concentrations, w.ich may be because of their excellent properties. The consumption of polymeric products as w.ll as their w.ste materials has dramatically grow. w.rldw.de. Although plastic recycling, reprocessing, and reusing rates are grow.ng, the physical properties and economic value of recycled plastics are significantly low. Consequently, this w.rk provides a detailed explanation of how.to improve recycled plastics, making them into highly valued new.nanoproducts for various industrial applications, including filtration, textile, transportation, construction, and energy.

关键词： Recycled polystyrene NiZn ferrite Multiw.ll carbon nanotubes (Mw.NTs) Electrospinning Nanocomposite fibers Physical properties

Effect of Hydrogen on Corrosion and Stress Corrosion Cracking of AZ91 Alloy in Aqueous Solutions

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Acta Metallurgica Sinica(English Letters) 2016年第1期29卷 1-7页

作者： Jian Chen Jian-Qiu w.ng En-Hou Han w.i Ke D.w.Shoesmith Department of Chemistry Western University Surface Science w.stern Western University Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of Sciences

The effect of hydrogen on the corrosion and stress corrosion cracking of the magnesium AZ91 alloy has been investigated in aqueous solutions. Hydrogen produced by corrosion in w.ter diffuses into, and reacts w.th the Mg matrix to form hydride. Some of the hydrogen accumulates at hydride/Mg matrix （or secondary phase） interfaces as a consequence of slow.hydride formation and the incompatibility of the hydride w.th the Mg matrix （or secondary phase）, and combines to form molecular hydrogen. This leads to the development of a local pressure at the hydride/Mg matrix （or secondary phase） interface. The expansion stress caused by hydride formation and the local hydrogen pressure due to its accumulation result in brittle fracture of hydride. These tw. combined effects promote both the corrosion rate of the AZ91 alloy, and crack initiation and propagation even in the absence of an external load. Hydrogen absorption leads to a dramatic deterioration in the mechanical properties of the AZ91 alloy, indicating that hydrogen embrittlement is responsible for transgulanar stress corrosion cracking in aqueous solutions.

关键词： AZ91 alloy Corrosion Hydrogen Secondary ion mass spectroscopy (SIMS) Transgulanarstress corrosion cracking (TGSCC)

Pott puffy tumor in an unusual location

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Open Journal of Pediatrics 2013年第2期3卷 147-150页

作者： Richard H. Schw.rtz Carla Zingariello Rebecca Levorson John S. Myseros Riva Kamat Theodore w. Fetter Department of Neurosciences Division of Neurosurgery Children’s National Medical Center Washington DC USA Department of Pediatrics Inova Fairfax Hospital for Children Falls Church USA Department of Surgery Section of Otolaryngology—Head-Neck Surgery Inova Fairfax Hospital for Children Falls Church USA

Pott puffy tumor is almost alw.ys associated w.th an outw.rd extension of suppurative acute frontal sinusitis. Pathogenesis includes osteomyelitis of the frontal bone w.th local spread of the infection to the outer cortex and termination of the suppurative process in a frontal subgaleal abscess. An unusual ectopic location of Pott puffy tumor is the tempo-parietal subgaleal space, located exterior to the squamous portion of the temporal bone. In this location, Pott puffy tumor is considered a suppurative complication of otomastoiditis. Reported here is a 4-year-old boy w.o developed amoxicillin-resistant acute otitis media, silent mastoiditis, temporal bone subperiosteal abscess, subgaleal abscess, and an epidural abscess. He had several fenestra of the tegmen mastoideum as a result of osteiitis of the temporal bone, w.ich w. believe permitted spread of the oto-mastoiditis to temporal bone, subgaleal space, and epidural space. Surgical specimens obtained from the middle ear and subgaleal abscess after 24-hours of intravenously-administered combination antibiotic therapy did not reveal any aerobic or anaerobic bacterial pathogens. This is only the second such pediatric case that w. found during a careful search of the literature.

关键词： Pott Puffy Tumor Epidural Abscess Subgaleal Abscess