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Procyanidin C1 Modulates the Microbiome to Increase FOXO1 Signaling and Valeric Acid Levels to Protect the Mucosal Barrier in Inflammatory Bowel Disease

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Engineering 2024年第11期42卷 108-120页

作者： Xifan Wang Pengjie Wang Yixuan Li Huiyuan Guo Ran Wang Siyuan Liu Ju Qiu Xiaoyu Wang Yanling Hao Yunyi Zhao Haiping Liao zhongju zou Josephine Thinwa Rong Liu Department of Obstetrics and Gynecology Columbia UniversityNew YorkNY 10032USA Food Laboratory of Zhongyuan Luohe 462000China Department of Internal Medicine Department of MicrobiologyUT Southwestern Medical CenterDallas 75390-9030USA

Inflammatory bowel disease(IBD)refers to a pair of prevalent conditions(Crohn’s disease and ulcerative colitis)distinguished by persistent inflammation of the large *** C1(PCC1)is a natu-rally occurring substance derived from grape seeds that has demonstrated notable anti-inflammatory *** study examines the potential utility of PCC1 as a treatment for IBD and subsequently examines the host-cell-and microbiome-related mechanisms underlying the detected therapeutic *** with a classic dextran sodium sulfate(DSS)-induced mouse IBD model,we show that PCC1 protects the mucosal barrier and thereby confers strong protective effects against ***1 pretreatment resulted in anti-inflammatory effects and protection against multiple pathological phenotypes in the IBD model mice,including reduced weight loss,lower disease activity index(DAI)totals,and enhanced colon size,as well as obviously beneficial effects on the mucosal barrier(e.g.,barrier thickness and activity of mucus-degrading enzymes).We also analyzed the autophagy marker microtubule-associated protein1 light chain 3(LC3)and found that the level of LC3 was significantly elevated in the intestinal epithelial cell samples of the PCC1-pretreatment group as compared with the non-model mice ***1 altered the fecal microbiome composition,which included elevating the abundance of Akkermansia muci-niphila and Christensenella *** microbiome transplant(FMT)experiments showed that deliver-ing a microbiome from PCC1-treated animals into PCC1-naïve animals conferred *** profiling revealed that both the PCC1-pretreatment and PCC1 FMT groups had elevated levels of the microbiota-derived metabolite valeric acid,and supplementation with this short-chain fatty acid(SCFA)also conferred strong protection against ***,inhibitor experiments confirmed that the beneficial effects of valeric acid on the mucus layer are mediated by FOXO1 signaling in the goble

关键词： Inflammatory bowel disease Mucosal Barrier Autophagy

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On Endomorphism Monoids of Finite Kleene Algebras

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Algebra Colloquium 2019年第3期26卷 507-518页

作者： Jie Fang zhongju Sun School of Mathematics and System Science Guangdong Polytechnic Normal University Guangzhou 510665China

An endomorphism monoid of an algebra *** said to be a band if every endomorphism on A is an idempotent,and it is said to be a demi-band if every noninject ive endomorphism on A is an *** precisely determine finite Kle... 详细信息

关键词： endomorphism monoid band Kleene algebra

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不同混交林配置模式对库布齐沙漠风沙土壤粒度特征的影响

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水土保持研究 2025年第1期32卷 101-109,120页

作者：李天扬蒙仲举陈晓燕李浩年徐志明内蒙古农业大学沙漠治理学院呼和浩特010018 内蒙古自治区社会科学院呼和浩特010010 鄂尔多斯市腾达勘察设计有限公司内蒙古鄂尔多斯017010

[目的]通过分析不同混交林模式对库布奇沙漠土壤粒度特征的影响,为沙地人工林高效,可持续经营提供科学依据。[方法]选择库布齐沙漠沿黄段具有代表性的4种混交林配置模式,取0-80 cm土层深度土样,采用激光粒度法进行土壤粒度的测定,并计... 详细信息

[目的]通过分析不同混交林模式对库布奇沙漠土壤粒度特征的影响,为沙地人工林高效,可持续经营提供科学依据。[方法]选择库布齐沙漠沿黄段具有代表性的4种混交林配置模式,取0-80 cm土层深度土样,采用激光粒度法进行土壤粒度的测定,并计算土壤平均粒径(Mz)、分选系数(δ)、偏度(SK)、峰度(KG)和分形维数特征等。[结果](1)研究区的优势粒径为细砂与中砂。4种不同植物配置模式对土壤粒径有明显细化作用,黏粒、粉粒、极细砂含量相较对照组CK分别增加了141.37%~415.38%,105.75%~724.73%,64.93%~1597.36%。(2)4种植被配置模式营建后,不同深度土层平均粒径均有明显上升,幅度为2.44%~20.33%。(3)比对不同配置模式下土壤的粒度参数后,发现分形维数的值与峰度值呈正相关,与平均粒径呈负相关。[结论]土壤粒径的细化程度与配置模式有关,不同植物配置模式对土壤粒径细化作用主要集中于表层,且细化效果随土层深度的增加而逐渐降低。不同深度土层平均粒径均有明显上升,土壤颗粒的分选等级降低,颗粒分布变得更加离散;土壤颗粒分布呈现逐渐趋于宽平;土壤颗粒向正偏发展;不同土层深度土壤颗粒分形维数均有显著增加(p<0.05)。

关键词：库布齐沙漠不同配置模式土壤粒径分形维数

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Impact of utility-scale solar photovoltaic array on the aeolian sediment transport in Hobq Desert, China

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Journal of Arid Land 2021年第3期13卷 274-289页

作者： TANG Guodong MENG zhongju GAO Yong DANG Xiaohong College of Desert Control Science and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China

Deserts are ideal places to develop ground-mounted large-scale solar photovoltaic (PV) powerstation. Unfortunately, solar energy production, operation, and maintenance are affected bygeomorphological changes caused by surface erosion that may occur after the construction of the solar PVpower station. In order to avoid damage to a solar PV power station in sandy areas, it is necessary toinvestigate the characteristics of wind-sand movement under the interference of solar PV array. The studywas undertaken by measuring sediment transport of different wind directions above shifting dunes andthree observation sites around the PV panels in the Hobq Desert, China. The results showed that the twoparameterexponential function provides better fit for the measured flux density profiles to the near-surfaceof solar PV array. However, the saltation height of sand particles changes with the intersection anglebetween the solar PV array and wind direction exceed 45°. The sediment transport rate above shifting duneswas always the greatest, while that around the test PV panels varied accordingly to the wind ***, the aeolian sediment transport on the solar PV array was significantly affected by wind *** value of sand inhibition rate ranged from 35.46% to 88.51% at different wind directions. When theintersection angle exceeds 45°, the mean value of sediment transport rate above the solar PV array reducesto 82.58% compared with the shifting dunes. The results of our study expand our understanding of theformation and evolution of aeolian geomorphology at the solar PV footprint. This will facilitate the designand control engineering plans for solar PV array in sandy areas that operate according to the wind regime.

关键词： aeolian sediment transport mass flux density profiles sand-fixation shelter efficacy solar photovoltaic array

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Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting

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Research 2022年第3期2022卷 117-131页

作者： Xin Wang zhongju Ye Shen Lin Lin Wei Lehui Xiao State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research Key Laboratory of Phytochemical R&D of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410082China

Self-propelled nanomotors have shown enormous potential in biomedical ***,we report on a nanozymepowered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under nearinfrared(NIR)laser *** nanomotor is constructed by the asymmetric decoration of platinum nanoparticles(PtNPs)at the bottom of gold nanocups(GNCs).PtNPs with robust peroxidase-(POD-)like activity are employed not only as propelling elements for nanomotors but also as continuous O_(2)generators to promote photodynamic therapy via catalyzing endogenous H_(2)O_(2)*** to the Janus structure,asymmetric propulsion force is generated to trigger the shortranged directional diffusion,facilitating broader diffusion areas and more efficient cellular searching and *** cascade strategy combines key capabilities,i.e.,endogenous substrate-based self-propulsion,active cellular targeting,and enhanced dual-modal therapy,in one multifunctional nanomotor,which is crucial in advancing self-propelled nanomotors towards eventual therapeutic agents.

关键词： endogenous shaped Active

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Rapid Unconscious Acquisition of Conditioned Fear with Low-Spatial-Frequency but Emotionally Neutral Stimuli

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Research 2024年第1期2023卷 753-762页

作者： Yujie Chen Si Chen zhongju Sun Xilei Zhang Xiangyong Yuan Liang Wang Yi Jiang State Key Laboratory of Brain and Cognitive Sciences CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Chinese Institute for Brain Research Beijing 102206China CAS Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing 100101China

It has long been proposed that emotionally“prepared”(i.e.,fear-related)stimuli are privileged in the unconscious acquisition of conditioned ***,as fear processing is suggested to highly depend on the coarse,low-spatial-frequency(LSF)components of the fear-related stimuli,it is plausible that LSF may play a unique role in the unconscious fear conditioning even with emotionally neutral ***,we provided empirical evidence that,following classical fear conditioning,an invisible,emotionally neutral conditioned stimulus(CS+)with LSF,but not with high spatial frequency(HSF),can rapidly elicit stronger skin conductance responses(SCRs)and larger pupil diameters than its CS−*** comparison,consciously perceived emotionally neutral CS+with LSF and HSF elicited comparable *** together,these results support that the unconscious fear conditioning does not necessarily entail emotionally prepared stimuli but prioritizes LSF information processing and highlight the crucial distinctions between the unconscious and the conscious fear *** findings not only coincide with the postulation that a rapid,spatial-frequency-dependent subcortical route is engaged in unconscious fear processing but also suggest the existence of multiple routes for conscious fear processing.

关键词： neutral necessarily diameters

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Curved carbon photo-oxygenation catalysts for the suppression and nanoscopic imaging ofβ-amyloid peptides fibrillation

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Nano Research 2022年第4期15卷 3387-3397页

作者： Yuanyuan Ma zhongju Ye Chen Zhang Yanjun Zhao Hai-bin Luo Lehui Xiao College of Chemistry Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin 300071China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China School of Pharmaceutical Science&Technology Tianjin UniversityTianjin 300072China

The progression of Alzheimer’s disease(AD)is characterized with the deposition and aggregation ofβ-amyloid(Aβ).Visualizing Aβaggregates at high spatial resolution is beneficial for AD diagnosis and ***,we designed a new molecule by conjugating corannulene(Cor)with rhodamine B isothiocyanate(Rhb),namely Cor-Rhb,for the nanoscopic imaging and modulating Aβpeptide *** low duty cycle,high photon output and sufficient switching cycles enable Cor-Rhb suitable for localization-based nanoscopic fluorescence *** find that Cor-Rhb can inhibit Aβpeptides fibrillization and interact directly with mature fibrils,triggering their disaggregation under light *** reduced Aβ-mediated cytotoxicity after the addition of Cor-Rhb is also *** explorations suggest that Cor-Rhb displays great potential as a multifunctional therapeutic agent against amyloid-related diseases,and may largely facilitate a variety of super-resolution based biological applications.

关键词： nanoscopic imaging β-amyloid reactive oxygen species fluorescence imaging fibrillation

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Damaged apple detection with a hybrid YOLOv3 algorithm

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Information Processing in Agriculture 2024年第2期11卷 163-171页

作者： Meng Zhang Huazhao Liang zhongju Wang Long Wang Chao Huang Xiong Luo Schoolof Computer and Communication Engineering University of Science and Technoogy BejingBejing 1083China lShunde Innovation SchoolUniversity of Science and Technology BeijingFoshan 528399China

This paper proposes an improved You Only Look Once(YOLOv3)algorithm for automatically detecting damaged apples to promote the automation of the fruit processing *** the proposed method,a clustering method based on Rao-1 algorithm is introduced to optimize anchor box *** clustering method uses the intersection over the union to form the objective function and the most representative anchor boxes are generated for normal and damaged apple *** verify the feasibility and effectiveness of the proposed method,real apple images collected from the Internet are *** with the generic YOLOv3 and Fast Region-based Convolutional Neural Network(Fast R-CNN)algorithms,the proposed method yields the highest mean average precision value for the test ***,it is practical to apply the proposed method for intelligent apple detection and classification tasks.

关键词： Rao algorithm Apple detection Clustering Smart agriculture

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Seeing around the corner:an analytic approach for predictive maintenance using sensor data

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Journal of Management Analytics 2015年第4期2卷 333-350页

作者： zhongju Zhang Pengzhu Zhang Department of Operations and Information Management University of Connecticut School of BusinessStorrsUSA Department of Management Information Systems Antai College of Economics and ManagementShanghai Jiaotong UniversityShanghai 200030China Department of Information Systems W.P.Carey School of BusinessArizona State UniversityTempe85287

Technological advancements such as the industrial Internet of Things now allow companies to continuously monitor the operating conditions of expensive equipment using *** the tremendous amount of sensor data flowing in continuously,equipment makers are seeking innovative analytical solutions to turn operational data to help guide their tactical and strategic *** sensor data on wind turbine operations and service records from a top Fortune 100 company in the energy industry,we showcase techniques to map out operational-level data for analysis,and develop several analytical models(a sequence analysis,a logistic regression and a survival model)to help predict and evaluate equipment failure *** analyses highlight the significant value propositions of sensor data in the big data *** implications as well as extensions of the proposed predictive models are discussed.

关键词： predictive maintenance data analytics survival analysis business intelligence

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Blinking CsPbBr_(3) perovskite nanocrystals for the nanoscopic imaging of electrospun nanofibers

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Nano Research 2021年第5期14卷 1397-1404页

作者： Tianyu Chen Mengna Huang zhongju Ye Jianhao Hua Shen Lin Lin Wei Lehui Xiao State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin300071China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research Ministry of EducationKey Laboratory of Phytochemical R&D of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha410081China

Blinking fluorophore perovskite nanocrystals (NCs) were employed to image the fine structure of the polystyrene (PS) electrospun fibers. The conditions of CsPbBr3 NCs embedded and dispersed into PS were investigated and optimized. The stochastic optical reconstruction microscopy is employed to visualize the fine structure of the resulted CsPbBr3@PS electrospun fibers at sub-diffraction limit. The determined resolution in the reconstructed nanoscopic image is around 25.5 nm, which is much narrower than that of conventional fluorescence image. The complex reticulation and multicompartment in bead sub-diffraction-limited structures of CsPbBr3@PS electrospun fibers were successfully mapped with the help of the stochastic blinking properties of CsPbBr3 NCs. This work demonstrated the potential applications of CsPbBr3 perovskite NCs in super-resolution fluorescence imaging to reconstruct the sub-diffraction-limited features of polymeric material.

关键词： CsPbBr_(3) perovskite nanocrystals polystyrene electrospun nanofiber super-resolution optical imaging

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