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Microstructure and Fracture Morphology in the Welding Zone of Cr18Mo2 Ferritic Stainless Steel

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Journal of Materials Science & Technology 1996年第6期12卷 452-456页

作者： Li, YJ zou, zd Thompson, M Dept. of Materials Engineering Shandong University of Technology Jinan 250061 China

Microstructure, precipitates and fracture morphology in the weld metal and he heat-affected zone (HAZ) of Cr18Mo2 ferritic stainless steel have been studied by means of metalloscope, SEM, TEM and X-ray diffractometer. Experimental results indicate that crystalline grain coarsening in HAZ is one of the reason resulting in the embrittlement fracture in the welding zone of the Ferritic stainless steel. Some precipitates (TiC, TiN and Cr2N) in the steel promote production and development of the brittle cracks. in practical applications, the welding heat input should be as small as possible to prevent embrittlement caused by HAZ grain coarsening.

关键词： Stainless steel

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Microstructure, Impact Toughness and TEM Analysis in the CGHAZ of HQ130 High Strength Steel

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Journal of Materials Science & Technology 1999年第6期15卷 555-558页

作者： zou, zd Li, YJ Yin, SK Shandong Univ Technol Jinan 250061 Peoples R China

Microstructure and impact toughness in the coarse grain heat-affected zone (CGHAZ) of HQ130 high strength steel were studied by using the weld thermo-simulation test. Fracture morphology and fine structure in the CGHAZ were analyzed by means of SEM, TEM and electron diffraction. Experimental results indicated that the impact toughness and hardness in the CGHAZ (T-m = 1350 degrees C) decreased with increasing cooling time (t(8/5)), and fracture morphology changed from dimple fracture into cleavage fracture. The reason for the toughness decrease is the formation of upper bainite. During application, the welding heat input should be strictly limited, to reduce brittleness in the CGHAZ of HQ130 steel.

关键词： Steel

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Does City Shape Affect China's Economic Development?

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China & World Economy 2024年第1期32卷 21-56页

作者： Wei zou Fei Yang Economics and Management School Wuhan UniversityChina

This paper constructs a general equilibrium spatial urban model and measures city geometric compactness using the patch-shape index based on evidence from satellite imagery and basic vector maps of China.It adopts the ordinary least squares and instrumental variable approaches to examine the effect of city shape on the urban development of 279 Chinese cities at or above the prefecture level.The empirical results show that there was a significant negative correlation between city shape and economic outcomes.Specifically,every 1 percentage point increase in the patch-shape index led to a decrease in city-scale GDP by 0.009 percent,housing prices by 0.044 percent,and wages by 0.024 percent.More compact urban layouts attracted an inflow of households and firms,stimulated city economic growth,and were associated with increased housing prices and wage rates.The paper considers the cities'initial conditions,trends in population changes(expanding,shrinking,and stagnant cities),and geographic factors,and finds that the results are robust.An array of policy implications can be drawn from the research.

关键词： city footprint compactness economic development urban spatial shape

A Bus Planning Algorithm for FPC Design in Complex Scenarios

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Chinese Journal of Electronics 2024年第2期33卷 346-352页

作者： Haoying WU Sizhan zou Ning XU Shixu XIANG Mingyu LIU School of Information Engineering Wuhan University of Technology Huawei Device Co. Ltd.

Flexible printed circuit(FPC) design in complex scenarios has a list of pin concentration areas, which lead to extremely congested intersection regions while connecting the pins. Currently, it is challenging to explore the routability and to find topologically non-crossing and routable paths manually for the nets timely. The existing bus planning methods cannot offer optimal solutions concerning the special resource distribution of the FPC design. To investigate an effective way to shorten the routing time of FPC and achieve enhanced performance, a bus planning algorithm is proposed to tackle complex area connection problems. On the basis of the pin location information, the routing space is partitioned and generally represented as an undirected graph, and the topological non-crossing relationship between different regions is obtained using the dynamic pin sequence. Considering the routability and electrical constraints, a heuristic algorithm is proposed to search the optimal location of the crossing point on the region boundary. Experimental results on industrial cases show that the proposed algorithm realize better performance in terms of count and routability in comparison with numerous selected state-of-the-art router and methods.

关键词： Flexible printed circuit Routability Non-crossing topology Heuristic algorithm

Recent Progress in All-Solution-Processed Organic Solar Cells

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Chinese Journal of Chemistry 2024年第2期42卷 190-198页

作者： Yixuan Xu Qian Wang Wentao zou Xu Zhang Yanna Sun Yuanyuan Kan Ping Cai Ke Gao School of Materials Science and Engineering&Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilinGuangxi 541004China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Science Center for Material Creation and Energy ConversionInstitute of Frontier and Interdisciplinary ScienceShandong UniversityQingdaoShandong 266237China

All-solution-processed organic solar cells(OSCs)(from the bottom electrode to the top electrode)are highly attractive thanks to their low cost,lightweight and high-throughput production.However,achieving highly efficient all-solution-processed OSCs remains a significant challenge.One of the key issues is the lack of high-quality solution-processed electrode systems that can replace indium tin oxide(ITO)and vacuum-deposited metal electrodes.In this paper,we comprehensively review recent advances in all-solution-processed osCs,and classified the devices as the top electrode materials,including silver nanowires(AgNWs),conducting polymers and composite conducting materials.The correlation between electrode materials,properties of electrodes,and device performance in all-solution-processed OSCs is elucidated.In addition,the critical roles of the active layer and interface layer are also discussed.Finally,the prospects and challenges of all-solution-processed OSCs are presented.

关键词： Organic solar cells All-solution-processed organic solar cells Solution-processed electrodes High performance Silver nanowires Conductive polymers Composite conducting materials

A novel polyionic liquid with lubricity and viscosity-increasing dual functionalities as the additive in aqueous lubrication system

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Friction 2024年第4期12卷 698-710页

作者： Bo YU Kun zou Rui WANG Qiang CHEN Rui DONG Xiao LIU Jiaying ZHANG Wenquan LV Qiangliang YU Meirong CAI Feng ZHOU College of Science Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264006China Institute of Polymer Materials Nanjing Forestry UniversityNanjing 210037China

The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids.The rheological behavior of aqueous lubricating fluids with PPM has been characterized to confirm PPM’s function as a viscosity modifier.The tribological behavior of aqueous lubricating fluids with PPM has been investigated on SRV-V and MTM testing machines.It was found that PPM has excellent viscosity-increasing,lubricating,and anti-wear properties as an additive for aqueous,which can be attributed to the ability of PPM to form the protective film and boundary tribofilm generated from complex tribochemical reaction on rubbing surface.The obtained PPM with dual functions of anti-corrosion additives and viscosity index improver can play an important role in diverse lubrication regimes.

关键词： polyionic liquid lubricant additives viscosity modifier lubrication regime

Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li Zhi Ye Xinqian Hu Xiaoyan He Jia Wang Gaofeng Chen Chengyu zou Daichao Xu Hongbing Zhang Junying Yuan Yunhong Zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no cure.Receptor-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of ALS.Primidone has been identified as an old drug that can also inhibit RIPK1 kinase.We conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1G93A mice and ALS patients.SOD1G93A mice treated with primidone showed significant delay of symptomatic onset and improved motor performance.One-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(P<0.0001).Serum RIPK1 levels were correlated positively with the severity of bulbar symptoms(P<0.05).Our study suggests that serum levels of RIPK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS patients.Repurposing primidone may provide a promising therapeutic strategy for ALS.The effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

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Signal Transduction and Targeted Therapy 2024年第1期9卷 105-149页

作者： Yumin Wang Jing Hu Shuang Wu Joshua S.Fleishman Yulin Li Yinshi Xu Wailong zou Jinhua Wang Yukuan Feng Jichao Chen Hongquan Wang Department of Respiratory and Critical Care Medicine Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300060PR China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430000PR China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Outpatient Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050PR China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060PR China

Ferroptosis,a unique modality of cell death with mechanistic and morphological differences from other cell death modes,plays a pivotal role in regulating tumorigenesis and offers a new opportunity for modulating anticancer drug resistance.Aberrant epigenetic modifications and posttranslational modifications(PTMs)promote anticancer drug resistance,cancer progression,and metastasis.Accumulating studies indicate that epigenetic modifications can transcriptionally and translationally determine cancer cell vulnerability to ferroptosis and that ferroptosis functions as a driver in nervous system diseases(NSDs),cardiovascular diseases(CVDs),liver diseases,lung diseases,and kidney diseases.In this review,we first summarize the core molecular mechanisms of ferroptosis.Then,the roles of epigenetic processes,including histone PTMs,DNA methylation,and noncoding RNA regulation and PTMs,such as phosphorylation,ubiquitination,SUMOylation,acetylation,methylation,and ADP-ribosylation,are concisely discussed.The roles of epigenetic modifications and PTMs in ferroptosis regulation in the genesis of diseases,including cancers,NSD,CVDs,liver diseases,lung diseases,and kidney diseases,as well as the application of epigenetic and PTM modulators in the therapy of these diseases,are then discussed in detail.Elucidating the mechanisms of ferroptosis regulation mediated by epigenetic modifications and PTMs in cancer and other diseases will facilitate the development of promising combination therapeutic regimens containing epigenetic or PTM-targeting agents and ferroptosis inducers that can be used to overcome chemotherapeutic resistance in cancer and could be used to prevent other diseases.In addition,these mechanisms highlight potential therapeutic approaches to overcome chemoresistance in cancer or halt the genesis of other diseases.

关键词： diseases epigenetic overcome

Computed tomography radiogenomics:A potential tool for prediction of molecular subtypes in gastric stromal tumor

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1296-1308页

作者： Xiao-Nan Yin Zi-Hao Wang Li zou Cai-Wei Yang Chao-Yong Shen Bai-Ke Liu Yuan Yin Xi-Jiao Liu Bo Zhang Gastric Cancer Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Paediatric Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND Preoperative knowledge of mutational status of gastrointestinal stromal tumors(GISTs)is essential to guide the individualized precision therapy.AIM To develop a combined model that integrates clinical and contrast-enhanced computed tomography(CE-CT)features to predict gastric GISTs with specific genetic mutations,namely KIT exon 11 mutations or KIT exon 11 codons 557-558 deletions.METHODS A total of 231 GIST patients with definitive genetic phenotypes were divided into a training dataset and a validation dataset in a 7:3 ratio.The models were constructed using selected clinical features,conventional CT features,and radiomics features extracted from abdominal CE-CT images.Three models were developed:ModelCT sign,modelCT sign+rad,and model CTsign+rad+clinic.The diagnostic performance of these models was evaluated using receiver operating characteristic(ROC)curve analysis and the Delong test.RESULTS The ROC analyses revealed that in the training cohort,the area under the curve(AUC)values for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic)for predicting KIT exon 11 mutation were 0.743,0.818,and 0.915,respectively.In the validation cohort,the AUC values for the same models were 0.670,0.781,and 0.811,respectively.For predicting KIT exon 11 codons 557-558 deletions,the AUC values in the training cohort were 0.667,0.842,and 0.720 for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic),respectively.In the validation cohort,the AUC values for the same models were 0.610,0.782,and 0.795,respectively.Based on the decision curve analysis,it was determined that the model_(CT sign+rad+clinic)had clinical significance and utility.CONCLUSION Our findings demonstrate that the combined modelCT_(sign+rad+clinic)effectively distinguishes GISTs with KIT exon 11 mutation and KIT exon 11 codons 557-558 deletions.This combined model has the potential to be valuable in assessing the genotype of GISTs.

关键词： Gastrointestinal stromal tumor Radiomics Gene mutation Computed tomography Model