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Hemorrhagic transformation in patients with large-artery atherosclerotic stroke is associated with the gut microbiota and lipopolysaccharide

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Neural Regeneration Research 2024年第7期19卷 1532-1540页

作者： Qin Huang Minping Wei Xianjing feng Yunfang Luo Yunhai Liu jian Xia Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Peking University People’s HospitalBeijingChina Clinical Research Center for Cerebrovascular Disease of Hunan Province Central South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Hemorrhagic transformation is a major complication of large-artery atheroscle rotic stroke(a major ischemic stro ke subtype)that wo rsens outcomes and increases *** of the gut microbiota is an important feature of stroke,and some specific bacteria and bacterial metabolites may contribute to hemorrhagic transformation *** aimed to investigate the relationship between the gut microbiota and hemorrhagic transformation in largearte ry atheroscle rotic stro *** observational retrospective study was *** May 2020 to September 2021,blood and fecal samples were obtained upon admission from 32 patients with first-ever acute ischemic stroke and not undergoing intravenous thrombolysis or endovascular thrombectomy,as well as 16 healthy *** with stro ke who developed hemorrhagic transfo rmation(n=15)were compared to those who did not develop hemorrhagic transformation(n=17)and with healthy *** gut microbiota was assessed through 16S ribosomal ribonucleic acid *** also examined key components of the lipopolysaccharide pathway:lipopolysaccharide,lipopolysaccharide-binding protein,and soluble *** observed that bacterial diversity was decreased in both the hemorrhagic transformation and non-hemorrhagic transfo rmation group compared with the healthy *** patients with ischemic stro ke who developed hemorrhagic transfo rmation exhibited altered gut micro biota composition,in particular an increase in the relative abundance and dive rsity of members belonging to the Enterobacteriaceae *** lipopolysaccharide and lipopolysaccharide-binding protein levels were higher in the hemorrhagic transformation group compared with the non-hemorrhagic transfo rmation ***,lipopolysaccharide-binding protein,and soluble CD14 concentrations were associated with increased abundance of Enterobacte ***,the role of the gut microbiota in hemorrhagic transformation was evaluated using

关键词： gut microbiota hemorrhagic transformation inflammation lipopolysaccharide stroke

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A Transparent Photoresist Made of Titanium Dioxide Nanoparticle-Embedded Acrylic Resin with a Tunable Refractive Index for UV-Imprint Lithography

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Engineering 2024年第6期37卷 96-104页

作者： Yinglu Liu Dan Wang Changlin Liu Qianqian Hao jian Li Jie-Xin Wang Xiuyun Chen Peng Zhong Xibin Shao jian-feng Chen State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China BOE Technology Group Co. Ltd.Beijing 100176China

Transparent photoresists with a high refractive index(RI)and high transmittance in visible wavelengths have promising functionalities in optical *** work reports a kind of tunable optical material composed of titanium dioxide nanoparticles embedded in acrylic resin with a high RI for ultraviolet(UV)-imprint *** hybrid film exhibits a tunable RI of up to 1.67(589 nm)after being cured by UV light,while maintaining both a high transparency of over 98%in the visible light range and a low haze of less than 0.05%.The precision machining of optical microstructures can be imprinted easily and efficiently using the hybrid resin,which acts as a light guide plate(LGP)to guide the light from the side to the top in order to conserve the energy of the display *** preliminary studies based on both laboratory and commercial experiments pave the way for exploiting the unparalleled optical properties of nanocomposite resins and promoting their industrial application.

关键词： Photoresist Tunable refractive index Hanson solubility Ultraviolet imprint Organic-inorganic composites

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Charge-controlled compositional/microstructural regulations and electrochemical actuation performance of bulk nanoporous Ni-Pd alloys

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Rare Metals 2024年第10期43卷 5305-5317页

作者： Fu-Quan Tan Qing-Guo Bai Bin Yu jian-feng Wang Zhong-Hua Zhang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and EngineeringShandong University School of Applied Physics and Materials Wuyi University Ira A.Fulton School of Engineering Arizona State University

Bulk nanoporous （np） metallic actuators have attracted increasing attention due to their large strain and low stimulation ***,studies focusing upon the combined effect of composition and structure on the actuation performance of metallic actuators are relatively scarce,and its underlying mechanism needs to be clarified Herein,a series of bulk np-NiPd samples with differen compositions and microstructures were fabricated using a dealloying-coarsening-dealloying strategy and chargecontrolled electrochemical dealloying,and the process involves only one component of precursor *** has been found that the np-NiPd cubes show a composition/structure-dependent mechanical property and electrochemical actuation ***,the npNi70Pd30sample with a homogeneously porous structure and good network connectivity exhibits significantly larger strain amplitude and faster strain rate than other hierarchically porous NiPd samples (np-Ni50Pd50and npNi20Pd80).Moreover,the np-Ni70Pd30sample demonstrates good actuation stability with high strain retention after hundreds of ***,the maximum strain amplitude （1.17%） is even comparable to that of advanced leadfree piezoceramic,and the maximum strain rate exceeds those of many reported metallic actuator *** work indicates that good network connectivity plays a vita role in facilitating large/fast strain response in metallic actuators.

关键词： Actuation stability Bulk nanoporous NiPd Electrochemical dealloying Good network connectivity Metallic actuators

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肠内免疫营养治疗在慢性阻塞性肺疾病急性发作患者中的临床应用

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解放军医学杂志 2015年第5期40卷 411-414页

作者：张志成邹剑峰海军总医院重症医学科北京100048

目的探讨应用肠内免疫营养制剂对于慢性阻塞性肺疾病急性加重(A ECO P D)患者营养状况的改善效果及对免疫和急性炎性反应的影响。方法纳入2013年1月-2014年6月在海军总医院ICU住院且需行机械通气的AECOPD患者62例,随机分为免疫营养组(n=... 详细信息

目的探讨应用肠内免疫营养制剂对于慢性阻塞性肺疾病急性加重(A ECO P D)患者营养状况的改善效果及对免疫和急性炎性反应的影响。方法纳入2013年1月-2014年6月在海军总医院ICU住院且需行机械通气的AECOPD患者62例,随机分为免疫营养组(n=32,给予瑞能)和对照组(n=30,给予本院营养科自制匀浆膳)。两组使用等热量肠内营养,营养素经鼻肠管给予。入院当天及第14、18天抽取静脉血,检测血清白蛋白(ALB)、前白蛋白(PA)、转铁蛋白(TFN)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平,同时在床旁测上臂肌围(UAMC),比较两组14d脱机率及28d内的机械通气时间。结果免疫营养组患者14d脱机率明显高于对照组,28d内机械通气时间少于对照组(P<0.05);PA、TFN及UAMC等营养指标明显高于对照组(P<0.05),IL-6、CRP、TNF-α等免疫指标明显低于对照组(P<0.05)。结论 AECOPD患者应用免疫肠内营养支持较匀浆膳能更好地改善患者的营养状态、免疫功能,并可下调急性炎症反应水平,提高早期撤机成功率,是一种更为合适的营养支持方法。

关键词：肺疾病,慢性阻塞性营养支持呼吸,人工

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Mineralogical properties and co-sintering characteristics of fluxed iron ore with magnetite concentrates

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Journal of Iron and Steel Research International 2024年第2期31卷 318-328页

作者： Le-le Niu Zheng-jian Liu jian-liang Zhang Yao-zu Wang Zhen-xing Yang Si-da Li Chang-dong Shan Ben feng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of Artificial Intelligence University of Science and Technology BeijingBeijing100083China Xinxing Casting Pipe Xinjiang Co. Bayingol841300XinjiangChina

To investigate the feasibility of co-sintering of fluxed iron ore with magnetite concentrates, the mineralogical properties of a novel fluxed iron ore were studied using particle size analysis, microscopic morphology characterization, and X-ray diffraction Rietveld analysis. Following that, the experiments for granulation performance and basic sintering characteristics were designed under seven different fluxed iron ore ratios, and the integrated ranking of different fluxed iron ore ratios was determined using gray relation analysis. Finally, the results of the industrial trails were combined with the feasibility analysis. Test and experimental results show that the fraction of the fluxed iron ore particles larger than 0.5 mm can account for more than 48%, and the particles have two morphologies: spherical-rough and flaky-smooth. Ca elements are found in the form of calcite (CaCO3) and dolomite (CaMg(CO3)2). The average particle size of granules and powder removal rate can be improved from 2.50 to 3.16 mm and 39.60% to 24.20%, respectively, with the increase in the fluxed iron ore ratio. Furthermore, the fluxed iron ore can improve assimilability and liquid fluidity of magnetite concentrates. In terms of overall granulation performance and sintering characteristics, the fluxed iron ore ratios are graded from best to worst as follows: 12%, 15%, 9%, 18%, 21%, 6% and 3%. The industrial trails show that when the fluxed iron ore ratio is increased, the beneficial effect of the superior sintering characteristics of the fluxed iron ore itself is ideally balanced with the negative effect of the lower amount of additional CaO at 12% ratio, and thus, it is feasible to bring the fluxed iron ore into production at a level of roughly 12%.

关键词： Fluxed iron ore Magnetite concentrate Granulation performance Sintering characteristics Gray relation analysis

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Understanding the Thermal Impedance of Silicone Rubber/Hexagonal Boron Nitride Composites as Thermal Interface Materials

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Chinese Journal of Polymer Science 2024年第3期42卷 352-363,I0008页

作者： Yuan Ji Shi-Da Han Hong Wu Shao-Yun Guo feng-Shun Zhang jian-Hui Qiu The State Key Laboratory of Polymer Materials Engineering Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyPolymer Research InstituteSichuan UniversityChengdu 610065China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Department of Mechanical Engineering Faculty of Systems Science and TechnologyAkita Prefectural UniversityAkita 015-0055Japan

Silicone rubber(SR) composites are most widely used as thermal interface materials(TIMs) for electronics heat dissipation. Thermal impedance as the main bottleneck limiting the performance of TIMs is usually neglected. Herein, the thermal impedance of SR composites loaded with different levels of hexagonal boron nitride(h-BN) as TIMs was elaborated for the first time by the ASTM D 5470 standard test and finite element analysis. It was found that elastic modulus and surface roughness of SR composites increased with the increase of h-BN content, indicating that the conformity was reduced. When the assembly pressure was 0.69 MPa, there existed an optimal h-BN content at which the contact resistance was minimum(0.39 K·cm^(2)·W^(-1)). Although the decreased bond line thickness(BLT) by increasing the assembly pressure was beneficial to reduce the thermal impedance, the proper assembly pressure should be selected to prevent the warpage of the contact surfaces and the increase in contact resistance, according to the compression properties of the SR composites. This study provides valuable insights into fabrication of high-performance TIMs for modern electronic device applications.

关键词： Thermal interface materials Hexagonal boron nitride Thermal impedance Surfaces

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流向强迫作用下的液体初始雾化机制及动力学特征

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推进技术 2020年第2期41卷 353-361页

作者：陈潜邹建锋周程林袁炎炎浙江大学航空航天学院浙江杭州310027

使用Volume of fluid(VOF)方法和基于树形数据结构的自适应算法来研究射流雾化的破碎过程以及扰动对射流破碎机理产生的影响。在无扰动情况下,液体射流的头部、液丝和液滴随着射流时间的发展不断发生演变。射流头部先呈现蘑菇状外形,随... 详细信息

使用Volume of fluid(VOF)方法和基于树形数据结构的自适应算法来研究射流雾化的破碎过程以及扰动对射流破碎机理产生的影响。在无扰动情况下,液体射流的头部、液丝和液滴随着射流时间的发展不断发生演变。射流头部先呈现蘑菇状外形,随后液丝生成,并慢慢转变成网兜状,直至断裂形成小液滴。在周期性流向强迫的作用下,射流液柱的表面会形成周期波,其液丝破裂形成液滴的时机与稳定射流情形相比会有所提前,射流形成的头部更趋于扁平,最终生成的液滴数量更多。低中频阶段,随着扰动频率的增大,射流未扰动液柱长度(L)逐渐缩短,液滴直径的概率密度分布(PDF)趋于尖锐,液滴平均直径(SMD)增大。在高频阶段,随着扰动频率的增大,L会随之增大,液滴直径的PDF分布变得平缓,SMD会减小。

关键词：燃烧室射流破碎扰动波雾化频率液滴

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Flow interaction between a stationary cylinder and a downstream elastic cylinder

Flow interaction between a stationary cylinder and a downstr...

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第十届全国分离流、旋涡和流动控制会议

作者： CHEN Wen-qu, REN An-lu, zou jian-feng and DENG jian (Institution of Fluid Engmeering, Zhejiang University, Hangzhou Zhejiang 310027, China)

The vortex-induced vibration of an elastic cylinder in a upstream wake was simulated numerically using Arbitrary Lagrangian-Eulerian （ALE） method. The dynamic response and the vortex structure of this system were investigated in detail. Four conclusions can be drawn from the achieved data. （ⅰ） Compared with the system of a single elastic cylinder, the flow-induced response is suppressed for large mass ratio, while enhanced for small mass ratio and the flow-induced response is not a discontinuous function of the frequency ratio （f / f, f is the natural frequency of the cylinder and f is the vortex shedding frequency of the single stationary cylinder） any more. （ⅱ） The frequency ratio in the resonance band of the present system is close to but less than 1.0. For the case of a single elastic cylinder, the resonance band contains the frequency ratios in both sides of 1.0. （ⅲ） The system of small mass ratio has much broader resonance band than the system of large mass ratio has. The mass ratio has little effect on the position of the frequency band. （ⅳ） Four kinds of vortex patterns, i.e. 2P, P+S, 2S, and 2P+S, are observed when changing the frequency ratio and the spacing ratio in the simulations.

关键词： flow over two circular cylinders flow-induced vibration dynamic response vortex mode

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Formation mechanism of fault accommodation zones under combined stress in graben basin:Implications from geomechanical modeling

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Petroleum Science 2024年第1期21卷 54-76页

作者： Qi-Qiang Ren Jin-Liang Gao Rong-Tao jiang Jin Wang Meng-Ping Li jian-Wei feng Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China jianghan Oilfield Oil and Gas Production Capacity Construction Management Center Chongqing408000China Sinopec Chongqing Fuling Shale Gas Exploration and Development Company Chongqing408000China College of Energy Chengdu University of TechnologyChengdu 610059SichuanChina School of Geoscience China University of Petroleum(East China)Qingdao 266580ShandongChina

A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults *** numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation *** study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical *** three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation *** with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben *** the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were *** by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:During the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale *** the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly *** junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation *** the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were

关键词： Fault accommodation zone Graben basin Fault activity Tectonic physical simulation experiment Finite element numerical simulation Dongxin fault zone

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Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

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Zoological Research 2024年第1期45卷 125-135页

作者： jian-Chao Liang Zhi-feng Ding Chun-Lin Li Yi-Ming Hu Zhi-Xin Zhou Gan-Wen Lie Xiao-Nan Niu Wen-Bin Huang Hui-jian Hu Xing-feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China Huizhou Institute of Forestry(Huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity ***,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the Hu Line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal *** and PBD were calculated and partitioned into turnover and nestedness components using a moving window *** representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental *** distance was considered to assess the impact of dispersal *** partitioning analysis was applied to assess the relative roles of these *** general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental ***,different dominant environmental filters on either side of the Hu Line led to divergent beta diversity ***,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,***,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous *** results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological *** a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete ***,a comprehensive understanding of large-scale beta diversity patterns and effective pla

关键词： Beta diversity Environmental filtering Dispersal limitation Hu Line Species dispersal ability Breeding birds

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