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Journal of Animal Science and Biotechnology 2024年第2期15卷 519-534页

作者： Changming Hong Yujian Huang Shuting Cao Li Wang Xuefen Yang Shenglan Hu Kaiguo Gao zongyong jiang Hao Xiao State Key Laboratory of Swine and Poultry Breeding Industry Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South ChinaGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Provincial Key Laboratory of Animal Breeding and NutritionMaoming BranchGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouChina Institute of Animal Science Guangdong Academy of Agricultural Sciences1 Dafeng 1st StreetGuangzhou 510640China

Oxidative stress has been associated with a number of physiological problems in swine,including reduced production efficiency.Recently,although there has been increased research into regulatory mechanisms and antioxidant strategies in relation to oxidative stress-induced pig production,it remains so far largely unsuccessful to develop accurate models and nutritional strategies for specific oxidative stress factors.Here,we discuss the dose and dose intensity of the causes of oxidative stress involving physiological,environmental and dietary factors,recent research models and the antioxidant strategies to provide theoretical guidance for future oxidative stress research in swine.

关键词： Accurate models Dose Nutritional strategies Oxidative stress Swine

Alterations in intestinal microbiota composition coincide with impaired intestinal morphology and dysfunctional ileal immune response in growing-finishing pigs under constant chronic heat stress

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Journal of Animal Science and Biotechnology 2022年第3期13卷 769-786页

作者： Yunxia Xiong Shuting Cao Hao Xiao Qiwen Wu Hongbo Yi zongyong jiang Li Wang State Key Laboratory of Livestock and Poultry Breeding Key Laboratory of Animal Nutrition and Feed Science in South China Ministry of AgricultureMaoming BranchGuangdong Laboratory for Lingnan Modern AgricultureGuangdong Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640China

Background:Previous studies had shown that short-term acute heat stress(HS)affected the host’s metabolism and intestinal microbiota independent of feed intake(FI)reduction,and long-term calorie restriction caused intestinal morphological injuries and gut microbial alterations.However,research on the effects of constant chronic HS on intestinal microbial composition and the roles of FI reduction played in is limited.This study aimed to investigate the effects of 7-day constant chronic HS on the composition of intestinal microbes in growing-finishing pigs,and its relationship with pigs’performance,intestinal morphology,and ileal immune response.Twenty-four growingfinishing pigs(Duroc×Large White×Landrace,30±1 kg body weight)were randomly assigned to three treatments(n=8),1)thermal neutral(TN)conditions(25±1℃)with ad libitum FI,2)HS conditions(35±1℃)with ad libitum FI,3)pair-fed(PF)with HS under TN conditions to discriminate the confounding effects of dissimilar FI,and the FI was the previous day’s average FI of HS.The small intestinal segments(duodenum,jejunum,and ileum)and feces were collected on d 8.Results:Results indicated that HS drastically declined(P<0.05)average daily gain(ADG)and average daily feed intake(ADFI)(about 61%)in comparison with TN,and caused hyperpyrexia,meanwhile PF caused hypothermia.Morphological observation by light and electron microscopes showed that both HS and PF treatment decreased(P<0.05)the villus and microvillus height compared with TN.Additionally,HS increased(P<0.05)protein expression of heat shock protein 70 in the duodenum,jejunum,and ileum.Furthermore,the expression of tight junction protein zonula occluden-1(ZO-1)in the duodenum and ileum,and Occludin in the ileum were enhanced(P<0.05)compared with TN and PF.Moreover,HS significantly enhanced(P<0.05)the mRNA relative expression of inflammatory cytokines(TLR-2,TLR-4,and tumor necrosis factor-α(TNF-α),IL-6,IL-8,PG1–5,β-defensin 2(pBD-2)),mucins(mucin-1 and mucin-2)and P65 protein level in the ileal mucosa tissue.Intestinal micro

关键词： Constant chronic heat stress Growing-finishing pigs Ileal immune response Intestinal microbiota Performance

Dietary resveratrol attenuation of intestinal inflammation and oxidative damage is linked to the alteration of gut microbiota and butyrate in piglets challenged with deoxynivalenol

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1555-1571页

作者： Yueqin Qiu Jun Yang Li Wang Xuefen Yang Kaiguo Gao Cui Zhu zongyong jiang State Key Laboratory of Livestock and Poultry Breeding Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionMaoming BranchGuangdong Laboratory for Lingnan Modern AgricultureInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640China College of Animal Science South China Agricultural UniversityGuangzhou 510642China School of Life Science and Engineering Foshan UniversityFoshan 528225China

Background:Deoxynivalenol(DON)is a widespread mycotoxin that induces intestinal inflammation and oxidative stress in humans and animals.Resveratrol(RES)effectively exerts anti-inflammatory and antioxidant effects.However,the protective effects of RES on alleviating DON toxicity in piglets and the underlying mechanism remain unclear.Therefore,this study aimed to investigate the effect of RES on growth performance,gut health and the gut microbiota in DON-challenged piglets.A total of 64 weaned piglets[Duroc×(Landrace×Yorkshire),21-d-old,6.97±0.10 kg body weight(BW)]were randomly allocated to 4 treatment groups(8 replicate pens per treatment,each pen containing 2 males;n=16 per treatment)for 28 d.The piglets were fed a control diet(CON)or the CON diet supplemented with 300 mg RES/kg diet(RES group),3.8 mg DON/kg diet(DON)or both(DON+RES)in a 2×2 factorial design.Results:DON-challenged piglets fed the RES-supplemented diet had significantly decreased D-lactate concentrations and tumor necrosis factor alpha(TNF-α)and interleukin 1 beta(IL-1β)mRNA and protein expression,and increased zonula occludens-1(ZO-1)mRNA and protein expression compared with those of DON-challenged piglets fed the unsupplemented diet(P<0.05).Compared with unsupplemented DON-challenged piglets,infected piglets fed a diet with RES showed significantly decreased malondialdehyde(MDA)levelsand increased mRNA expression of antioxidant enzymes and antioxidant genes(i.e.,GCLC,GCLM,HO-1,SOD1 and NQO-1)and glutamatecysteine-ligase modulatory subunit(GCLM)protein expression(P<0.05).Moreover,RES supplementation significantly abrogated the increase in the proportion of TUNEL-positive cells and the protein expression of caspase3 in DON-challenged piglets(P<0.05).Finally,RES supplementation significantly increased the abundance of Roseburia and butyrate concentrations,while decreasing the abundances of Bacteroides and unidentified-Enterobacteriaceae in DON-challenged piglets compared with DON-challenged piglets alone(P<0.05).Conclusions:RES supplementation imp

关键词： Deoxynivalenol Gut health Gut microbiota Inflammation Oxidative damage Piglets Resveratrol

Fecal scores and microbial metabolites in weaned piglets fed different protein sources and levels

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Animal Nutrition 2018年第1期4卷 31-36页

作者： Xiaolu Wen Li Wang Chuntian Zheng Xuefen Yang Xianyong Ma Yunpeng Wu Zhuang Chen zongyong jiang Key Laboratory of Animal Nutrition and Feed Science in South China Ministry of AgricultureState Key Laboratory of Livestock and Poultry BreedingGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural Sciences Agro-Biological Gene Research Center Guangdong Academy of Agricultural Sciences

This experiment studied the effects of dietary protein sources and levels on the gut health of piglets,p H value,and concentrations of microbial metabolites(ammonia-N,volatile fatty acids [VFA],and polyamines) in the distal colonic and proximal colonic digesta of piglets weaned at 21 d of age.A total of 150 early-weaned piglets were allotted randomly to 5 diets: 1) control diet(CT; 17% CP),2) CT formulated with more soy protein concentrate(SPC19; 19% CP),3) more fish meal(FM19; 19% CP),4) CT formulated with more soy protein concentrate(SPC23; 23% CP),and 5) more fish meal(FM23; 23%CP).Results showed high protein level increased fecal score(P 0.05).The p H value and ammonia-N concentration of digesta in the proximal and distal colon of FM23 were significantly higher(P 0.05).Histamine and spermidine concentrations of FM23 were higher than those of other treatments(P < 0.05).Propionic acid and butyric acid concentrations in the distal colon were higher of FM23 than of FM19(P < 0.05); putrescine,histamine and spermidine were higher of FM23 than of LP and FM19(P < 0.05).It was concluded that high dietary CP content increased microbial metabolites(ammonia-N,histamine,putrescine) in colonic digesta and aggravated piglets' diarrhea.

关键词： Piglet Protein level Protein source Microbial metabolites Diarrhea

Effects of dietary valine supplementation during late gestation on the reproductive performance and mammary gland development of gilts

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Journal of Animal Science and Biotechnology 2020年第2期11卷 514-526页

作者： Long Che Mengmeng Xu Kaiguo Gao Li Wang Xuefen Yang Xiaolu Wen Hao Xiao zongyong jiang State Key Laboratory of Livestock and Poultry Breeding Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of AgricultureGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesNo.1 Dafeng StreetWushan RdTianhe DistrictGuangzhou 510640GuangdongChina College of Animal Science and Technology Henan University of Animal Husbandry and EconomyZhengzhou 450046HenanChina

Background:Mammary gland development during late gestation in gilts is a major factor that alters the composition of colostrum and growth performance of piglets.Plasma valine is taken up and metabolized extensively by the mammary gland;however,the effects of valine on mammary gland development during late gestation are still unclear.Thirty primiparous gilts were divided into three treatment groups(n=10)and received one of the three diets starting on day 75 of gestation until the day of farrowing.The total dietary valine to lysine ratio of the three diets was 0.63(LV),0.73(MV),and 0.93(HV),respectively.Results:Dietary valine supplementation during late gestation did not affect(P>0.05)the litter size and weight at farrowing;however,the piglet weight and average daily gain at weaning were linearly increased(P0.05)was observed in the indices related to mammary development and the mTOR signaling pathway at day 21 of lactation.Conclusion:The results revealed that increasing the total dietary valine to lysine ratio to 0.93 during late gestation significantly enhances the piglet weight and average daily gain at weaning probably due to improved development of mammary gland.

关键词： Gilt Mammary gland Piglet growth Valine

Dietary supplementation with a high dose of daidzein enhances the antioxidant capacity in swine muscle but experts pro-oxidant function in liver and fat tissues

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Journal of Animal Science and Biotechnology 2016年第3期7卷 412-422页

作者： Wei Chen Xianyong Ma Yingcai Lin Yunxia Xiong Chuntian Zheng Youjun Hu Deqian Yu zongyong jiang Institute of Animal Science Guangdong Academy of Agricultural SciencesGuangzhou 510640People's Republic of China The Key Laboratory ofAnimal Nutrition and Feed Science(South China)of Ministry of Agriculture GuangzhouPeople's Republic of China State Key Laboratory of Livestockand Poultry Breeding GuangzhouPeople's Republic of China Guangdong Public Laboratory of Animal Breeding and Nutrition GuangzhouPeople's Republic of China Guangdong Key Laboratory of Animal Breeding and Nutrition GuangzhouPeople's Republic of China

Background： Although isoflavones are natural dietary antioxidants, they may have toxicological effects. This study aimed to evaluate the redox system in tissues of finishing pigs by supplementation with high dose of daidzein（640 mg/kg）.Results： The supplementation of high dose of daidzein for 64 d increased the activity of superoxide dismutase and total antioxidant capacity in longissimus muscle but down-regulated the expression of reactive oxygen species（ROS）-producing enzyme NADPH oxidase-2 and cyclooxygenase-2. In contrast, high-level supplementation with daidzein exerted pro-oxidant changes in back fat, abdominal fat, liver, and plasma, as reflected by increased contents of malondialdehyde, a lipid peroxidation product, in these tissues. Furthermore, daidzein supplementation resulted in higher expression of ROS-producing enzymes, including NADPH oxidase-1 and cyclooxygenase-1in liver, 5-lipoxygenase（5-LOX） in backfat and NADPH oxidase-2 both in abdominal fat and backfat. The supplementation of daidzein did not affect meat quality parameters in longissimus muscle, including marbling score,eye muscle areas, intramuscular fat, shear force, drip loss, p H and meat color.Conclusions： This experiment suggests that dietary supplementation of finishing pigs with daidzein at a high dose level improves redox status in muscle but exerts pro-oxidant effect in liver and fat tissues.

关键词： Anti-/pro-oxidant enzyme Daidzein Fat Liver Muscle Pigs

面向SAR目标识别深度网络可理解的类激活映射方法

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雷达学报（中英文） 2024年第2期13卷 428-442页

作者：崔宗勇杨致远蒋阳曹宗杰杨建宇电子科技大学信息与通信工程学院成都611731

随着深度学习方法在合成孔径雷达(SAR)图像解译领域的广泛应用,SAR目标识别深度网络可理解性问题逐渐受到学者的关注。类激活映射(CAM)作为常用的可理解性算法,能够通过热力图的方式,直观展示对识别任务起作用的显著性区域。然而作为一... 详细信息

随着深度学习方法在合成孔径雷达(SAR)图像解译领域的广泛应用,SAR目标识别深度网络可理解性问题逐渐受到学者的关注。类激活映射(CAM)作为常用的可理解性算法,能够通过热力图的方式,直观展示对识别任务起作用的显著性区域。然而作为一种事后解释的方法,其只能静态展示当次识别过程中的显著性区域,无法动态展示当输入发生变化时显著性区域的变化规律。该文将扰动的思想引入类激活映射,提出了一种基于SAR背景杂波特性类激活映射方法(SCC-CAM),通过对输入图像引入同分布的全局扰动,逐步向SAR识别深度网络施加干扰,使得网络判决发生翻转,并在此刻计算网络神经元输出激活值的变化程度。该方法既能解决添加扰动可能带来的扰动传染问题,又能够动态观察和度量目标识别网络在识别过程中显著性区域的变化规律,从而增强深度网络的可理解性。在MSTAR数据集和OpenSARShip-1.0数据集上的试验表明,该文提出的算法具有更加精确的定位显著性区域的能力,相比于传统方法,在平均置信度下降率、置信度上升比例、信息量等评估指标上,所提算法具有更强的可理解性,能够作为通用的增强网络可理解性的方法。

关键词： SAR目标识别网络可理解性 SAR杂波特性类激活映射面积约束置信度下降率

Effects of protein sources and levels in antibiotic-free diets on diarrhea,intestinal morphology, and expression of tight junctions in weaned piglets

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Animal Nutrition 2015年第3期1卷 170-176页

作者： Yunpeng Wu zongyong jiang Chuntian Zheng Li Wang Cui Zhu Xuefen Yang Xiaolu Wen Xianyong Ma Key Laboratory of Animal Nutrition and Feed Science in South China Ministry of Agriculture State Key Laboratory of Livestock and Poultry BreedingGuangdong Public Laboratory of Animal Breeding and Nutrition Institute of Animal Science Guangdong Academy of Agricultural Sciences College of Animal Science South China Agricultural University Agro-biological Gene Research Center Guangdong Academy of Agricultural Sciences

This study examined effects of dietary protein sources and levels on intestinal health of 21 to 35 d-old weaned piglets fed antibiotics-free diets. A total of 150 weaned piglets(21 d of age) were allotted to 5 dietary treatment groups. Diets were formulated, based on corn-soybean meal, with different protein sources(fish meal and soy protein concentrate) to provide different dietary CP levels. Piglets within 5 dietary treatments were fed diets as follows, respectively: 1) control diet of 17% CP(control); 2) 19% CP diets formulated with more soy protein concentrate(SPC19); 3) fish meal(FM19); 4) 23.7% CP diets formulated with more soy protein concentrate(SPC23); 5) fish meal(FM23). The results showed that piglets from control group had higher ADG and lower incidence of diarrhea compared with those of other groups(P < 0.05). The incidence of diarrhea of piglets in FM19 group was lower than those from SPC23 group and FM23 group(P < 0.05). With the higher CP levels, villous height and villous height to crypt depth ratio of piglets in the duodenum and jejunum were decreased(P < 0.05), but crypt depth was increased(P < 0.05). Comparing control group and other groups, we found the expression of inflammatory cytokines interleukin-1β(IL-1β) and interferon-γ(IFN-γ) were increased(P < 0.05) in the jejunum and colon of piglets, as did cystic fibrosis transmembrane conductance regulators(CFTR) in the distal colon. The relative transcript abundance of Zonula occludens-1(ZO-1) in the jejunum, and occludin in the jejunum and ileum of piglets fed 23.7% CP diets were reduced compared with those fed control diet(P < 0.05). In conclusion, the 17% CP diet without in-feed antibiotics helped improve growth performance and relief of diarrhea of 21 to 35 d-old weaned piglets. Dietary CP level, rather than its source(either fish meal or soy protein concentrate), has more significant impacts on the growth performance and intestinal health of 21 to 35 d-old weaned piglets when fed antibiotics-free diets.

关键词： Dietary protein Weaned piglets Diarrhea Intestinal health Tight junction protein Antibiotic-free diets

Effects of different forms of yeast Saccharomyces cerevisiae on growth performance,intestinal development,and systemic immunity in early-weaned piglets

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Journal of Animal Science and Biotechnology 2016年第1期7卷 78-85页

作者： zongyong jiang Shaoyong Wei Zhilin Wang Cui Zhu Shenglan Hu Chuntian Zheng Zhuang Chen Youjun Hu Li Wang Xianyong Ma Xuefen Yang Key Laboratory of Animal Nutrition and Feed(South China) Ministry of Agriculture of ChinaState Key Laboratory of Livestock and Poultry BreedingGuangdong Public Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural Sciences Agro-biological Gene Research Center Guangdong Academy of Agricultural Sciences

The present study was conducted to determine effects of different forms of yeast （Saccharomyces cerevisiae, strain Y200007） on the growth performance, intestinal development, and systemic immunity in early-weaned piglets. A total of 96 piglets （14-d old, initial average body weight of 4.5 kg） were assigned to 4 dietary treatments：（1） basa diet without yeast （Control）; （2） basal diet supplemented with 3.00 g/kg live yeast （LY）; （3） basal diet supplemented with 2.66 g/kg heat-killed whole yeast （HKY）; and （4） basal diet supplemented with 3.00 g/kg superfine yeast powders （SFY）. Diets and water were provided ad libitum to the piglets during 3-week experiment. Growth performance of piglets was measured weekly. Samples of blood and small intestine were collected at days 7 and 21 of experiment. Dietary supplementation with LY and SFY improved G：F of piglets at days ]-21 of the experiment （P 〈 0.05） compared to Control group. Serum concentrations of growth hormone （GH）, triiodothyronine （T3）, tetraiodothyronine （T4）, and insulin growth factor 1 （iGF-1） in piglets at day 21 of the experiment were higher when fed diets supplemented with LY and SFY than those in Control group （P 〈 0.05）. Compared to Control group, contents of serum urea nitrogen of piglets were reduced by the 3 yeast-supplemented diets （P 〈 0.05）. Diets supplemented with LY increased villus height and villus-to-crypt ratio in duodenum and jejunum of piglets （P 〈 0.05） compared to other two groups at day 7 of the experiment. Feeding diets supplemented with LY and SFY increased （P 〈 0.05） serum concentrations of IgA, IL-2, and IL-6 levels in piglets compared to Control. The CD4＋/CD8＋ ratio and proliferation of T-lymphocytes in piglets fed diets supplemented with LY were increased compared to that of Control group at day 7 of the experiment （P 〈 0.05）. In conclusion, dietary supplementation with both LY and SFY enhanced feed conversion, small intestinal development, and systemic immunity in early-weaned piglets, with better improvement in feed conversion by

关键词： Growth performance Immunity Intestinal development Piglets Saccharomyces cerevisiae Yeast

代谢组学在胃肠道微生物研究中的应用（英文）

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Science Bulletin 2016年第15期61卷 1151-1153页

作者： Shijuan Yan Jianfeng Huang Zhongjian Chen zongyong jiang Xue Li Zhuang Chen Agro-biological Gene Research Center Guangdong Academy of Agricultural Sciences Institute of Pharmaceutical Research South China Normal University

On May 13,2016,the American government launched a121-million USD investment for the National Microbiome Initiative(NMI),which aims to provide an in-depth understanding of microbiomes in order to develop new applications in the areas of human health,food security,and environmental restoration[1].NMI also calls for projects to develop platform technologies,reference libraries,and databases for microbiome research in all habitats,including in the human gut.As an important platform technology,metabolomics is able to characterize

关键词：代谢组学肠道菌群应用微生物美国政府人类健康环境恢复食品安全