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Glibenclamide pretreatment attenuates early hematoma expansion of warfarin-associated intracerebral hemorrhage in rats by alleviating perihematomal blood-brain barrier dysfunction

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Chinese Neurosurgical Journal 2024年第1期10卷 8-19页

作者： zongwei Zeng Liang Liang Zhou feng Peiwen Guo Xiaoke Hao Jishu Xian Hua feng Yujie Chen Zhi Chen Department of Neurosurgery and State Key Laboratory of Trauma Burn and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Neurosurgery The 945Th Hospital of PLAYaanSichuan Province 625099China Department of Rehabilitation Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Key Laboratory of Precision Neuromedicine and Neuroregeneration Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Clinical Research Center for Neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Background Hematoma expansion is a determinant of poor outcome of intracerebral hemorrhage but occurs frequently,especially in warfarin-associated intracerebral hemorrhage(W-ICH).In the present study,we employ the warfarin-associated intracerebral hemorrhage(W-ICH)rat model,to explore the efficacy and potential mechanism of glibenclamide pretreatment on hematoma expansion after intracerebral hemorrhage,hoping to provide proof of concept that glibenclamide in stroke primary and secondary prevention is also potentially beneficial for intracerebral hemorrhage patients at early stage.Methods In the present study,we tested whether glibenclamide,a common hypoglycemic drug,could attenuate hematoma expansion in a rat model of W-ICH.Hematoma expansion was evaluated using magnetic resonance imaging;brain injury was evaluated by brain edema and neuronal death;and functional outcome was evaluated by neurological scores.Then blood-brain barrier integrity was assessed using Evans blue extravasation and tight junction-related protein.Results The data indicated that glibenclamide pretreatment significantly attenuated hematoma expansion at 24 h after W-ICH,thus mitigating brain edema and neuronal death and promoting neurological function recovery,which may benefit from alleviating blood-brain barrier disruption by suppressing matrix metallopeptidase-9.Conclusions The results indicate that glibenclamide pretreatment in stroke primary and secondary prevention might be a promising therapy for hematoma expansion at the early stage of W-ICH.

关键词： Intracerebral hemorrhage Warfarin Glibenclamide Hematoma expansion Blood-brain barrier Matrix metallopeptidase-9

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Quantized anomalous Hall resistivity achieved in molecular beam epitaxy-grown Mn Bi2Te4 thin films

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National Science Review 2024年第2期11卷 24-32页

作者： Yunhe Bai Yuanzhao Li Jianli Luan Ruixuan Liu Wenyu Song Yang Chen Peng-Fei Ji Qinghua Zhang Fanqi Meng Bingbing Tong Lin Li Yuying Jiang zongwei Gao Lin Gu Jinsong Zhang Yayu Wang Qi-Kun Xue Ke He Yang feng Xiao feng State Key Laboratory of Low Dimensional Quantum Physics Department of Physics Tsinghua University Institute of Physics Chinese Academy of Sciences School of Materials Science and Engineering Tsinghua University Beijing Academy of Quantum Information Sciences Frontier Science Center for Quantum Information Hefei National Laboratory Southern University of Science and Technology

The intrinsic magnetic topological insulator MnBi2Te4provides a feasible pathway to the high-temperature quantum anomalous Hall（QAH） effect as well as various novel topological quantum phases. Although quantized transport properties have been observed in exfoliated MnBi2Te4thin flakes, it remains a big challenge to achieve molecular beam epitaxy（MBE）-grown MnBi2Te4thin films even close to the quantized regime. In this work, we report the realization of quantized anomalous Hall resistivity in MBE-grown MnBi2Te4thin films with the chemical potential tuned by both controlled in situ oxygen exposure and top gating. We find that elongated post-annealing obviously elevates the temperature to achieve quantization of the Hall resistivity, but also increases the residual longitudinal resistivity, indicating a picture of high-quality QAH puddles weakly coupled by tunnel barriers. These results help to clarify the puzzles in previous experimental studies on MnBi2Te4and to find a way out of the big difficulty in obtaining MnBi2Te4samples showing quantized transport properties.

关键词： intrinsic magnetic topological insulator quantized anomalous Hall resistivity molecular beam epitaxy quantized transport property

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Soil temperature and moisture sensitivities of soil CO_2 efflux before and after tillage in a wheat field of Loess Plateau,China

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Journal of Environmental Sciences 2011年第1期23卷 79-86页

作者： Hongxing Zhang Xiaoke Wang zongwei feng Junzhu Pang Fei Lu Zhiyun Ouyang Hua Zheng Wenzhao Liu Dafeng Hui State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water Resources Shaanxi 722400 China Department of Biological Sciences Tennessee State University 3500 John A. Merritt Blvd. Nashville TN 37209 USA

As a conventional farming practice, tillage has lasted for thousands of years in Loess Plateau, China. Although recent studies show that tillage is a prominent culprit to soil carbon loss in croplands, few studies have investigated the influences of tillage on the responses of soil CO2 efflux （SCE） to soil temperature and moisture. Using a multi-channel automated CO2 efflux chamber system, we measured SCE in situ continuously before and after the conventional tillage in a rain fed wheat field of Loess Plateau, China. The changes in soil temperature and moisture sensitivities of SCE, denoted by the Q10 value and linear regression slope respectively, were compared in the same range of soil temperature and moisture before and after the tillage. The results showed that, after the tillage, SCE increased by 1.2-2.2 times; the soil temperature sensitivity increased by 36.1%-37.5%; and the soil moisture sensitivity increased by 140%-166%. Thus, the tillage-induced increase in SCE might partially be attributed to the increases in temperature and moisture sensitivity of SCE.

关键词： soil CO2 efflux Loess Plateau moisture sensitivity temperature sensitivity tillage wheat field

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神经损伤是轮胎橡胶衍生污染物6PPDQ引起虹鳟急性毒性的重要原因

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Science Bulletin 2024年第5期69卷 621-635页

作者：廖晓亮陈智锋欧诗平刘倩怡林善鸿周嘉明王玉洁蔡宗苇 Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and HealthSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China

N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine quinone(6PPDQ)has attracted significant attention due to its highly acute lethality to sensitive salmonids.However,studies investigating the mechanisms underlying its acute toxicity have been lacking.In this work,we demonstrated the sensitivity of rainbow trout to 6PPDQ-induced mortality.Moribund trout exhibited significantly higher brain concentrations of 6PPDQ compared to surviving trout.In an in vitro model using human brain microvascular endothelial cells,6PPDQ can penetrate the blood–brain barrier and enhance blood–brain barrier permeability without compromising cell viability.The time spent in the top of the tank increased with rising6PPDQ concentrations,as indicated by locomotion behavior tests.Furthermore,6PPDQ influenced neurotransmitter levels and m RNA expression of neurotransmission-related genes in the brain and exhibited strong binding affinity to target neurotransmission-related proteins using computational simulations.The integrated biomarker response value associated with neurotoxicity showed a positive linear correlation with trout mortality.These findings significantly contribute to filling the knowledge gap between neurological impairments and apical outcomes,including behavioral effects and mortality,induced by6PPDQ.

关键词： Emerging contaminant Rainbow trout Neurotransmission Locomotor activity Molecular dynamics simulation

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关于GB/T 28181《公共安全视频监控联网系统信息传输、交换、控制技术要求》标准在应用中的若干问题分析

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信息技术与信息化 2024年第3期 170-174页

作者：侯晨涛曹志捷冯宗伟公安部第三研究所上海200031

GB/T 28181《公共安全视频监控联网系统信息传输、交换、控制技术要求》标准是为视频监控联网系统的方案设计、系统检测、验收以及与之相关设备研发、生产制定的国家推荐性标准,在借鉴国际通用标准的基础上,经过一定程度的定制化以满足... 详细信息

GB/T 28181《公共安全视频监控联网系统信息传输、交换、控制技术要求》标准是为视频监控联网系统的方案设计、系统检测、验收以及与之相关设备研发、生产制定的国家推荐性标准,在借鉴国际通用标准的基础上,经过一定程度的定制化以满足国内的具体需求。针对视频监控联网设备及平台,依照GB/T 28181-2022标准在实际应用过程中遇到的部分问题进行分析,并提出相应的解决建议,以供相关从业者参考。

关键词： GB/T 28181 视频监控联网国家标准问题分析

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阿魏酸对CT-26的细胞凋亡和细胞自噬相关通路的影响

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食品与发酵工业 2024年第6期50卷 367-371页

作者：陈杉彬赵东栾春光乔宗伟郑佳张强冯政王德良中国食品发酵工业研究院有限公司北京100015 宜宾五粮液股份有限公司四川宜宾644000 酒类品质与安全国际联合研究中心北京100015

为了深入明晰酚酸类物质阿魏酸的具体功能机理,以其对CT-26细胞自噬、凋亡、细胞增殖和迁移为评价手段,考察阿魏酸对细胞生理活性的影响,阐明酚酸类物质阿魏酸具体作用机理,为中草药中有效成分阿魏酸的具体功效提供实验数据和理论依据... 详细信息

为了深入明晰酚酸类物质阿魏酸的具体功能机理,以其对CT-26细胞自噬、凋亡、细胞增殖和迁移为评价手段,考察阿魏酸对细胞生理活性的影响,阐明酚酸类物质阿魏酸具体作用机理,为中草药中有效成分阿魏酸的具体功效提供实验数据和理论依据。研究中采用不同浓度梯度的阿魏酸处理CT-26细胞,考察阿魏酸对CT-26细胞生理活性的影响。在一定浓度范围内,阿魏酸能够抑制CT-26细胞的增殖、提高细胞自噬水平,同时在一定程度上抑制CT-26细胞的迁移能力。进一步的研究表明,阿魏酸通过促进凋亡通路上游的caspase3蛋白剪切为Cleaved caspase3,进而调控凋亡关键蛋白Bcl-2和BCL2-Associated X蛋白(Bax)的比值,最终促进了结肠癌细胞凋亡,以此保护细胞的正常生理活动。阿魏酸可通过促进细胞自噬并调控凋亡通路Bcl-2来抑制细胞活性,进而促进细胞凋亡。研究结果为明确中草药中有效成分阿魏酸的生物活性物质作用提供了实验数据。

关键词：阿魏酸 CT-26细胞细胞自噬凋亡

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Investigation of PM_(2.5) pollution during COVID-19 pandemic in Guangzhou,China

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Journal of Environmental Sciences 2022年第5期34卷 443-452页

作者： Luyao Wen Chun Yang Xiaoliang Liao Yanhao Zhang Xuyang Chai Wenjun Gao Shulin Guo Yinglei Bi Suk-Ying Tsang Zhi-feng Chen Zenghua Qi zongwei Cai Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyRm 510Engineering Facility Building No.3Guangzhou 510006China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina Guangzhou Meteorological Public Service Center Guangzhou Meteorological ServiceGuangzhou 510006China School of Life Sciences The Chinese University of Hong KongHong KongChina

The COVID-19 pandemic has raised awareness about various environmental issues,includ-ing PM_(2.5) pollution.Here,PM_(2.5) pollution during the COVID-19 lockdown was traced and an-alyzed to clarify the sources and factors influencing PM_(2.5) in Guangzhou,with an emphasis on heavy pollution.The lockdown led to large reductions in industrial and traffic emissions,which significantly reduced PM_(2.5) concentrations in Guangzhou.Interestingly,the trend of PM_(2.5) concentrations was not consistent with traffic and industrial emissions,as minimum concentrations were observed in the fourth period(3/01-3/31,22.45 μg/m^(3))of the lockdown.However,the concentrations of other gaseous pollutants,e.g.,SO_(2),NO_(2) and CO,were corre-lated with industrial and traffic emissions,and the lowest values were noticed in the sec-ond period(1/24-2/0_(3))of the lockdown.Meteorological correlation analysis revealed that the decreased PM_(2.5) concentrations during COVID-19 can be mainly attributed to decreased in-dustrial and traffic emissions rather than meteorological conditions.When meteorological factors were included in the PM_(2.5) composition and backward trajectory analyses,we found that long-distance transportation and secondary pollution offset the reduction of primary emissions in the second and third stages of the pandemic.Notably,industrial PM_(2.5) emis-sions from western,southern and southeastern Guangzhou play an important role in the formation of heavy pollution events.Our results not only verify the importance of control-ling traffic and industrial emissions,but also provide targets for further improvements in PM_(2.5) pollution.

关键词： PM_(2.5)pollution COVID-19 pandemic PM_(2.5)composition Meteorological analysis Source appointment

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One-pot synthesis of FeNxC as efficient catalyst for high-performance zinc-air battery

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Journal of Energy Chemistry 2022年第3期31卷 100-106,I0004页

作者： Yang Li Kuanda Xu Qi Zhang Zhi Zheng Shunning Li Qinghe Zhao Can Li Cheng Dong zongwei Mei feng Pan Shixue Dou School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055GuangdongChina Institute for Superconducting and Electronic Materials University of WollongongWollongongNSW 2522Australia College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018ZhejiangChina

Rechargeable zinc-air batteries(ZAB)with a high theoretical energy density of 1086 Wh kg^(-1),have received tremendous research attention.However,the practical application of ZABs is still limited by high polarization and poor energy efficiency(low power density)due to the sluggish 4 electrons(e^(-))/oxygen(O_(2))kinetics over the air electrode.Here,a noble-metal-free Fe Nx C electrocatalyst is developed via a onepot approach,which provides a high density of the oxygen reduction reaction(ORR)active site and facilitates the ORR kinetics.Accordingly,the as-assembled Zn-air battery displayed a low charge–discharge voltage gap of 0.71 V at 10 m A cm^(-2),a remarkable peak power density as high as 181.2 m W cm^(-2),as well as the long-term durability for hundreds of hours,among the top level of those reported previously.Our work provides a major boost for the practical application of Zn-air battery in the future.

关键词： FeNxC Oxygen reduction reaction Zinc-air battery

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Stability of soil organic carbon changes in successive rotations of Chinese fir(Cunninghamia lanceolata(Lamb.) Hook) plantations

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Journal of Environmental Sciences 2009年第3期21卷 352-359页

作者： ZHANG Jian WANG Silong feng zongwei WANG Qingkui Huitong Experimental Station of Forest Ecology Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China Department of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Huitong National Research Station of Forest Ecosystem Huitong 418307 China Graduate University of Chinese Academy of Sciences Beijing 100039 China

The importance of soil organic carbon （SOC） under forests in the global carbon cycle depends on the stability of the soil carbon and its availability to soil microbial biomass. We investigated the effects of successive rotations of Chinese fir （Cunninghamia lanceolata （Lamb.） Hook） plantations on the stability of SOC and its availability to microbes by adopting the two-step hydrolysis with H2SO4 and density fractionation. The results showed that successive rotations of Chinese fir decreased the quantity of total SOC, recalcitrant fraction, and carbohydrates in Labile Pool I （LPI）, and microbial properties evidently, especially at 0-10 cm horizon. However, cellulose included in Labile Pool Ⅱ （LP Ⅱ） and the cellulose/total carbohydrates ratio increased in successive rotations of Chinese fir. The noncellulose of carbohydrates included in LPI maybe highly available to soil microbial biomass. Hence the availability of SOC to microbial biomass declined over the successive rotations. Although there was no significant change in recalcitrance of SOC over the successive rotations of Chinese fir, the percentage of heavy fraction to total SOC increased, suggesting that the degree of physical protection for SOC increased and SOC became more stable over the successive rotations. The degradation of SOC quality in successive rotation soils may be attributed to worse environmental conditions resulted from disturbance that related to ＂slash and burn＂ site preparation. Being highly correlated with soil microbial properties, the cellulose/total carbohydrates ratio as an effective indicator of changes in availability of SOC to microbial biomass brought by management practices in forest soils.

关键词： Chinese fir plantation forest soils organic carbon microbial property biochemical quality density fractionation

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Constructing low-valent Ni nanoparticles for highly selective CO_(2) reduction

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Chinese Chemical Letters 2022年第1期33卷 424-427页

作者： Kuanda Xu Shisheng Zheng Yang Li Honghao Chu Qi Xiong zongwei Mei Qinghe Zhao Luyi Yang Shunning Li feng Pan School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China

The electroreduction of CO_(2)(CO_(2)RR)into value-added chemicals is a sustainable strategy for mitigating global warming and managing the global carbon balance.However,developing an efficient and selective catalyst is still the central challenge.Here,we developed a simple two-step pyrolysis method to confine low-valent Ni-based nanoparticles within nitrogen-doped carbon(Ni-NC).As a result,such Ni-based nanoparticles can effectively reduce CO_(2)to CO,with a maximum CO Faradaic efficiency(FE)of 98%at an overpotential of 0.8 V,as long as good stability.Experimental and the density functional theory(DFT)calculation results reveal that low-valent Ni plays a key role in activity and selectivity enhancement.This study presents a new understanding of Ni-based CO_(2)RR,and provides a simple,scalable approach to the synthesis of low-valent catalysts towards efficient CO_(2)RR.

关键词： CO_(2)reduction reaction Ni-based catalysts Electrocatalytic selectivity Low-valent catalyst DFT calculation

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