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A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

Signal Transduction and Targeted Therapy 2024年第7期9卷 3112-3129页

作者： Yuzheng Zhou zongpeng chen Sijie Liu Sixu Liu Yujie Liao Ashuai Du Zijun Dong Yongxing Zhang Xuan chen Siyi Tao Xin Wu Aroona Razzaq Gang Xu De-an Tan Shanni Li Youwen Deng Jian Peng Shuyan Dai Xu Deng Xianwen Zhang Taijiao Jiang Zheng Zhang Gong cheng Jincun Zhao Zanxian Xia Department of Cell Biology School of Life SciencesCentral South University410013 ChangshaChina Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and Technology518112 ShenzhenChina Department of Basic Medicine School of MedicineHunan Normal University410081 ChangshaChina Department of spine surgery The Third Xiangya HospitalCentral South University410013 ChangshaChina School of Basic Medical Sciences Anhui Medical University230032 HefeiChina Hunan Key Laboratory of Neurorestoratology 921 Hospital of Joint Logistics Support Force People’s Liberation Army of China(The Second Affiliated Hospital of Hunan Normal University)410003 ChangshaHunanChina Department of Geriatric Surgery Xiangya HospitalCentral South University410008 ChangshaChina Xiangya School of Pharmaceutical Sciences Central South University410013 ChangshaChina Institute of Infectious Diseases Shenzhen Bay Laboratory518132 ShenzhenChina Guangzhou Laboratory 510005 GuangzhouChina Tsinghua University-Peking University Joint Center for Life Sciences School of MedicineTsinghua University100084 BeijingChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouChina Hunan Key Laboratory of Animal Models for Human Diseases Hunan Key Laboratory of Medical Genetics&Center for Medical GeneticsSchool of Life SciencesCentral South University410008 ChangshaChina

The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune *** its significance,the precise regulatory mechanisms underlying its function remain *** the present study,we unveil that the ORF9b protein of SARS-CoV-2,including emerging mutant strains like Delta and Omicron,can undergo ubiquitination at the K67 site and subsequent degradation via the proteasome pathway,despite certain mutations present among these ***,our investigation further uncovers the pivotal role of the translocase of the outer mitochondrial membrane 70(TOM70)as a substrate receptor,bridging ORF9b with heat shock protein 90 alpha(HSP90α)and Cullin 5(CUL5)to form a *** this complex,CUL5 triggers the ubiquitination and degradation of ORF9b,acting as a host antiviral factor,while HSP90αfunctions to stabilize ***,treatment with HSP90 inhibitors such as GA or 17-AAG accelerates the degradation of ORF9b,leading to a pronounced inhibition of SARS-CoV-2 ***-cell sequencing data revealed an up-regulation of HSP90αin lung epithelial cells from COVID-19 patients,suggesting a potential mechanism by which SARS-CoV-2 may exploit HSP90αto evade the host *** study identifies the CUL5-TOM70-HSP90αcomplex as a critical regulator of ORF9b protein stability,shedding light on the intricate host–virus immune response dynamics and offering promising avenues for drug development against SARS-CoV-2 in clinical settings.

关键词： stability modulator offering

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On the Reactivation of the Pre-Existing Normal Fault

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World Journal of Mechanics 2018年第5期8卷 210-217页

作者： Shuping chen zongpeng chen State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum Beijing China Jackson School of Geosciences University of Texas at Austin Austin USA

The reactivation of pre-existing faults is a common phenomenon in a basin. This paper discusses the relationship between the pre-existing faults and the newly formed Coulomb shear fractures regarding pore fluid pressures. Based on the Coulomb fracture criterion and Byerlee frictional sliding criterion, an equation relating pore pressure coefficient (λe), minimum dip angle (αe) of the reactive pre-existing fault and the intersection point depth (z) between the pre-existing fault and a newly formed Coulomb shear fault in an extensional basin, is established in this paper. This equation enhanced the understanding on the reactivation of pre-existing faults and can be used to calculate paleo-pore fluid pressures. The bigger the pore fluid pressure in a pre-existing fault is, the less the minimum dip angle for a reactive pre-existing fault will be. The minimum dip angle is less in shallow area than that in deep area. This will be of significance in petroleum exploration and development.

关键词： Coulomb Criterion Frictional Sliding Criterion Pre-Existing Fault Pore Fluid Pressure Reactivation

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Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

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A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao Liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation

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Track correlation algorithm based on CNN-LSTM for swarm targets

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Journal of Systems Engineering and Electronics 2024年第2期35卷 417-429页

作者： chen Jinyang WANG Xuhua chen Xian Research Institute for National Defense Engineering Academy of Military SciencesLuoyang 471023China Information Engineering University Zhengzhou 450001China School of Computer Science and Technology Xidian UniversityXi’an 710071China

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for *** this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm ***, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

关键词： track correlation correlation accuracy rate swarm target convolutional neural network(CNN) long short-term memory(LSTM)neural network

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Two-stage Planning Method for Energy Router Considering Its Optimal Operation in Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 605-616页

作者： Meifu chen Mingchao Xia Qifang chen School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China

An energy router can effectively optimize the network loss and power quality of distribution networks. The optimal configuration of the energy router is relatively complex because issues dynamically influence each other, such as the location of the energy router, optimal number and capacity of its ports, and building new distribution lines for the ports. Presently, there has been very few research studies on the practical problems for the energy router. In this paper, a planning model of an energy router combined with the distribution network is established, which fully exploits the active and reactive power control abilities of the energy router to optimize the operation of the grid. The configuration problem is decoupled into two stages. The upper layer determines the location of the energy router and the parameters of the candidate new distribution lines for the ports. The lower layer calculates the optimal configuration of the energy router by minimizing the total annual cost. Because of the same rated bus voltage in the distribution network, the existing structure of the energy router is changed to be more applicable for the distribution network, and then the power flow model of the energy router is also modified. Due to the nonlinearity of the model, the planning model is converted into a mixed-integer second-order cone model to solve efficiently. In addition, some core factors influencing the optimal scheme of the energy router are also analyzed in this paper. Simulation results show that the optimal scheme of the energy router can significantly improve the economic deployment of the energy router, and optimize the network loss and power quality of the distribution network.

关键词： Capacity allocation distribution network energy router optimal operation

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Aerial target threat assessment based on gated recurrent unit and self-attention mechanism

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Journal of Systems Engineering and Electronics 2024年第2期35卷 361-373页

作者： chen chen QUAN Wei SHAO Zhuang School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Intelligent Control and Decision of Complex Systems Beijing 100081China

Aerial threat assessment is a crucial link in modern air combat, whose result counts a great deal for commanders to make decisions. With the consideration that the existing threat assessment methods have difficulties in dealing with high dimensional time series target data, a threat assessment method based on self-attention mechanism and gated recurrent unit(SAGRU) is proposed. Firstly, a threat feature system including air combat situations and capability features is established. Moreover, a data augmentation process based on fractional Fourier transform(FRFT) is applied to extract more valuable information from time series situation features. Furthermore, aiming to capture key characteristics of battlefield evolution, a bidirectional GRU and SA mechanisms are designed for enhanced ***, after the concatenation of the processed air combat situation and capability features, the target threat level will be predicted by fully connected neural layers and the softmax classifier. Finally, in order to validate this model, an air combat dataset generated by a combat simulation system is introduced for model training and testing. The comparison experiments show the proposed model has structural rationality and can perform threat assessment faster and more accurately than the other existing models based on deep learning.

关键词： target threat assessment gated recurrent unit(GRU) self-attention(SA) fractional Fourier transform(FRFT)

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Planning Model for Energy Routers Considering Peer-to-Peer Energy Transactions Among Multiple Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1026-1043页

作者： Meifu chen Mingchao Xia Qifang chen School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China IEEE

A high proportion of renewable energy affects the power quality of distribution networks,and surplus energy will be sold to the upstream grid at a low *** this paper,considering peer-to-peer energy transactions,the energy router-based multiple distribution networks are analyzed to solve the above problems and realize collaborative consumption of renewable ***,the investing cost of an energy router is high,and research on the economic operation of energy routers in distribution networks is ***,this paper establishes a planning model for energy routers considering peer-to-peer energy transactions among distribution networks,and explores the benefits of peer-to-peer energy transactions through energy router based multiple distribution networks.A structure of an energy router suitable for peer-to-peer energy transactions is selected,and a power flow calculation model based on a multilayer structure is *** energy router’s scheduling model is established,and unique functions of the energy router and revenue of each distribution network are considered.A power flow calculation model based on peer-to-peer interconnection of multiple distribution networks through energy routers is also ***,simulation results verify the effectiveness of the proposed planning *** show that peer-topeer energy transaction among distribution networks through energy routers can effectively reduce the comprehensive cost of distribution networks,significantly improve the power quality of the distribution networks,and reduce the impact of power fluctuation on the upstream grid incurred by the distribution network.

关键词： Capacity allocation energy router multiple distribution networks peer-to-peer energy transaction power flow optimization

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Atomically Dispersed Ruthenium Catalysts with Open Hollow Structure for Lithium-Oxygen Batteries

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Nano-Micro Letters 2024年第2期16卷 154-164页

作者： Xin chen Yu Zhang Chang chen Huinan Li Yuran Lin Ke Yu Caiyun Nan chen chen Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Solid State ChemistryUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084People’s Republic of China Beijing Key Laboratory of Energy Conversion and Storage Materials Institution College of ChemistryBeijing Normal UniversityBeijing 100875People’s Republic of China

Lithium–oxygen battery with ultrahigh theoretical energy density is considered a highly competitive next-generation energy storage device,but its practical application is severely hindered by issues such as difficult decomposition of discharge products at ***,we have developed N-doped carbon anchored atomically dispersed Ru sites cathode catalyst with open hollow structure(h-RuNC)for Lithium–oxygen *** one hand,the abundance of atomically dispersed Ru sites can effectively catalyze the formation and decomposition of discharge products,thereby greatly enhancing the redox *** the other hand,the open hollow structure not only enhances the mass activity of atomically dispersed Ru sites but also improves the diffusion efficiency of catalytic ***,the excellent activity from atomically dispersed Ru sites and the enhanced diffusion from open hollow structure respectively improve the redox kinetics and cycling stability,ultimately achieving a high-performance lithium–oxygen battery.

关键词： Atomically dispersed Open hollow structure Discharge product Lithium Oxygen battery

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Thin paints for durable and scalable radiative cooling

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Journal of Energy Chemistry 2024年第3期90卷 176-182,I0006页

作者： Shanquan Liu Fei Zhang Xingyu chen Hongjie Yan Wei chen Meijie chen School of Energy Science and Engineering Central South UniversityChangsha 410083HunanChina School of Intelligent Manufacturing Ecosystem Xi'an Jiaotong-Liverpool UniversitySuzhou 215400JiangsuChina

Passive daytime radiative cooling(PDRC) is environment-friendly without energy input by enhancing the coating's solar reflectance(R_(solar)) and thermal emittance(ε_(LWIR)) in the atmosphere's long-wave infrared transmission ***,high R_(solar) is usually achieved by increasing the coating's thickness,which not only increases materials' cost but also impairs heat ***,the desired high R_(solar) is vulnerable to dust pollution in the *** this work,a thin paint was designed by mixing hBN plates,PFOTS,and IPA. R_(solar)=0.963 and ε_(LWIR)=0.927 was achieved at a thickness of 150 μm due to the high backscattering ability of scatters.A high through-plane thermal conductivity(~1.82 W m^(-1) K^(-1)) also can be *** addition,the porous structure coupled with the binder PFOTS resulted in a contact angle of 154°,demonstrating excellent durability under dust *** experiments showed that the thin paint can obtain a 2.3℃ lower temperature for sub-ambient cooling than the reference PDRC coating in the ***,the above-ambient heat dissipation performance can be enhanced by spraying the thin paint on a 3D heat sink,which was 15.7℃ lower than the reference 1D structure,demonstrating excellent performance for durable and scalable PDRC applications.

关键词： Radiative cooling Heat dissipation Solar reflectance Thermal emittance Contact angle

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