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Blockade of Syk modulates neutrophil immune-responses via the mTOR/RUBCNL-dependent autophagy pathway to alleviate intestinal inflammation in ulcerative colitis

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Precision Clinical Medicine 2023年第4期6卷 213-225页

作者： Fengqin Zhu Dehuai Jing huihui Zhou zongjing hu Yan Wang Guiyuan Jin Yonghong Yang Guangxi Zhou Department of Gastroenterology Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China Medical Research Center Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China

Background:Ulcerative colitis(UC)is a progressive chronic inflammatory *** play a critical role in regulating in-testinal mucosal homeostasis in *** tyrosine kinase(Syk)is involved in several inflammatory ***,we evaluated the effects and underlying mechanisms of Syk on neutrophil immune-responses in ***:Syk expression in the colonic tissues of patients with UC was determined using quantitative reverse transcription-polymerase chain reaction(qRT-PCR),western blotting,and *** biopsies from patients with UC were obtained for single-cell *** isolated from peripheral blood were pre-treated with R788(a Syk inhibitor)and gene differences were determined using RNA *** functions were analyzed using qRT-PCR,flow cytometry,and Transwell assay.R788 was administered daily to mice with dextran sulfate sodium(DSS)-induced colitis to verify the effects of Syk on intestinal ***:Syk expression was increased in inflamed mucosa and neutrophils of patients with UC and positively correlated with dis-ease *** inhibition of Syk in neutrophils decreased the production of pro-inflammatory cytokines,chemokines,neutrophil extracellular traps,reactive oxygen species,and *** and migration of neutrophils were sup-pressed by Syk *** blockade ameliorated mucosal inflammation in DSS-induced murine colitis by inhibiting neutrophil-associated immune ***,Syk regulated neutrophil immune-responses via the mammalian target of rapamycin kinase/rubicon-like autophagy enhancer-dependent autophagy ***:Our findings indicate that Syk facilitates specific neutrophil functional responses to mucosal inflammation in UC,and its inhibition ameliorates mucosal inflammation in DSS-induced murine colitis,suggesting its potential as a novel therapeutic target for UC treatment.

关键词： Syk UC neutrophils autophagy

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粒细胞集落刺激因子动员骨髓干细胞治疗肝脏疾病的研究

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胃肠病学和肝病学杂志 2011年第1期20卷 21-24页

作者：胡宗晶韩明子金世柱高福来哈尔滨医科大学附属第二医院消化内科黑龙江哈尔滨150086 吉林大学附属第一医院消化内科

粒细胞集落刺激因子(G-CSF)是一种促进粒细胞增殖的细胞因子,被广泛应用于各种原因引起的粒细胞减少症并取得了较好的疗效。随着干细胞技术研究的进展,G-CSF作为干细胞动员剂,也得到了广泛的应用。近年来发现G-CSF对肝脏有保护作用,能... 详细信息

粒细胞集落刺激因子(G-CSF)是一种促进粒细胞增殖的细胞因子,被广泛应用于各种原因引起的粒细胞减少症并取得了较好的疗效。随着干细胞技术研究的进展,G-CSF作为干细胞动员剂,也得到了广泛的应用。近年来发现G-CSF对肝脏有保护作用,能够修复受损的肝脏。本文旨在对G-CSF动员骨髓干细胞治疗肝脏疾病进行概述。

关键词：粒细胞集落刺激因子动员骨髓干细胞肝脏疾病

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Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong hu Wenyi Lian Kang hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

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Test and evaluation of modified TADAS devices with different grades of steel

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Earthquake Engineering and Engineering Vibration 2020年第2期19卷 451-464页

作者： Li zongjing Shu Ganping School of Civil Engineering Southeast UniversityNanjing 211189China

Triangular-plate added damping and stiffness(TADAS)devices are reliable metallic energy dissipaters for seismic upgrading used in design and retrofitting of civil *** TADAS devices are designed with closedended *** this study,a modified form of the TADAS device is proposed with open-ended slots in order to reduce the manufacture cost,facilitate the assembling and avoid abrupt stiffness *** and monotonic loading tests are then conducted to investigate the mechanical characteristics of the modified TADAS devices with regular Q345 steel and lowyield point LY160 steel triangular *** test results show that although the hysteresis performances are stable,the cyclic hardening behavior is different between the TADAS specimens with different grades of *** TADAS specimen with LY160 triangular plates exhibits more significant overstrength behavior than the one with Q345 triangular plates in cyclic loading,which is unsuitable to be described by the classic Bouc-Wen ***,a modified Bouc-Wen model is proposed to describe such overstrength *** is shown that the modified model is able to simulate different extent of overstrength behavior in cyclic loading,based on which the cyclic hardening behavior of the TADAS specimen with LY160 triangular plates can be well described.

关键词： TADAS hysteresis Bouc-Wen model monotonic cyclic overstrength

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骨髓干细胞分离技术的探讨

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胃肠病学和肝病学杂志 2010年第6期19卷 569-572页

作者：高福来韩明子金世柱胡宗晶车德馨哈尔滨医科大学附属二院消化内科黑龙江哈尔滨150086 吉林大学第一医院胃肠内科哈尔滨医科大学附属二院普外科黑龙江哈尔滨150086

骨髓干细胞的研究一直是生命科学的热点,而干细胞的提取是这些研究的基础,尤其是纯化、分离骨髓细胞得到单一特定的干细胞更为重要,因此寻找一种简单、易行的纯化方式是解决这些问题的有效途径。因为只有纯化提取所需的干细胞才能进一... 详细信息

骨髓干细胞的研究一直是生命科学的热点,而干细胞的提取是这些研究的基础,尤其是纯化、分离骨髓细胞得到单一特定的干细胞更为重要,因此寻找一种简单、易行的纯化方式是解决这些问题的有效途径。因为只有纯化提取所需的干细胞才能进一步研究其作用,然而如何选择合适的干细胞分离纯化技术是一个比较棘手的问题,本文旨在对常用的骨髓干细胞的纯化方法做一综述。

关键词：骨髓干细胞分离

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P21活化激酶4在胃肠道间质瘤中的表达及意义

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胃肠病学和肝病学杂志 2024年第4期33卷 372-374,380页

作者：高福来赵东强谢长顺李莉胡宗晶郑岳秦皇岛市第一医院消化内科河北秦皇岛066000 河北医科大学第二医院消化内科济宁医学院附属医院消化内科

目的通过研究不同危险度胃肠道间质瘤(gastrointestinal stromal tumor,GIST)中P21活化激酶4(P21-activated kinase 4,PAK4)的表达量,探讨PAK4与GIST危险度的关系。方法选取2020年10月至2021年4月秦皇岛市第一医院病理诊断为GIST患者24例,根据共识将患者分为高危组、中危组、低危组,通过病理切片来确定不同危险度组的PAK4的表达量,并根据Callow计算方法对不同危险度组进行评分。结果PAK4随着GIST危险度增加表达升高,并且与正常对照组织及瘤旁组织相比,GIST中的PAK4表达量升高。结论PAK4表达量与GIST危险度相关,并且随着危险度升高,表达量也升高。

关键词： P21活化激酶4 胃肠道间质瘤危险度

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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基质细胞衍生因子-1对小鼠急性肝损伤修复的实验研究

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胃肠病学和肝病学杂志 2011年第3期20卷 233-236页

作者：高福来韩明子金世柱胡宗晶杨凌燕哈尔滨医科大学附属二院消化内科黑龙江哈尔滨150086 吉林大学第一医院胃肠内科

目的探索基质细胞衍生因子对急性肝损伤修复的影响,并与单纯骨髓单个核细胞移植治疗肝损伤疗效相比较。方法建立小鼠CCl4-AAF肝损伤模型,从小鼠骨髓分离骨髓单个核细胞。实验A组经腹腔向模型小鼠体内注入基质细胞衍生因子,实验B组经尾... 详细信息

目的探索基质细胞衍生因子对急性肝损伤修复的影响,并与单纯骨髓单个核细胞移植治疗肝损伤疗效相比较。方法建立小鼠CCl4-AAF肝损伤模型,从小鼠骨髓分离骨髓单个核细胞。实验A组经腹腔向模型小鼠体内注入基质细胞衍生因子,实验B组经尾静脉向模型小鼠体内注入单个核细胞,对照C组经尾静脉向模型小鼠体内注入生理盐水,在第2周、3周、4周,从各组取出相同的小鼠处死,通过测肝功能指标(AST、ALT、TBil)和肝组织病理切片,比较各组小鼠肝损伤修复的差异。结果分别在第2周、3周、4周测得的SDF-1组(A组)和单个核细胞组(B组)的数值比较(U/L):ALT(第2周:19.0±2.0 vs 19.7±4.7,P>0.05;第3周:19.0±5.0 vs 14.5±2.5,P>0.05;第4周:40.0±17.0 vs 15.0±3.0,P>0.05);AST(第2周:117.1±18.0 vs 116.7±20.0,P>0.05;第3周:97.5±5.0 vs 104.5±23.5,P>0.05;第4周:177.3±61.0 vs 105.0±49.1,P>0.05);TBil(第2周:1.8±0.1 vs 1.9±0.3,P>0.05;第3周:1.75±0.55 vs 1.5±0.4,P>0.05;第4周:1.8±0.6 vs 1.5±0.3,P>0.05)。在病理方面第2周、4周时A组及B组肝细胞仍有肿胀,但组织结构较急性损伤时有明显改善。结论基质细胞衍生因子和单个核细胞都能够促进肝损伤的修复,在病理方面骨髓单个核细胞对损伤修复效果更明显一些。

关键词：基质细胞衍生因子-1 急性肝损伤修复

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大鼠急性肝损伤后经门静脉自体骨髓单个核细胞移植对宿主凝血机制的影响

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胃肠病学和肝病学杂志 2011年第11期20卷 1050-1053页

作者：刘佰玲韩明子蒋晶超高福来胡宗晶哈尔滨医科大学第二附属医院消化内科河北省秦皇岛市第一医院消化内科

目的观察经门静脉大鼠自体骨髓单个核细胞移植后是否形成肝内及肝外血栓。方法应用CCl4/2-AAF制备大鼠急性肝损伤模型,从大鼠骨髓分离骨髓単个核细胞。实验A组:经门静脉注射骨髓单个核细胞0.3 mL/只;B组:经门静脉注射生理盐水0.3 mL/只... 详细信息

目的观察经门静脉大鼠自体骨髓单个核细胞移植后是否形成肝内及肝外血栓。方法应用CCl4/2-AAF制备大鼠急性肝损伤模型,从大鼠骨髓分离骨髓単个核细胞。实验A组:经门静脉注射骨髓单个核细胞0.3 mL/只;B组:经门静脉注射生理盐水0.3 mL/只;分别于移植后两周处死大鼠,取心、肝、肺、脑、肾、脾等组织观察大鼠这些器官有无血栓形成。结果各器官血栓形成情况:HE染色观察移植后2周心、肝、肺、脑、肾均无血栓形成。结论通过门静脉移植的骨髓单个核细胞在急性肝损伤的大鼠各个器官均无血栓形成。

关键词：骨髓单个核细胞血栓急性肝损伤移植

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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