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Signal response amplification of scale-free networks

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Chinese Science Bulletin 2011年第34期56卷 3623-3629页

作者： liu zonghua Institute of Theoretical Physics and Department of Physics East China Normal University Shanghai 200062 China

In many animals and insects, hearing is very acute to the faintest of sounds; the underlying mechanism can be explained by self-tuning. Recently, signal response amplification has been shown to be implemented through networks exhibiting scale-free topology, which has potential applications in artificial information processing systems and devices. We review in this paper the main results obtained in networked double-well oscillators and briefly discuss future research directions.

关键词：无尺度网络信号响应放大信息处理系统参展规模自由拓扑听证会振荡器

pH-responsive vaccine delivery systems for improving cellular immunity

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Progress in Natural Science:Materials International 2020年第5期30卷 609-617页

作者： zonghua liu Linghong Huang Wei Xue Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Department of Biomedical Engineering Jinan University

Immune vaccination is a critically important strategy in disease prevention and treatment. In vaccination, efficient vaccine carriers are necessary to augment the immune response initiated by vaccines generally with weak immunogenecity. Nowadays, commercially available vaccine/carrier formulations induce effective humoral immunity but weak or none cellular immunity. However, in practice, cellular rather than humoral immunity plays the key role in treating some intractable diseases such as AIDS and cancers, in which the elicited cytotoxic T lymphocytes can directly kill HIV-infected or cancer cells. To trigger potent cellular immunity, the carriers should help antigens escape from endosomal/lysosomal degradation and release them directly into the cytosol of antigen presenting cells. To this aim, such kind of vaccine carriers should be rationally designed and prepared in terms of their structure and physiochemical properties. Here, we summarized the recent advances in p H-responsive vaccine carriers exclusively developed for improving cellular immunity.

关键词： Vaccination Vaccine delivery systems Cellular immunity pH-responsive

Understanding the mechanisms of brain functions from the angle of synchronization and complex network

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Frontiers of physics 2022年第3期17卷 165-187页

作者： Tianwei Wu Xinhua Zhang zonghua liu School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Jinhua Middle School Shanghai 200333China

The human brain is the most complicated and fascinated system and executes various important brain functions, but its underlying mechanism is a long-standing problem. In recent years, based on the progress of complex network science, much attention has been paid to this problem and many important results have been achieved, thus it is the time to make a summary to help further studies. For this purpose, we here make a brief but comprehensive review on those results from the aspect of brain networks, i.e., from the angle of synchronization and complex network. First, we briefly discuss the main features of human brain and its cognitive functions through synchronization. Then, we discuss how to construct both the anatomical and functional brain networks, including the pathological brain networks such as epilepsy and Alzheimer’s diseases. Next, we discuss the approaches of studying brain networks. After that, we discuss the current progress of understanding the mechanisms of brain functions, including the aspects of chimera state, remote synchronization, explosive synchronization, intelligence quotient, and remote propagation. Finally, we make a brief discussion on the envision of future study.

关键词： brain functions complex network synchronization chimera state remote synchronization explosive synchronization intelligence quotient remote propagation

Thermal-siphon phenomenon and thermal/electric conduction in complex networks

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National Science Review 2020年第2期7卷 270-277页

作者： Kezhao Xiong zonghua liu Chunhua Zeng Baowen Li State Key Laboratory of Precision Spectroscopy and Department of Physics East China Normal University Department of Physics University of Colorado Boulder Institute of Physical and Engineering Sciences Faculty of Science Kunming University of Science and Technology Department of Mechanical Engineering University of Colorado Boulder

In past decades, a lot of studies have been carried out on complex networks and heat conduction in regular lattices. However, very little attention has been paid to the heat conduction in complex networks. In this work, we study(both thermal and electric) energy transport in physical networks rewired from 2D regular lattices. It is found that the network can be transferred from a good conductor to a poor conductor,depending on the rewired network structure and coupling scheme. Two interesting phenomena were discovered:(i) the thermal-siphon effect—namely the heat flux can go from a low-temperature node to a higher-temperature node and(ii) there exits an optimal network structure that displays small thermal conductance and large electrical conductance. These discoveries reveal that network-structured materials have great potential in applications in thermal-energy management and thermal-electric-energy conversion.

关键词： complex network heat conduction non-linear dynamics thermoelectric properties

Spatial multi-scaled chimera states of cerebral cortex network and its inherent structure-dynamics relationship in human brain

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National Science Review 2021年第1期8卷 56-68页

作者： Siyu Huo Changhai Tian Muhua Zheng Shuguang Guan Changsong Zhou zonghua liu State Key Laboratory of Precision Spectroscopy and Department of Physics East China Normal University School of Data Science Tongren University Department of Physics Centre for Nonlinear Studies and Beijing-Hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems (Hong Kong) Institute of Computational and Theoretical StudiesHong Kong Baptist University Department of Physics Zhejiang University

Human cerebral cortex displays various dynamics patterns under different states, however the mechanism how such diverse patterns can be supported by the underlying brain network is still not well *** brain has a unique network structure with different regions of interesting to perform cognitive *** coupled neural mass oscillators on human cortical network and paying attention to both global and local regions, we observe a new feature of chimera states with multiple spatial scales and a positive correlation between the synchronization preference of local region and the degree of symmetry of the connectivity of the region in the network. Further, we use the concept of effective symmetry in the network to build structural and dynamical hierarchical trees and find close matching between them. These results help to explain the multiple brain rhythms observed in experiments and suggest a generic principle for complex brain network as a structure substrate to support diverse functional patterns.

关键词： synchronization chimera state cerebral cortex network neural mass model

Enhancement of intranasalmucosal immunization of mucosal vaccines by ultrasonic treatment

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Bio-Design and Manufacturing 2023年第4期6卷 405-422页

作者： Haowei Xu Yang Liao Mankovskaya Svetlana Deguang Yang Huaibin Wan zonghua liu Department of Biomedical Engineering Jinan UniversityGuangzhou 510632China Department of Laboratory Medicine General Hospital of Southern Theatre Command of PLAGuangzhou 510010China Institute of Physiology of NAS of Belarus MinskBelarus Department of Cardiology Heyuan Shenhe People’s HospitalThe Fifth Affiliated HospitalJinan UniversityHeyuan 517475China

The pathogens of most infectious diseases invade the host through mucosal sites,and immunization with mucosal vaccines is the best means of combating these infectious *** delivery and nasal delivery are the most common methods of mucosal ***,the delivery process is inefficient,and mucosal vaccination is ineffective because the vaccine formulation is easily and rapidly removed and has difficulty in crossing the mucosal *** this paper,we investigated whether the mucosal immune response could be enhanced by ultrasound facilitation of nasal mucosal delivery of vaccine *** this purpose,we used manganese dioxide(MnO2)as the vaccine carrier/adjuvant,coated with chitosan oligosaccharide(COS)to enhance mucosal adsorption,and further physically adsorbed model antigen ovalbumin(OVA)to construct a nanoparticulate vaccine formulation MnO2@COS@*** treatment was found to promote antigen delivery and recruitment of dendritic cells(DCs)and macrophages as well as T-cell infiltration in nasal mucosal tissues through nasal mucosal immunization *** ultrasound assistance,MnO2@COS@OVA particles promoted the maturation of DCs in vitro and in vivo and promoted the production of effector memory T cells in vivo and cytokine secretion by splenocytes in *** particular,ultrasound treatment significantly increased the levels of secretory IgA antibodies in the nasal mucosa and genital tract mucosa of experimental *** addition,the experimental data showed that the MnO2@COS@OVA particles had good biocompatibility and caused no significant damage to the nasal mucosal and vital organ *** data suggest that ultrasound treatment can promote the induction of efficient immune responses to mucosal vaccines and provide new ideas for the opening and clinical translation of mucosal vaccines.

关键词： Mucosal vaccine Ultrasound treatment MnO2 Nasal delivery

Comparative QTL analysis of maize seed artificial aging between an immortalized F_2 population and its corresponding RILs

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The Crop Journal 2016年第1期4卷 30-39页

作者： Bin Wang Zhanhui Zhang Zhiyuan Fu zonghua liu Yanmin Hu Jihua Tang State Key Laboratory of Wheat and Maize Crop Science/Collaborative Innovation Center of Henan Grain Crops Henan Agricultural University College of Agronomy Henan University of Science and Technology

Seed aging decreases the quality and vigor of crop seeds,thereby causing substantial agricultural and economic losses in *** identify genetic differences in seed aging between homozygotes and heterozygotes in maize,the seeds of a set of recombinant inbred lines(RILs) and an immortalized F_2(IF_2) population were subjected to artificial aging treatments for 0,2,3,and 4 days under 45℃ and 85%relative humidity and seed vigor was then evaluated in a field *** vigor of all entries tested decreased sharply with longer aging treatment and seed vigor decreased more slowly in heterozygotes than in ***-nine QTL were detected for four measured seed vigor traits in the RIL(28QTL) and IF_2(21 QTL) *** one QTL,qGP5,was detected in both populations,indicating that the genes involved in anti-aging mechanisms differed between inbred lines and *** QTL were identified to be responsible for multiple seed vigor traits simultaneously in the RIL and IF_2 populations under artificial aging *** QTL may include major genes for seed vigor or seed *** qVI4 b and qGE3 a detected in the RIL population coincided with genes ZmLOX1 and ZmPLD1 in the same respective chromosomal *** QTL would be useful for screening for anti-aging genes in maize breeding.

关键词： Maize(Zea mays L.) Seed vigor Artificial aging QTL mapping Seed storage

Systematic dissection of disease resistance to southern corn rust by bulked-segregant and transcriptome analysis

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The Crop Journal 2022年第2期10卷 426-435页

作者： Xiaohuan Mu Zhuangzhuang Dai Zhanyong Guo Hui Zhang Jianping Yang Xinke Gan Jiankun Li zonghua liu Jihua Tang Mingyue Gou State Key Laboratory of Wheat and Maize Crop Science Collaborative Innovation Center of Henan Grain CropsCollege of AgronomyHenan Agricultural UniversityZhengzhou 450002HenanChina

Southern corn rust(SCR) is a destructive maize disease caused by Puccinia polysora Underw. To investigate the mechanism of SCR resistance in maize, a highly resistant inbred line, L119 A, and a highly susceptible line, Lx9801, were subjected to gene mapping and transcriptome analysis. Bulked-segregant analysis coupled with whole-genome sequencing revealed several quantitative trait loci(QTL) on chromosomes 1, 6, 8, and 10. A set of 25 genes, including two coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) genes, were identified as candidate genes for a major-effect QTL on chromosome 10. To investigate the mechanism of SCR resistance in L119 A, RNA-seq of P. polysorainoculated and non-inoculated plants of L119 A and Lx9801 was performed. Unexpectedly, the number of differentially expressed genes in inoculated versus non-inoculated L119 A plants was about 10 times that of Lx9801, with only 29 common genes identified in both lines, suggesting extensive gene expression changes in the highly resistant but not in the susceptible line. Based on the transcriptome analysis, one of the CC-NBS-LRR candidate genes was confirmed to be upregulated in L119 A relative to Lx9801 independently of P. polysora inoculation. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that transcription factors, as well as genes involved in defense responses and metabolic processes, were dominantly enriched, with the phenylpropanoid biosynthesis pathway most specifically activated. Consistently, accumulation of phenylpropanoid-derived lignin, especially S lignin, was drastically increased in L119 A after P. polysora inoculation, but remained unchanged in Lx9801, suggesting a critical role of lignin in SCR resistance. A regulatory network of defense activation and metabolic change in SCR-resistant maize upon P. polysora infection is described.

关键词： Maize Southern corn rust BSA-seq RNA-seq Lignin

A peptide chain release factor 2a gene regulates maize kernel development by modulating mitochondrial function

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The Crop Journal 2023年第6期11卷 1731-1741页

作者： Hui Zhang Yijian Feng Kunyang Song Guofang Li Jiao Jin Jingjing Gao Yongtian Qin Hongqiu Wang Jinpeng Cheng zonghua liu Jihua Tang Zhiyuan Fu Key Laboratory of Wheat and Maize Crops Science/Collaborative Innovation Center of Henan Grain Crops/College of Agronomy Henan Agricultural UniversityZhengzhou 450046HenanChina The Shennong Laboratory Zhengzhou 450002HenanChina Hebi Academy of Agricultural Sciences Hebi 458030HenanChina Yunnan Tang Jihua Expert Workstation/Zhaotong Academy of Agricultural Sciences Zhaotong 657000YunnanChina

Mitochondrial protein translation that is essential for aerobic energy production includes four essential steps of the mitochondrial ribosome cycle,namely,initiation,elongation,termination of the polypeptide,and ribosome *** termination initiates when a stop codon enters the A site of the mitochondrial ribosome where it is recognized by a dedicated peptide release factor(RF).However,RFs and mechanisms involved in translation in plant mitochondria,especially in monocotyledons,remain largely ***,we identified a crumpled kernel(crk5 allele)mutant,with significantly decreased kernel size,100-kernel weight,and an embryo-lethal *** Crk5 allele was isolated using map-based cloning and found to encode a mitochondrial localization *** it is an ortholog of Arabidopsis mitochondrial RF2a,we named the gene ***2a is missing the 5th–7th exons in the crk5 resulting in deletion of domains containing motifs GGQ and SPF that are essential for release activity of RF,mitochondrial ribosome binding,and stop codon *** blot and qRT-PCR analyses indicate that the crk5 mutation results in abnormal mitochondrion structure and ***,we observed a feedback loop in the crk5 with up-regulated transcript levels detected for several mitochondrial ribosome and mitochondrial-related components,in particular mitochondrial complexes CI,CIV,and a ribosome assembly related ***,our data support a crucial role for ZmmtRF2a in regulation of mitochondrial structure and function in maize.

关键词： Embryo lethality Mitochondrion Peptide release factor 2 Zea mays