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4K腹腔镜右半结肠癌D3根治术手术要点

中华消化外科杂志 2021年第S1期20卷 38-42页

作者：杨烈周总光四川大学华西医院胃肠外科

腹腔镜右半结肠癌D3根治术,应严格遵循无瘤原则和全结肠系膜切除术原则,整块切除病灶及其淋巴引流区域,沿Toldt间隙精准解剖,保证足够切缘和彻底淋巴结清扫。采用4K腹腔镜将超高清画面呈现于超大显示屏,更有利于术者分辨解剖平面,进行... 详细信息

腹腔镜右半结肠癌D3根治术,应严格遵循无瘤原则和全结肠系膜切除术原则,整块切除病灶及其淋巴引流区域,沿Toldt间隙精准解剖,保证足够切缘和彻底淋巴结清扫。采用4K腹腔镜将超高清画面呈现于超大显示屏,更有利于术者分辨解剖平面,进行精准解剖。

关键词：结肠肿瘤 D3根治术并发症 4K分辨率腹腔镜检查

Association of T cell factor-4 mRNA expression with clinicopathological characteristics of colorectal cancer

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The Chinese-German Journal of Clinical Oncology 2008年第10期7卷 584-586页

作者： Junfeng Wang zongguang zhou Dianchao Wu Department of Colorectal Cancer Tianjin Medical University Cancer Hospital Tianjin 300060 China Institute of Digestive Surgery West China Hospital Sichuang University Chengdu 610041 China

Objective： To study the expression of T-cell transcription factor-4 （Tcf-4） gene in human colorectal cancer （CRC） and the relationship between Tcf-4 gene and progression of CRC. Methods： Quantitative real time RT-PCR was used to de- tect the expression of Tcf-4 mRNA in 31 CRC and para-cancerous tissues. The correlation of expression of the Tcf-4 gene with clinicopathologicel characteristics of CRC was also analyzed. Results： Compared with normal tissues, up-regulation of Tcf4 mRNAwas observed in 31 CRC tissues （t = 2.188, P = 0.037）. The expression values of Tcf-4 mRNA in Dukes A, B, C and D were 8.38 ＋ 1.92, 6.93 ＋ 1.44, 6.00 ＋ 1.26 and 3.50 ＋ 0.71 respectively. Analyzed by one-way ANOVA, there were significant differences in the expressions of Tcf-4 in different Dukes stages （F = 6.454, P = 0.002）. Moreover, the over-expression of Tcf-4 was significantly correlated with lymph node metastases. However the expression of Tcf-4 was no correlation with the age, gender of patients and cell differentiation of CRC in this study. Conclusion： The higher expression level of Tcf-4 mRNA in CRC tissues suggested that the over-expression of Tcf-4 gene may be related to the development and invasion of CRC.

关键词： colorectal cancer Tcf-4 mRNA quantitative real time RT-PCR

Neurons generated from carcinoma stem cells support cancerprogression

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Signal Transduction and Targeted Therapy 2017年第1期2卷 320-329页

作者： Ran Lu Chuanwen Fan Wenqi Shangguan Yuan Liu Yu Li Yanna Shang Dongqin Yin Shengliang Zhang Qiaorong Huang Xue Li Wentong Meng Hong Xu zongguang zhou Jiankun Hu Weimin Li Lunxu Liu Xianming Mo Laboratory of Stem Cell Biology State Key Laboratory of Biotherapy/Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengduChina Institute of Digestive Surgery State Key Laboratory of Biotherapy/Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengduChina Department of Gastrointestinal Surgery State Key Laboratory of Biotherapy/Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengduChina Laboratory of Gastric Cancer State Key Laboratory of Biotherapy/Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine State Key Laboratory of Biotherapy/Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengduChina Department of Thoracic Surgery State Key Laboratory of Biotherapy/Collaborative Innovation Center of BiotherapyWest China hospitalSichuan UniversityChengduChina.

Recent evidences show that nervous system acts as a crucial part of cancer *** of nerve fibers into cancer microenvironment has an important active role in cancer *** stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been ***,how the nervous system is built in cancer is largely *** we show that a fraction of cancer stem cells(CSCs)derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor *** stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer *** down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse *** data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression.

关键词： cancer inhibited stimulation

Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis

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Signal Transduction and Targeted Therapy 2022年第3期7卷 934-947页

作者： Xiaobo Zheng Jinen Song Chune Yu zongguang zhou Xiaowei Liu Jing Yu Guangchao Xu Jiqiao Yang Xiujing He Xin Bai Ya Luo Yu Bao Huifang Li Lie Yang Mingqing Xu Nan Song Xiaodong Su Jie Xu Xuelei Ma Hubing Shi Laboratory of Integrative Medicine Clinical Research Center for BreastState Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation Center610041 ChengduSichuanChina Frontier Science Center for Disease Molecular Network West China HospitalSichuan University610041 ChengduSichuanChina Institute of Digestive Surgery Sichuan Universityand Department of Gastrointestinal SurgeryWest China HospitalWest China School of MedicineSichuan University610041 ChengduSichuanChina Research Core Facility West China HospitalSichuan University610041 ChengduSichuanChina Department of Gastrointestinal Surgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan Universityand Collaborative Innovation Center for Biotherapy610041 ChengduSichuanChina Department of Liver Surgery West China HospitalSichuan University610041 ChengduSichuanChina Beijing Institute of Tropical Medicine Beijing Friendship HospitalCapital Medical University100050 BeijingChina Biomedical Pioneering Innovation Center(BIOPIC) and State Key Laboratory of Protein and Plant Gene ResearchPeking University100871 BeijingChina Institutes of Biological Sciences Zhongshan-Xuhui HospitalFudan University200032 ShanghaiChina Department of biotherapy State Key Laboratory of BiotherapyCancer CenterWest China HospitalSichuan University610041 ChengduSichuanChina

The adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal ***,cellular heterogeneity in aberrant epithelial cells limits our understanding of carcinogenesis in colorectal ***,we performed a single-cell RNA sequencing survey of 54,788 cells from patient-matched tissue samples,including blood,normal tissue,para-cancer,polyp,and colorectal cancer.

关键词： colorectal cancer adenoma

局部进展期中低位直肠癌新辅助放化疗后的治疗选择

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中华胃肠外科杂志 2014年第11期17卷 1068-1071页

作者：王自强周总光四川大学华西医院胃肠外科成都610041

直肠癌放化疗出现临床完全缓解或显著缓解后密切观察及局部切除已成为中低位直肠癌治疗的新治疗策略.但由于放化疗后分期准确性低、临床与病理缓解的低符合率以及淋巴结转移状态的不确定性等因素,保留直肠治疗策略的确切适应证尚存争议... 详细信息

直肠癌放化疗出现临床完全缓解或显著缓解后密切观察及局部切除已成为中低位直肠癌治疗的新治疗策略.但由于放化疗后分期准确性低、临床与病理缓解的低符合率以及淋巴结转移状态的不确定性等因素,保留直肠治疗策略的确切适应证尚存争议,应结合放化疗疗效及放化疗前肿瘤分期确定具体治疗方式,对分期较早（如：cT0-2）放化疗显著缓解（如：ypT0-1）的中低位直肠癌患者可选择密切观察或局部切除,局切后根据病理结果决定后续治疗策略,反之仍宜直接施行根治性手术.根治性手术方式可根据放化疗后分期重新评估,宜在放化疗后6～12周内进行。

关键词：直肠肿瘤新辅助放化疗外科手术治疗策略

骨髓间充质干细胞旁分泌因子治疗重症急性胰腺炎的潜能

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生物医学工程学杂志 2015年第1期32卷 245-248页

作者：陈珂玲(综述) 周总光(综述) 周斌(综述) 李园(审校) 四川大学生物治疗国家重点实验室消化外科研究室成都610041

骨髓间充质干细胞(BMSC)移植是重症急性胰腺炎(SAP)治疗的研究热点。但在临床应用中,该治疗方式却遇到了诸多技术及伦理问题。BMSC的旁分泌因子具有与细胞移植同样的疗效,且可减少上述生物安全问题,具有更安全、更易操控的治疗优势。本... 详细信息

骨髓间充质干细胞(BMSC)移植是重症急性胰腺炎(SAP)治疗的研究热点。但在临床应用中,该治疗方式却遇到了诸多技术及伦理问题。BMSC的旁分泌因子具有与细胞移植同样的疗效,且可减少上述生物安全问题,具有更安全、更易操控的治疗优势。本文就BMSC旁分泌因子在SAP中的治疗潜能作一综述,注射含旁分泌因子的BMSC培养上清有望成为未来SAP细胞治疗的新策略。

关键词：重症急性胰腺炎骨髓间充质干细胞旁分泌因子

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4K腹腔镜直肠癌侧方淋巴结清扫与关键技术

中华消化外科杂志 2021年第S1期20卷 73-78页

作者：杨盈孟文建王自强周总光四川大学华西医院胃肠外科

侧方淋巴转移是中低位直肠癌的主要转移方式,也是导致术后局部复发的重要原因。单纯放化疗对控制侧方淋巴结转移效果不佳,而侧方淋巴结清扫术因增加术后泌尿及性功能障碍发生率而备受争议。4K超高清腹腔镜系统可提供更高清的手术视野和... 详细信息

侧方淋巴转移是中低位直肠癌的主要转移方式,也是导致术后局部复发的重要原因。单纯放化疗对控制侧方淋巴结转移效果不佳,而侧方淋巴结清扫术因增加术后泌尿及性功能障碍发生率而备受争议。4K超高清腹腔镜系统可提供更高清的手术视野和更细腻的细节分辨,有利于侧方淋巴结清扫术中对盆腔自主神经、髂内血管等重要解剖结构的识别和显露,最终达到良好的肿瘤根治效果及脏器功能保护。因此,选择性施行侧方淋巴结清扫术可降低病人盆腔复发风险。笔者通过手术实例探讨4K腹腔镜系统用于保留盆腔自主神经的直肠癌侧方淋巴结清扫范围与关键技术。

关键词：直肠肿瘤侧方淋巴结转移侧方淋巴结清扫手术三间隙清扫 4K分辨率腹腔镜检查

加速康复外科模式下结直肠癌患者出院后短期生活质量现状及影响因素分析

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中华医学杂志 2019年第22期99卷 1707-1711页

作者：杨婕贺育华蒋理立周总光李卡四川大学华西医院胃肠外科成都610041 四川大学华西护理学院成都610041

目的了解加速康复外科模式下结直肠癌患者出院后短期生活质量现状,并探讨影响因素。方法分别于出院时、术后1个月采用出院准备度量表、癌症患者生活质量量表对加速康复外科模式下127例结直肠癌患者进行调查。结果结直肠癌患者术后1个月... 详细信息

目的了解加速康复外科模式下结直肠癌患者出院后短期生活质量现状,并探讨影响因素。方法分别于出院时、术后1个月采用出院准备度量表、癌症患者生活质量量表对加速康复外科模式下127例结直肠癌患者进行调查。结果结直肠癌患者术后1个月时生活质量总体健康状况领域得分为(66.8±18.8)分,学历、术式、肠造口以及出院准备度是其影响因素。结论加速康复外科模式下结直肠癌患者出院后短期生活质量处于中等偏上水平。低学历、开腹手术、有肠造口以及出院准备度低的患者在术后1个月时生活质量较差,应将其作为医疗关注的重点对象。

关键词：加速康复外科结直肠癌生活质量影响因素

胃癌4K腹腔镜手术操作标准专家共识(2020版)

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中华消化外科杂志 2020年第5期19卷 455-464页

作者：无余佩武周总光郑民华赵永亮何显力中国研究型医院学会机器人与腹腔镜外科专业委员会中国医师协会内镜医师分会腹腔镜外科专业委员会中华医学会外科学分会腹腔镜与内镜外科学组陆军军医大学第一附属医院普通外科重庆400038 四川大学华西医院胃肠外科中心成都610041 上海交通大学医学院附属瑞金医院普通外科 200025 不详

胃癌是我国常见恶性肿瘤,其发病率在恶性肿瘤中排名第2位,病死率排名第3位,每年新发及死亡病例数均接近全世界的50%[1-2]。胃癌的治疗是以手术为核心的综合性治疗,手术的彻底性,手术操作的规范化与标准化都对患者预后具有重要影响。我... 详细信息

胃癌是我国常见恶性肿瘤,其发病率在恶性肿瘤中排名第2位,病死率排名第3位,每年新发及死亡病例数均接近全世界的50%[1-2]。胃癌的治疗是以手术为核心的综合性治疗,手术的彻底性,手术操作的规范化与标准化都对患者预后具有重要影响。我国胃癌患者主要以进展期为主,胃癌D2淋巴结清扫术作为患者治疗的标准手术方式已广泛开展[3-4]。

关键词：胃肿瘤手术标准 4K腹腔镜淋巴结清扫神经保护共识