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CCS Chemistry 2024年第10期6卷 2420-2426页

作者： Shixue Zhang Liang cheng jian-Qing Qi Zongbin jia Long Zhang Lei jiao Xingwei Guo Sanzhong Luo Center of Basic Molecular Science(CBMS) Department of ChemistryTsinghua UniversityBeijing 100084

Enamine-derived radicals are crucial intermediates in singly occupied molecular orbital(SOMO)***,observing them directly is elusive and remains a long-standing ***,an advanced time-resolved electron paramagnetic resonance technique was employed to characterize and monitor the key intermediates in photoredox transformations by primary aminocatalysis on a microsecond *** transient enamine radical cation,generated by single electron transfer(SET),and the deprotonated form ofα-imino radical intermediates were directly observed for the first time,both spectroscopically and *** reactions with styrene,enamine radical cation was found to be faster thanα-imino radical by one order of *** revealed the subtle role of deprotonation associated with secondary enamine radical cation in the photoredox transformations by primary aminocatalysis.

关键词： aminocatalysis radical chemistry electron paramagnetic resonance direct observation time-resolved technique

Noninvasive Detection of Cerebral Blood Flow and Blood Oxygen Based on Inductive Sensing Technology and Near Infrared Spectroscopy

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Journal of Beijing Institute of Technology 2024年第3期33卷 204-212页

作者： cheng Zhou Zexiang Lyu Maoting Zhang Xin Zou Liang Wei Feng Wang Mingxin Qin jia Xu jian Sun College of Biomedical Engineering Army Medical UniversityChongqing 400038China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Department of Medical Engineering Xinqiao HospitalChongqing 400037China

The synchronous monitoring of cerebral blood flow and blood oxygen levels plays a pivotal role in the prevention,diagnosis,and treatment of cerebrovascular *** study introduces a novel noninvasive device utilizing inductive sensing and near-infrared spectroscopy technology to facilitate simultaneous monitoring of cerebral blood flow and blood oxygen *** device consists of modules for cerebral blood flow monitoring,cerebral blood oxygen monitoring,control,communication,and a host *** experiments conducted on healthy subjects,it was confirmed that the device can effectively achieve synchronous monitoring and recording of cerebral blood flow and blood oxygen *** results demonstrate the device’s capability to accurately measure these signals *** technology enables dynamic monitoring of cerebral blood flow and blood oxygen signals with potential clinical applications in preventing,diagnosing,treating cerebrovascular diseases while reducing their associated harm.

关键词： cerebrovascular disease synchronous monitoring inductive sensing near infrared spec-troscopy(NIRS)

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Natural product chlorogenic acid achieves pharmacological activity and health protection via regulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Ke Fu Shu Dai Yafang Zhang jia Gong cheng Wang Chenhao Yao Shenglin Zhang cheng Peng Yunxia Li State Key Laboratory of Southwestern Chinese Medicine Resources， Key Laboratory of Standardization for Chinese Herbal Medicine， Ministry of Education， School of Pharmacy， chengdu University of Traditional Chinese Medicine College of Enology， Northwest A&F University

Chlorogenic acid (CA) is a natural plant-derived polyphenol compound that is widely present in beverages (coffee and tea)， fruits (blueberry， apple， and mulberry)， and medicinal plants (Lonicera japonica， Eucommia ulmoides， and Cichorium intybus). In recent years， CA has attracted extensive attention due to its various health benefits， such as anti-inflammatory， immunomodulatory， anti-obesity， anti-diabetes mellitus， and neuroprotection activities. Interestingly， the low bioavailability of CA corresponds to high bioactivity， which raises a key scientific question of how low bioavailability CA can achieve high biological activity. In this review， we highlight the gut microbiota as a key target for connecting the two by summarizing a large amount of evidence. Specifically， the composition and abundance of gut microbiota， its metabolites， intestinal immunity， barrier function and so on were all changed under different pathological conditions such as inflammatory bowel disease， liver disease， kidney disease， cardiovascular disease， diabetes mellitus， obesity， etc. Conversely， these changes could be reversed by CA. In a word， CA could achieve pharmacological activity as well as health-protective effects by modulating intestinal immune and barrier function， gut microbiota composition， gut microbiota metabolites， and signaling pathways. This review provides new targets for the prevention and treatment of diseases by CA. Meanwhile， regulating the composition of the gut microbiota through natural products may be a potential strategy to achieve health protection.

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Rapid progress of an iris metastasis from esophageal cancer:a case report and review of literature

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1557-1567页

作者： Meng Xie Xing-Hua Wang Jun-Jie Yang Zi-Xuan Su jia-Hui Huang Peng-cheng Li Fa-Gang jiang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocular metastatic *** emission tomographycomputed tomography played a crucial role in identifying primary sites and systemic *** treatment combined with systemic therapy effectively reduced tumor size,preserved useful vision,and improved the patient’s survival rate.A comparison was made of the characteristics of iris metastases from esophageal cancer and lung cancer,including age,gender,tumor characteristics,and *** challenges associated with diagnosis and treatment are discussed,highlighting the implications for clinical practice.

关键词： iris metastasis esophageal cancer positron emission tomography-computed tomography review

基于改进动态窗口的车库AGV路径规划及仿真

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系统仿真学报 2024年第10期36卷 2265-2276页

作者：马宗方张琳旋宋琳王嘉西安建筑科技大学信息与控制工程学院陕西西安710055

针对在智能车库环境下,移动机器人(AGV)在作业过程中面临着复杂路径环境下的路径规划和实时避障,提出一种改进的蚁群算法与动态窗口法(DWA)相结合的混合算法。在全局规划中引入自适应调整信息素挥发系数,融合角度参数建立车库方向信息... 详细信息

针对在智能车库环境下,移动机器人(AGV)在作业过程中面临着复杂路径环境下的路径规划和实时避障,提出一种改进的蚁群算法与动态窗口法(DWA)相结合的混合算法。在全局规划中引入自适应调整信息素挥发系数,融合角度参数建立车库方向信息素矩阵,增大目标点引导能力,扩大蚂蚁的方向选择性;在局部规划中设计基于椭圆方程的障碍物距离评价子函数的改进动态窗口法,并提取改进蚁群算法的全局关键节点作为新增的路径评价子函数,在全局路径的约束下,保持动态规划的最优性。仿真结果表明:改进算法较传统算法能够较好地应对突发的动静态障碍物,更符合AGV实际作业过程中在多重环境因素的影响下的动态规划要求。

关键词：车库AGV 蚁群算法动态窗口法动静态避障路径规划椭圆方程

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Enriched electrophilic oxygen species facilitate acidic oxygen evolution on Ru-Mo binary oxide catalysts

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Nano Research 2024年第3期17卷 1165-1172页

作者： Yaya Wang Yunzhou Wen Yumeng cheng Xinhong Chen Mengjiao Zhuansun Tongbao Wang Jun Li Debora Meira Huarui Sun Jun Wei jia Zhou Yuhang Wang Sisi He Shenzhen Key Laboratory of Flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China School of Science Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123China Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai 200240China Science Division Canadian Light SourceSaskatoonSKS7N 2V3Canada Photon Science Division Argonne National LaboratoryLemontIL60439USA School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China

The polymer electrolyte membrane(PEM)electrolyzers are burdened with costly iridium(Ir)-based catalysts and high operation overpotentials for the oxygen evolution reaction(OER).The development of earth-abundant,highly active,and durable electrocatalysts to replace Ir is a critical step in reducing the cost of green hydrogen *** we develop a Ru5Mo4Ox binary oxide catalyst that exhibits high activity and stability in acidic *** electron-withdrawing property of Mo enriches the electrophilic surface oxygen species,which promotes acidic OER to proceed via the adsorbate evolution *** a result,we achieve a 189 mV overpotential at 10 mA·cm^(-2) and a Tafel slope of 48.8 mV·dec^(-1).Our catalyst demonstrates a substantial 18-fold increase in intrinsic activity,as evaluated by turnover frequency,compared to commercially available RuO_(2) and IrO_(2) ***,we report a stable OER operation at 10 mA·cm^(-2) for 100 h with a low degradation rate of 2.05 mV·h^(-1).

关键词： electrocatalysis oxygen evolution reaction(OER) ruthenium(Ru)-based oxide molybdenum electrophilic oxygen

Mechanism of mesenchymal stem cells in liver regeneration:Insights and future directions

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World Journal of Stem Cells 2024年第9期16卷 842-845页

作者： Yu-Xin Jin Hang-Qi Hu jia-cheng Zhang Xi-Yan Xin Yu-Tian Zhu Yang Ye Dong Li Department of Traditional Chinese Medicine Peking University Third HospitalBeijing 100191China

Mesenchymal stem cells(MSCs)are a prevalent source for stem cell therapy and play a crucial role in modulating both innate and adaptive immune ***-alcoholic fatty liver disease(NAFLD)is characterized by the accumulation of triglycerides in liver cells and involves immune system activation,leading to histological changes,tissue damage,and clinical symptoms.A recent publication by jiang et al,highlighted the potential of MSCs to mitigate in NAFLD progression by targeting various molecular pathways,including glycolipid metabolism,inflammation,oxidative stress,endoplasmic reticulum stress,and *** this editorial,we comment on their research and discuss the efficacy of MSC therapy in treating NAFLD.

关键词： Mesenchymal stem cells Liver regeneration Non-alcoholic fatty liver disease Immune cells Therapeutic strategy

Application value of indocyanine green fluorescence imaging in guiding sentinel lymph node biopsy diagnosis of gastric cancer: Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1883-1893页

作者： Qi-jia Zhang Zhi-cheng Cao Qin Zhu Yu Sun Rong-Da Li Jin-Long Tong Qin Zheng Department of Oncology The Second Hospital of NanjingAffiliated to Nanjing University of Chinese MedicineNanjing 210003Jiangsu ProvinceChina Department of Gastrointestinal Surgery Qilu Hospital of Shandong UniversityJinan 250063Shandong ProvinceChina

BACKGROUND Gastric cancer is a common malignant tumor of the digestive system worldwide,and its early diagnosis is crucial to improve the survival rate of *** green fluorescence imaging(ICG-FI),as a new imaging technology,has shown potential application prospects in oncology *** meta-analysis to study the application value of ICG-FI in the diagnosis of gastric cancer sentinel lymph node biopsy is helpful to comprehensively evaluate the clinical effect of this technology and provide more reliable guidance for clinical *** To assess the diagnostic efficacy of optical imaging in conjunction with indocya-nine green(ICG)-guided sentinel lymph node(SLN)biopsy for gastric *** Electronic databases such as PubMed,Embase,Medline,Web of Science,and the Cochrane Library were searched for prospective diagnostic tests of optical imaging combined with ICG-guided SLN *** 12.0 software was used for analysis by combining the"bivariable mixed effect model"with the"midas"*** true positive value,false positive value,false negative value,true negative value,and other information from the included literature were extracted.A literature quality assessment map was drawn to describe the overall quality of the included literature.A forest plot was used for heterogeneity analysis,and P50%),meta-regression analysis and subgroup analysis were *** were *** Optical imaging involves two methods:Near-infrared(NIR)imaging and fluorescence imaging.A combination of optical imaging and ICG-guided SLN biopsy was useful for *** positive likelihood ratio was

关键词： Gastric neoplasms Sentinel lymph nodes Near infrared imaging Fluorescence imaging Indocyanine green Meta-analysis

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

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Bone Research 2024年第2期12卷 334-348页

作者： Ziqian Xiang Pengfei Zhang Chunwang jia Rongkun Xu Dingren Cao Zhaoning Xu Tingting Lu Jingwei Liu Xiaoxiong Wang cheng Qiu Wenyang Fu Weiwei Li Lei cheng Qiang Yang Shiqing Feng Lianlei Wang Yunpeng Zhao Xinyu Liu Department of Orthopaedics Qilu Hospital of Shandong UniversityJinan 250012China University of Health and Rehabilitation Sciences Qingdao 226000China Xiangya School of Medicine Central South UniversityChangsha 410013China School of Nursing and Rehabilitation Shandong UniversityJinan 250012China Department of Pediatrics Cangzhou Central HospitalCangzhou 061011China Department of Pediatric Surgery Qilu Hospital of Shandong UniversityJinan 250012China Department of Pathology Qilu Hospital of Shandong UniversityJinan 250012China Department of Spine Surgery Tianjin HospitalTianjin UniversityTianjin 30021China The Second Hospital of Shandong University Cheeloo College of MedicineShandong UniversityJinan 250012China

To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be ***,Piezo1 channel was identified as a key iron transporter in response to mechanical ***1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron ***,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical ***,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.

关键词： stress overload channel

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Waterproofing Technology of Underground Subway Tunnels

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Journal of Architectural Research and Development 2024年第3期8卷 110-116页

作者： Ruiquan Liu Jinxiao jia Xi cheng China Merchants Chongqing Highway Engineering Testing Center Co. Ltd.Chongqing 400060China

The waterproof construction of subway tunnels is a crucial and challenging aspect of subway tunnel *** excellent waterproof construction technology is essential to ensure that the construction meets design requirements and guarantees the safe operation of subway *** paper focuses on discussing waterproof construction technology for subway station *** analyzing the main methods and techniques of underground tunnel construction,as well as the key techniques and difficulties of waterproofing construction,this paper examines the waterproofing construction project of Guangzhou Metro Culture Park Station as a case *** analyzes the methods,quality management practices,and safety management strategies applied in the *** paper serves as a reference for tunnel engineering design and construction units in our country,offering insights into effective waterproof construction techniques for subway tunnels.

关键词： Concealed tunnel Waterproof construction Quality management Safety management