检索结果-南通市图书馆

Gut microbiota in muscular atrophy development,progression,and treatment:New therapeutic targets and opportunities

The Innovation 2023年第5期4卷 96-108页

作者： Shujie Chen Puxuan Zhang Huimin Duan Jie Wang Yuyueyang Qiu zongbin cui Yulong Yin Dan Wan Liwei Xie State Key Laboratoryof Apied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Cuture Clletion and AplicatinGuangdong Open Laboratory ofApplied MicrobiologyInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China Department of Endocrinology and Metabolism Zhujiang HospitalSouthern Medical Univer sityGuangzhou 510280China Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 100000China School of Public Health Xinxiang Medical UniversityXinxiang 453003China Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agroecological Processes in Subtropical RegionIstitute of Subtropical AgricutureChinese Academy of SciencesChangsha 410125China University of the Chinese Academy of Sciences Beijing 101408China Department of Stomatology Shunde Hospital Southern Medical University(The First People's Hospital of ShundeFoshan)Foshan 528308China Department of Life Sciences Imperial College LondonLondon SW72AZUK Department of Biology Grinnell CollgeGrinellIA 501122USA

Skeletal muscle atrophy is a debilitating condition that significantly affects quality of life and often lacks effective treatment options.Muscle atrophy can have various causes,including myogenic,neurogenic,and other factors.Recent investigation has underscored a compelling link between the gut microbiota and skeletal muscle.Discerning the potential differences in the gut microbiota associated with muscle atrophy-related diseases,understanding their influence on disease development,and recognizing their potential as intervention targets are of paramount importance.This review aims to provide a comprehensive overview of the role of the gut microbiota in muscle atrophy-related diseases.We summarize clinical and pre-clinical studies that investigate the potential for gut microbiota modulation to enhance muscle performance and promote disease recovery.Furthermore,we delve into the intricate interplay between the gut microbiota and muscle atrophy-related diseases,drawing from an array of studies.Emerging evidence suggests significant differences in gut microbiota composition in individuals with muscle atrophy-related diseases compared with healthy individuals.It is conceivable that these alterations in the microbiota contribute to the pathogenesis of these disorders through bacterium-related metabolites or inflammatory signals.

关键词： atrophy diseases alterations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New glimpses of caveolin-1 functions in embryonic development and human diseases

引用

Frontiers in Biology 2011年第5期6卷 367-376页

作者： Saijun MO Shengli YANG zongbin cui Department of Basic Oncology College of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China Key Laboratory of Biodiversity and Conservation of Aquatic Organism Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China

Caveolin-1(Cav-1)isoforms,including Cav-1αand Cav-1β,were identified as integral membrane proteins and the major components of caveolae.Cav-1 proteins are highly conserved during evolution from Caenorhabditis elegans to human and are capable of interacting with many signaling molecules through their caveolin scaffolding domains to regulate the activities of multiple signaling pathways.Thus,Cav-1 plays crucial roles in the regulation of cellular proliferation,differentiation and apoptosis in a cell-specific and contextual manner.In addition,Cav-1 is essential for embryonic development of vertebrates owing to its regulation of BMP,Wnt,TGF-βand other key signaling molecules.Moreover,Cav-1 is mainly expressed in terminally differentiated cells and its abnormal expression is often associated with human diseases,such as tumor progression,cardiovascular diseases,fibrosis,lung regeneration,and diseases related to virus.In this review,we will further discuss the potential of Cav-1 as a target for disease therapy and multiple drug resistance.

关键词： Caveolin-1 signal transduction embryonic development human diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Generation and Characterization of a Transgenic Zebrafish Expressing the Reverse Tetracycline Transactivator

引用

Journal of Genetics and Genomics 2013年第10期40卷 523-531页

作者： Qilin Gu Xiaojie Yang Xiaozhen He Qing Li zongbin cui The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences Institute of HydrobiologyChinese Academy of Sciences University of Chinese Academy of Sciences

Conditional expression of a target gene during zebrafish development is a powerful approach to elucidate gene functions. The tetracycline-controlled systems have been successfully used in the modulation of gene expression in mammalian cells, but few lines of zebrafish carrying these systems are currently available. In this study, we had generated a stable transgenic zebrafish line that ubiquitously expressed the second-generation of reverse Tet transactivator （rtTA-M2）. Southern blotting analysis and high-throughput genome sequencing verifed that a single copy of rtTA-M2 gene had stably integrated into the zebrafish genome. After induction with doxycycline （Dox）, a strong green fluorescent protein （GFP） was seen in rtTA-transgenic eggs injected with pTRE--EGFP plasmids. The fluorescent signal gradually decreased after the withdrawal of Dox and disappeared. However, leaky expression of GFP was undetectable before Dox- induction. Additionally, transgenic embryos expressing rtTA-M2 exhibited no obvious defects in morphological phenotypes, hatching behavior and expression patterns of developmental marker genes, suggesting that rtTA-M2 had little effect on the development of transgenic zebrafish. Moreover, expressed Dickkopf-1 （DKK1） in pTRE-DKKl-injected embryos led to alterations in the expression of marker genes associated with Wnt signaling. Thus, this rtTA-transgenic zebrafish can be utilized to dissect functions of genes in a temporal manner.

关键词： Zebrafish Transgene Tet-on system Reverse Tet transactivator Doxycycline

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nucleoporin 62-like protein activates canonical Wnt signaling through facilitating the nuclear import of β-catenin in zebrafish

Nucleoporin 62-like protein activates canonical Wnt signalin...

引用

第二届全国发育生物学大会

作者： Xiaojie Yang zongbin cui Institute of Hydrobiology Chinese Academy of Sciecnes

Background:Nucleoporin p62(Nup62)is localized in the central channel of nuclear pore complexes(NPCs)and participates the control of nuclear pore permeability and nucleocytolasmic shuttling.However,develop-mental roles of Nup62 in vertebrates remain largely unclear.Results:Zebrafish Nup62-like protein(Nup621)is an orthologue of mammalian Nup62.The nup621 gene is maternally expressed,but its transcripts are ubiquitously distributed during early embryogenesis and en-riched in the head,pharyngal and intestine of developing embryos.Activation of Wnt/p-catenin pathway positively modulates the nup621 transcription,while Bmp signaling acts downstream of Wnt/p-catenin sig-naling to negatively regulate the nup621expression.Overexpression of nup621 dorsalized embryos and en-hanced gastrula convergence and extension(CE)movements.Conthrarily,knockdown of Nup621 led to vent-ralized embryos,an impediment to CE movements and defects in specification of midline organ progenitors.Mechanistically,Nup621 acts as an activator of Wnt/p-catenin signaling through interaction with and nuclear import of P-catenin-1/2 in zebrafish.Conclusions:Nup621 regulates dorsoventral patterning,gastrula CE movements and proper specification of midline organ precursors through mediating the nuclear import of p-catenins in zebrafish.

关键词： Nucleoporin 62-like Canonical Wnt signaling Dorsoventral patterning

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

鱼类低温应激和损伤的信号通路与调控机制

引用

河南师范大学学报（自然科学版） 2023年第3期51卷 11-21页

作者：崔宗斌任静龙勇广东省科学院微生物研究所广州510070 中国科学院水生生物研究所武汉430072

许多优良水产养殖鱼类不耐低温,冬季冷害常导致大量养殖鱼类死亡和巨大经济损失,严重制约着我国水产养殖业的发展.低温胁迫可导致鱼类在大分子、细胞、组织、器官和系统水平出现严重损伤现象,进而影响鱼体的神经、免疫、心血管等系统功... 详细信息

许多优良水产养殖鱼类不耐低温,冬季冷害常导致大量养殖鱼类死亡和巨大经济损失,严重制约着我国水产养殖业的发展.低温胁迫可导致鱼类在大分子、细胞、组织、器官和系统水平出现严重损伤现象,进而影响鱼体的神经、免疫、心血管等系统功能.鱼体对低温胁迫的响应依赖于细胞内的各种生物学过程和信号传导通路.鱼体细胞内的Ca^(2+)、MAPK、FoxO、自噬等信号通路可感知和传递低温信号,并启动低温应激反应,以增强鱼体的低温耐受能力.同时,低温胁迫也能激活鱼体细胞内的p53、凋亡、坏死等信号通路,促进细胞和鱼体死亡.细胞内存活和死亡信号通路之间的相互作用和动态平衡,决定组织、细胞的损伤程度和鱼体生存.通过重点介绍相关研究的新进展,为深入解析鱼类低温适应分子机制和抗寒育种提供参考.

关键词：鱼类低温胁迫低温耐受低温适应信号通路

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于DNA条形码技术的浮游动物休眠卵种类鉴定:以洞庭湖流域常德柳叶湖为例

引用

湖泊科学 2020年第1期32卷 154-163页

作者：于文波王庆魏南梁迪文杨宇峰崔宗斌暨南大学生态学系广州510632 中国科学院水生生物研究所武汉430072

以洞庭湖流域的典型城市湖泊常德柳叶湖表层沉积物中浮游动物休眠卵为研究对象,采用DNA条形码技术进行种类鉴定,从191个休眠卵中成功获得101条有效序列,鉴定成功率约为53%.根据NCBI数据库比对成功鉴定休眠卵9科12属11种,另有6个样品鉴... 详细信息

以洞庭湖流域的典型城市湖泊常德柳叶湖表层沉积物中浮游动物休眠卵为研究对象,采用DNA条形码技术进行种类鉴定,从191个休眠卵中成功获得101条有效序列,鉴定成功率约为53%.根据NCBI数据库比对成功鉴定休眠卵9科12属11种,另有6个样品鉴定到属或科;3个类群的种间遗传距离平均为种内遗传距离的68倍,表明可以利用线粒体细胞色素c氧化酶第一亚基编码基因(COⅠ)对休眠卵进行有效物种鉴定.通过Neighbor-Joining树进行系统发育分析,发现所鉴定的物种与其参比序列聚类为一支,所有物种分别聚为独立的一个支系,不同物种可有效区分.研究结果均表明,COⅠ基因作为DNA条形码可以实现沉积物中浮游动物休眠卵的物种鉴定.

关键词：浮游动物休眠卵 DNA条形码技术 COⅠ基因洞庭湖流域柳叶湖

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Zebrafish Models to Study Wound Healing and Fibrotic Diseases:Opportunities & Challenges

Zebrafish Models to Study Wound Healing and Fibrotic Disease...

引用

中国遗传学会“发育、遗传和疾病”研讨会

作者： zongbin cui Institute of Hydrobiology Chinese Academy of Sciences Wuhan Hubei 430072

Wound healing is a process of repairing damaged tissues that is generally categorized into three overlapped phases.In the inflammatory phase,bacteria and debris are phagocytized and removed. Recrui

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

ABC转运蛋白研究的新进展

引用

生物技术通报 2008年第5期24卷 35-41页

作者：马云芳梁国鲁裴得胜崔宗斌西南大学中国科学院水生生物研究所武汉430072 中国科学院水生生物研究所

ABC转运蛋白主要包括P-糖蛋白、多药耐药相关蛋白和乳腺癌耐药蛋白,它们属于同一家族,具有保守的功能结构域和多样化的生物学功能。ABC转运蛋白部分成员的过表达与肿瘤细胞的多药耐药性(MDR)密切相关,是导致化疗失败的主要原因。随着对... 详细信息

ABC转运蛋白主要包括P-糖蛋白、多药耐药相关蛋白和乳腺癌耐药蛋白,它们属于同一家族,具有保守的功能结构域和多样化的生物学功能。ABC转运蛋白部分成员的过表达与肿瘤细胞的多药耐药性(MDR)密切相关,是导致化疗失败的主要原因。随着对MDR机制认识的深入,针对多药耐药蛋白的特异结构域已设计出多种形式的MDR逆转药物。近年来发现,ABC转运蛋白广泛存在于多种正常的组织和器官,参与药物和内、外源毒素的吸收、分布和排泄,行使解毒和防御保护的作用。因此,通过转植ABC转运蛋白基因有可能降低经济鱼类、虾等水产品中有毒污染物的积累。

关键词： ABC转运蛋白组织防御基因转移水产养殖

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

鱼类精子携带的外源基因导入

引用

水生生物学报 1996年第3期20卷 242-247页

作者：李国华崔宗斌朱作言黄善衔中国科学院水生生物研究所广东中山市水产研究所

将鲤鱼（或泥鳅）精子在保存液内与人生长激素（ｈＧＨ）重组质粒ＤＮＡ保温，再与鲤（或泥鳅）卵受精。由此发育的鱼苗经ＤＮＡ分子杂交和ＰＣＲ检测证明，３３．３％（或３７．０％）的个体带ｈＧＨ基因，其拷贝数在４—１５０／细胞... 详细信息

将鲤鱼（或泥鳅）精子在保存液内与人生长激素（ｈＧＨ）重组质粒ＤＮＡ保温，再与鲤（或泥鳅）卵受精。由此发育的鱼苗经ＤＮＡ分子杂交和ＰＣＲ检测证明，３３．３％（或３７．０％）的个体带ｈＧＨ基因，其拷贝数在４—１５０／细胞之间。在一定条件下，精子可作为携带外源基因的载体，通过受精作用产生转基因鱼。

关键词：鱼纲精子基因转移外源基因

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lzts2 regulates convergence & extension movements and dorsoventral patterning through nuclear export ofβ-catenin in zebrafish

Lzts2 regulates convergence & extension movements and dorsov...

引用

2010·第一届斑马鱼学术研讨会

作者： Yuanyuan Li,Qing Li and zongbin cui (Institute of Hydrobiology,Chinese Academy of sciences,Wuhan,Hubei 430072,P.R.China)

Leucine zipper tumor suppressor 2(Lzts2) has been shown to function in cell cycle regulation and progression of various tumors,but its activities in vertebrate development remain to be defined.Herein,we demonstrate that Izts2 transcripts are of maternal origin in early embryos of zebrafish.Bmp signaling positively

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：