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Clinical reasoning: a 20-year-old woman with coma and quadriplegia

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World Journal of Emergency Medicine 2023年第2期14卷 169-170页

作者： shao-wei Zheng hong-hong Pei Long-fei Pan Department of Emergency Medicine the Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China

Dear editor,Subacute combined degeneration(SCD) of the spinal cord, which is mainly caused by vitamin B12 deficiency, reveals damage in posterior and lateral columns and peripheral nerves. The CNS and cranial nerves are rarely involved except in children.[1,2]Spinal cord MRI abnormal long T1 and T2 signs in the posterior funiculus has specificity for the diagnosis.[3]There have been many case reports about SCD induced by nitrous oxide anaesthesia or entertainment.

关键词： nerves vitamin specificity

Blue and Violet Cerenkov Second Harmonic Generation of Laser Diodes in Proton Exchanged MgO:LiNbO_(3) Optical Waveguide

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Chinese Physics Letters 1996年第10期13卷 741-743页

作者： MU Xiao-dong shao zong-shu ZHANG Heng-li KONG Qing-yu JIANG Min-hua National Laboratory of Crystal Materials Shandong UniversityJinan 250100

Using the Cerenkov second harmonic generation, 478 nm blue and 402nm violet light are generated by direct frequency doubling of 956 and 804 nm diode lasers in a same proton exchanged MgO:LiNbO3 waveguide. Under the low fundamental guide wave power of less than 1mW, the estimated value of the output blue and violet light power is in the order of 0.1-0.01μW.

关键词： Waveguide violet doubling

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector

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Science China(Technological Sciences) 2014年第12期57卷 2523-2529页

作者： WANG Yuan Qing zong Liang HENG Yue Kun WANG zong Yi ZHOU Yan HOU shao Jing QIN Zhong Hua MA Xiao Yan Key Laboratory of Civil Engineering Safety and Durability of China Education Ministry Department of Civil EngineeringTsinghua University Central Detector Group Institute of High Energy Physics (IHEP) School of Civil and Architectural Engineering Wuhan University Key Laboratory of New Technology for Construction of Cities in Mountain Area Department of Civil EngineeringChongqing University

After the success of the Daya Bay experiment, the Jiangmen Underground Neutrino Observatory （JUNO） was launched to measure neutrino-mass hierarchy and oscillation parameters and to study other neutrino physics. Its central detector is set for antineutrinos from reactors, the Earth, the atmosphere, and the Sun. The main requirements of the central detector are con- tainment of 20 kt of liquid scintillator, as the target mass, and 3% energy resolution. It is about a ball-shape detector of 38.5 m with -75% coverage of PMT on its inner surface. The design of such a huge detector is a big challenge because it must meet the requirements for several different types of physics measurement and possess the feasibility and reliability in its structure and engineering, all at reasonable time and cost. One option for the JUNO central detector is a hyper-scale acrylic ball sub- merged in the water to shield the background. This paper proposes a structural scheme for such an acrylic ball that is supported by a stainless-steel truss, inspired by point-supported glass-curtain walls in civil engineering. The preliminary design of the scheme is completed and verified by finite element （FE） method using ABAQUS. FE analysis shows that the scheme can con- trol the stress level of the acrylic ball within the limit of 5 to 10 MPa, in accordance with the demand of the design objective of the central detector. The scheme is of outstanding global stability and allows various chocces on local connections. We prove that the scheme is of good feasibility and should be a reasonable option for the central detector.

关键词： neutrino central detector acrylic stainless-steel truss point-supported glass-curtain wall

Toric intraocular collamer lens with anterior chamber maintainer for myopic astigmatism following penetrating keratoplasty:a case report

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 330-332页

作者： zong-Ming Zhuang Hao-Yu Li shao-Jian Tan Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Jingliang Eye Hospital of Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous RegionChina

Dear Editor,I am zong-Ming Zhuang,from the Department of Ophthalmology,the First Affiliated Hospital of Guangxi Medical University,Nanning,China.I am writing to present a case of toric intraocular collamer lens(TICL)implantation for myopic astigmatism after penetrating keratoplasty(PK)with anterior chamber maintainer(ACM)and without ophthalmic viscoelastic surgical device(OVD).The current study was conducted in accordance with the Declaration of Helsinki principles,the patient signed a written informed consent.

关键词： maintain implantation intraocular

Autophagy and its role in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第36期30卷 4014-4020页

作者： Bo-zong shao Wen-Gang Zhang Zhen-Yu Liu En-Qiang Linghu Department of Gastroenterology First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China

Gastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system,such as the esophagus,stomach,colon,rectum,pancreas,liver,small intestine,and bile *** role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant *** paper seeks to evaluate the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research ***,we delve into inflammation-related gastrointestinal conditions,including ulcerative colitis,Crohn’s disease,and pancreatitis,as well as gastrointestinal cancers such as esophageal,gastric,and colorectal ***,we provide commentary on a recent publication by Chang et al in the World Journal of *** objective is to offer fresh perspectives on the mechanisms and therapeutic approaches for these gastrointestinal *** review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant *** discussed,the role of autophagy in gastrointestinal diseases is complex and,at times,*** harness the full therapeutic potential of autophagy in treating these conditions,more in-depth research is imperative.

关键词： Autophagy Inflammation Cancer Inflammatory bowel disease Pancreatitis

The Scheme to Determine the Convergence Term of the Galerkin Method for Dynamic Analysis of Sandwich Plates on Nonlinear Foundations

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Acta Mechanica Solida Sinica 2021年第1期34卷 1-11页

作者： hong-Yan Chen Hu Ding shao-Hua Li Li-Qun Chen Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematicsand MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversitygShanghai 200444China State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversitxyShiyiazhuang 050043China

The vibration of a plate resting on elastic foundations under a moving load is of great significance in the design of many engineering fields,such as the vehicle-pavement system and the aircraft-runway *** or runways are always laminated *** Galerkin truncation method is widely used in the research of *** number of truncation terms directly affects the convergence and accuracy of the response ***,the selection of the number of truncation terms has not been clearly stated.A nonlinear viscoelastic foundation model under a moving load is *** on the natural frequency of linear undisturbed derivative systems,the truncation terms are used to determine the convergence of vibration *** criterion for the convergence of the Galerkin truncation term is *** scheme is related to the natural frequency with high efficiency and *** the dynamic response of the sandwich beam under a moving load,the feasibility of the scheme is *** effects of different system parameters on the scheme and the truncation convergence of dynamic response are *** research in this paper can be used as a reference for the study of the vibration of elastic foundation ***,the model established and the truncation analysis method proposed are helpful for studying the vibration of vehicle-pavement system and related systems.

关键词： ndwich plate Galerkin method Convergence Nonlinear foundation

Clinical characteristics and corticosteroid therapy in patients with autoimmune-hepatitis-induced liver failure

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World Journal of Gastroenterology 2014年第23期20卷 7473-7479页

作者： Bing Zhu shao-Li You Zhi-hong Wan hong-Ling Liu Yi-Hui Rong hong Zang shao-Jie Xin Liver Failure Treatment and Research Center 302~(nd) Military Hospital

AIM: To investigate the clinical features, response to corticosteroids, and prognosis of autoimmune hepatitis (AIH)-induced liver failure in China.

关键词： Autoimmune hepatitis Liver failure Autoantibody Prognosis Corticosteroid therapy

Research on the Limit Value of Shape Coefficient of Rural Residences in Severe Cold Regions

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Journal of Harbin Institute of Technology(New Series) 2014年第4期21卷 43-46页

作者： hong Jin Kai Chen Teng shao School of Architecture Harbin Institute of Technology

Shape coefficient is a significant factor accounting for building energy consumption. In order to decrease the building energy consumption of rural residence in severe cold regions,this paper from the perspective of regulating the shape coefficient limit value,applies the field survey method to statistic and analyze the shape,width and depth of rural residence in severe cold regions and concludes the distribution characteristics and scope of building area. On this basis,though calculating and analyzing the relations between shape coefficient and length-width ratio under different building areas,meanwhile comprehensive considering the building function,farmers' living mode and requirements etc,it put forward that the shape coefficient of rural residence in severe cold regions should below 0. 8. It has important significance for guiding the rural energy-saving house design and construction of severe cold regions.

关键词： severe cold regions rural residences shape coefficient