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Radiofrequency ablation for single hepatocellular carcinoma 3 cm or less as first-line treatment

World Journal of Gastroenterology 2015年第17期21卷 5287-5294页

作者： Jun Gao shao-hong Wang Xue-Mei Ding Wen-Bing Sun Xiao-Long Li zong-Hai Xin Chun-Min Ning Shi-Gang Guo Department of Hepatobiliary Surgery Beijing Chaoyang Hospital Affiliated to Capital Medical University Department of General Surgery Affiliated Hospital of Chifeng University Department of General Surgery Zhanhua People’s Hospital Department of General Surgery Chaoyang Central Hospital

AIM:To evaluate long-term outcomes of radiofrequency(RF) ablation as first-line therapy for single hepatocellular carcinoma(HCC) ≤ 3 cm and to determine survival and prognostic ***:We included all 184 patients who underwent RF ablation as a first-line treatment for single HCC ≤ 3 cm between April 2005 and December *** to the criteria of Livraghi,the 184 patients were divided into two groups:those suitable for surgical resection(84 cases) and those unsuitable for surgical resection(100 cases).The primary endpoints were the overall survival(OS) rate and safety;the secondary endpoints were primary technique effectiveness and recurrence ***:There were 19(10.3%) cases of ablation related minor *** complete tumor ablation rate after one RF session was 97.8%(180/184).The rate of local tumor progression,extrahepatic metastases and intrahepatic distant recurrence were 4.9%(9/184),9.8%(18/184) and 37.5%(69/184),*** the 184 patients,the 1-,3-,and 5-year OS rates were 99.5%,81.0%,and 62.5%,*** 1-,3-,and 5-year OS rates were 100%,86.9%,and 71.4%,respectively,in those suitable for surgical resection and 99.0%,76.0%,and 55.0%,respectively,in those unsuitable for surgical resection(P = 0.021).On univariate and multivariate analyses,poorer OS was associated with Child-Pugh B class and portal hypertension(P < 0.05).CONCLUSION:RF ablation is a safe and effective treatment for single HCC ≤ 3 *** OS rate of patients suitable for surgical resection was similar to those reported in surgical series.

关键词： Hepatocellular carcinoma Radiofrequencyablation Therapeutic efficacy Safety Survival

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Group Connectivity and Group Colorings of Graphs -- A Survey

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Acta Mathematica Sinica,English Series 2011年第3期27卷 405-434页

作者： hong-Jian LAI Xiangwen LI Yehong shao Mingquan ZHAN College of Mathematics and System Sciences Xinjiang University Urumqi 830046 P. R. China Department of Mathematics West Virginia University Morgantown WV26506 USA Department of Mathematics Huazhong Normal University Wuhan 430070 P. R. China Department of Mathematics Ohio University Southern Campus Ironton OH 45638 USA Department of Mathematics Millersville University of Pennsylvania Millersville PA 17551 USA

In 1950s, Tutte introduced the theory of nowhere-zero flows as a tool to investigate the coloring problem of maps, together with his most fascinating conjectures on nowhere-zero flows. These have been extended by Jaeger et al. in 1992 to group connectivity, the nonhomogeneous form of nowhere-zero flows. Let G be a 2-edge-connected undirected graph, A be an （additive） abelian group and A＊ = A - {0}. The graph G is A-connected if G has an orientation D（G） such that for every map b ： V（G） → A satisfying ∑v∈V（G）b（v）： 0, there is a function f ： E（G） → A＊ such that for each vertex v ∈ V（G）, the total amount of f-values on the edges directed out from v minus the total amount of f-values on the edges directed into v is equal to b（v）. The group coloring of a graph arises from the dual concept of group connectivity. There have been lots of investigations on these subjects. This survey provides a summary of researches on group connectivity and group colorings of graphs. It contains the following sections. 1. Nowhere-zero Flows and Group Connectivity of Graphs 2. Complete Families and A-reductions 3. Reductions with Edge-deletions, Vertex-deletions and Vertex-splitting 4. Group Colorings as a Dual Concept of Group Connectivity 5. Brooks Theorem, Its Variations and Dual Forms 6. Planar Graphs 7. Group Connectivity of Graphs 7.1 Highly Connected Graphs and Collapsible Graphs 7.2 Degrees Conditions 7.3 Complementary Graphs 7.4 Products of Graphs 7.5 Graphs with Diameter at Most 2 7.6 Line Graphs and Claw-Free Graphs 7.7 Triangular Graphs 7.8 Claw-decompositions and All Tutte-orientations

关键词： Group connectivity group connectivity number group coloring group chromatic number

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Action of Schwann Cells Implanted in Cerebral Hemorrhage Lesion

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Biomedical and Environmental Sciences 2007年第1期20卷 47-51页

作者： hong WAN shao-DONG ZHANG JUN-HUA LI Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China

Objective To investigate whether there is neogenesis of myelin sheath and neuron after transplantation of Schwann cells into cerebral hemorrhage lesion. Methods Schwann cells were expanded, labeled with BrdU in vitro and transplanted into rat cerebral hemorrhage with blood extracted from femoral artery and then injected into the basal nuclei. Double immunohistochemistry staining and electron microscopy were used to detect the expression of BrdU/MBP and BrdU/GAP-43 and remyelination. Results BrdU/MBP double positive cells could be seen at 1 week up to 16 weeks after transplantation of Schwann cells. Thin remyelination was observed under electron microscope. GAP-43 positive cells appeared after 12 weeks and were found more in Hippocamp. Conclusions Grafted Schwann cells participate in remyelination and promoter nerve restore in rat cerebral hemorrhage.

关键词： Schwann cell MBP GAP-43

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TBK1 as a regulator of autoimmunity and antitumor immunity

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Cellular & Molecular Immunology 2018年第8期15卷 743-745页

作者： Jian-hong Shi Xiaoping Xie shao-Cong Sun Central Laboratory Affiliated Hospital of Hebei University212 Yuhua East RoadBaoding 07100China Department of Immunology The University of Texas MD Anderson Cancer Center7455 Fannin StreetBox 902HoustonTX 77030USA

TANK-binding kinase 1(TBK1)and its homolog IκB kinase(IKK)epsilon(IKKε,also known as IKKi)are serine/threonine kinases that are well known for their functions to mediate type I interferon(IFN-I)induction in antiviral innate immune responses.1 Various microbial components,or pathogen associated molecular patterns(PAMPs),activate TBK1 and IKKεvia stimulating pattern-recognition receptors(PRRs)in innate immune *** activation,TBK1 or IKKε(hereafter called TBK1/IKKε)phosphorylates the transcription factors IRF3 and IRF7 to trigger their dimerization and nuclear translocation,leading to induction of IFN-I gene expression.1,2 In this innate immune signaling pathway,TBK1 and IKKεdisplay functional redundancies,although TBK1 seems to be more crucial than IKKε.3,4 It is increasingly clear that the function of TBK1 and IKKεis beyond the regulation of antiviral innate immunity.

关键词： expression. immunity hereafter

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Radial Basis Function Neural Networks-Based Modeling of the Membrane Separation Process: Hydrogen Recovery from Refinery Gases

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Journal of Natural Gas Chemistry 2006年第3期15卷 230-234页

作者： Lei Wang Cheng shao Hai Wang hong Wu Institute of Advanced Control Technology Dalian University of Technology Dalian 116024 China Tianbang National Engineering Research Center of Membrane Technology Co. Ltd Dalian 116023 China Sinopec Zhenhai Refining and Chemical Company Limited Ningbo 315200 China

Membrane technology has found wide applications in the petrochemical industry, mainly in the purification and recovery of the hydrogen resources. Accurate prediction of the membrane separation performance plays an important role in carrying out advanced process control （APC）. For the first time, a soft-sensor model for the membrane separation process has been established based on the radial basis function （RBF） neural networks. The main performance parameters, i.e, permeate hydrogen concentration, permeate gas flux, and residue hydrogen concentration, are estimated quantitatively by measuring the operating temperature, feed-side pressure, permeate-side pressure, residue-side pressure, feed-gas flux, and feed-hydrogen concentration excluding flow structure, membrane parameters, and other compositions. The predicted results can gain the desired effects. The effectiveness of this novel approach lays a foundation for integrating control technology and optimizing the operation of the gas membrane separation process.

关键词： membrane separation hydrogen recovery soft sensor RBF neural networks refinery operation optimization

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Hot deformation behaviors of a 9Cr oxide dispersion-strengthened steel and its microstructure characterization

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International Journal of Minerals,Metallurgy and Materials 2019年第5期26卷 597-610页

作者： Yu shao Li-ming Yu Yong-chang Liu zong-qing Ma Hui-jun Li Jie-feng Wu State Key Lab of Hydraulic Engineering Simulation and Safety Tianjin Key Lab of Composite and Functional Materials Tianjin University Institute of Plasma Physics Chinese Academy of Sciences

The hot deformation behaviors of a 9 Cr oxide dispersion-strengthened(9 Cr-ODS) steel fabricated by mechanical alloying and hot isostatic pressing(HIP) were investigated. Hot compression deformation experiments were conducted on a Gleeble 3500 simulator in a temperature range of 950–1100°C and strain rate range of 0.001–1 s^(-1). The constitutive equation that can accurately describe the relationship between the rheological stress and the strain rate of the 9 Cr-ODS steel was established, and the deformation activation energy was calculated as 780.817 kJ/mol according to the data obtained. The processing maps of 9 Cr-ODS in the strain range of 0.1–0.6 were also developed. The results show that the region with high power dissipation efficiency corresponds to a completely recrystallized structure. The optimal processing conditions were determined as a temperature range of 1000–1050°C with strain rate between 0.003 and 0.01 s^(-1).

关键词： hot deformation constitutive equations processing maps microstructural evolution

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Center for Elliptic Quantum Group Eτ，η(sln)

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Communications in Theoretical Physics 2003年第1期39卷 67-72页

作者： Zhao shao-You Shi Kang-Jie Yue Rui-hong Department of Physics Beijing Institute of Technology Beijing 100081 China Institute of Modern Physics Northwest University Xi'an 710069 China

We give the center of the elliptic quantum group in general cases. Based on the dynamical Yang-Baxter relation and the fusion method, we prove that the center commutes with all generators of the elliptic quantum group. Then for a kind of assumed form of these generators, we find that the coefficients of these generators form a new type of closed algebra. We also give the center for the algebra.

关键词：凝聚物理椭圆量子群 YangBaxter关系式

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Recursive Bayesian Algorithm for Identification of Systems with Non-uniformly Sampled Input Data

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International Journal of Automation and computing 2018年第3期15卷 335-344页

作者： shao-Xue Jing Tian-hong Pan Zheng-Ming Li School of Electrical Information and Engineering Jiangsu University Department of Electrical Engineering Huaian College of Information and Technology

To identify systems with non-uniformly sampled input data, a recursive Bayesian identification algorithm with covariance resetting is proposed. Using estimated noise transfer function as a dynamic filter, the system with colored noise is transformed into the system with white noise. In order to improve estimates, the estimated noise variance is employed as a weighting factor in the algorithm. Meanwhile, a modified covariance resetting method is also integrated in the proposed algorithm to increase the convergence rate. A numerical example and an industrial example validate the proposed algorithm.

关键词： Parameter estimation discrete time systems Gaussian noise Bayesian algorithm covariance resetting.

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Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis

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Chinese Journal of Cancer 2017年第3期36卷 121-130页

作者： hong-Yan Xie Zhi-Min shao Da-Qiang Li Shanghai Cancer Center and Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Cancer Institute Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Key Laboratory of Breast Cancer in Shanghai Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Department of Breast Surgery Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China

Distant metastasis to specific target organs is responsible for over 90%of breast cancer?related deaths,but the underlying molecular mechanism is *** evidence suggests that the interplay between breast cancer cells and the target organ microenvironment is the key determinant of organ?specific metastasis of this lethal ***,we highlight new findings and concepts concerning the emerging role of the tumor microenvironment in breast cancer metastasis;we also discuss potential therapeutic intervention strategies aimed at targeting compo?nents of the tumor microenvironment.

关键词： Breast cancer Invasion and metastasis Tumor microenvironment

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The Synthesis of 1-Aryl-5-Fluorouracil

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Chinese Chemical Letters 2000年第10期11卷 865-866页

作者： Jin zong YOU shao Yuan CHEN Omar ISHRUD Yan Guang WANG Yao Zu CHEN Department of Chemistry Zhejiang UniversityHangzhou 310027 National Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000

A series of new type substituted 5-fluorouracil derivatives, 1-aryl-5-fluorouracil (4a-4f), were synthesized via diaryliodonium salts and the structure of the title compound was finally confirmed by IR, UV. H-1-NMR. M... 详细信息

关键词： synthesis 1-aryl-5-fluorouracil

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