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Usefulness of human epididymis protein 4 in predicting cytoreductive surgical outcomes for advanced ovarian tubal and peritoneal carcinoma

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Chinese Journal of Cancer Research 2015年第3期27卷 309-317页

作者： Zhijian Tang Xiaohong Chang xue Ye Yi Li Hongyan Cheng heng Cui Gynecology Oncology Center Peking University People's Hospital

Objective： Human epididymis protein 4（HE4） is a promising biomarker of epithelial ovarian cancer（EOC）. But its role in assessing the primary optimal debulking（OD） of EOC remains unknown. The purpose of this study is to elucidate the ability of preoperative HE4 in predicting the primary cytoreductive outcomes in advanced EOC, tubal or peritoneal ***： We reviewed the records of 90 patients with advanced ovarian, tubal or peritoneal carcinoma who underwent primary cytoreduction at the Department of Obstetrics and Gynecology of Peking University People＇s Hospital between November 2005 and October 2010. Preoperative serum HE4 and CA125 levels were detected with EIA kit. A receiver operating characteristic（ROC） curve was used to determine the most useful HE4 cut-off value. Logistic regression analysis was performed to identify significant preoperative clinical characteristics to predict optimal primary ***： OD was achieved in 47.7%（43/48） of patients. The median preoperative HE4 level for patients with OD vs. suboptimal debulking was 423 and 820 pmol/L, respectively（P〈0.001）. The areas under the ROC curve for HE4 and CA125 were 0.716 and 0.599, respectively（P=0.080）. The most useful HE4 cut-off value was 473 pmol/L. Suboptimal cytoreduction was obtained in 66.7%（38/57） of cases with HE4 ≥473 pmol/L compared with only 27.3%（9/33） of cases with HE4 〈473 pmol/L. At this threshold, the sensitivity, specificity, positive predictive value（PPV） and negative predictive value（NPV） for diagnosing suboptimal debulking were 81%, 56%, 67%, and 73%, respectively. Logistic regression analysis showed that the patients with HE4 ≥473 pmol/L were less likely to achieve OD（odds ratio =5.044, P=0.002）.Conclusions： Preoperative serum HE4 may be helpful to predict whether optimal cytoreductive surgery could be obtained or whether extended cytoreduction would be needed by an interdisciplinary team.

关键词： Human epididymis protein 4 (HE4) advanced epithelial ovarian cancer (EOC) optimal cytoreduction CA125

Influence of basicity and temperature on bonding phase strength,microstructure,and mineralogy of high-chromium vanadium–titanium magnetite

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International Journal of Minerals,Metallurgy and Materials 2018年第8期25卷 871-880页

作者： Wei-dong Tang Xiang-xin xue Song-tao Yang Li-heng Zhang Zhuang Huang School of Metallurgy Northeastern University

To develop a smelting process for the comprehensive utilization of high-chromium vanadium-titanium magnetite(HCVTM),the micro-sinter test was applied to investigate the influence of basicity and temperature on the HCVTM *** bonding phase strength(BS) was tested via an electronic universal testing *** phase transformations of the HCVTM sinters were detected via X-ray diffraction(XRD),whereas the structure and mineralogy of the HCVTM sinters under different temperatures and basicities were detected via scanning electron microscopy in combination with energy-dispersive spectroscopy(SEM–EDS).Our results demonstrate that the BS of the HCVTM sinters exhibits a slightly increasing tendency with an increase in temperature when the basicity is 2.4 and within the range of 2.8–*** cracks,small size crystals,and dependent phase structures are generated by increasing the sinter *** BS is lower than 4000 N when the basicity is 2.2 and *** the temperature is in the range of 1280–1300?C,the BS exceeds 4000 N with the basicity of 2.0,2.4,and 3.4–*** pore size of the HCVTM sinters increases with the increase of the *** perovskite decreases,whereas the silicate phase increases with basicity higher than *** study provides theoretical and technical foundations for the effective production of HCVTM sinters.

关键词： ironmaking magnetite sintering bonding phase strength

Discrimination of industrial products by on-line near infrared spectroscopy with an improved dendrogram

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Chinese Chemical Letters 2011年第10期22卷 1241-1244页

作者： Jing Jing Liu heng Xu Wen Sheng Cai xue Guang Shao Research Center for Analytical Sciences College of Chemistry Nankai University Tianjin 300071 China

Near infrared（NIR） spectroscopy technique has shown great power and gained wide acceptance for analyzing complicated *** present work is to distinguish different brands of tobacco products by using on-line NIR spectroscopy and pattern recognition ***,since each brand contains a large number of samples,an improved dendrogram was proposed to show the classification of different *** results suggest that NIR spectroscopy combined with principal component analysis （PCA） and hierarchical cluster analysis（HCA） performs well in discrimination of the different brands,and the improved dendrogram could provide more information about the difference of the brands.

关键词： Near infrared spectroscopy Principal component analysis Hierarchical cluster analysis Tobacco products

Formation and fluorescent mechanism of red emissive carbon dots from o-phenylenediamine and catechol system

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Light(Science & Applications) 2022年第11期11卷 2687-2697页

作者： Pengfei Li Shanshan xue Lu Sun Xupeng zong Li An Dan Quo Xiayan Wang Zaicheng Sun Center of Excellence for Environmental Safety and Biological Effects Bejing Key Laboratory for Green Catalysis and SeparationDepartment of ChemistryBeijing Universityof Technology100124 BejingChina

Carbon dots(CDs)as the advancing fluorescent carbon nanomaterial have superior potential and ***,the ambiguous photoluminescence(PL)mechanism and intricate structure-function relationship become the greatest hindrances in the development and applications of ***,red emissive CDs were synthesized in high yield from O-phenylenediamine(oPD)and catechol(CAT).The PL mechanism of the CDs is considered as the molecular state fluorophores because 5,14-dihydroquinoxalino[2,3-b]phenazine(DHQP)is separated and exhibits the same PL properties and behavior as the *** include the peak position and shape of the PL emission and PL excitation and the emission dependence on pH and solvent *** of them display close PL lifetime *** on these,we deduce that DHQP is the fluorophore of the red emissive CDs and the PL mechanism of CDs is similar to *** the PL emission of CDs,the electron of the molecule state can transfer to *** formation process of DHQP is further confirmed by the reaction intermediates(phthalazine,dimers)and *** findings provide insights into the PL mechanism of this type of CDs and may guide the further development of tunable CDs for tailored properties.

关键词： properties mechanism catechol

Lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups

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Biomedical and Environmental Sciences 2009年第5期22卷 423-429页

作者： Yu-MEI ZHANG xue-ZHONG LIU HAO LU LI MEI zong-PING LIU College of Veterinary Medicine Yangzhou University Yangzhou 225009 Jiangsu China College of Veterinary Medicine Northwest Sci-Tech University of Agriculture and Forestry Yangling 712100 Shaanxi China

Objective To assess lipid peroxidation and ultrastructural modifications in rat brains following perinatal exposure to lead （Pb） and/or cadmium （Cd）. Methods Female rats were divided into four groups： control group, Pb （300 mg/L） group, Cd group （10 mg/L） and Pb＋Cd （300 mg/L, 10 mg/L） group. The compounds were delivered in the drinking water throughout pregnancy and lactation. Results The levels of compounds in blood and brain of the Pb＋Cd group were similar to those of other groups, but the effects of Pb＋Cd on pups＇ body and brain weights were higher than on other compounds. Electron microscopy revealed that Pb and Cd had effects on mitochondrial swelling, disruption and cristae loss, Nissl body dissolution, degenerated organelles and vacuoles, cytomembrane disappearance, and nuclear chromoplasm concentration. The activity of glutathione peroxidase （GSH-Px）, superoxide dismutase （SOD）, catalase （CAT）, acetylcholinesterase （ACHE） was decreased, whereas the activity of maleic dialdehyde （MDA） was increased. Conclusion Perinatal exposure to low doses of Pb and Cd can produce alterations in lipid peroxidation and ultrastructural modifications in rat brains, and exposure to both metals can result in greater damages.

关键词： Lead Cadmium Lipid peroxidation Ultrastructure Brain Rat

Secondary recrystallization of Goss texture in magnetostrictive Fe–Ga-based sheets

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Rare Metals 2020年第11期39卷 1288-1294页

作者： Chao Yuan xue-Xu Gao Ji-heng Li Xiao-Qian Bao State Key Laboratory of Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

To avoid the unfavorable effect of precipitates on magnetic properties,low addition of 0.16 wt%NbC was employed in Fe_(82.5)Ga_(17.5)alloy,and 0.27 mm sheets were successfully prepared by a rolling *** Goss texture was obtained in Fe-Ga sheets by two-stage annealing *** sulfur annealing in quartz ampoules was made to produce the preferred growth of Goss texture,with a 51%increase in the observed saturation magnetostriction,from 87×10^(-6)in the Ar-annealed sheets to 132×10^(-6)in the S-annealed ***,large amounts of S-rich and Nb-rich precipitates were formed in the S-annealed ***-temperature annealing of the S-annealed sheets at 1,200℃under a flow hydrogenargon atmosphere could effectively eliminate the precipitates and promote the selective growth of(110)grains due to the low surface *** grains(~2 cm)of secondary recrystallization were achieved in the final annealed sheets,with the maximum average saturation magnetostriction of 180×10^(-6).

关键词： Fe–Ga alloy Goss texture Magnetostriction Secondary recrystallization

Mechanism of Annealing Softening of Rolled or Forged Tool Steel

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Journal of Iron and Steel Research International 2003年第1期10卷 40-43页

作者： LIU zong-chang GAO Zhan-yong DONG xue-dong DAI Jian-ming Baotou University of Iron and Steel Technology Fushun Special Steel Ltd Co

The steel specimens of nominal composition 0.3C-1.0Cr-1.0Mn-2.0Si-1.0Ni- 0.04 Nb were quenched and tempered or isothermally quenched from various temperatures. It is found that the steel quenched and tempered with a tensile strength of 1 500-1 600 MPa has a K ISCC (critical stress intensity factor) value below 15.0 MPa·m 1/2 . The steel isothermally quenched with a tensile strength of 1 350-1 750 MPa has a K ISCC value about 20.0 MPa·m 1/2 . In addition, with increase of isothermal quenching temperature, the tensile strength decreases greatly and K ISCC value does not pronouncedly change. The microstructure of isothermally quenched specimens is composed of bainite and retained austenite. The delayed fracture resistance is dependent on the stability of austenite, which is in turn related to the retained austenite volume fraction and carbon content in austenite.

关键词： high strength steel heat treatment mixed microstructure delayed fracture

Magnetostriction and magnetization of <110> oriented Tb0.27Dy0.73Fe1.95 alloys with different compressive prestresses

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Rare Metals 2020年第2期39卷 176-180页

作者： Xing Mu Hai-Jun Tang xue-Xu Gao Xiao-Qian Bao Ji-heng Li State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing100083China China Academy of Civil Aviation Science and Technology Beijing100028China

oriented Tb0.27Dy0.73Fe1.95 alloys were studied under different applied compressive *** saturation magnetostriction by 500×10-6 is obtained for the sample under 5 MPa than that under no applied *** understand the effect of prestress on the magnetostrictive coefficient,differential magnetostrictive coefficient,relative permeability and coercive force were studied in *** results show that the maximum differential magnetostrictive coefficient is about 37 x 10-9 m·A-1,about two times that without *** addition,the saturation magnetostriction coefficient increases gradually with the stress increasing,while the maximum differential magnetostrictive coefficient *** saturation inductions under different stresses are similar to a value of about 1.1 *** relative permeability decreases with stress increasing.

关键词： Tb-Dy-Fe Compressive prestress Magnetostriction

Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-Min Zeng Di-Wei Zheng Ting Pan Xing-Lan Ding Yun Zhang Chi-Hui Yang Si-xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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