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Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 289-306页

作者： Chen Qiu yu-Kai Xiang Xuan-Bo Da Hong-Lei Zhang Xiang-yu Kong Nian-zong hou Cheng Zhang Fu-Zhou Tian yu-Long Yang Center of Gallbladder Disease Shanghai East HospitalInstitute of Gallstone DiseaseSchool of MedicineTongji UniversityShanghai 200092China General Surgery Center Chengdu Military General HospitalChengdu 610083Sichuan ProvinceChina

BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface ***,these enzymes play a significant role in the development of diverse *** To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression *** study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and *** Set Enrichment Analysis was utilized to pinpoint associated ***,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was *** PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy *** expression of PLA2G2A was correlated with poorer overall survival in CCA ***,the study delineated pathways and miRNAs associated with these *** Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for *** increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.

关键词： PLA2G2A PLA2G12B Diagnostic Prognostic biomarkers cholangiocarcinoma

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Transport patterns and numerical simulation of heavy metal pollutants in soils of lead–zinc ore mines

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Journal of Mountain Science 2021年第9期18卷 2345-2356页

作者： CAO Jie XIE Cheng-yu hou Zhi-ru College of Environment and Resources Xiangtan UniversityXiangtan 411105China School of Metallurgy and Environment Central South UniversityChangsha 410083China

Exploring transport patterns of soil contaminants is essential for solving the problem of heavy metal contamination in mine *** this study,contamination of Pb,Zn,and Cd in the mountain soils of the lead–zinc ore mines in Ganxi Township,Hengdong County,Hunan Province,China was investigated,and their transport patterns were further explored using a soil-column model and numerical simulation *** total,111 mine soil samples were collected and placed into six experimental soil *** controlling the water flow,a control soil column group(CK),two mixed soil columns X1 with daily water flows of 1 and 5 L,and three mixed soil columns X3 with daily water flows of 2,3,and 4 L were *** results showed that the residual fraction of Pb accounted for 71.93%of the content on average,whereas the exchangeable fractions of Zn,Cd,and Fe-Mn oxide-bound fractions of Zn and Cd accounted for 28.60%,31.07%,and 43.2%and 53.54%of the content,***,Zn,and Cd in the soils of the CK,X1,and X3 groups mainly were accumulated at a depth from approximately 0 to 20 cm,and the content at this depth accounted for 60.09%of that at a 0~40 cm *** soil at a depth range of 0~10 cm was most seriously contaminated,and the proportion of content was 32.39%of that at a 0~40 cm *** simulation showed that on the 5 th day,the pollutant transport range was 0~24 cm,and on the 9 th day,the pollutant transport range exceeded 40 *** the 15 th day,the transport capacity of pollutants at depths of 0~40 cm was close to the stable state,but the soil at a depth of 0~10 cm was still heavily *** results reflect the transport pattern of heavy metal pollutants in the soil of lead–zinc ore mines and may provide a reliable scientific support for the prevention of heavy metal contamination in mine environments.

关键词： Mountain Mine soil Heavy metals Numerical simulations Pollutants Transport patterns

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An efficient algorithm for generating a spherical multiple-cell grid

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Acta Oceanologica Sinica 2022年第5期41卷 41-50页

作者： Fang hou Zhiyi Gao Jianguo Li Fujiang yu National Marine Environmental Forecasting Center Beijing100081China Met Office ExeterEX13PBUK

This paper presents an efficient algorithm for generating a spherical multiple-cell(SMC)*** algorithm adopts a recursive loop structure and provides two refinement methods:(1)an arbitrary area refinement method and(2)a nearshore refinement *** experiments are carried out,and the results show that compared with the existing grid generation algorithm,this algorithm is more flexible and operable.

关键词： spherical multiple-cell grid wave model WAVEWATCH III grid generation algorithm

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Long-Term Settlement Characterization of High-Filling Foundation in the Mountain Excavation and City Construction Area of the Yan’an New District,China

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Journal of Earth Science 2023年第6期34卷 1908-1915页

作者： Xiaokun hou Shengwen Qi Yongtang yu Jianguo Zheng Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Sciences Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China China United Northwest Institute for Engineering Design&Research Co. Ltd.Xi'an 710077China China Jikan Research Institute of Engineering Investigations and Design Co. Ltd.Xi'an 710021China

Mountain Excavation and City Construction(MECC)represents a prominent anthropogenic endeavor aimed at facilitating urban expansion in the Loess Plateau of *** is important to comprehend the long-term settlement behavior at MECC engineering sites to effectively assess the project’s success in reshaping landscapes and expanding urban *** this study,a typical MECC project,specifically the upstream area of the Liujiagou Valley within the new district of Yan’an City,is selected as a case study to investigate long-term settlement *** research involved conducting creep tests on soil samples with varying dry densities and moisture content and continuous in-situ monitoring of ground surface settlement at 17 specific ***,a numerical model was developed and calibrated using the in-situ monitoring data to predict the long-term *** findings reveal that an increase in soil dry density and a decrease in soil water content contribute to reduced ***,settlement primarily manifests within the filled areas,with greater soil thickness exacerbating settlement *** time,cumulative settlement exhibits a progressively diminishing rate of deformation until it attains a stable *** results provide insights for assessing the long-term stability of MECC projects,facilitating decision-making in future endeavors within this region.

关键词： Loess Plateau of China long-term settlement in-situ observation numerical analysis engineering geology

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Spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice in multiple dimensions during 1979 to 2020

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Acta Oceanologica Sinica 2024年第3期43卷 102-114页

作者： yu Guo Xiaoli Wang He Xu Xiyong hou CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China University of Chinese Academy of Sciences Beijing 100049China

Arctic sea ice is broadly regarded as an indicator and amplifier of global climate *** rapid changes in Arctic sea ice have been widely ***,the spatiotemporal changes in the horizontal and vertical dimensions of Arctic sea ice and its asymmetry during the melt and freeze seasons are rarely quantified simultaneously based on multiple sources of the same long time *** this study,the spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice were investigated from both the horizontal and vertical dimensions during 1979–2020 based on remote sensing and assimilation *** results indicated that Arctic sea ice was declining at a remarkably high rate of–5.4×10^(4) km^(2)/a in sea ice area(SIA)and–2.2 cm/a in sea ice thickness(SIT)during 1979 to 2020,and the reduction of SIA and SIT was the largest in summer and the smallest in ***,compared with other sub-regions,SIA showed a sharper declining trend in the Barents Sea,Kara Sea,and East Siberian Sea,while SIT presented a larger downward trend in the northern Canadian Archipelago,northern Greenland,and the East Siberian *** to the seasonal trend of sea ice on sub-region scale,the reduction rate of SIA exhibited an apparent spatial heterogeneity among seasons,especially in summer and winter,i.e.,the sub-regions linked to the open ocean exhibited a higher decline rate in winter;however,the other sub-regions blocked by the coastlines presented a greater decline rate in *** SIT,the sub-regions such as the Beaufort Sea,East Siberian Sea,Chukchi Sea,Central Arctic,and Canadian Archipelago always showed a higher downward rate in all ***,a striking freeze-thaw asymmetry of Arctic sea ice was also *** sea ice changes in different dimensions,sea ice over most regions in the Arctic showed an early retreat and rapid advance in the horizontal dimension but late melting and gradual freezing in the vertical *** amount of sea ice me

关键词： Arctic sea ice sea ice area sea ice thickness spatiotemporal variation freeze-thaw asymmetry

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The effect of nanoparticles on reservoir wettability alteration:a critical review

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Petroleum Science 2021年第1期18卷 136-153页

作者： Hilmy Eltoum yu-Long Yang Ji-Rui hou Unconventional Petroleum Research Institute China University of Petroleum-BeijingBeijing 102249China

A novel concept of treating oil reservoirs by nanofluids is being developed to improve oil recovery and reduce the trapped oil in hydrocarbon *** show great potential in enhancing oil recovery under ambient *** this paper,the approaches of wettability alteration by using nanofluid,stability of nanofluids,and the most reliable wettability alteration mechanisms associated with variant types of nanoparticles have been ***,the parameters that have a significant influence on nanofluid flooding have been ***,the recent studies of the effect of nanoparticles on wettability alteration have been summarised and ***,this paper presents possible opportunities and challenges regarding wettability alteration using nanofluids.

关键词： Enhanced oil recovery(EOR) Nanofluid injection Wettability alteration Nanoparticles Contact angle

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A bound on judicious bipartitions of directed graphs

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Science China Mathematics 2020年第2期63卷 297-308页

作者： Jianfeng hou Huawen Ma Xingxing yu Xia Zhang Center for Discrete Mathematics and Theoretical Computer Science Fuzhou UniversityFuzhou 350116China School of Mathematics Georgia Institute of TechnologyAtlantaGA 30332USA School of Mathematics and Statistics Shandong Normal UniversityJinan 250014China

Judicious partitioning problems on graphs ask for partitions that bound several quantities simultaneously,which have received much attention ***(2005)asked the following natural question:What is the maximum constant cdsuch that every directed graph D with m arcs and minimum outdegree d admits a bipartition V(D)=V_1∪V_2 satisfying min{e(V_1,V_2),e(V_2,V_1)}cdm?Here,for i=1,2,e(V_i,V_(3-i))denotes the number of arcs in D from V_i to V_(3-i).Lee et al.(2016)conjectured that every directed graph D with m arcs and minimum outdegree at least d 2 admits a bipartition V(D)=V_1∪V_2 such that min{e(V_1,V_2),e(V_2,V_1)}≥((d-1)/(2(2 d-1))+o(1))*** this paper,we show that this conjecture holds under the additional natural condition that the minimum indegree is also at least d.

关键词： directed graph partition outdegree indegree tight component

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Speed planning and energy management strategy of hybrid electric vehicles in a car-following scenario

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Control Theory and Technology 2022年第2期20卷 185-196页

作者： Shengyan hou Hong Chen yu Zhang Jinwu Gao State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022JilinChina Department of Control Science and Engineering Jilin UniversityChangchun 130025JilinChina Department of Control Science and Engineering Tonji UniversityShanghai 200092China Suzhou Zhito Technology Co. Ltd.Suzhou 215129JiangsuChina

The development of intelligent connected technology has brought opportunities and challenges to the design of energy management strategies for hybrid electric ***,to achieve car-following in a connected environment while reducing vehicle fuel consumption,a power split hybrid electric vehicle was used as the research object,and a mathematical model including engine,motor,generator,battery and vehicle longitudinal dynamics is ***,with the goal of vehicle energy saving,a layered optimization framework for hybrid electric vehicles in a networked environment is *** speed planning problem is established in the upper-level controller,and the optimized speed of the vehicle is obtained and input to the lower-level ***,after the lower-level controller reaches the optimized speed,it distributes the torque among the energy sources of the hybrid electric vehicle based on the equivalent consumption minimum *** simulation results show that the proposed layered control framework can achieve good car-following performance and obtain good fuel economy.

关键词： Hybrid electric vehicle Car-following Speed planning Energy management strategy

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Consistent batch fusion for decentralized multi-robot cooperative localization

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Control Theory and Technology 2024年第4期22卷 638-651页

作者： Ning Hao Fenghua He yu Yao Yi hou School of Astronautics Harbin Institute of TechnologyXidazhi StreetHarbin150000HeilongjiangChina

This paper investigates the problem of decentralized multi-robot cooperative *** problem involves collaboratively estimating the poses of a group of robots with respect to a common reference coordinate system using robot-to-robot relative measurements and intermittent absolute measurements in a distributed *** address this problem,we present a decentralized fusion method that enables batch updating to handle relative measurements from multiple robots *** method can improve both the accuracy and computational efficiency of cooperative *** reduce communication costs and reliance on connectivity,we do not maintain the inter-robot state ***,we adopt a covariance intersection(CI)technique to design an upper bound that replaces unknown joint *** propose an optimization method to determine a tight upper bound for the correlations in the joint *** consistency and convergence of our proposed algorithm is theoretically ***,we conduct Monte Carlo numerical simulations and real-world experiments to demonstrate that the proposed method outperforms existing approaches in terms of both accuracy and consistency.

关键词： Multi-robot cooperative localization Decentralized fusion Consistency Covariance intersection

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Synthesis and Excellent Antibacterial Activity of Ag_(2)O-Loaded Carboxymethyl Starch Nanocomposites

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Journal of Ocean University of China 2023年第3期22卷 728-734页

作者： WAN Lina yu Liangmin hou Jin ZHAO Xia Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationCollege of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China Shandong Key Laboratory of Corrosion Science Institute of OceanologyChinese Academy of SciencesQingdao 266100China

Carboxymethyl starch/silver oxide nanocomposites(CMS-Ag_(2)O NCs)were successfully fabricated by modifying carboxymethyl starch(CMS)with Ag_(2)O obtained from an aqueous AgNO_(3)solution as silver ***_(2)O nanoparticles(NPs)formed on the surface of CMS by ion *** on SEM images,the diameters of Ag_(2)O NPs were determined to be between 50 and 100 *** the XRD spectra of CMS-Ag_(2)O NCs,the new diffraction peaks appeared at 33.88°and 38.08°,which were attributed to the Ag_(2)O *** to the XPS analysis,Ag 3d_(5/2)and Ag 3d_(3/2)peaks in CMS-Ag_(2)O NCs were fitted into two main peaks centered at 367.6 eV and 373.6 eV,which were attributed to Ag^(+).The antibacterial efficiencies of CMS-Ag_(2)O NCs against Escherichia coli,Staphylococcus aureus,Pseudoalteromonas tetraodonis,Micrococcus luteus,and Shewanella putrefaciens were determined to be 99.6%,99.7%,99.4%,99.5%,and 99.6%,*** antibacterial efficiencies of CMS-Ag_(2)O NCs against the bacterial species were all greater than 99%.Therefore,these results indicated that CMS-Ag_(2)O NCs was highly effective as a bactericidal agent against multiple bacterial ***-Ag_(2)O NCs can be further applied to antifouling coating.

关键词： antibacterial activity silver oxide nanoparticles carboxymethyl starch

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