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Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury via TXNIP regulation

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World Journal of Stem Cells 2024年第10期16卷 873-895页

作者： Feng-Dan Wang Yi Ding Jian-Hong Zhou En Zhou Tian-Tian zhang Yu-qi Fan qing He zong-qi zhang Cheng-Yu Mao Jun-Feng zhang Jing Zhou Department of Cardiology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Anesthesiology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

BACKGROUND Myocardial ischemia-reperfusion injury(MIRI)poses a prevalent challenge in current reperfusion therapies,with an absence of efficacious interventions to address the underlying *** To investigate whether the extracellular vesicles(EVs)secreted by adipose mesenchymal stem cells(ADSCs)derived from subcutaneous inguinal adipose tissue(IAT)underγ-aminobutyric acid(GABA)induction(GABA-EVs^(IAT))demonstrate a more pronounced inhibitory effect on mitochondrial oxidative stress and elucidate the underlying *** We investigated the potential protective effects of EVs derived from mouse ADSCs pretreated with *** assessed cardiomyocyte injury using terminal deoxynucleotidyl transferase dUTP nick end-labeling and Annexin V/propidium iodide *** integrity of cardiomyocyte mitochondria morphology was assessed using electron microscopy across various intervention *** explore the functional RNA diversity between EVs^(IAT)and GABA-EVs^(IAT),we employed microRNA(miR)*** a dual-luciferase reporter assay,we confirmed the molecular mechanism by which EVs mediate thioredoxin-interacting protein(TXNIP).Western blotting and immunofluorescence were conducted to determine how TXNIP is involved in mediation of oxidative stress and mitochondrial *** Our study demonstrates that,under the influence of GABA,ADSCs exhibit an increased capacity to encapsulate a higher abundance of miR-21-5p within ***,this leads to a more pronounced inhibitory effect on mitochondrial oxidative stress compared to EVs from ADSCs without GABA intervention,ultimately resulting in myocardial *** a molecular mechanism level,EVs regulate the expression of TXNIP and mitigating excessive oxidative stress in mitochondria during MIRI process to rescue *** Administration of GABA leads to the specific loading of miR-21-5p into EVs by ADSCs,thereby regulating the expression of *** EVs derived from

关键词： Extracellular vesicles Myocardial ischemia-reperfusion injury Adipose-derived mesenchymal stem cells Gammaaminobutyric acid Thioredoxin-interacting protein

Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai Hypertension Detail Management Program

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Frontiers of Medicine 2010年第1期4卷 67-70页

作者： Xin-Jian LI Min-Na CHENG Yu-Heng WANG Sun MIAO zong-qi zhang Yi-Sheng CHEN Wei LU Department of Cardiovascular Disease Prevention Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China

A community-based multi-center randomized controlled trial was conducted to evaluate the effectiveness of blood pressure control for hypertension patients in communities in urban Shanghai by integrated *** present,patients(n=1395)from four communities have completed follow-up for one year,including the intervention group(n=921)and usual care group(n=474).The intervention programs included disease manage-ment by a care *** pressure of each patient was measured *** with the control group,the net change of mean systolic blood pressure(SBP)was–6.75(95%CI:–7.79 to–5.71,P<0.001)mmHg,mean diastolic blood pressure(DBP)was–4.29(95%CI:–5.08 to–3.49,P<0.001)mmHg,and mean pulse pressure(PP)was–2.46(95%CI:–3.50 to–1.43,P<0.001)mmHg in the intervention *** net change extent was larger in patients with regular pharmacological treatment than in those with irregular pharmacological treatment or non-pharmacological *** measures of integrated intervention for hypertension patients in communities can lower signiﬁ-cantly not only SBP and DBP,but also *** is suggested that measures of integrated intervention can decrease the risk of cardiovascular diseases in hypertension patients.

关键词： hypertension community pharmacological adherence control of blood pressure

Identification of transcription factors contributing to vitamin C synthesis during Rosa roxburghii fruit development by integrating transcriptomics and metabolomics

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Horticultural Plant Journal 2025年第1期11卷 123-132页

作者： Liyao Su Tian zhang zong-Ming(Max)Cheng State Key Laboratory of Crop Genetics and Germplasm Enhancement College of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China

Ascorbic acid, also referred to as vitamin C(Vc), is an important nutrient found in fruits and vegetables that promotes produce quality and human health. Rosa roxburghii is an underutilized natural fruit that contains very high levels of Vc. However, the Vc content of R. roxburghii varies considerably during plant development and ripening. To better understand the molecular mechanisms that underlie fluctuations in Vc content of R. roxburghii fruit at different developmental stages, we performed transcriptomic and metabolomic analyses and identified two significant gene networks/modules and 168 transcription factors directly involved in Vc synthesis. Promoter analysis of two core genes involved in Vc synthesis, RrGGP and RrGalUR, revealed the presence of a retroviral long terminal repeat(LTR) insert in the RrGalUR promoter. Using yeast one-hybrid and dual-luciferase assays, we demonstrated that the transcription factors RrHY5H and RrZIP9 bind to the promoter of RrGGP to promote its expression. RrZIP6 and RrWRKY4 bind to the LTR in the RrGalUR promoter to promote its expression. Our results reveal a molecular mechanism that controls Vc synthesis and accumulation in R. roxburghii fruit.

关键词： Rosa roxburghii Vitamin C WGCNA Transcriptome Metabolome

NiNC Catalysts in CO_(2)-to-CO Electrolysis

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Nano-Micro Letters 2025年第4期17卷 363-366页

作者： Hao zhang Menghui qi Yong Wang Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Chemistry University of OxfordOxford OX13TAUK Advanced Materials and Catalysis Group Department of ChemistryInstitute of CatalysisZhejiang UniversityHangzhou 310058People’s Republic of China

CO_(2)-to-CO electrolyzer technology converts carbon dioxide into carbon monoxide using electrochemical methods,offering significant environmental and energy benefits by aiding in greenhouse gas mitigation and promoting a carbon circular *** study by Strasser et *** Nature Chemical Engineering presents a high-performance CO_(2)-to-CO electrolyzer utilizing a NiNC catalyst with nearly 100%faradaic efficiency,employing innovative diagnostic tools like the carbon crossover coefficient(CCC)to address transport-related failures and optimize overall ***’s research demonstrates the potential of NiNC catalysts,particularly NiNC-IMI,for efficient CO production in CO_(2)-to-CO electrolyzers,highlighting their high selectivity and ***,challenges such as localized CO_(2)depletion and mass transport limitations underscore the need for further optimization and development of diagnostic tools like *** for optimizing catalyst structure and operational parameters offer avenues for enhancing the performance and reliability of electrochemical CO_(2)reduction catalysts.

关键词： NiNC catalysts CO_(2)-to-CO electrolyzer Faradaic efficiency Carbon crossover coefficient(CCC) Mesoporous structures

Dual-role regulator of a novel miR-3040 in photoperiod-mediated wing dimorphism and wing development in green peach aphid

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Insect Science 2025年第1期32卷 80-94页

作者： Yun-Hui zhang Xin qian Xin zong Shi-Heng An Shuo Yan Jie Shen College of Plant Protection Henan Agricultural UniversityZhengzhouChina Department of Plant Biosecurity College of Plant ProtectionChina Agricultural UniversityBeijingChina

Wing dimorphism is regarded as an important phenotypic plasticity involved in the migration and reproduction of ***,the signal transduction and regulatory mechanism of wing dimorphism in aphids are still ***,the optimal environmental conditions were first explored for inducing winged offspring of green peach aphid,and the short photoperiod was the most important environmental cue to regulate wing *** to 16 L:8 D photoperiod,the proportion of winged offspring increased to 90%under 8 L:16 D ***,5 differentially expressed microRNAs(miRNAs)in aphids treated with long and short photoperiods were identified using small RNA sequencing,and a novel miR-3040 was identified as a vital miRNA involved in photoperiod-mediated wing *** specifically,the inhibition of miR-3040 expression could reduce the proportion of winged offspring induced by short photoperiod,whereas its activation increased the proportion of winged offspring under long ***,the expression level of miR-3040 in winged aphids was about 2.5 times that of wingless aphids,and the activation or inhibition of miR-3040 expression could cause wing deformity,revealing the dual-role regulator of miR-3040 in wing dimorphism and wing *** summary,the current study identified the key environmental cue for wing dimorphism in green peach aphid,and the first to demonstrate the dual-role regulator of miR-3040 in photoperiod-mediated wing dimorphism and wing development.

关键词： miR-3040 Myzus persicae photoperiod wing development wing dimorphism

Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming zhang Hanyu Wu qi Chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China China University of Petroleum Beijing 102299China

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH_(3)/O_(2)and the production of N_(2)/H_(2)change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH_(3)by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O(1S).However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also hel

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 198-210页

作者： Long Wang qi Wu zong-Wen zhang Hui zhang Hui Jin Xin-Liang Zhou Jia-Yin Liu Dan Li Yan Liu Zhi-Song Fan Department of Oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Colony-stimulating factor 3(CSF3)and its receptor(CSF3R)are known to promote gastric cancer(GC)growth and ***,their effects on the immune microenvironment remain *** analysis indicated a potential link between CSF3R expression and the immunosuppressive receptor leukocyte immunoglobulin-like receptor B2(LILRB2)in *** hypothesized that CSF3/CSF3R may regulate LILRB2 and its ligands,angiopoietin-like protein 2(ANGPTL2)and human leukocyte antigen-G(HLA-G),contributing to *** To investigate the relationship between CSF3/CSF3R and LILRB2,as well as its ligands ANGPTL2 and HLA-G,in *** Transcriptome sequencing data from The Cancer Genome Atlas were analyzed,stratifying patients by CSF3R *** expressed genes and immune checkpoints were ***(IHC)was performed on GC *** analyses of CSF3R,LILRB2,ANGPTL2,and HLA-G were conducted using The Cancer Genome Atlas data and IHC *** cells were treated with CSF3,and expression levels of LILRB2,ANGPTL2,and HLA-G were measured by quantitative reverse transcriptase-polymerase chain reaction and western *** Among 122 upregulated genes in high CSF3R expression groups,LILRB2 showed the most significant *** results indicated high expression of LILRB2(63.0%),ANGPTL2(56.5%),and HLA-G(73.9%)in GC *** positive correlations existed between CSF3R and LILRB2,ANGPTL2,and HLA-G mRNA levels(P0.05).CSF3 increased LILRB2,ANGPTL2,and HLA-G expression in GC *** nuclear ribonucleoprotein H1 modulation significantly altered their expression,impacting CSF3’s regulatory *** The CSF3/CSF3R pathway may contribute to immunosuppression in GC by upregulating LILRB2 and its ligands,with heterogeneous nuclear ribonucleoprotein H1 playing a regulatory role.

关键词： Gastric cancer Immunosuppressive receptor Colony-stimulating factor 3 Colony-stimulating factor 3 receptor Leukocyte immunoglobulin-like receptor B2 Angiopoietin-like protein 2 Human leukocyte antigen-G Heterogeneous nuclear ribonucleoprotein H1

Elastohydrodynamic Lubrication Performance of Curvilinear Cylindrical Gears Based on Finite Element Method

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1585-1609页

作者： Xuegang zhang Yingjie Dong Xian Wei Ruiqi Wang qi zhang School of Intelligent Manufacturing Panzhihua UniversityPanzhihua617000China Panzhihua Hangyu New Material Technology Co. Ltd.Panzhihua617000China School of Intelligent Manufacturing Chengdu Industrial Vocational Technical CollegeChengdu610218China

The fixed-setting face-milled curvilinear cylindrical gear features teeth that are arc-shaped along the longitudinal *** researchers hypothesize that this arc-tooth may enhance the lubrication conditions of the *** study focuses on this type of gear,employing both finite element analysis(FEA)and analytical methods to determine the input parameters required for elastohydrodynamic lubrication(EHL)*** effects of assembly errors,tooth surface modifications,load,and face-milling cutter radius on the lubrication performance of these gears are systematically *** finite element model(FEM)of the gear pair is utilized to calculate the coordinates of contact points on the tooth surface and the corresponding contact pressures at the tooth surface nodes throughout a meshing ***,the normal load on specific gear teeth is determined using a gradient-based *** speed,slip-to-roll ratio,and effective radius near the contact points on the tooth surface are derived through analytical *** data obtained from FEA serve as input parameters for EHL *** lubrication performance of the curvilinear cylindrical gear is evaluated through example *** findings indicate that using FEA to provide input parameters for EHL simulations can reveal the occurrence of edge contact phenomena during gear meshing,allowing for a more accurate representation of the gear’s lubrication *** lubrication performance of the curvilinear cylindrical gear is shown to be independent of the face-milling cutter radius but is significantly influenced by the size of the contact pattern on the tooth *** gears with larger contact patterns demonstrate superior lubrication performance.

关键词： FEM EHL curvilinear cylindrical gear lubrication performance analysis

Atmospheric reductive catalytic fractionation of lignocellulose integrated with one-pot catalytic conversion of carbohydrate yielding valuable lignin monomers and platform chemicals from corn straw

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Green Energy & Environment 2025年第1期10卷 161-172页

作者： Meng-Ying Liu Zhe-Hui zhang Xue-qi Wang qian Sun Chen zhang Yu Li Zhuohua Sun Katalin Barta Feng Peng Tong-qi Yuan State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijing100083China Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Department of Chemistry Organic and Bioorganic ChemistryUniversity of GrazHeinrichstrasse 28/II8010 GrazAustria

Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent ***,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps *** key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene *** utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling *** the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.

关键词： Atmospheric reductive catalytic fractionation Corn straw Ethylene glycol Raney Ni 5-Methoxymethylfurfural