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Social function scores and influencing factors in patients with residual depressive symptoms

World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： zong-Ling Liao Xiao-Li pu Zhi-Yi Zheng Jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

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Magnaporthe Rab5 homologs show distinct functions in nerve growth factor(NGF)-mediated neurite outgrowth and cell differentiation

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Journal of Integrative Agriculture 2015年第5期14卷 823-829页

作者： QI Yao-yao LIANG Zhi-min zhou Jie WANG zong-hua LU Guo-dong LI Guang-pu Key Laboratory of Biopesticides and Chemical Biology Ministry of Education/Fujian Agriculture and Forestry University Department of Biochemistry and Molecular Biology University of Oklahoma Health Sciences Center

Nerve growth factor（NGF） binds to TrkA and forms a NGF/TrkA complex at the cell surface,which is then internalized into signaling endosomes and promotes neuronal survival and neurite *** small GTPase Rab5 is reported to localize on the plasma membrane and early endosomes,regulating endosome *** was reported that endogenous Rab5 function may need to be suppressed during NGF-induced neurite outgrowth and cell *** Rab5 homologs（MoRab5A：MGG_06241 and MoRab5B：MGG_01185） were characterized from the rice blast fungus Magnaporthe oryzae,and MoRab5 B was identified as the Rab5 ortholog promoting early endosomal fusion,while MoRab5 A specialized to perform a non-redundant function in endosomal *** this study,we examined whether MoRab5 A and MoRab5 B play different roles in NGF-induced neurite outgrowth and cell differentiation in PC12 cells（a rat pheochromocytoma cell line）.Our data showed that MoRab5 B is a negative regulator of NGF signaling and neurite outgrowth in PC12 cells,similar to human Rab5（hRab5）.MoRab5B：WT inhibits NGF signaling-dependent neurite outgrowth while the dominant-negative MoRab5 B mutant（MoRab5B：DN） enhances NGF signaling and neurite *** contrast,MoRab5A：WT and MoRab5A：DN both significantly promote NGF-induced neurite outgrowth,indicating that MoRab5 B is more similar to hRab5 than MoRab5 A in the regulation of NGF signal transduction.

关键词： TrkA suppressed endogenous regulating specialized transduction neuronal signaling eGFP sorting

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TESTING LINEAR AND NONLINEAR GRANGER CAUSALITY IN CSI300 FUTURES AND SPOT MARKETS BASED ON NEW CONCEPTS OF NONLINEAR POSITIVE/NEGATIVE SPILLOVER

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Journal of Systems Science & Complexity 2014年第4期27卷 729-742页

作者： zhou pu LU Fengbin WANG Shouyang Risk Management Unit Bank of China Head Office Academy of Mathematics and Systems Science Chinese Academy of Sciences

supported by the National Natural Science Foundation of China under Grant Nos.71125005 70871108 and 70810107020;; Outstanding Talents Funds of Organization Department Beijing Committee of CPC

关键词： China stock market negative volatility spillover nonlinear Granger causality test riskabsorption volatility spillover.

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Coevolution of global brachiopod palaeobiogeography and tectonopalaeogeography during the Carboniferous

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Journal of Palaeogeography 2021年第3期10卷 284-301页

作者： Ning Li Cheng-Wen Wang pu zong Yong-Qin Mao College of Earth Sciences Jilin UniversityChangchun 130061Jilin ProvinceChina International Center of Future Science Dinosaur Evolution Research CenterJilin UniversityChangchun 130061Jilin ProvinceChina Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Guizhou Mountain Resources Research Institution Guiyang 550001Guizhou ProvinceChina

The global brachiopod palaeobiogeography of the Mississippian is divided into three realms, six regions, and eight provinces, while that of the Pennsylvanian is divided into three realms, six regions, and nine provinces. On this basis,we examined coevolutionary relationships between brachiopod palaeobiogeography and tectonopalaeogeography using a comparative approach spanning the Carboniferous. The appearance of the Boreal Realm in the Mississippian was closely related to movements of the northern plates into middle–high latitudes. From the Mississippian to the Pennsylvanian, the palaeobiogeography of Australia transitioned from the Tethys Realm to the Gondwana Realm,which is related to the southward movement of eastern Gondwana from middle to high southern latitudes. The transition of the Yukon–Pechora area from the Tethys Realm to the Boreal Realm was associated with the northward movement of Laurussia, whose northern margin entered middle–high northern latitudes then. The formation of the six palaeobiogeographic regions of Mississippian and Pennsylvanian brachiopods was directly related to "continental barriers", which resulted in the geographical isolation of each region. The barriers resulted from the configurations of Siberia, Gondwana, and Laurussia, which supported the Boreal, Tethys, and Gondwana realms, respectively. During the late Late Devonian–Early Mississippian, the Rheic seaway closed and North America(from Laurussia) joined with South America and Africa(from Gondwana), such that the function of "continental barriers" was strengthened and the differentiation of eastern and western regions of the Tethys Realm became more distinct. In the Barents Ocean tectonic domain during the Pennsylvanian, the brachiopods on the northern margin of the Barents Ocean formed the Verkhoyansk–Taymyr Province, while those on the southern margin formed the Yukon–Pechora Province. The Mongolia–Okhotsk Province was formed by brachiopods of the Mongolia–Okhotsk Ocean tectoni

关键词： Carboniferous Brachiopod Palaeobiogeography Tectonopalaeogeography Coevolution

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Even-odd-dependent optical transitions of zigzag monolayer black phosphorus nanoribbons

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Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 91-101页

作者： pu Liu XianZhe Zhu XiaoYing zhou GuangHui zhou Kai Chang Department of Physics Key Laboratory for Low-Dimensional Structures and Quantum Manipulation(Ministry of Education)Synergetic Innovation Center for Quantum Effects and Applications of HunanHunan Normal UniversityChangsha410081China SKLSM Institute of SemiconductorsChinese Academy of SciencesBeijing100083China

We analytically study the electronic structure and optical properties of zigzag-edged phosphorene nanoribbons(ZPNRs) using the tight-binding Hamiltonian and Kubo formula. By directly solving the discrete Schrodinger equation, we obtain the energy spectra and wavefunctions for N-ZPNR(where N is the number of transverse zigzag atomic chains) and classify the eigenstates according to the lattice symmetry. Then, we obtain the optical transition selection rule of ZPNRs on the basis of symmetry analysis and analytical expressions of optical transition matrix elements. Under incident light that is linearly polarized along the ribbon, we determine that the optical transition selection rule for N-ZPNR with even-or odd-N is qualitatively different. Specifically, for even-N ZPNRs, the inter-(intra-) band selection rule is ?n =odd(even) because the parity of the wavefunction corresponding to the n-th subband in the conduction(valence) band is(-1)~n[(-1)~((n+1))] owing to the presence of C(2x) symmetry. However, the optical transitions between any subbands are possible owing to the absence of C(2x) symmetry. Our results provide a further understanding on the electronic states and optical properties of ZPNRs, which are useful for explaining the optical experiment data on ZPNR samples.

关键词： zigzag-edged phosphorene nanoribbons band structure light absorption selection rules

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Downward current electron beams observed at the dipolarization front

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Chinese Science Bulletin 2013年第8期58卷 913-919页

作者： ZHENG Hao FU SuiYan zong QuiGang pu ZuYin School of Earth and Space Sciences Peking University

The strong field-aligned pitch angle distribution of electrons is observed right at the dipolarization front (DF) before the arriving of a high speed flow when the four Cluster satellites are traveling in the magnetotail around 15 R E on July 22, 2001. The increased electron fluxes only last for a short time period at the DF, corresponding to just a few bouncing periods for 1 keV electrons. The field-aligned current contributed by these electrons agrees well with that calculated by the magnetic field observations by four satellites at the front. These electron streams are found in the energy range of 0.2-2 keV, peak around 1 keV. It is suggested that these downward current electrons may be originated near the aurora region by some kinds of potential structure. The occurrence of these electrons implies that the formation of the dipolarization front and the associated field-aligned current play an important role in the magnetosphere-ionosphere coupling.

关键词：场向电流电子束极化 Cluster 电离层耦合磁场观测能量范围高速流

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Temporal and Spatial Distribution of the Late Devonian (Famennian) Strata in the Northwestern Border of the Junggar Basin, Xinjiang, Northwestern China

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Acta Geologica Sinica(English Edition) 2017年第4期91卷 1413-1437页

作者： MA Xueping ZHANG Meiqiong zong pu ZHANG Yubo Lü Dan The Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space Sciences Peking University Beijing 100871 China Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China

The base of the Saerba Member （Mbr） of the Hongguleleng Formation （Fm.） probably lies in the Famennian Palmatolepis crepida Zone; the Longkou Mbr is probably a sedimentary wedge that thins out northwards; the Duguer Mbr has an approximate age from the upper part of the Pa. marginifera Zone or the Lower Pa. rugosa trachytera Zone through the top of the Pa. perlobata postera Zone; the Wulan Mbr has an age approximately corresponding to the whole Pa. gracilis expansa Zone. In the Bulongguoer section, the Lower Mbr of the Hongguleleng Fro. corresponds to Famennian Pa. crepida Zone through Pa. marginifera Zone; the Middle Mbr probably ranges from the Pa. r. trachytera Zone through the Pa. g. expansa Zone. The basal Namu Mbr of the Heishantou Fm. is probably the product during and after the Hangenberg Event in the upper part of the Siphonodellapraesulcata Zone, which is still within the Devonian. In this context, the underlying Chasi Mbr may approximately correspond to the lower part of the S. praesulcata Zone （before the Hangenberg Event）. Lateral distribution of strata indicates that the Upper Devonian in the Gennaren and Saerba areas each constitutes a structure of syncline, which differs from the previous recognition of a monocline structure.

关键词： Junggar Bulongguoer Hongguleleng Formation Heishantou Formation "Hebukehe"Formation Xinjiang

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Image-Based Flow Prediction of Vocal Folds Using 3D Convolutional Neural Networks

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Journal of Bionic Engineering 2024年第2期21卷 991-1002页

作者： Yang Zhang Tianmei pu Jiasen Xu Chunhua zhou College of Astronautics Nanjing University of Aeronautics and AstronauticsNanjing210016China College of Electrical Energy and Power EngineeringYangzhou UniversityYangzhou225127China College of Aeronautics Nanjing University of Aeronautics and AstronauticsNanjing210016China

In this work,a three dimensional(3D)convolutional neural network(CNN)model based on image slices of various normal and pathological vocal folds is proposed for accurate and efficient prediction of glottal *** 3D CNN model is composed of the feature extraction block and regression *** feature extraction block is capable of learning low dimensional features from the high dimensional image data of the glottal shape,and the regression block is employed to flatten the output from the feature extraction block and obtain the desired glottal flow *** input image data is the condensed set of 2D image slices captured in the axial plane of the 3D vocal folds,where these glottal shapes are synthesized based on the equations of normal vibration *** output flow data is the corresponding flow rate,averaged glottal pressure and nodal pressure distributions over the glottal *** 3D CNN model is built to establish the mapping between the input image data and output flow *** ground-truth flow variables of each glottal shape in the training and test datasets are obtained by a high-fidelity sharp-interface immersed-boundary *** proposed model is trained to predict the concerned flow variables for glottal shapes in the test *** present 3D CNN model is more efficient than traditional Computational Fluid Dynamics(CFD)models while the accuracy can still be retained,and more powerful than previous data-driven prediction models because more details of the glottal flow can be *** prediction performance of the trained 3D CNN model in accuracy and efficiency indicates that this model could be promising for future clinical applications.

关键词： Vocal folds Computational fluid dynamics Machine learning 3D convolutional neural network

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Two-Stage Approach for Targeted Knowledge Transfer in Self-Knowledge Distillation

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2270-2283页

作者： Zimo Yin Jian pu Yijie zhou Xiangyang Xue the School of Computer Science Fudan University the Institute of Science and Technology for Brain Inspired Intelligence Fudan University IEEE

Knowledge distillation(KD) enhances student network generalization by transferring dark knowledge from a complex teacher network. To optimize computational expenditure and memory utilization, self-knowledge distillation(SKD) extracts dark knowledge from the model itself rather than an external teacher network. However, previous SKD methods performed distillation indiscriminately on full datasets, overlooking the analysis of representative samples. In this work, we present a novel two-stage approach to providing targeted knowledge on specific samples, named two-stage approach self-knowledge distillation(TOAST). We first soften the hard targets using class medoids generated based on logit vectors per class. Then, we iteratively distill the under-trained data with past predictions of half the batch size. The two-stage knowledge is linearly combined, efficiently enhancing model performance. Extensive experiments conducted on five backbone architectures show our method is model-agnostic and achieves the best generalization ***, TOAST is strongly compatible with existing augmentation-based regularization methods. Our method also obtains a speedup of up to 2.95x compared with a recent state-of-the-art method.

关键词： Cluster-based regularization iterative prediction refinement model-agnostic framework self-knowledge distillation(SKD) two-stage knowledge transfer

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