检索结果-南通市图书馆

Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

Neural Regeneration Research 2019年第4期14卷 613-620页

作者： Wen-Bo Zhou zong-ning miao Bin Zhang Wei Long Fang-Xiu Zheng Jing Kong Bin Yu Changzhou Women and Children Health Hospital Affiliated to Nanjing Medical University The Stem Cell Research Laboratory Wuxi Third People's Hospital

Studies have shown that the natural flavonoid luteolin has neurotrophic activity. In this study, we investigated the effect of luteolin in a mouse model of Down syndrome. Ts65 Dn mice, which are frequently used as a model of Down syndrome, were intraperitoneally injected with 10 mg/kg luteolin for 4 consecutive weeks starting at 12 weeks of age. The Morris water maze test was used to evaluate learning and memory abilities, and the novel object recognition test was used to assess recognition memory. Immunohistochemistry was performed for the neural stem cell marker nestin, the astrocyte marker glial fibrillary acidic protein, the immature neuron marker DCX, the mature neuron marker NeuN, and the cell proliferation marker Ki67 in the hippocampal dentate gyrus. Nissl staining was used to observe changes in morphology and to quantify cells in the dentate gyrus. Western blot assay was used to analyze the protein levels of brain-derived neurotrophic factor(BDNF) and phospho-extracellular signal-regulated kinase 1/2(p-ERK1/2) in the hippocampus. Luteolin improved learning and memory abilities as well as novel object recognition ability, and enhanced the proliferation of neurons in the hippocampal dentate gyrus. Furthermore, luteolin increased expression of nestin and glial fibrillary acidic protein, increased the number of DCX^+ neurons in the granular layer and NeuN^+ neurons in the subgranular region of the dentate gyrus, and increased the protein levels of BDNF and p-ERK1/2 in the hippocampus. Our findings show that luteolin improves behavioral performance and promotes hippocampal neurogenesis in Ts65 Dn mice. Moreover, these effects might be associated with the activation of the BDNF/ERK1/2 pathway.

关键词： nerve regeneration luteolin hippocampus Ts65Dn mice neurogenesis ERK BDNF nestin GFAP NeuN Down syndrome neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface integrity characterization of thirdgeneration nickel-based single crystal blade tenons after ultrasonic vibration-assisted grinding

引用

Chinese Journal of Aeronautics 2025年第1期38卷 235-253页

作者： Biao ZHAO Hexu YOU Qing miao Wenfeng DING ning QIAN Jiuhua XU National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Mechanical Engineering Suzhou University of Science and TechnologySuzhou 215009China

Machined surface integrity of workpieces in harsh environments has a remarkable influence on their ***,the complexity of the new type of machining hinders a comprehensive understanding of machined surface integrity and its formation mechanism,thereby limiting the study of component *** increasing demands for high-quality machined workpieces in aerospace industry applications,researchers from academia and industry are increasingly focusing on post-machining surface *** profile grinding test was conducted on a novel single-crystal superalloy to simulate the formation of blade tenons,and the obtained tenons were characterized for surface integrity elements under various operating *** revealed that ultrasonic vibration-assisted grinding(UVAG)led to multiple superpositions of abrasive grain trajectories,causing reduced surface roughness(an average reduction of approximately29.6%)compared with conventional *** examining the subsurface layer of UVAG using transmission electron microscopy,the results revealed that the single-crystal tenon grinding subsurface layer exhibited a gradient evolution from the near-surface to the *** evolution was characterized by an equiaxed nanocrystalline layer measuring 0.34μm,followed by a submicrocrystalline grain-forming zone spanning 0.6μm and finally,a constituent phase-twisted dis-torted deformation zone over 0.62μ*** normal grinding conditions,the tenon exhibited low surface hardening(not exceeding 15%),and residual compressive stresses were observed on its *** cases where grinding burns occurred,a white layer appeared on the tenon's surface,which demonstrated varying thicknesses along the teeth from top to root due to thermal-force-structural coupling ***,these burns introduced residual tensile stresses on the tenon's surface,potentially substantially affecting its fatigue *** paper enhances our understanding of UVAG pro

关键词： Single-crystal blade tenon Seeded gel abrasives Ultrasonic vibration-assisted profile grinding Surface integrity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human amniotic epithelial cells combined with silk fibroin scaffold in the repair of spinal cord injury

引用

Neural Regeneration Research 2016年第10期11卷 1670-1677页

作者： Ting-gang Wang Jie Xu Ai-hua Zhu Hua Lu zong-ning miao Peng Zhao Guo-zhen Hui Wei-jiang Wu Department of Neurology Wuxi Third People's Hospital Department of Neurosurgery Wuxi Third People's Hospital First Affiliated Hospital Soochow University

Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial scaffold materials, such as fibroin, for nerve repair. However, such approaches are challenged by ethical and practical issues. Amniotic tissue, a clinical waste product, is abundant, and amniotic epithe- lial cells are pluripotent, have low immunogenicity, and are not the subject of ethical debate. We hypothesized that amniotic epithelial cells combined with silk fibroin scaffolds would be conducive to the repair of spinal cord injury. To test this, we isolated and cultured amniotic epithelial cells, and constructed complexes of these cells and silk fibroin scaffolds. Implantation of the cell-scaffold complex into a rat model of spinal cord injury resulted in a smaller glial scar in the damaged cord tissue than in model rats that received a blank scaffold, or amniotic epithelial cells alone. In addition to a milder local immunological reaction, the rats showed less inflammatory cell infiltration at the trans- plant site, milder host-versus-graft reaction, and a marked improvement in motor function. These findings confirm that the transplantation of amniotic epithelial ceils combined with silk fibroin scaffold can promote the repair of spinal cord injury. Silk fibroin scaffold can provide a good nerve regeneration microenvironment for amniotic epithelial cells.

关键词： nerve regeneration spinal cord injury amniotic epithelial cells silk fibroin scaffold transplantation glial scar microenvironment immunological reaction rejection neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Increased frequency and clinical significance of myeloidderived suppressor cells in human colorectal carcinoma

引用

World Journal of Gastroenterology 2012年第25期18卷 3303-3309页

作者： Hong-Li Sun, Xin Zhou, Yi-Feng Xue Ke Wang, Yun-Feng ShenI Jing-Jue Mao Hong-Feng Guo zong-ning miao Department of Hematology Wuxi People'sHospitalWuxi 214023 JiangProvlnce China Department of General Surgery Wuxi Third People'sHospital.Wuxi 214023 Jiangsu Province China The Stem Cell Research Laboratory WuxiThird People's Hospital Wuxi 214023 Jiangsu Province China Department of Clinical Laboratory Wuxi People'sHospital Wuxi 214023 Jiangsu Province China

AIM： To investigate the frequency and clinical signifi- cance of the myeloid-derived suppressor cells （MDSC） in human colorectal carcinoma （CRC）. METHODS： Samples of peripheral blood and tumor tis- sue from 49 CRC patients were analyzed. Mononuclear cells were isolated by FicolI-Hypaque density gradient centrifugation and were subjected to a flow cytometry- based immunophenotypic analysis. RESULTS： A considerable increase in the percentage of CD33＋HLA-DR MDSCs was observed in the periph- eral blood （1.89% ：1= 0.75%） and tumor tissues （2.99%±1.29%） of CRC patients as compared with that in theperipheral blood of healthy controls （0.54%±0.35%）. This expanded CD33＋HLA-DR subset exhibited imma- ture myeloid cell markers, but not lineage markers, and showed up-regulation of CD18/CD11b expression as compared with the MDSCs from healthy donors. Fur- ther studies showed that the MDSC proportion in CRC peripheral blood was correlated with nodal metastasis （P = 0.023）, whereas that in tumor tissues was cor- related with nodal/distant metastasis （P = 0.016/P = 0.047） and tumor stage （P = 0.028）, suggesting the involvement of MDSCs in CRC tumor development. CONCLUSION： Characterization of MDSCs in CRC sug- gests the clinical significance of circulating and tumor- infiltrating MDSCs and may provide new insights into the CRC immunotherapy targeting MDSCs.

关键词： Myeloid-derived suppressor cell Colorectalcarcinoma Tumor metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Occurrence of phthalate esters in the yellow and Yangtze rivers of china:Risk assessment and source apportionment

引用

Journal of Environmental Sciences 2025年第3期149卷 628-637页

作者： Qinkui miao Wenxiang Ji Huiyu Dong Ying Zhang College of Environmental Science and Engineering Nankai UniversityTianjin 300350China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Phthalate esters(PAEs),recognized as endocrine disruptors,are released into the environment during usage,thereby exerting adverse ecological *** study investigates the occurrence,sources,and risk assessment of PAEs in surface water obtained from 36 sampling points within the Yellow River and Yangtze River *** total concentration of PAEs in the Yellow River spans from124.5 to 836.5 ng/L,with Dimethyl phthalate(DMP)(75.4±102.7 ng/L)and Diisobutyl phthalate(DiBP)(263.4±103.1 ng/L)emerging as the predominant *** exhibit a pattern of upstream(512.9±202.1 ng/L)>midstream(344.5±135.3 ng/L)>downstream(177.8±46.7 ng/L).In the Yangtze River,the total concentration ranges from 81.9 to 441.6 ng/L,with DMP(46.1±23.4 ng/L),Diethyl phthalate(DEP)(93.3±45.2 ng/L),and DiBP(174.2±67.6 ng/L)as the primary *** levels follow a midstream(324.8±107.3 ng/L)>upstream(200.8±51.8 ng/L)>downstream(165.8±71.6 ng/L)*** should be directed towards the moderate ecological risks of DiBP in the upstream of HH,and both the upstream and midstream of CJ need consideration for the moderate ecological risks associated with Di-n-octyl phthalate(DNOP).Conversely,in other regions,the associated risk with PAEs is either low or *** main source of PAEs in Yellow River is attributed to the release of construction land,while in the Yangtze River Basin,it stems from the accumulation of pollutants in lakes and forests discharged into the *** findings are instrumental for pinpointing sources of PAEs pollution and formulating control strategies in the Yellow and Yangtze Rivers,providing valuable insights for global PAEs research in other major rivers.

关键词： Phthalates Spatial variation Potential sources Risk assessment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Decision making module based on stochastic magnetic tunnel junctions

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 198-205页

作者： Yifan miao Li Zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal UniversityBeijing 100875China Institute for Nanoelectric Devices and Quantum Computing Fudan UniversityShanghai 200433China Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan UniversityShanghai 200433China

In biological neural systems,noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences,we design a decision-making module based on spintronic devices,utilizing superparamagnetic tunnel junctions as artificial *** feasibility of this decision-making module is verified through circuit *** a multi-layer perceptron as an example,the module significantly improves the accuracy of the perceptron in the handwritten digit recognition ***,the spintronic decision-making module offers advantages over the conventional pooling methods,such as adaptive decision time,high performance and the absence of analog-to-digital *** decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

引用

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong miao Michael S.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng Li Meifeng Cai Shengjun miao Yuan Li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

围栏封育对藏北高寒草地植物多样性与生态系统多功能性的影响

引用

草地学报 2025年第2期33卷 596-608页

作者：李振威缪雨珏宗宁中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室北京100101 中国科学院大学北京100049

本研究选择藏北高原降雨梯度带四种类型高寒草地(高寒草甸、高寒草甸草原、高寒草原、高寒荒漠草原),通过测定围栏封育与自由放牧样地中与养分循环和牧草供给等功能密切相关的指标,利用平均值法和多阈值法来探讨围栏封育工程对生态系统... 详细信息

本研究选择藏北高原降雨梯度带四种类型高寒草地(高寒草甸、高寒草甸草原、高寒草原、高寒荒漠草原),通过测定围栏封育与自由放牧样地中与养分循环和牧草供给等功能密切相关的指标,利用平均值法和多阈值法来探讨围栏封育工程对生态系统多功能性的影响。结果表明:高寒草地植物多样性、物种丰富度和生态系统多功能性都会随降水量减少而降低(P<0.05)。围栏封育显著提高植物多样性、物种丰富度以及地上生物量。进一步分析发现,生态系统多功能性与Margalef指数、Simpson指数和Shannon-Weiner指数、物种丰富度均呈显著正相关(P<0.05),而与Pielou指数不相关。多阈值法显示围栏封育和自由放牧样地物种丰富度对生态系统多功能性的有效驱动分别在1%~84%和5%~82%阈值区间内,最大效应值分别是0.69和0.70。综上,围栏封育会使植物多样性发生变化,进而影响生态系统多功能性,保护物种多样性对于维持生态系统多功能性具有重要意义。

关键词：生态系统多功能性植物多样性藏北高寒草地围栏封育与自由放牧平均值法多阈值法

来源：

维普期刊数据库

同方期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

引用

Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu miao Yu Yuhang Song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：