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Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori

World Journal of Gastroenterology 2024年第24期30卷 3086-3105页

作者： Miao-Miao Lin Shan-Shan Yang Qiu-Yue Huang Guang-Hui Cui Xiao-Fen Jia Yao Yang zong-ming shi Hui Ye Xue-Zhi Zhang Department of Integrated Traditional Chinese and Western Medicine Peking University First HospitalBeijing 100034China Institute of Integrated Traditional Chinese and Western Medicine Peking UniversityBeijing 100034China

BACKGROUND Helicobacter pylori(HP),the most common pathogenic microorganism in stomach,can induce inflammatory reactions in the gastric mucosa,causing chronic gastritis and even gastric *** infection affects over 4.4 billion people globally,with a worldwide infection rate of up to 50%.The multidrug resistance of HP poses a serious challenge to *** has been monstrated that compared to bismuth quadruple therapy,Qingre Huashi decoction(QHD)combined with triple therapy exhibits comparable eradication rates but with a lower incidence of adverse reactions;in addition,QHD directly inhibit and kill HP in *** In this study,12 HP strains were isolated in vitro after biopsy during gastroscopy of HP-infected *** vitro,the minimum inhibitory concentration(MIC)values for clinical HP strains and biofilm quantification were determined through the E-test method and crystal violet staining,*** most robust biofilm-forming strain of HP was selected,and QHD was evaluated for its inhibitory and bactericidal effects on the strain with strong biofilm *** assessment was performed using agar dilution,E-test,killing dynamics,and transmission electron microscopy(TEM).The study also explored the impact of QHD on antibiotic resistance in these HP strains with strong biofilm *** violet method,scanning electron microscopy,laser confocal scanning microscopy,and(p)ppGpp chromatographic identification were employed to evaluate the effect of QHD on biofilm in strong biofilm-forming HP *** effect of QHD on biofilm and efflux pump-related gene expression was evaluated by quantitative polymerase chain ***-targeted metabolomics with UHPLC-MS/MS was used to identify potential metabolic pathways and biomarkers which were different between the NC and QHD *** HP could form biofilms of different degrees in vitro,and the intensity of formation was associated with the drug resistance of the *** had str

关键词： Qingre Huashi decoction Helicobacter pylori Drug resistance Biofilm Metabolomics

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Actinidia chinensis *** extract downregulates the Wnt/β-catenin pathway to treat gastric cancer:a mechanism study based on network pharmacology

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Traditional Medicine Research 2023年第7期8卷 35-46页

作者： Ying-ming Chu Qiu-Yue Huang Ting-Xin Wang Nan Yang Xiao-Fen Jia zong-ming shi Hui Ye Xue-Zhi Zhang Department of Integrated Traditional Chinese and Western Medicine Peking University First HospitalBeijing 100034China Institute of Integrated Traditional Chinese and Western Medicine Peking UniversityBeijing 100191China Institute(College)of Integrative Medicine Dalian Medical UniversityDalian 116000China

Background:Actinidia chinensis ***(AcRoots)have been applied as an anti-inflammatory and antitumor drug in the treatment of gastric cancer(GC).However,their mechanisms against GC cells remain *** investigate the anticancer effect of AcRoots in GC and the possible underlying mechanism by using network ***:Differentially expressed genes between gastric precancerous lesions and cancer were analyzed in Gene Expression Omnibus datasets,and these genes were overlapped with potential targets of *** targets and pathways for AcRoots treatment of GC predicted by network ***,we used the GC cell line HGC27 to explore the molecular mechanisms in the context of hub genes in apoptosis,invasion,metastasis,and epithelial to mesenchymal transition-promoting *** docking between hub targets and active drug components was also ***:Network pharmacological analysis suggested that the potential mechanism was related to the Wnt pathway and predicted nine hub *** in vitro studies,AcRoots significantly decreased HGC27 cell viability and promoted apoptosis by upregulating caspase3 and downregulating ***,it suppressed invasion and metastasis as well as the expression of epithelial to mesenchymal transition-related *** addition,AcRoots affected the phosphorylation level of GSK3β(Ser9)in the Wnt pathway to promote the degradation ofβ-catenin,resulting in the downregulation of the downstream target genes c-myc,cyclin D1 and *** the experimental results were consistent with the network pharmacology ***:This study combined network pharmacology with in vitro experiments to provide valid evidence for the clinical promotion of AcRoots.

关键词： gastric cancer Actinidia chinensis Planch.root network pharmacology Wnt/β-catenin pathway traditional Chinese medicine bioinformatics

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Vortex identification based on the Liutex method and its effect on fish passage upstream

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Journal of Hydrodynamics 2024年第1期36卷 130-141页

作者： Chun-ying Shen Rui-guo Yang Xiao-tao shi ming-ming Wang shi-hua He Faculty of Electrical Power Engineering Kunming University of Science and TechnologyKunming650500China Hubei International Science and Technology Cooperation Base of Fish Passage China Three Gorges UniversityYichang443002China Shanghai Investigation Design and Research Institute Co.LtShanghai200434China

Fishway research is important for mitigating the fragmentation of river habitats caused by hydraulic *** vertical slit fishway is a broadly used fishway type because of its high efficiency and adaptability to water ***,the resulting vortex current disrupts the fish passage hence directly affecting fish *** study aims to accurately capture the vortex structure in the fishway and analyze the effect of vortex elements(vortex structure,vortex intensity,etc.)on *** conducted an analysis of the 3-D current flow field in the fishway through the utilization of an experimental model and the large eddy simulation(LES)***,we captured the vortex information in the fishway at different flow rates using the Liutex vortex identification method and investigated the effect of the vortex on fish *** results revealed that the structures inside the fishway pool occupy most of the room,however,the areas with higher vortex strength were primarily located in the vortex near the vertical seam and the mainstream,the vortex strength inside the fishway gradually increases with increasing flow,suppressing fish *** experienced significantly increased resistance when encountering strong *** suggests that the vortex may act as a physical barrier to fish *** findings highlight the potential negative effects of vortex on fish movement and reiterate the importance of understanding vortex dynamics for aquatic environmental *** an effective tool for identifying vortices in fluid flow,the Liutex method demonstrates features of vortex within the fishway,thereby providing important insights into the interaction between fluid dynamics and aquatic organisms.

关键词： Vertical slit fishway vortex identification method Liutex large eddy simulation(LES) fish experiment computational fluid dynamics

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Prevention and forecasting of rock burst hazards in coal mines

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Mining Science and Technology 2009年第5期19卷 585-591页

作者： DOU Lin-ming LU Cai-ping MU zong-long GAO ming-shi State Key Laboratory for Coal Resource and Mine Safety China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Rock bursts signify extreme behavior in coal mine strata and severely threaten the safety of the lives of miners, as well as the effectiveness and productivity of miners. In our study, an elastic-plastic-brittle model for the deformation and failure of coal/rock was established through theoretical analyses, laboratory experiments and field testing, simulation and other means, which perfectly predict sudden and delayed rock bursts. Based on electromagnetic emission (EME), acoustic emission (AE) and microseism (MS) effects in the process from deformation until impact rupture of coal-rock combination samples, a multi-parameter identification of premonitory technology was formed, largely depending on these three forms of emission. Thus a system of classification for forecasting rock bursts in space and time was established. We have presented the intensity weakening theory for rock bursts and a strong-soft-strong (3S) structural model for controlling the impact on rock surrounding roadways, with the objective of laying a theoretical foundation and establishing references for parameters for the weakening control of rock bursts. For the purpose of prevention, key technical parameters of directional hydraulic fracturing are revealed. Based on these results, as well as those from deep-hole controlled blasting in coal seams and rock, integrated control techniques were established and anti-impact hydraulic props, suitable for roadways subject to hazards from rockbursts have also been developed. These technologies have been widely used in most coal mines in China, subject to these hazards and have achieved remarkable economic and social benefits.

关键词：岩爆灾害煤矿预报预防

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Combustion mechanism of benzene in iron ore sintering process:experimental and simulation

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Journal of Iron and Steel Research(International) 2024年第1期31卷 195-203页

作者： Zhi-gang Que Jin-ming shi Xian-bin Ai Institute of Energy Research Jiangxi Academy of ScienceNanchang330096JiangxiChina Jiangxi Carbon Neutralization Research Center Nanchang330096JiangxiChina

Benzene is a typical component of volatile organic compounds(VOCs)in the iron ore sintering flue *** combustion behavior of benzene directly affects the emission of VOCs in iron ore sintering *** effects of temperature,benzene,and oxygen concentrations on the conversion ratio of benzene were investigated by experiments and numerical *** experiments were carried out in a tube reactor at temperatures of 773-1098 K,benzene concentrations of 0.01-0.03 vol.%,and oxygen concentrations of 10-21 vol.%.The numerical simulation was performed with the plug flow model in the CHEMKIN program based on a kinetic model that consists of 132 chemical species and 772 elementary step-like *** experimental results reveal that increasing the temperature and benzene concentration could signifi-cantly promote benzene *** is attributed to the increase in the reaction rates of all steps in the pathway for forming CO_(2)and H_(2)*** addition,due to the large equivalent ratio of oxygen to benzene,the conversion ratio of benzene remained constant at different oxygen *** simulation results were in good agreement with the experimental results and indicated that six elementary reactions dominated the formations of CO_(2)and H_(2)*** oxidations of C_(6)H_(5)O,CO,and C_(5)H_(4)O intermediates to CO_(2)were the limiting steps in the reaction pathways.

关键词： Benzene Volatile organic compound Iron ore sinter Combustion Simulation Temperature Oxygen

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Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices

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Chemical Research in Chinese Universities 2024年第2期40卷 255-267页

作者： NAN Hexin CAI ming KUANG shi NIE Zhou State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan Provincial Key Laboratory of Biomacromolecular Chemical BiologyHunan UniversityChangsha410082P.R.China

The cell membrane is a critical barrier for cellular homeostasis,integral to signaling and intercellular communication,and vital for understanding cellular functions and disease *** its microenvironment is crucial for uncovering the molecular basis of physiological and pathological processes associated with the cell membrane,driving the development of bioanalytical toolkits capable of dynamically monitoring the cell surface *** the continuous advancement of functional nucleic acids and dynamic DNA nanotechnology,DNA nanodevices with controllable nanosized geometry,specific molecular recognition,and selective membrane-localization properties offer a versatile platform for probing the cell membrane *** this review,we summarize the current biosensing and membrane-anchoring mechanisms of DNA nanodevices and highlight their use in studying key cell membrane events,including membrane lipid dynamics,transmembrane transport,receptor dimerization,and signal ***,we discuss the challenges and potential future applications of DNA nanodevices in advancing cell membrane biology research and biomedical applications.

关键词： DNA nanodevice Cell membrane Cellular micro-environment Monitoring

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Locally and globally uniform approximations for ruin probabilities of a nonstandard bidimensional risk model with subexponential claims

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 98-113页

作者： LIU Zai-ming GENG Bing-zhen WANG shi-jie School of Mathematics and Statistics Central South UniversityChangsha 410083China School of Big Data and Statistics Anhui UniversityHefei 230601China

Consider a nonstandard continuous-time bidimensional risk model with constant force of interest,in which the two classes of claims with subexponential distributions satisfy a general dependence structure and each pair of the claim-inter-arrival times is arbitrarily *** some mild conditions,we achieve a locally uniform approximation of the finite-time ruin probability for all time horizon within a finite *** we further assume that each pair of the claim-inter-arrival times is negative quadrant dependent and the two classes of claims are consistently-varying-tailed,it shows that the above obtained approximation is also globally uniform for all time horizon within an infinite interval.

关键词： bidimensional risk model asymptotic formula subexponential distribution consistently varying tail ruin probability

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An approximate analytical model for unconventional reservoir considering variable matrix blocks and simultaneous matrix depletion

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Petroleum Science 2024年第1期21卷 352-365页

作者： Kai-Xuan Qiu Jia Li Dong Feng shi-ming Wei Gang Lei Jiangmen Laboratory of Carbon Science and Technology Jiangmen529100GuangdongChina The Hong Kong University of Science and Technology(Guangzhou) Guangzhou511400GuangdongChina China University of Geosciences(Beijing) Beijing100083China China University of Petroleum(Beijing) Beijing102249China China University of Geosciences(Wuhan) Wuhan430074HubeiChina Shenzhen Research Institute China University of GeosciencesShenzhen518063GuangdongChina

In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture *** has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture *** addition,most of the existing models are solved analytically based on Laplace transform and numerical ***,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix *** simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the ***,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by ***,a relationship between oil rate and production time in real-time space is *** new model is verified against classical analytical *** the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,***,the new model also has an excellent agreement with the numerical *** model is then applied to two actual tight oil wells completed in western Canada sedimentary *** identifying the flow regime,the solution suitably matches the field production data,and the model parameters are *** these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.

关键词： Analytical solution Unconventional reservoir Variable matrix Simultaneous flow

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Reflective ultrathin light-sheet microscopy with isotropic 3D resolutions

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Photonics Research 2024年第2期12卷 271-281页

作者： YUE WANG DASHAN DONG WENKAI YANG RENXI HE ming LEI KEBIN shi State Key Laboratory for Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology School of Life Sciencesand Biomedical Pioneering Innovation Center(BIOPIC)Peking UniversityBeijing 100871China School of Physics Xi’an Jiaotong UniversityXi’an 710049China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Light-sheet fluorescence microscopy(LSFM)has played an important role in bio-imaging due to its advantages of high photon efficiency,fast speed,and long-term imaging *** perpendicular layout between LSFM excitation and detection often limits the 3D resolutions as well as their ***,we report on a reflective type light-sheet microscope with a mini-prism used as an optical path *** conventional high NA objectives can be used both in excitation and detection with this *** resolutions in 3D down to300 nm could be achieved without *** proposed method also enables easy transform of a conventional fluorescence microscope to high performance light-sheet microscopy.

关键词： resolution excitation light

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Multimodal Fusion of Brain Imaging Data: Methods and Applications

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Machine Intelligence Research 2024年第1期21卷 136-152页

作者： Na Luo Weiyang shi Zhengyi Yang ming Song Tianzi Jiang Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Institute of AutomationChinese Academy of SciencesBeijing 100190China Research Center for Augmented Intelligence Zhejiang LaboratoryHangzhou 311100China

Neuroimaging data typically include multiple modalities,such as structural or functional magnetic resonance imaging,dif-fusion tensor imaging,and positron emission tomography,which provide multiple views for observing and analyzing the *** lever-age the complementary representations of different modalities,multimodal fusion is consequently needed to dig out both inter-modality and intra-modality *** the exploited rich information,it is becoming popular to combine multiple modality data to ex-plore the structural and functional characteristics of the brain in both health and disease *** this paper,we first review a wide spectrum of advanced machine learning methodologies for fusing multimodal brain imaging data,broadly categorized into unsupervised and supervised learning *** by this,some representative applications are discussed,including how they help to under-stand the brain arealization,how they improve the prediction of behavioral phenotypes and brain aging,and how they accelerate the biomarker exploration of brain ***,we discuss some exciting emerging trends and important future ***,we intend to offer a comprehensive overview of brain imaging fusion methods and their successful applications,along with the chal-lenges imposed by multi-scale and big data,which arises an urgent demand on developing new models and platforms.

关键词： Multimodal fusion supervised learning unsupervised learning brain atlas cognition brain disorders

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