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Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes:A meta-analysis

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World Journal of Diabetes 2023年第10期14卷 1573-1584页

作者： Chu lin zong-lin li Xiao-ling Cai Sui-Yuan Hu Fang Lv Wen-Jia Yang li-Nong Ji Department of Endocrinology and Metabolism Peking University People's HospitalBeijing 100044China

BACKGROUND Chiglitazar is an emerging pan-agonist of all peroxisome proliferator activated receptors(PPAR)-α,δandγ,and has therapeutic potential for type 2 diabetes(T2D).However,to date,no clinical studies or meta-analyses have compared the efficacy and safety of chiglitazar and traditional PPAR-γagonist thiazolidinediones(TZDs).A meta-analysis concerning this topic is therefore *** To compare the efficacy and safety of chiglitazar and TZD in patients with *** PubMed,Medline,Embase,the Cochrane Central Register of Controlled Trials,Reference Citation Analysis and *** websites were searched from August 1994 to March *** controlled trials(RCTs)of chiglitazar or TZD vs placebo in patients with T2D were *** comparisons and sensitivity analyses were implemented to evaluate multiple efficacy and safety endpoints of *** We included 93 RCTs that compared TZD with placebo and one that compared chiglitazar with *** efficacy endpoints,the augmented dose of chiglitazar resulted in greater reductions in hemoglobin(Hb)A1c[weighted mean difference(WMD)=-0.15%,95%confidence interval(CI):-0.27 to-0.04%],triglycerides(WMD=-0.17 mmol/L,95%CI:-0.24 to-0.11 mmol/L)and alanine aminotransferase(WMD=-5.25 U/L,95%CI:-8.50 to-1.99 U/L),and a greater increase in homeostasis model assessment-β(HOMA-β)(WMD=17.75,95%CI:10.73-24.77)when compared with TZD *** safety endpoints,the risks of hypoglycemia,edema,bone fractures,upper respiratory tract infection,urinary tract infection,and weight gain were all comparable between the augmented dose of chiglitazar and *** patients with baseline HbA1c≥8.5%,body mass index≥30 kg/m^(2)or diabetes durationlitazar compared with *** Augmented dose of chiglitazar,a pan-activator of PPARs,may serve as an antidiabetic agent with preferable glycemic and lipid control

关键词： Chiglitazar Thiazolidinedione Glycemic control β-cell function Drug safety

Secondary sentinel lymph node tracing technique: a new method for tracing lymph nodes in radical gastrectomy for advanced gastric cancer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第11期16卷 897-903页

作者： zong-lin li Huai-wu JIANG Min SONG liang XU Dong XIA Qing liU Department of Gastrointestinal Surgery the First Affiliated Hospital of Sichuan Medical University Department of Gastrointestinal Surgery the Second Affiliated Hospital of North Sichuan Medical College Department of Laboratory Medicine the First Affiliated Hospital of Sichuan Medical University

Objective： To explore the feasibility and clinical value of secondary sentinel lymph node （SSLN） tracing technique in radical gastrectomy for advanced gastric cancer （AGC）. Methods： From January 2009 to June 2011,247 patients who suffered from gastric angle cancer with metastasis in No. 3 group lymph nodes were divided randomly into groups A and B. Methylthioninium chloride was injected into the peripheral tissue of the metastatic No. 3 group lymph nodes of 138 patients in group A before tumor resections. SSLNs were traced and individual lymphadenectomies were carried out based on the biopsy results of the SSLNs. Standard D2 radical gastrectomies were carried out directly on 109 patients in group B. Postoperative follow-up and survival analysis were carried out for patients in both groups. Results： SSLNs were found in 114 （82.6%） patients in group A. Ninety of those patients （78.9%） demonstrated existing metastasis in SSLNs. According to Kaplan-Meier＇s method, the postoperative 3-year cumulative survival rates were 63.5% and 47.5%, and the median survival time were 40 and 36 months for the patients of groups A and B, respectively （P〈0.05）. Conclusions： The SSLN tracing technique is feasible in radical gastrectomy for AGC. It gives surgeons important information about the terminal status of lymph node metastasis and provides some scientific basis for individual lymphadenectomy.

关键词： Secondary sentinel lymph node (SSLN) Advanced gastric cancer (AGC) Individual lymphadenectomy Survival analysis

奇异线性系统在执行器饱和受限下不变集条件的改进(英文)

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控制理论与应用 2014年第7期31卷 955-961页

作者：李元龙林宗利上海交通大学自动化系系统控制与信息处理教育部重点实验室上海200240 弗吉尼亚大学Charles L.Brown电机与计算机工程系美国弗吉尼亚州夏洛茨维尔22904-4743

本文考虑饱和线性反馈下奇异线性系统扩大吸引域估计的问题.根据每个输入是否饱和,将输入空间分成若干子区域.在每个子区域内部,系统模型中没有显示的部分状态的时间导数可被显式表达.利用含有全部系统状态的二次Lyapunov函数,建立一组... 详细信息

本文考虑饱和线性反馈下奇异线性系统扩大吸引域估计的问题.根据每个输入是否饱和,将输入空间分成若干子区域.在每个子区域内部,系统模型中没有显示的部分状态的时间导数可被显式表达.利用含有全部系统状态的二次Lyapunov函数,建立一组双线性矩阵不等式形式的改进的不变集条件.该组条件下,二次Lyapunov函数的水平集可诱导出一个吸引域估计.为得到最大的吸引域估计,构建了以这些双线性矩阵不等式为约束条件的优化问题,并为其求解给出了迭代算法.仿真结果表明本文得到的吸引域估计明显大于现有结果.

关键词：奇异系统执行器饱和稳定性分析吸引域不变集

Study on EPDM/Boron Mud Composites

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Study on EPDM/Boron Mud Composites

激光熔覆Fe-Ti-V-C合金微观组织与磨损性能

2012 China Functional Materials Technology and Industry Forum

作者： Dong-han li zong-lin li li-qun Zhao Shenyang University of Chemical technology School of Materials Science and Engineering

In this paper,the EPDM/boron mud composites are prepared by changing the amount of boron mud,paraffin oil and *** order to investigate the effect of the fillers on the properties of composites,the aging-resistance,mechanical properties and SEM of composites are tested and *** results show that when paraffin oil is 10 phr,coumarone is 3 phr and the boron mud is 20 phr,the composite has optimal properties.

关键词： Boron mud Coumarone Paraffin oil EPDM Composites

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机械工程学报 2017年第2期53卷 67-73页

作者：宗琳李荣广张小玲沈阳化工大学机械工程学院沈阳110142

采用激光熔覆技术在20G基体上制备五组不同Ti质量分数的Fe-Ti-V-C系合金,利用金相显微镜、扫描电子显微镜、X射线衍射仪、显微硬度计和磨料磨损试验机等仪器对各熔覆层的显微组织、硬度和耐磨性进行测试和分析。试验结果表明:五组合金... 详细信息

采用激光熔覆技术在20G基体上制备五组不同Ti质量分数的Fe-Ti-V-C系合金,利用金相显微镜、扫描电子显微镜、X射线衍射仪、显微硬度计和磨料磨损试验机等仪器对各熔覆层的显微组织、硬度和耐磨性进行测试和分析。试验结果表明:五组合金熔覆层基体组织均由铁素体和马氏体构成;随着熔覆层中Ti质量分数的增加,针状马氏体基体组织转变为板条马氏体;初生(Ti,V)C的形态由树枝状和花瓣状向颗粒状转变,同时碳化物(Ti,V)C的数量逐渐增多,当Ti质量分数为14.7%时,碳化物的数量达到最高值。熔覆层截面显微硬度梯度分布合理,表层硬度达到700~950 HV0.2。湿砂磨粒磨损试验表明:适量Ti显著提高了熔覆层的耐磨性,熔覆层中随着Ti质量分数的提高,耐磨性先降低后提高,当Ti质量分数为14.7%时,大量颗粒状(Ti,V)C均匀弥散分布在铁素体及板条马氏体基体上,使得熔覆层具有最佳的耐磨性。

关键词：激光熔覆耐磨性显微组织 Fe-Ti-V-C合金

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饱和约束控制系统的吸引域估计

控制与决策 2018年第5期33卷 824-834页

作者：林宗利李元龙美国弗吉尼亚大学电机与计算机工程系夏洛茨维尔229044743 上海交通大学系统控制与信息处理教育部重点实验室上海200240

饱和约束控制系统的吸引域估计是非线性系统领域的一个基本问题,主要涉及到饱和约束的处理和Lyapunov函数的选取.围绕这两个关键问题,梳理了解决饱和约束控制系统吸引域估计问题的一系列方法,总结了文献及最近的一些研究结果.

关键词：饱和约束控制系统吸引域执行器饱和 Lyapunov函数

Smart Gas Sensors:Recent Developments and Future Prospective

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Nano-Micro Letters 2025年第3期17卷 55-86页

作者： Boyang zong Shufang Wu Yuehong Yang Qiuju li Tian Tao Shun Mao College of Environmental Science and Engineering Biomedical Multidisciplinary Innovation Research InstituteShanghai East HospitalState Key Laboratory of Pollution Control and Resource ReuseTongji University1239 Siping RoadShanghai 200092People’s Republic of China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092People’s Republic of China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280People’s Republic of China

Gas sensor is an indispensable part of modern society withwide applications in environmental monitoring,healthcare,food industry,public safety,*** the development of sensor technology,wireless communication,smart monitoring terminal,cloud storage/computing technology,and artificial intelligence,smart gas sensors represent the future of gassensing due to their merits of real-time multifunctional monitoring,earlywarning function,and intelligent and automated *** electronicand optoelectronic gas sensors have been developed for high-performancesmart gas *** the development of smart terminals and the maturityof integrated technology,flexible and wearable gas sensors play an increasingrole in gas *** review highlights recent advances of smart gassensors in diverse *** structural components and fundamentalprinciples of electronic and optoelectronic gas sensors are described,andflexible and wearable gas sensor devices are ***,sensorarray with artificial intelligence algorithms and smart gas sensors in“Internet of Things”paradigm are ***,the challengesand perspectives of smart gas sensors are discussed regarding the future need of gas sensors for smart city and healthy living.

关键词： Smart gas sensor Electronic sensor Optoelectronic sensor Flexible and wearable sensor Artificial intelligence

First observation results of Macao Science Satellite-1 on lightning-induced electron precipitation

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Science China Earth Sciences 2025年第1期68卷 1-10页

作者： Yongping WANG Yixin SUN Qiugang zong Gaopeng LU Xudong GU Ze-Jun HU Bin li Key Laboratory for Polar Science Ministry of Natural Resources Polar Research Institute of China Institute of Space Physics and Applied Technology Peking University State Key Laboratory of Lunar and Planetary Science Macau University of Science and Technology School of Earth and Space Sciences University of Science and Technology of China School of Electronic Information Wuhan University

The Medium-energy Electron Spectrometers(MES) is a space-borne instrument onboard Macao Science Satellite-1(MSS-1) dedicated to monitoring the typical charged particle radiation characteristics in the satellite orbit and the process of their occurrence and development, including short bursts of lightning-induced electron precipitation(LEP).This paper presents the first results of the LEP measurements by the MSS-1.47 LEP events are identified with the routine operation for 3 months since satellite launch, all within the range of 1.5lightning discharges are definitively geo-located for these LEP *** LEP events occur within lightning and consist of 40–300 keV electrons.A preliminary observation result indicates that, with medium-energy electron detectors, MSS-1can present in-situ observations of large regions of enhanced background precipitation and reveal their fine spatiotemporal characteristics and spectral *** collaborative VLF ground-based measurements at the Great Wall Station, Antarctica also have a good correspondence with LEP measurements of *** observations also imply that lightning activity has a modulation effect on the energetic electron energy-spatial structure.

关键词： lightning-induced electron precipitation Inner radiation belts Energetic electrons Macao Science Satellite-1

基于系统输出的嵌套饱和系统抗饱和补偿器设计

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控制理论与应用 2023年第2期40卷 187-195页

作者：赖文馨李元龙林宗利上海交通大学自动化系上海200240 系统控制与信息处理教育部重点实验室上海200240 上海工业智能管控工程技术研究中心上海200240 美国弗吉尼亚大学电机与计算机工程系美国夏洛茨维尔22904-4743

针对嵌套输入饱和系统的吸引域扩大问题,本文提出了一种基于系统输出的抗饱和补偿器激发策略,将被控系统输出信号经性能补偿器馈入到抗饱和补偿器激发环节中,形成蕴含系统实时性能信息的抗饱和激发新机制,克服了传统抗饱和激发机制无法... 详细信息

针对嵌套输入饱和系统的吸引域扩大问题,本文提出了一种基于系统输出的抗饱和补偿器激发策略,将被控系统输出信号经性能补偿器馈入到抗饱和补偿器激发环节中,形成蕴含系统实时性能信息的抗饱和激发新机制,克服了传统抗饱和激发机制无法直接反映系统性能的缺点.基于上述抗饱和控制新框架,本文建立了抗饱和补偿器及性能补偿器存在的充分条件,并依此构建了优化问题求解最优补偿器增益以实现扩大闭环系统吸引域的目的.仿真结果表明本文方法的有效性.

关键词：非线性控制系统嵌套饱和抗饱和吸引域

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