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Effect of plastic deformation on diffusion-rolling bonding of steel sandwich plates

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Journal of University of Science and Technology Beijing 2006年第6期13卷 532-537页

作者： hong Li Jingtao han Materials Science and Engineering School University of Science and Technology Beijing Beijing 10083 China

Diffusion bonding is one of the most important techniques for composite materials, while bonding temperature, holding time,and rolling reduction are the key parameters that affect the bonding strength of sandwich plates. To study the effect of plastic deformation on the bonding strength, laboratory experiments were carried on a Gleeble Thermal Simulator to imitate the diffusion-rolling bonding under different reductions for steel sandwich plates. The bonding strength and interlayer film thickness were measured, and the element diffusion was analyzed using line scanning. The relationship between the bonding strength and “diffused interlayer” thickness was investigated. It has been found that the bonding strength increases with reduction, whereas the interlayer film thickness decreases gradually as the reduction increases. The diffusion under plastic deformation is obviously enhanced in comparison with that of nil reduction. The mechanism of plastic deformation effect on the diffusion bonding and related models have been discussed.

关键词： steel sandwich plate diffusion-bonding plastic deformation bonding strength interlayer film thickness diffusion mechanism models

Retrieval strategy for failed satellite on tether’s optimal balance swing angle

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Journal of Systems Engineering and Electronics 2019年第4期30卷 749-759页

作者： han Yanhua hong Junting College of Astronautics Nanjing University of Aeronautics and Astronautics

A retrieval control strategy for failed satellite,which is connected to a servicing spacecraft by a tether,is *** Lagrange analytical mechanics based dynamics modeling for the system composed of a servicing spacecraft,a tether and a failed satellite,is presented under the earth center inertia coordinate system,then model simplification is conducted under the assumption that the failed satellite’s mass is far smaller than the servicing spacecraft’s,meanwhile the tether’s length is far smaller than the size of the servicing spacecraft’s *** shows that the retrieval process is intrinsically unstable as the Coriolis force functions is a negative damping.A retrieval strategy based on only the tether’s tension is designed,resulting in the fastest retrieval *** the proposed strategy,firstly,the tether’s swing angle amplitude is adjusted to 45?by deploying/retrieving the tether;then the tether swings freely with fixed length until it reaches negative maximum angle–45?;finally,the tether is retrieved by the pre-assigned exponential *** simplicity,only the coplanar situation,that the tether swings in the plane of the servicing spacecraft’s orbit,is *** simulation verifies the effectiveness of the strategy proposed.

关键词： tethered space tug(TST) retrieval control strategy failed satellite space debris on-orbit service

Taiji data challenge for exploring gravitational wave universe

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Frontiers of physics 2023年第6期18卷 93-106页

作者： Zhixiang Ren Tianyu Zhao Zhoujian Cao zong-Kuan Guo Wen-Biao han hong-Bo Jin Yue-Liang Wu Taiji Laboratory for Gravitational Wave Universe University of Chinese Academy of Sciences(UCAS)Beijing 100049China Peng Cheng Laboratory Shenzhen 518055China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences UCASBeijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Astronomy and Space Science UCASBeijing 100049China International Centre for Theoretical Physics Asia-Pacific(ICTP-AP UNESCO)UCASBeijing 100190China Shanghai Frontiers Science Center for Gravitational Wave Detection Shanghai 200240China Key Laboratory of Computational Astrophysics National Astronomical ObservatoriesBeijing 100101China

The direct observation of gravitational waves(GWs)opens a new window for exploring new physics from quanta to cosmos and provides a new tool for probing the evolution of *** detection in space covers a broad spectrum ranging over more than four orders of magnitude and enables us to study rich physical and astronomical *** is a proposed space-based gravitational wave(GW)detection mission that will be launched in the *** will be exposed to numerous overlapping and persistent GW signals buried in the foreground and background,posing various data analysis *** order to empower potential scientific discoveries,the Mock Laser Interferometer Space Antenna(LISA)data challenge and the LISA data challenge(LDC)were *** LDC provides a baseline framework,the first LDC needs to be updated with more realistic simulations and adjusted detector responses for Taiji’s *** this paper,we review the scientific objectives and the roadmap for Taiji,as well as the technical difficulties in data analysis and the data generation strategy,and present the associated data *** contrast to LDC,we utilize second-order Keplerian orbit and second-generation time delay interferometry ***,we employ a new model for the extreme-mass-ratio inspiral waveform and stochastic GW background spectrum,which enables us to test general relativity and measure the non-Gaussianity of curvature ***,we present a comprehensive showcase of parameter estimation using a toy *** showcase not only demonstrates the scientific potential of the Taiji data challenge(TDC)but also serves to validate the effectiveness of the *** the first data challenge for Taiji,we aim to build an open ground for data analysis related to Taiji sources and *** details can be found on the official website(***).

关键词： gravitational wave universe evolution Taiji data challenge

Tofacitinib for ulcerative colitis: A promising treatment option

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World Journal of Gastroenterology 2024年第40期30卷 4386-4392页

作者： zong-Qiang han Li-Na Wen Department of Laboratory Medicine Beijing Xiaotangshan HospitalBeijing 102211China Department of Clinical Nutrition Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

A single center retrospective clinical study revealed the efficacy and safety of tofa-citinib in the treatment of ulcerative colitis(UC).This study has clinical reference value but also has some *** studies,including this clinical trial,have shown that tofacitinib could be a promising treatment option for UC,but further clinical research is required to prove this point.

关键词： Tofacitinib Ulcerative colitis Efficacy Safety Clinical trials

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

Application of G-quadruplex targets in gastrointestinal cancers:Advancements,challenges and prospects

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1149-1173页

Genomic instability and inflammation are considered to be two enabling characteristics that support cancer development and progression.G-quadruplex structure is a key element that contributes to genomic instability and inflammation.G-quadruplexes were once regarded as simply an obstacle that can block the transcription of oncogenes.A ligand targeting G-quadruplexes was found to have anticancer activity,making G-quadruplexes potential anticancer ***,further investigation has revealed that G-quadruplexes are widely distributed throughout the human genome and have many functions,such as regulating DNA replication,DNA repair,transcription,translation,epigenetics,and inflammatory response.G-quadruplexes play double regulatory roles in transcription and *** this review,we focus on G-quadruplexes as novel targets for the treatment of gastrointestinal *** summarize the application basis of G-quadruplexes in gastrointestinal cancers,including their distribution sites,structural characteristics,and physiological *** describe the current status of applications for the treatment of esophageal cancer,pancreatic cancer,hepatocellular carcinoma,gastric cancer,colorectal cancer,and gastrointestinal stromal tumors,as well as the associated ***,we review the prospective clinical applications of G-quadruplex targets,providing references for targeted treatment strategies in gastrointestinal cancers.

关键词： G-quadruplex Pancreatic cancer Liver cancer Gastric cancer Colorectal cancer Gastrointestinal stromal tumor

Anomaly monitoring and early warning of electric moped charging device with infrared image

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Optoelectronics Letters 2025年第3期 136-141页

作者： LI Jiamin han Bo JIANG Mingshun School of Control Science and Engineering Shandong University

Potential high-temperature risks exist in heat-prone components of electric moped charging devices, such as sockets,interfaces, and controllers. Traditional detection methods have limitations in terms of real-time performance and monitoring scope. To address this, a temperature detection method based on infrared image processing has been proposed:utilizing the median filtering algorithm to denoise the original infrared image, then applying an image segmentation algorithm to divide the image.

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Mechanical and damage evolution properties of sandstone under triaxial compression

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International Journal of Mining Science and Technology 2016年第4期26卷 601-607页

作者： zong Yijiang han Lijun Wei Jianjun Wen Shengyong State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology Xuzhou 221116 China Jiangsu Collaborative Innovation Center for Building Energy Saving and Construction Technology Jiangsu Jianzhu Institute Xuzhou 221116 China

To study the mechanical and damage evolution properties of sandstone under triaxial compression, we analyzed the stress strain curve characteristics, deformation and strength properties, and failure process and characteristics of sandstone samples under different stress states. The experimental results reveal that peak strength, residual strength, elasticity modulus and deformation modulus increase linearly with confining pressure, and failure models transform from fragile failure under low confining pressure to ductility failure under high confining pressure. Macroscopic failure forms of samples under uniaxial compression were split failure parallel to the axis of samples, while macroscopic failure forms under uniaxial compression were shear failure, the shear failure angle of which decreased linearly with confin- ing pressure. There were significant volume dilatation properties in the loading process of sandstone under different confining pressures, and we analyzed the damage evolution properties of samples based on acoustic emission damage and volumetric dilatation damage, and established damage constitutive model, realizing the real-time Quantitative evaluation of samnles damage state in loading process.

关键词： Rock mechanics Mechanical properties Dilatation Damage evolution Failure characteristics

Mechanobiology in vascular remodeling

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National Science Review 2018年第6期5卷 933-946页

作者： Yue han Kai Huang Qing-Ping Yao zong-Lai Jiang Institute of Mechanobiology & Medical Engineering School of Life Sciences & BiotechnologyShanghai Jiao Tong University School of Biological Science & Medical Engineering Beijing Advanced Innovation Center for Biomedical Engineering Beihang University

Vascular remodeling is a common pathological process in cardiovascular diseases and includes changes in cell proliferation, apoptosis and differentiation as well as vascular homeostasis. Mechanical stresses, such as shear stress and cyclic stretch, play an important role in vascular remodeling. Vascular cells can sense the mechanical factors through cell membrane proteins, cytoskeletons and nuclear envelope proteins to initiate mechanotransduction, which involves intercellular signaling, gene expression, and protein expression to result in functional regulations. Non-coding RNAs, including micro RNAs and long non-coding RNAs, are involved in the regulation of vascular remodeling processes. Mechanotransduction triggers a cascade reaction process through a complicated signaling network in cells. High-throughput technologies in combination with functional studies targeting some key hubs and bridging nodes of the network can enable the prioritization of potential targets for subsequent investigations of clinical translation. Vascular mechanobiology, as a new frontier field of biomechanics, searches for principles of stress-growth in vasculature to elucidate how mechanical factors induce biological effects that lead to vascular remodeling,with the goal of understanding the mechanical basis of the pathological mechanism of cardiovascular diseases at the cellular and molecular levels. Vascular mechanobiology will play a unique role in solving the key scientific problems of human physiology and disease, as well as generating important theoretical and clinical results.

关键词： mechanobiology vascular remodeling cardiovascular disease mechanotransduction endothelial cell vascular smooth muscle cell nuclear envelope microRNA