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Chinese Medical Journal 2021年第5期134卷 576-578页

作者： Xin-Xin Zhu zong-hao feng Lin-Zhi Liu Yan Zhang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Obstetrics and Gynecology Beijing Tsinghua Changgung HospitalBeijing 102218China

This study investigated the effect of liraglutide(an analog of human glucagon-like peptide-1[GLP-1])on the proliferation of Ishikawa(IK)and human endometrial carcinoma(HEC)-IB endometrial cancer(EC)cell lines,identified whether liraglutide enhances the anti-tumor effect of progesterone,and explored the role of liraglutide in progesterone receptor(PGR)expression in EC cell lines and potential pathways.

关键词： endometrial cancer progesterone

Effect of High-fat Diet-induced Disorders on Rat with Endometrial Hyperplasia and Adiponectin System in Circulation and Uterus

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Chinese Medical Journal 2017年第15期130卷 1831-1837页

作者： Chen-Guano Shang Zhao-Hui Liu Xiao-Hui Wang zong-hao feng Yan Zhang Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China

Background：Epidemiologic and genetic studies suggest a link between insulin resistance （IR） and endometrial cancer,and endometrial hyperplasia （EH） is a precancerous stage of endometrial *** is an adipokine which previously shown to be a risk factor for endometrial *** aim of the study was to develop a rat model of IR and EH and evaluate adiponectin system in circulation and ***：This study was a 46-week animal trial from February 2014 to January *** Sprague-Dawley rats were fed with high-fat diet （HFD） for 40 weeks to induce *** by ovariectomization,rats were orally administrated to 173-estradiol （E2） for 4 weeks to induce EH and then sacrificed.A total of 36 rats were divided into four groups：E2,HFD,HFD ＋ E2,and control *** were analyzed with Student＇s t-test,one-way analysis of variance （ANOVA）,and Mann-Whitney ***-square was used to evaluate the score of ***：The thickness ofendometrial,glandular epithelium,and myometrium in the HFD-E2 group were higher than the E2 group （F=59.02,F=23.51 and F =12.53,respectively,all P 〈 0.00 1）.Plasma adiponectin levels in the E2 group were lower than those in the control group,and the levels in the HFD-E2 group were lower than those in the HFD group （F =13.15,P 〈 0.05）.However,after normalized to visceral adipose tissue,compared to the control group,plasma adiponectin levels were decreased in rat with HFD in the absence or presence of E2,respectively （F =6.72,P 〈 0.05）.Adiponectin gene （F =10.48,P 〈 0.05） and protein （P 〈 0.05） levels in uterus in the HFD-E2 group were higher than those in the HFD ***：This study manifests that IR can effectively modulate EH,which suggests the involvement of energetic metabolism in uterine *** combination effects of IR and EH modulate circulating adiponectin ***,adiponectin gene and protein levels in uterus are mainly response to estradiol.

关键词： Adiponectin: Adiponectin Receptors Estradiol Insulin Resistance

On optimal streaming kernelization algorithms

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Science China(Information Sciences) 2024年第8期67卷 337-338页

作者： hao feng Wei YANG Jianer CHEN School of Computer Science Guangzhou University Department of Computer Science and Engineering Texas A&M University

The streaming model has been a popular model in big data computation. Streaming kernelization algorithms can be regarded as data compression processes on streaming data. In this study, we give a general method for developing computational lower bounds for streaming kernelization algorithms that is applicable to a large class of computational problems. As an example, we use the method to prove computational lower bounds for the well-known problem d-Hi TTin GSET.

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Agronomic performances of biodegradable and non-biodegradable plastic film mulching on a maize cropping system in the semi-arid Loess Plateau,China

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Pedosphere 2024年第1期34卷 88-96页

作者： hao ZHANG Mengqiong CHEN Ruiquan QIAO Fan DING hao feng Rui JIANG Research Center for Cultural Landscape Protection and Ecological Restoration China-Portugal Belt and Road Cooperation Laboratory of Cultural Heritage Conservation ScienceGold Mantis School of ArchitectureSoochow UniversitySuzhou 215006China Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of AgricultureCollege of Natural Resources and EnvironmentNorthwest A&F UniversityYangling 712100China College of Land and Environment Shenyang Agricultural UniversityShenyang 110866China Institute of Soil and Water Conservation Northwest A&F UniversityYangling 712100China

Biodegradable plastic film mulch (PFM) is considered an alternative to non-biodegradable PFM to mitigate the negative impacts of residual ***,the agronomic performance of biodegradable PFM in comparison to non-biodegradable PFM still needs to be *** this study,we evaluated the effects of biodegradable and non-biodegradable PFM on soil physicochemical properties,microbial community,and enzyme activities,as well as maize growth *** and non-biodegradable PFM both increased soil temperature,water content,N content,and microbial biomass and maize yield by up to 30%,but decreased soil enzyme activities as compared to no mulching (control,CK).Most soil physicochemical properties,microbial community,and enzyme activities were similar under non-biodegradable and biodegradable PFM at the early stages of maize ***,at the late stages,soil temperature,water content,mineral N,NO_(3)^(-)-N,ammonia monooxygenase (AMO) activity,and total phospholipid fatty acids (PLFAs) decreased under biodegradable PFM owing to film *** PFM increased soil temperature,water content,and total PLFAs at the early stages of maize growth but decreased soil mineral N and total PLFAs at the late stages,as compared to black *** soil temperature and N availability were the major factors affecting soil microbial community,microbial activity decreased after the fragmentation of biodegradable PFM,owing to the decreased soil temperature,water content,and mineral ***,biodegradable PFM could decrease NO_(3)^(-)-N accumulation in topsoil by decreasing N transformation due to the lower microbial and N-related enzyme (e.g.,AMO) activities,compared with non-biodegradable PFM,which may avoid negative environmental impacts,such as NO_(3)^(-)-N leaching or gas emission after *** yield,height,aboveground biomass,and N uptake under biodegradable PFM were similar to those under non-biodegradable PFM during maize growth,implying that biodegrad

关键词： black plastic film mulching enzyme activity film fragmentation microbial community phospholipid fatty acid white plastic film mulching

Interaction Mechanisms between Natural Debris Flow and Rigid Barrier Deflectors:A New Perspective for Rational Design and Optimal Arrangement

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1679-1699页

作者： Yu Huang Beilei Liu Dianlei feng hao Shi Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China Department of Hydraulic Engineering College of Civil EngineeringTongji UniversityShanghai200092China

Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention ***,the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further *** date,few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster *** investigate the effect of rigid barrier deflectors on impact mechanisms,a numerical model using the smoothed particle hydrodynamics(SPH)method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without *** model was validated using laboratory flume test data from the ***,the model was used to investigate the influence of the deflector angle and multi-barrier *** optimal configuration of multi-barriers was analyzed with consideration to the barrier height and distance between the barriers,because these metrics have a significant impact on the viscous flow pile-up,run-up,and overflow *** investigation considered the energy dissipation process,retention efficiency,and dead-zone *** with bare barriers with similar geometric characteristics and spatial distribution,rigid barriers with deflectors exhibit superior effectiveness in preventing the overflow and overspilling of viscous debris *** for the rational design of deflectors and the optimal arrangement of multi-barriers are provided to mitigate geological disasters.

关键词： Rigid barrier deflectors deflector angle single-barrier dual-barrier arrangements viscous debris flow over-spilling delta-plus-SPH

Coexistence of All-Order Topological States in a Three-Dimensional Phononic Topological Crystalline Insulator

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Research 2024年第2期2023卷 511-518页

作者： Hua-Shan Lai hao Chen Chu-hao Xia Si-Yuan Yu Cheng He Yan-feng Chen National Laboratory of Solid State Microstructures&Department of Materials Science and Engineering Nanjing UniversityNanjng 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjng 210093China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University Nanjing 210093China

Classical-wave topological materials lacking intrinsic half-integer spins are less robust while more ***,we explore a single 3-dimensional phononic topological crystalline insulator that simultaneously exhibits a whole family of first-order quadratic surface,second-order hinge,and third-order corner states within the same *** a topological crystalline insulator hosting all-order phases originates from the different topological nature when hierarchically projected onto different facets and lower dimensions,thus free from trivial cladding *** work offers an ideal platform for either robust wave propagation or localization in on-demand dimensions and may facilitate dimension division multiplexing technology.

关键词： topological dimensions crystalline

Multi-scale hash encoding based neural geometry representation

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Computational Visual Media 2024年第3期10卷 453-470页

作者： Zhi Deng haoyao Xiao Yining Lang hao feng Juyong Zhang School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China Alibaba Artificial Intelligence Governance Laboratory Alibaba GroupHangzhou 310017China

Recently, neural implicit function-basedrepresentation has attracted more and more attention,and has been widely used to represent surfacesusing differentiable neural networks. However, surfacereconstruction from point clouds or multi-view imagesusing existing neural geometry representations stillsuffer from slow computation and poor accuracy. Toalleviate these issues, we propose a multi-scale hashencoding-based neural geometry representation whicheffectively and efficiently represents the surface asa signed distance field. Our novel neural networkstructure carefully combines low-frequency Fourierposition encoding with multi-scale hash encoding. Theinitialization of the geometry network and geometryfeatures of the rendering module are accordinglyredesigned. Our experiments demonstrate that theproposed representation is at least 10 times faster forreconstructing point clouds with millions of *** also significantly improves speed and accuracyof multi-view reconstruction. Our code and modelsare available at https://***/Dengzhi-USTC/Neural-Geometry-Reconstruction.

关键词： neural geometry representation hash encoding point cloud reconstruction multi-view reconstruction

Remote copper-catalyzed enantioselective substitution of yne-thiophene carbonates

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Science China Chemistry 2024年第4期67卷 1175-1180页

作者： hao-Dong Qian Xiang Li Tingrui Yin Wei-feng Qian Chunhui Zhao Cuiju Zhu hao Xu CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology of Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Here,we describe a strategy for the copper-catalyzed asymmetric heteroarylation of yne-thiophene carbonates with indoles via remote *** key to the success of this strategy lies in the design of the alkynyl group at the ortho-position of the heterocycle thiophene,enabling the formation of a triarylmethane moiety via very remote ***,the concept of remote copper-catalyzed asymmetric transformation extends not only to yne-allylic esters but also to yne-aryl *** reaction readily provides a diverse array of chiral triarylmethanes with high efficiency,enantioselectivity,and excellent functional group ***,facile follow-up transformations underscore their potential utility in the synthesis of various enantioenriched building *** mechanistic studies support the plausibility of the remote substitution pathway.

关键词： remote substitution copper catalyst asymmetric catalysis triaryl methanes

Identification of crucial roles of transcription factor IhfA on high production of free fatty acids in Escherichia coli

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Synthetic and Systems Biotechnology 2024年第1期9卷 144-151页

作者： Lixia Fang Ziyi Han Xueru feng Xueyan hao Mengxiao Liu hao Song Yingxiu Cao Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityChina

Transcription factor engineering has unique advantages in improving the performance of microbial cell factories due to the global regulation of gene *** analyses and reverse engineering enable learning and subsequent incorporation of novel design strategies for further ***,we identify the role of the global regulator IhfA for overproduction of free fatty acids(FFAs)using CRISPRi-facilitated reverse engineering and cellular physiological *** the differentially expressed genes in the ihfAL􀀀strain,a total of 14 beneficial targets that enhance FFAs production by above 20% are identified,which involve membrane function,oxidative stress,and *** membrane-related genes,the engineered strains obtain lower cell surface hydrophobicity and increased average length of membrane lipid *** oxidative stress-related genes,the engineered strains present decreased reactive oxygen species(ROS)*** gene modulations enhance cellular robustness and save cellular resources,contributing to FFAs *** study provides novel targets and strategies for engineering microbial cell factories with improved FFAs bioproduction.

关键词： Free fatty acids CRISPRi ihfA Cell membrane ROS

Absorption-dominant EMI shielding performance of multiple folded Bi_(2)Se_(3)/PVDF nanocomposite films

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Journal of Materiomics 2024年第1期10卷 27-36页

作者： Xinyi Pu Zunpeng feng Siyuan Sun Ke Bi Yanan hao State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing100876China Chinese Academy of Engineering Innovation Strategy Beijing100088China

Absorption-dominant electromagnetic interference(EMI)shielding materials are promising in reducing electromagnetic radiation pollution,but their preparation processes are usually difficult and unsuitable for large-scale *** this work,multiple folded Bi_(2)Se_(3)/PVDF nanocomposite films were fabri-cated by using a convenient tape-casting method and multiple folding,which can be easily extended in industrial *** EMI shielding effectiveness(SE)of the composite materials was investigated,which shows typical absorption-dominant behavior and can substantially reduce secondary ***,for the 35%(in volume)Bi_(2)Se_(3)/PVDF nanocomposite film,the SE_(A)of single-layered film with a thickness of 60 mm reaches 20 dB while SE_(R)is lower than 5 *** folding the film into eight layers,the SE_(A)increased to 50 dB while SE_(R)remains below 5 *** method provides an effective way to the fabrication of absorption-dominant electromagnetic absorption(EMA)and EMI shielding material.

关键词： Electromagnetic interference shielding(EMI) Electromagnetic wave absorption Bismuth selenide Composite