检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

《中州集》四库提要的文本系统与学术重建

中国典籍与文化 2024年第1期 54-63页

作者：张傲上海大学

《中州集》四库提要在最初的翁方纲分纂稿、《四库全书荟要总目提要》、各阁书前提要与最终成型的《四库全书总目》之间存在较大差异,不同阶段的差异体现了四库提要定型的动态过程。在这一过程中,四库馆臣出于对《中州集》隐没的担忧,... 详细信息

《中州集》四库提要在最初的翁方纲分纂稿、《四库全书荟要总目提要》、各阁书前提要与最终成型的《四库全书总目》之间存在较大差异,不同阶段的差异体现了四库提要定型的动态过程。在这一过程中,四库馆臣出于对《中州集》隐没的担忧,通过有意识地舍弃、增补和替换,微妙地构建了《中州集》“集中之史”的地位。

关键词：中州集四库全书总目集中之史

Growth hormone improves insulin resistance in visceral adipose tissue after duodenal-jejunal bypass by regulating adiponectin secretion

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第6期15卷 1340-1352页

作者： Zi-Tian Liu Guang-Wei Yang Xiang Zhao Shuo-Hui Dong Yang Jiao Zheng Ge ao Yu Xi-Qiang zhang Xin-Zhen Xu Zhi-Qiang Cheng Xiang zhang Ke-Xin Wang Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Shandong University of Qilu Hospital(Qingdao)Qingdao 266000Shandong ProvinceChina

BACKGROUND The mechanism of improvement of type 2 diabetes after duodenal-jejunal bypass(DJB)surgery is not *** To study the morphological and functional changes in adipose tissue after DJB and explore the potential mechanisms contributing to postoperative insulin sensitivity improvement of adipose tissue in a diabetic male rat *** DJB and sham surgery was performed in a-high-fat-diet/streptozotocin-induced diabetic rat *** adipose tissue was weighed and observed under *** inguinal fat to represent subcutaneous adipose tissue(SAT)and mesangial fat to represent visceral adipose ***-sequencing was utilized to evaluate gene expression alterations *** hematoxylin and eosin staining,reverse transcription-quantitative polymerase chain reaction,western blot,and enzyme-linked immunosorbent assay were used to study the *** resistance was evaluated by *** After DJB,whole body blood glucose metabolism and insulin sensitivity in adipose tissue *** cell volume in both visceral adipose tissue(VAT)and SAT *** to SAT,VAT showed more significantly functional alterations after DJB and KEGG analysis indicated growth hormone(GH)pathway and downstream adiponectin secretion were involved in metabolic *** circulating GH and adiponectin levels and GH receptor and adiponectin levels in VAT *** experiment showed that GH stimulated adiponectin secretion and improve insulin *** GH improves insulin resistance in VAT in male diabetic rats after receiving DJB,possibly by increasing adiponectin secretion.

关键词： Growth hormone Insulin resistance Bariatric surgery Adipose tissue Adiponectin

Screening antimicrobial peptides and probiotics using multiple deep learning and directed evolution strategies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3476-3492页

作者： Yu zhang Li-Hua Liu Bo Xu Zhiqian zhang Min Yang Yiyang He Jingjing Chen Yang zhang Yucheng Hu Xipeng Chen Zitong Sun Qijun Ge Song Wu Wei Lei Kaizheng Li Hua Cui Gangzhu Yang Xuemei Zhao Man Wang Jiaqi Xia Zhen Cao ao Jiang Yi-Rui Wu Tidetron Bioworks Technology(Guangzhou)Co. Ltd.Guangzhou Qianxiang Bioworks Co.Ltd.Guangzhou 510000China Biology Department and Institute of Marine Sciences College of ScienceShantou UniversityShantou 515063China School of Basic Medical Sciences Hubei University of Science and TechnologyXianning 437100China School of Education Jianghan UniversityWuhan 430056China Yeasen Biotechnology(Shanghai)Co. Ltd.Shanghai 200000China School of Basic Medicine Jiamusi UniversityJiamusi 154000China

Owing to their limited accuracy and narrow applicability,current antimicrobial peptide(AMP)prediction models face obstacles in industrial *** address these limitations,we developed and improved an AMP prediction model using Comparing and Optimizing Multiple DEep Learning(COMDEL)algorithms,coupled with high-throughput AMP screening method,finally reaching an accuracy of 94.8%in test and 88%in experiment verification,surpassing other state-of-the-art *** conjunction with COMDEL,we employed the phage-assisted evolution method to screen Sortase in vivo and developed a cell-free AMP synthesis system in vitro,ultimately increasing AMPs yields to a range of 0.5-2.1 g/L within ***,by multi-omics analysis using COMDEL,we identified Lactobacillus plantarum as the most promising candidate for AMP generation among 35 edible *** this,we developed a microdroplet sorting approach and successfully screened three *** mutants,each showing a twofold increase in antimicrobial ability,underscoring their substantial industrial application values.

关键词： Antimicrobial peptide Deep learning Cell-free synthesis Probiotics L.plantarum

Comparative study of different machine learning models in landslide susceptibility assessment: A case study of Conghua District, Guangzhou, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Geology 2024年第1期7卷 104-115页

作者： ao zhang Xin-wen Zhao Xing-yuezi Zhao Xiao-zhan Zheng Min Zeng Xuan Huang Pan Wu Tuo Jiang Shi-chang Wang Jun He Yi-yong Li Wuhan Center China Geological SurveyMinistry of Natural Resources(Geosciences Innovation Center of Central South China)Wuhan 430205China Guangzhou Institute of Geological Survey Guangzhou 510080China Hubei Transportation Planning Design Institute Co. LtdWuhan 430050China

Machine learning is currently one of the research hotspots in the field of landslide *** clarify and evaluate the differences in characteristics and prediction effects of different machine learning models,Conghua District,which is the most prone to landslide disasters in Guangzhou,was selected for landslide susceptibility *** evaluation factors were selected by using correlation analysis and variance expansion factor *** four machine learning methods namely Logistic Regression(LR),Random Forest(RF),Support Vector Machines(SVM),and Extreme Gradient Boosting(XGB),landslide models were *** analysis and evaluation of the model were conducted through statistical indices and receiver operating characteristic(ROC)*** results showed that LR,RF,SVM,and XGB models have good predictive performance for landslide susceptibility,with the area under curve(AUC)values of 0.752,0.965,0.996,and 0.998,*** model had the highest predictive ability,followed by RF model,SVM model,and LR *** frequency ratio(FR)accuracy of LR,RF,SVM,and XGB models was 0.775,0.842,0.759,and 0.822,*** and XGB models were superior to LR and SVM models,indicating that the integrated algorithm has better predictive ability than a single classification algorithm in regional landslide classification problems.

关键词： Landslides susceptibility assessment Machine learning Logistic Regression Random Forest Support Vector Machines XGBoost Assessment model Geological disaster investigation and prevention engineering

基于遗传算法的多无人机塔杆巡检任务分配算法研究

在线全文

学校读者我要写书评

暂无评论

电力与能源 2024年第4期45卷 474-476+528页

作者：吴张傲国网湖北省电力有限公司荆州供电公司

“无人机+巡检车”作为一种新的电力系统巡检方式，受到广泛关注。驻车点的坐标、多无人机巡检所管辖区域内塔杆的分配是决定巡检效率的关键。首先，基于K-means聚类算法找到了所有塔杆坐标的聚类中心，即驻车点坐标；然后，以平均分配... 详细信息

“无人机+巡检车”作为一种新的电力系统巡检方式，受到广泛关注。驻车点的坐标、多无人机巡检所管辖区域内塔杆的分配是决定巡检效率的关键。首先，基于K-means聚类算法找到了所有塔杆坐标的聚类中心，即驻车点坐标；然后，以平均分配无人机巡检时间为目标函数搭建了无人机分配任务数学模型；最后，采用遗传算法优化目标函数，得到了最优无人机巡检任务分配。仿真算例表明，通过该方法分配的无人机的巡检时间十分接近，提高了巡检效率。

关键词：无人机巡检任务分配聚类算法遗传算法

Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2024年第3期37卷 352-363页

作者： Pianpian Zhao Zhimin Ying Chengda Yuan Haisheng zhang ao Dong Jianguo Tao Xiangjiao Yi Mengyuan Yang Wen Jin Weiliang Tian David Karasik Geng Tian Houfeng Zheng The Affiliated Hangzhou First People’s Hospital School of MedicineWestlake UniversityHangzhouZhejiangChina Westlake Laboratory of Life Sciences and Biomedicine HangzhouZhejiangChina Diseases&Population(DaP)Geninfo Lab School of Life SciencesWestlake UniversityHangzhouZhejiangChina Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhouZhejiangChina Department of Orthopedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Dermatology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiangChina Department of Global Statistics Eli Lilly and CompanyBranchburgNew JerseyUSA Azrieli Faculty of Medicine Bar-Ilan UniversitySafedIsrael Binzhou Medical University YantaiShandongChina

Background There is limited evidence suggesting that osteoporosis might exacerbate depressive symptoms,while more studies demonstrate that depression negatively affects bone density and increases fracture *** To explore the relationship between major depressive disorder(MDD)and fracture *** We conducted a nested case-control analysis(32670 patients with fracture and 397017 individuals without fracture)and a matched cohort analysis(16496 patients with MDD and 435492 individuals without MDD)in the same prospective UK Biobank data ***,we investigated the shared genetic architecture between MDD and fracture with linkage disequilibrium score regression and the MiXeR statistical *** used the conditional/conjunctional false discovery rate approach to identify the specific shared *** calculated the weighted genetic risk score for individuals in the UK Biobank and logistic regression was used to confirm the association observed in the prospective *** We found that MDD was associated with a 14%increase in fracture risk(hazard ratio(HR)1.14,95%CI 1.14 to 1.15,p<0.001)in the nested case-control analysis,while fracture was associated with a 72%increase in MDD risk(HR 1.72,95%CI 1.64 to 1.79,p<0.001)in the matched cohort analysis,suggesting a longitudinal and bidirectional ***,genetic summary data suggested a genetic overlap between MDD and ***,we identified four shared genomic loci,with the top signal(rs7554101)near *** protein encoded by SGIP1 is involved in cannabinoid receptor type 1 *** found that genetically predicted MDD was associated with a higher risk of fracture and vice *** addition,we found that the higher expression level of SGIP1 in the spinal cord and muscle was associated with an increased risk of fracture and *** The genetic pleiotropy between MDD and fracture highlights the bidirectional association observed in the epidemiological *** shared ge

关键词： fracture matched osteoporosis

Anti-Inflammatory Glycosaminoglycan Oligosaccharides from Colwellia psychrerythraea 34H Capsule:Synthesis and Biological Evaluation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第7期6卷 1698-1711页

作者： Zhongtang Li Xiaoyu Sun Yuchao Wang ao Sun Linbo Fu Tongtong Geng Zihui zhang Ximin Lv Qian Wang Jing Wang Baodi Gou Xiangbao Meng Zhongjun Li State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191

Capsular polysaccharides(CPS)of Colwellia psychrerythraea 34H consist of linear tetrasaccharides repeating units in a glycosaminoglycan-like *** biological function is likely involved in the cold adaptation of microbial *** low availability of these glycosaminoglycan structures greatly limits the study of their functions and biological ***,an efficient semisynthetic strategy for CPS tetrasaccharide derivatives is achieved by using disaccharide units degraded from hyaluronic *** new synthetic process is suitable for largescale preparation,and several rare tetrasaccharide derivatives containing GalA-GalNAc were readily obtained in high *** evaluation of their anti-inflammatory effects demonstrated that these CPS tetrasaccharides effectively attenuated the lipopolysaccharide-induced sepsis and acute lung injury by decreasing macrophage infiltration and secretion of microphage-related cytokines in *** these results suggest that this new type of CPS tetrasaccharide can be developed as an anti-inflammation agent.

关键词： glycosaminoglycan oligosaccharide glycosylation anti-inflammatory agent acute lung injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数字经济发展与新质生产力的生成逻辑

学术研究 2024年第5期 87-95页

作者：张翱孙久文中共浙江省委党校浙江省“八八战略”创新发展研究院浙江杭州311121 中国人民大学应用经济学院北京100872

全球正在经历数字化革命,以数据作为新型生产要素的数字经济变革传统生产方式,使生产力的突破性发展成为可能。本文将新质生产力作为一个整体概念,通过经济运行的资源配置模式和生产方式变革考察其生成逻辑。数字经济发展形成数据牵引,... 详细信息

全球正在经历数字化革命,以数据作为新型生产要素的数字经济变革传统生产方式,使生产力的突破性发展成为可能。本文将新质生产力作为一个整体概念,通过经济运行的资源配置模式和生产方式变革考察其生成逻辑。数字经济发展形成数据牵引,算法规制和算力驱动的资源配置新模式是生成新质生产力的基本逻辑。在传统生产力基础上,数字经济运行的“数据—算法—算力”机制发挥优化资源配置的作用,通过科技驱动的智能化,将传统生产力转变为新质生产力。在生产关系变化中,数字经济发展带来的规则和制度创新,对新质生产力发展起到促进作用。数字化已经成为摆脱传统经济增长模式和生产力发展路径的关键力量,应围绕数字经济构建新质生产力体系。

关键词：新质生产力数字经济数据要素

高压比离心压气机参数化造型与分流叶片位置优化

在线全文

学校读者我要写书评

暂无评论

工程热物理学报 2024年第4期45卷 1022-1030页

作者：顾云开刘艳张闯张傲刘思琪大连理工大学能源与动力学院大连116024 中国航空工业集团公司金城南京机电液压工程研究中心南京211106

为寻求分流叶片的最佳位置,本文以某跨声速高压比离心叶轮为研究对象,基于自开发带分流叶片离心叶轮参数化造型程序、CFD数值计算、拉丁超立方采样,结合多目标遗传算法进行优化设计。优化结果表明,对于所研究的叶轮,当分流叶片前缘盘侧... 详细信息

为寻求分流叶片的最佳位置,本文以某跨声速高压比离心叶轮为研究对象,基于自开发带分流叶片离心叶轮参数化造型程序、CFD数值计算、拉丁超立方采样,结合多目标遗传算法进行优化设计。优化结果表明,对于所研究的叶轮,当分流叶片前缘盘侧向主叶片压力面偏置,盖侧以近似相等的偏置量向主叶片吸力面偏置;尾缘略向压力面偏置;并且前缘出现后掠角时为分流叶片的最佳位置。该方案的设计点效率提升1.1%,压比提升0.72%。

关键词：离心压气机参数化造型分流叶片周向偏置前缘掠角