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Role and function of granin proteins in diabetes mellitus

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World Journal of Diabetes 2021年第7期12卷 1081-1092页

作者： zoltan Herold Marton Doleschall Aniko Somogyi Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest 1083Hungary Department of Internal Medicine and Hematology Semmelweis UniversityBudapest 1088Hungary Molecular Medicine Research Group Eotvos Lorand Research Network and Semmelweis UniversityBudapest 1089Hungary

The granin glycoprotein family consists of nine acidic proteins;chromogranin A(CgA),chromogranin B(CgB),and secretogranin II–*** are produced by a wide range of neuronal,neuroendocrine,and endocrine cells throughout the human *** major intracellular function is to sort peptides and proteins into secretory granules,but their cleavage products also take part in the extracellular regulation of diverse biological *** contribution of granins to carbohydrate metabolism and diabetes mellitus is a recent research *** is associated with glucose homeostasis and the progression of type 1 ***-14,CgA10-19,and CgA43-52 are peptide derivates of CgA,and act as CD4+or CD8+autoantigens in type 1 diabetes,whereas pancreastatin(PST)and catestatin have regulatory effects in carbohydrate ***,PST is related to gestational and type 2 *** has a crucial role in physiological insulin *** II and III have angiogenic activity in diabetic retinopathy(DR),and are novel targets in recent DR *** studies are beginning to investigate the potential use of granin derivatives as drugs to treat diabetes based on the divergent relationships between granins and different types of diabetes.

关键词： Granin Chromogranin A Chromogranin B Diabetes Mellitus Mice Inbred nonobese diabetic Secretogranin III

Fractal dimension and thermodynamic fluctuation properties of IDV light curves

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Research in Astronomy and Astrophysics 2011年第9期11卷 1031-1045页

作者： Chun-Sing Leung Jian-Yan Wei zoltan Kovlics Tiberiu Harko National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Department of Physics and Center for Theoretical and Computational Physics The University ofHong Kong Pok Fu Lam Road Hong Kong Hong Kong SAR China

Fractals are a basic tool for phenomenologicalty describing natural ob- jects having a high degree of temporal or spatial variability. From a physical point of view the fractal properties of natural systems can also be interpreted by using the standard formalism of thermodynamical fluctuations. We introduce and analyze the fractal dimension of the Intra-Day-Variability （IDV） light-curves of BL Lac objects, in the optical, radio and X-ray bands. A general description of the fluctuation spec- trum of these systems based on general thermodynamical principles is also proposed. Based on the general fractal properties of a given physical system, we also introduce the predictability index for the IDV light curves. We have explicitly determined the fractal dimension for the R-band observations of five blazars, as well as for the ra- dio band observations of the compact extragalactic radio source J 1128＋5925 and of several X-ray sources. Our results show that the fractal dimension of the optical and X-ray observations indicates an almost pure ＂Brownian noise＂（random walk） spectrum, with a very low predictability index, while in the radio band the predictability index is much higher. We have also studied the spectral properties of the IDV light curves and we have shown that their spectral index is very closely correlated with the corresponding fractal dimension.

关键词： galaxies -- quasars: emission lines -- instabilities -- gravitation

A Simple Kinetic Monte Carlo Approach for Epitaxial Submonolayer Growth

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Communications in Computational Physics 2008年第4期3卷 822-833页

作者： Robert Deak zoltan Neda Peter B.Barna Eotvos Lor and University Department of Materials ScienceH-1117 BudapestHungary Babe¸s-Bolyai University Department of Theoretical and Computational PhysicsCluj-NapocaRO-400084Romania Research Institute for Technical Physics and Materials Science H-1525BudapestP.O box 49Hungary

Two-component submonolayer growth on triangular lattice is qualitatively studied by kinetic Monte Carlo *** hopping barrier governing surface diffusion of the atoms is estimated using pair interaction *** degrees of freedoms enhancing the surface diffusion of atoms are also *** main advantages of the presented technique are the reduced number of free parameters and the clear diffusion activated mechanism for the segregation of different types of *** potential of this method is exemplified by reproducing(i)phase-boundary creation and dynamics related to vacancies and stacking faults;(ii)a special co-deposition and segregation process where the segregated atoms of the second component surround the islands formed by the first type of atoms.

关键词： Submonolayer epitaxial growth kinetic Monte Carlo pattern formation twocomponent systems segregation.

Ensemble Transform Sensitivity Method for Adaptive Observations

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Advances in Atmospheric Sciences 2016年第1期33卷 10-20页

作者： Yu ZHANG Yuanfu XIE Hongli WANG Dehui CHEN zoltan TOTH Nanjing University of Information Science and Technology Nanjing 210044 Chinese Academy of Meteorological Science Beijing 100081 Global Systems Division Earth System Research Laboratory NOAA Boulder CO 80305 USA Cooperative Institute for Research in the Atmosphere Colorado State University Fort Collins CO 80523 USA National Meteorological Centr Beijing 100081

The Ensemble Transform（ET） method has been shown to be useful in providing guidance for adaptive observation *** predicts forecast error variance reduction for each possible deployment using its corresponding transformation matrix in an ensemble *** this paper,a new ET-based sensitivity（ETS） method,which calculates the gradient of forecast error variance reduction in terms of analysis error variance reduction,is proposed to specify regions for possible adaptive *** is a first order approximation of the ET;it requires just one calculation of a transformation matrix,increasing computational efficiency（60%-80%reduction in computational cost）.An explicit mathematical formulation of the ETS gradient is derived and *** the ET and ETS methods are applied to the Hurricane Irene（2011） case and a heavy rainfall case for *** numerical results imply that the sensitive areas estimated by the ETS and ET are ***,ETS is much more efficient,particularly when the resolution is higher and the number of ensemble members is larger.

关键词： adaptive observation high impact weather ensemble transform

Pixel super-resolution using wavelength scanning

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Light(Science & Applications) 2015年第1期4卷 22-32页

作者： Wei Luo Yibo Zhang Alborz Feizi zoltan Gorocs Aydogan Ozcan Electrical Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCA 90095USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA

Undersampling and pixelation affect a number of imaging systems, limiting the resolution of the acquired images, whichbecomes particularly significant for wide-field microscopy applications. Various super-resolution techniques have been implemented to mitigate this resolution loss by utilizing sub-pixel displacements in the imaging system, achieved, for example, byshifting the illumination source, the sensor array and/or the sample, followed by digital synthesis of a smaller effective pixel bymerging these sub-pixel-shifted low-resolution images. Herein, we introduce a new pixel super-resolution method that is basedon wavelength scanning and demonstrate that as an alternative to physical shifting/displacements, wavelength diversity can beused to boost the resolution of a wide-field imaging system and significantly increase its space-bandwidth product. We confirmedthe effectiveness of this new technique by improving the resolution of lens-free as well as lens-based microscopy systems anddeveloped an iterative algorithm to generate high-resolution reconstructions of a specimen using undersampled diffraction patterns recorded at a few wavelengths covering a narrow spectrum (10–30 nm). When combined with a synthetic-aperture-baseddiffraction imaging technique, this wavelength-scanning super-resolution approach can achieve a half-pitch resolution of250 nm, corresponding to a numerical aperture of ~ 1.0, across a large field of view (420 mm^(2)). We also demonstrated theeffectiveness of this approach by imaging various biological samples, including blood and Papanicolaou smears. Compared withdisplacement-based super-resolution techniques, wavelength scanning brings uniform resolution improvement in all directionsacross a sensor array and requires significantly fewer measurements. This technique would broadly benefit wide-field imagingapplications that demand larger space-bandwidth products.

关键词： holographic imaging on-chip microscopy pixel super-resolution wavelength scanning wide-field imaging

Partition of Forecast Error into Positional and Structural Components

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Advances in Atmospheric Sciences 2021年第6期38卷 1012-1019页

作者： Isidora JANKOV Scott GREGORY Sai RAVELA zoltan TOTH Malaquías PEÑA Global Systems Laboratory NOAA/OARBoulderCO 80305USA General Atomics Electromagnetic Systems GroupLongmontCO 80501USA Earth Signals and Systems Group EarthAtmospheric and Planetary SciencesMassachusetts Institute of TechnologyCambridgeMA 02139USA Department of Civil and Environmental Engineering University of Connecticut StorrsCT 06269USA

Weather manifests in spatiotemporally coherent *** forecasts hence are affected by both positional and structural or amplitude *** has been long recognized by practicing forecasters(cf.,e.g.,Tropical Cyclone track and intensity errors).Despite the emergence in recent decades of various objective methods for the diagnosis of positional forecast errors,most routine verification or statistical post-processing methods implicitly assume that forecasts have no positional *** Forecast Error Decomposition(FED)method proposed in this study uses the Field Alignment technique which aligns a gridded forecast with its verifying analysis *** total error is then partitioned into three orthogonal components:(a)large scale positional,(b)large scale structural,and(c)small scale error *** use of FED is demonstrated over a month-long MSLP data *** expected,positional errors are often characterized by dipole patterns related to the displacement of features,while structural errors appear with single extrema,indicative of magnitude *** most important result of this study is that over the test period,more than 50%of the total mean sea level pressure forecast error variance is associated with large scale positional *** importance of positional error in forecasts of other variables and over different time periods remain to be explored.

关键词： forecast error orthogonal decomposition positional structural

Missense mutation of a class B heat shock factor is responsible for the tomato bushy root-2 phenotype

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Molecular Horticulture 2022年第1期2卷 51-62页

作者： zoltan Kevei Silva Demetryus Silva Ferreira Cristina Maria Perez Casenave Tomasz Kurowski Fady Mohareb Daniel Rickett Chris Stain Andrew J.Thompson Cranfield Soil and AgriFood Institute College RoadCranfield UniversityBedfordshire MK430ALUK Syngenta Crop Protection Jealott’s Hill International Research CentreBracknellBerkshire RG426EYUK

The bushy root-2(brt-2)tomato mutant has twisting roots,and slower plant *** we used whole genome resequencing and genetic mapping to show that brt-2 is caused by a serine to cysteine(S75C)substitution in the DNA binding domain(DBD)of a heat shock factor class B(HsfB)encoded by *** gene is orthologous to the Arabidopsis SCHIZORIZA gene,also known as *** brt-2 phenotype is very similar to Arabidopsis lines in which the function of AtHsfB4 is altered:a proliferation of lateral root cap and root meristematic tissues,and a tendency for lateral root cap cells to easily *** brt-2 S75C mutation is unusual because all other reported amino acid substitutions in the highly conserved DBD of eukaryotic heat shock factors are dominant negative mutations,but brt-2 is *** further show through reciprocal grafting that brt-2 exerts its effects predominantly through the root genotype even through BRT-2 is expressed at similar levels in both root and shoot *** AtHsfB4 is induced by root knot nematodes(RKN),and loss-of-function mutants of this gene are resistant to RKNs,BRT-2 could be a target gene for RKN resistance,an important trait in tomato rootstock ***&accession numbers SolycHsfB4a-Solyc04g078770.

关键词： Bushy root-2 Genetic mapping HsfB4 Root knot nematode resistance SCHIZORIZA Tomato

Exploration of spatial design issues at backpacker hostels in Budapest＇s historic center： Informality, density, and adaptability

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Frontiers of Architectural Research 2017年第2期6卷 157-168页

作者： Gergely Hory zoltan Major Peter Mullner Melinda Benko Department of Urban Planning and Design Faculty of Architecture Budapest University of Technologyand Economics Muegyetem rakpart. 3 1111 Budapest Hungary

This paper presents a practice-based research to achieve a deeper understanding of the spatial issues related to backpacker tourism, a booming industry in Budapest. The authors designed six backpacker hostels between 2013 and 2015, and of these, four are presently in operation. Hostels are the main infrastructures within the global network of backpacker tourism. Results from the design process revealed that the creation and operation of hostels are significantly influenced by three issues, namely, informality, density, and adaptability. These issues are negotiated on three interconnected tevels： the city, the building, and the interior. The authors developed an experimental structure for dormitory spaces as a conscious reaction to these issues. This experimental structure is presented and evaluated, and further paths of development are formulated based on the results.

关键词： Built environment Design knowledge Historic city center Interior design Backpacker hostels

Microstructural brain abnormalities,affective temperaments,and suicidal behavior in patients with major depression

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 200-214页

作者： Gianluca Serafini Mario Amore zoltan Rihmer Department of Neuroscience RehabilitationOphthalmologyGeneticsMaternal and Child HealthSection of PsychiatryUniversity of Genoa16132 GenoaItaly Department of Clinical and Theoretical Mental Health Semmelweis UniversityBudapestHungary and National Institute of Psychiatry and AddictionsH-1085 BudapestHungary

According to magnetic resonance imaging(MRI)studies,brain white matter(WM)abnormalities have been suggested to play a critical role in the pathogenesis of major depressive disorder(MDD)and related suicidal ***,MRI findings may be limited by low spatial resolution;therefore,an important contribution to the understanding of the role and significance of WM alterations derived by the development of the most recent magnetic resonance techniques,such as diffusion tensor imaging(DTI).Several DTI studies reported an association between altered WM integrity and MDD/suicidal *** WM abnormalities may be located in neural circuits critically implicated in emotional processes and mood regulation resulting in enhanced vulnerability to psychiatric *** abnormalities detected using DTI may contribute to functional deficits and help to clarify the pathophysiological mechanisms underlying MDD as well as suicidal *** a clinical point of view,research also suggested that affective temperaments may play a relevant role in the psychopathological characteristics of mood disorders,clinical trajectory of episodes and polarity,long‑term outcome and ***,only few studies investigated the association between affective temperaments and WM abnormalities and discussed their possible implications in patients with MDD and suicidal *** a comprehensive search of Medline database,the aim of the present study was to critically review the current literature on the association between WM alterations as assessed by MRI and DTI techniques,affective temperaments,MDD and suicidal behavior.

关键词： Affective temperaments major depression microstructural white matter lesions neuroimaging techniques suicidal behavior